Claims
- 1. A method of treating hypertension comprising administering to a host suffering therefrom a therapeutic effective amount of a compound of the formula ##STR10## wherein R.sub.a is independently hydrogen, lower alkyl, lower alkoxy, or halo;
- X is oxygen or sulfur;
- Y is OH or SH, and
- Ar is selected from the group consisting of ##STR11## wherein X' is oxygen or sulfur; R.sub.1 is R.sub.1 ' are each independently lower alkyl; R.sub.2 is CH.sub.2 OH, CHO, or CO.sub.2 R.sub.4 ; R.sub.3 is hydrogen, halo, or a pyrrole group attached at the nitrogen atom and unsubstituted or substituted by lower alkyl, and R.sub.4 is hydrogen or lower alkyl;
- a tautomer thereof and a pharmaceutically acceptable salt thereof.
- 2. A pharmaceutical composition adapted for administration as an antihypertensive agent comprising a therapeutic effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable excipient, diluent or carrier.
- 3. A method of treating hyperaldosteronism comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
- 4. A pharmaceutical composition adapted for administration as an agent for treating hyperaldosteronism comprising a therapeutic effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable excipient, diluent or carrier.
- 5. A method of treating congestive heart failure comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
- 6. A pharmaceutical composition adapted for administration as an agent for treating congestive heart failure comprising a therapeutic effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable excipient, diluent or carrier.
- 7. A method of treating glaucoma comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
- 8. A pharmaceutical composition adapted for administration as an agent for treating glaucoma comprising a therapeutic effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable excipient, diluent or carrier.
Parent Case Info
This is a divisional of U.S. application Ser. No. 899,395 filed Jun. 16, 1992, now U.S. Pat No. 5,210,204.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4618617 |
Yamamoto |
Oct 1986 |
|
5086053 |
Brodin et al. |
Feb 1992 |
|
5100897 |
Allen et al. |
Mar 1992 |
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5102897 |
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Apr 1992 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
899395 |
Jun 1992 |
|