Block copolymers and nano micelles comprising the same

Abstract

A block copolymer. The block copolymer has formula A-B-C, wherein A represents polyester, B represents polyamide, and C represents specific molecular groups or metal complexes. The invention also provides a nano micelle and drug carrier including the block copolymer.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

The invention can be more fully understood by reading the subsequent detailed description and examples with references made to the accompanying drawing, wherein:

FIG. 1 shows micelle CMC of the invention.

FIG. 2 shows polymer cytotoxicity of the invention.

FIG. 3 shows a growth inhibition assay for normal and cancer cells of the invention.

Claims

1. A block copolymer having formula A-B-C, wherein A comprises polyester, B comprises polyamide, and C comprises specific molecular groups or metal complexes.

2. The block copolymer as claimed in claim 1, wherein the block copolymer comprises diblock copolymer.

3. The block copolymer as claimed in claim 1, wherein the polyester comprises polylactide (PLA) or derivatives thereof.

4. The block copolymer as claimed in claim 1, wherein the polyamide comprises polyoxazoline (POz) or derivatives thereof.

5. The block copolymer as claimed in claim 1, wherein the specific molecular group recognizes cancer cells.

6. The block copolymer as claimed in claim 1, wherein the specific molecular group comprises folate.

7. The block copolymer as claimed in claim 6, wherein the block copolymer has formula (I)

8. The block copolymer as claimed in claim 7, wherein the initiator for ring-opening polymerization comprises hydrogen, alkyl, or hydroxyl groups.

9. The block copolymer as claimed in claim 7, wherein y/x is 0.1˜1,000.

10. The block copolymer as claimed in claim 1, wherein the specific molecular group comprises antibody.

11. The block copolymer as claimed in claim 1, wherein the metal complex comprises magnetic resonance imaging (MRI) contrast agents.

12. The block copolymer as claimed in claim 11, wherein the MRI contrast agent comprises chelates formed by diethylenetriaminepentaacetic acid (DTPA) and gadolinium ions (Gd3+) or indium (111In).

13. The block copolymer as claimed in claim 12, wherein the chelate formed by diethylenetriaminepentaacetic acid (DTPA) and gadolinium ions (Gd3+) or indium (111In) has a chelating ratio of about 1˜100 wt %.

14. The block copolymer as claimed in claim 12, wherein the block copolymer has formula (II)

15. The block copolymer as claimed in claim 14, wherein the initiator for ring-opening polymerization comprises hydrogen, alkyl, or hydroxyl groups.

16. The block copolymer as claimed in claim 14, wherein b/a is 0.1˜1,000.

17. A nano micelle comprising a plurality of block copolymers as claimed in claim 1 or a plurality of block copolymers comprising specific molecular groups and metal complexes.

18. The nano micelle as claimed in claim 17, wherein the nano micelle has a hydrophobic interior and hydrophilic exterior.

19. The nano micelle as claimed in claim 17, wherein the nano micelle has a diameter of about 10˜1,000 nm.

20. The nano micelle as claimed in claim 17, wherein the nano micelle has a diameter of about 20˜200 nm.

21. The nano micelle as claimed in claim 17, wherein the nano micelle has critical micelle concentration (CMC) of about 0.0001˜1 mg/mL.

22. The nano micelle as claimed in claim 17, wherein the nano micelle has a relaxivity of about 5.0˜6.0(mM·s)−.

23. A nano drug carrier, comprising: a nano micelle as claimed in claim 17; anda drug encapsulated thereinto.

24. The nano drug carrier as claimed in claim 23, wherein the drug comprises water-insoluble drugs.

25. The nano drug carrier as claimed in claim 23, wherein the drug comprises camptothecin, doxorubicin, or derivatives thereof.

26. The nano drug carrier as claimed in claim 23, wherein the nano drug carrier is delivered by oral, transdermal administration, injection, or inhalation.