Claims
- 1. A compound of formula I having the structure
- 2. The compound according to claim 1, wherein
A is 18wherein B is carbon or nitrogen; D is oxygen or sulfur; or a pharmaceutically acceptable salt thereof.
- 3. The compound according to claim 1, wherein
A is 19or a pharmaceutically acceptable salt thereof.
- 4. The compound according to claim 1, wherein
A is 20or a pharmaceutically acceptable salt thereof.
- 5. The compound according to claim 1 which is (4′-benzofuran-3-yl-biphenyl-4-yloxy)-acetic acid or a pharmaceutically acceptable salt thereof.
- 6. The compound according to claim 1 which is 2-(4′-benzofuran-3-yl-biphenyl-4-yloxy)-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 7. The compound according to claim 1 which is [4′-(2-bromo-benzofuran-3-yl)-biphenyl-4-yloxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 8. The compound according to claim 1 which is 2-[4′-(2-bromo-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 9. The compound according to claim 1 which is 4′-(2-butyl-benzofuran-3-yl)-biphenyl-4-ol or a pharmaceutically acceptable salt thereof.
- 10. The compound according to claim 1 which is [4′-(2-butyl-benzofuran-3-yl)-biphenyl-4-yloxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 11. The compound according to claim 1 which is 2-[4′-(2-butyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 12. The compound according to claim 1 which is 2-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 13. The compound according to claim 1 which is 2-[4′-(2-butyl-benzo[b]thiophene-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 14. The compound according to claim 1 which is 2-[4′-(2-benzyl-benzo[b]thiophene-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 15. The compound according to claim 1 which is 2-[4′-(2-benzoyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 16. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 17. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 18. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid tromethamine salt
- 19. The compound according to claim 1 which is (2R)- 2-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-propionic acid or a pharmaceutically acceptable salt thereof.
- 20. The compound according to claim 1 which is (R)-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-phenyl-acetic acid or a pharmaceutically acceptable salt thereof.
- 21. The compound according to claim 1 which is (2R)-2-{4′-[2-(4-fluoro-benzyl-benzo[b]thiophene-3-yl)-biphenyl4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 22. The compound according to claim 1 which is (2R)-2-{4′-[2-(4-methoxy-benzyl-benzo[b]thiophene-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 23. The compound according to claim 1 which is [4′-(2-butyl-benzo[b]thiophene-3-yl)-biphenyl-4-yloxy]-phenyl-acetic acid or a pharmaceutically acceptable salt thereof.
- 24. The compound according to claim 1 which is (2R)-2-{4′-[2-(hydroxy-phenyl-methyl)-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 25. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid methyl ester.
- 26. The compound according to claim I which is 2-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-2-methyl-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 27. The compound according to claim 1 which is (2R)-2-{4′-[2-(3,4-dimethoxy-benzyl)-benzo[b]thiophene-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 28. The compound according to claim 1 which is (2R)-2-{4′-[2-{2,4-dimethoxy-benzyl)-benzo[b]thiophene-3-yl)-biphenyl4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 29. The compound according to claim 1 which is (2R) 2-{4′-[2-(2,2-dimethyl-benzo[1,3]dioxo-5-ylmethyl)-benzo[b]thiophene -3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 30. The compound according to claim 1 which is (2R)-2-{4′-[2-(3,4-dihydroxy-benzyl)-benzo[b]thiophene-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 31. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-thiophene-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 32. The compound according to claim 1 which is 3-phenyl-2-[4′-(2-thiazole-2-ylmethyl-benzo[b]thiophene-3-yl)-biphenyl-4-yloxy]-propionic acid or a pharmaceutically acceptable salt thereof.
- 33. The compound according to claim 1 which is (2R)-3-phenyl-2-[4′-(2-pyridin-2-ylmethyl-benzo[b]thiophene-3-yl)-biphenyl-4-yloxy]-propionic acid sodium salt
- 34. The compound according to claim 1 which is (2R)-3-phenyl-2-[4′-(2-pyridin-2-ylmethyl-benzo[b]thiophene-3-yl)-biphenyl-4-yloxy]-propionic acid or a pharmaceutically acceptable salt thereof.
- 35. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-furo[2,3]pyridin-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 36. The compound according to claim 1 which is 4′-(2-benzyl-benzo[b]thiophene-3-yl)-3-bromo-biphenyl-4-ol or a pharmaceutically acceptable salt thereof.
- 37. The compound according to claim 1 which is 4′-(2-benzyl-benzo[b]thiophene-3-yl)-3,5-dibromo-biphenyl-4-ol or a pharmaceutically acceptable salt thereof.
- 38. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-benzo[b]thiophene-3-yl)-3-bromo-biphenyl4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 39. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-benzo[b]thiophene-3-yl)-3,5-dibromo-biphenyl-4-yloxyl-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 40. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-benzo[b]thiophene-3-yl)-4″-methoxy-[1,1′;3′,1″]terphenyl-4′-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 41. The compound according to claim 1 which is [(4,4″-dimethoxy-5′-{2-(phenylmethyl)benzo[b]thien-3-yl]phenyl}[1,1′;3′,1″-terphenyl]-2-yl)oxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 42. The compound according to claim 1 which is [4-(2-benzyl-benzo[b]-thiophen-3-yl)-5′-bromo-4″-methoxy[1,1′;3′,1″-terphenyl]-4′-yl)oxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 43. The compound according to claim 1 which is [4′-(2-benzyl-benzo[b]thiophene-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 44. The compound according to claim 1 which is [4′-(2-benzyl-benzo[b]thiophene-3-yl)-3-bromo-biphenyl-4-yloxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 45. The compound according to claim 1 which is (2S)-[4′-(2-benzyl-benzo[b]thiophene-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-4-phenyl-butyric acid or a pharmaceutically acceptable salt thereof.
- 46. The compound according to claim 1 which is 4-[4′-(2-benzyl-benzo[b]thiophene-3-yl)-3-bromo-biphenyl-4-yloxy]-butyric acid or a pharmaceutically acceptable salt thereof.
- 47. The compound according to claim 1 which is N-{(3R)-3-[4′-(2-benzyl-benzo[b]thiophen-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-3-carboxy-propyl]-phthalamic acid or a pharmaceutically acceptable salt thereof.
- 48. The compound according to claim 1 which is N-{(3R)-3-[4′-(2-benzyl-benzo[b]thiophen-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-3-methoxycarbonyl-propyl]-phthalamic acid or a pharmaceutically acceptable salt thereof.
- 49. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-benzo[b]thiophene-3-yl)-4″-chloro-[1,1′;3′,1″]terphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 50. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-4-phenyl-butyric acid or a pharmaceutically acceptable salt thereof.
- 51. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-benzo[b]-thiophen-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid or a pharmaceutically acceptable salt thereof.
- 52. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid or a pharmaceutically acceptable salt thereof.
- 53. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-benzofuran-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 54. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-benzofuran-3-yl)-3-bromo-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 55. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-benzofuran-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-4-methyl-pentanoic acid or a pharmaceutically acceptable salt thereof.
- 56. The compound according to claim 1 which is 2-[4′-(2-benzyl-benzofuran-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-hexanoic acid or a pharmaceutically acceptable salt thereof.
- 57. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-benzofuran-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-butyric acid or a pharmaceutically acceptable salt thereof.
- 58. The compound according to claim I which is (2S)-2-[4′-(2-benzyl-benzofuran-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-octanoic acid or a pharmaceutically acceptable salt thereof.
- 59. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-benzofuran-3-yl)-4″-methoxy-[1,1′;3′,1″]terphenyl-4′-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 60. The compound according to claim 1 which is [4-(2-benzyl-benz[b]-thiophen-3-yl)-5′-bromo-3″,4″-dimethoxy[1,1′;3′,1″-terphenyl]-4′-yl)oxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 61. The compound according to claim 1 which is [4-(2-benzyl-benzo[b]-thiophen-3-yl)-5′-bromo-3″-methoxy[1,1′;3′,1″-terphenyl]-4′-yl)oxy]- acetic acid or a pharmaceutically acceptable salt thereof.
- 62. The compound according to claim 1 which is [[3,3-dimethoxy-5-[4-[2-(phenylmethyl)benzyl-benzo[b]-thiophen-3-yl)-[1,1′;3′,1″-terphenyl]-4′-yl)oxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 63. The compound according to claim 1 which is [4-(2-benzyl-benzo[b]-thiophen-3-yl)-4″-methoxy[1,1′;3′,1″-terphenyl]-4′-yl)oxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 64. The compound according to claim 1 which is [4-(2-benzyl-benzo[b]-thiophen-3-yl)-3″,4″-dimethoxy[1,1′;3′,1″-terphenyl]-4′-yl)oxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 65. The compound according to claim 1 which is [4-(2-benzyl-benzo[b]-thiophen-3-yl)-3″,4″,5″-trimethoxy[1,1′;3′,1″-terphenyl]-4′-yl)oxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 66. The compound according to claim 1 which is [4-(2-benzyl-benzo[b]-thiophen-3-yl)-[1,1′;3′,1″-terphenyl]-4′-yl)oxy]-acetic acid or a pharmaceutically acceptable salt thereof.
- 67. The compound according to claim 1 which is 4-[4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-yloxymethyl]-benzoic acid or a pharmaceutically acceptable salt thereof.
- 68. The compound according to claim 1 which is (2S)-2-[4′-(1-benzyl-1H-benzimidazol-2-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 69. The compound according to claim 1 which is (2R)-2-[4′-(3-benzyl-3H-imidazol[4,5-b]pyridin-2-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid sodium salt.
- 70. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-4,5-dimethyl-thiophen-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 71. The compound according to claim 1 which is (2R)-2-[4′-(2-benzoyl-benzofuarn-3-yl)-3-nitro-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 72. The compound according to claim 1 which is (2R)-2-[4′-(2-benzyl-benzofuarn-3-yl)-3-nitro-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 73. The compound according to claim 1 which is (2R)-2-{4′-[2-(hydroxy-phenyl-methyl)-benzofuran-3-yl)-3-nitro-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 74. The compound according to claim 1 which is (2S)-2-[4′-(2-benzyl-benzofuarn-3-yl)-3,5-dimethyl-biphenyl-4-yloxy]-3-phenyl-propionic acid or a pharmaceutically acceptable salt thereof.
- 75. The compound according to claim 1 which is (2S)-2-[4′-(5-acetyl-thiophen-2-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid sodium salt.
- 76. A method of treating metabolic disorders mediated by insulin resistance or hyperglycemia in a mammal in need thereof which comprises administering to said mammal, a compound of formula I having the structure
- 77. A method of treating or inhibiting type II diabetes in a mammal in need thereof which comprises administering to said mammal, a compound of formula I having the structure
- 78. A method of modulating glucose levels in a mammal in need thereof which comprises administering to said mammal, a compound of formula I having the structure
- 79. A pharmaceutical composition which comprises a compound of formula I having the structure
Parent Case Info
[0001] This application claims the benefit of U.S. Provisional Application No. 60/113,654, which was converted from U.S. patent application Ser. No. 09/076,205, filed May 12, 1998, pursuant to a petition filed under 37 C.F.R. 1.53(c)(2)(i) on Nov. 24, 1998.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60113654 |
May 1998 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09307972 |
May 1999 |
US |
Child |
09798088 |
Mar 2001 |
US |