Claims
- 1. In a blood oxygenation device comprising a means for bringing blood into contact with a gas-permeable support means and a means for conveying oxygenating gas to the other side of the gas-permeable support means, the improvement which comprises: a coating comprising fluoroacylated ethyl cellulose as a gas-permeable coating on said gas-permeable support means and for being in contact with the blood; wherein said fluorinated ethyl cellulose has a calculated chemically combined fluorine content of at least about 10% by weight and a degree of substitution ranging from about 1.0 to about 2.75, and wherein substantially all residual hydroxyls, including ring-substituted hydroxyls, have been converted to fluorinated ester groups of the formula --OCO(CF.sub.2).sub.m CF.sub.3, wherein m is a number ranging from 1 to 6; said fluoroacylated ethyl cellulose containing, at most, trace amounts of residual hydroxyl groups as determined by infrared analysis.
- 2. Device according to claim 1, wherein said fluoroacylated ethyl cellulose has a chemically combined fluorine content of at least about 12% by weight.
- 3. Device according to claim 2, wherein said fluoroacylated ethyl cellulose averages about 0.5 to 1.6 perfluoroalkanoyl ester groups per disaccharide unit, said fluoroacylated ethyl cellulose having an ultimate tensile strength of at least 3000 pounds per square inch, a tensile modulus of at least 15,000 pounds per square inch, and more than twice the permeability to gaseous oxygen of the corresponding non-fluoroacylated ethyl cellulose.
- 4. A blood oxygenation device comprising:
- means for bringing blood of a living animal into contact with a major surface of a gas permeable membrane, and
- means for bringing oxygen gas into contact with the opposite major surface of said gas permeable membrane, said gas permeable membrane comprising an ethyl cellulose derivative which has a degree of substitution ranging from about 1.0 to about 2.75 and wherein substantially all residual hydroxyls, including substantially all ring-substituted hydroxyls, have been converted to fluorinated ester groups of the formula --OCO(CF.sub.2).sub.m CF.sub.3, wherein m is a number ranging from 1 to 6, said ethyl cellulose derivative containing, at most, trace amounts of residual hydroxyl groups as determined by infrared spectroscopic analysis; said ethyl cellulose derivative having a calculated chemically combined fluorine content of at least about 10% by weight.
- 5. A blood oxygenation device according to claim 4, wherein said ethyl cellulose derivative has about 4.4 to about 5.5 ethoxide groups and about 0.5 to about 1.0 perfluorobutyrate groups per disaccharide unit of said ethyl cellulose derivative, said ethyl cellulose derivative having a fluorine content of at least about 12% by weight.
Government Interests
The invention described herein was made in the course of work under a grant or award from the Department of Health, Education, and Welfare.
US Referenced Citations (7)
Foreign Referenced Citations (1)
Number |
Date |
Country |
1,120,373 |
Jul 1968 |
UK |
Non-Patent Literature Citations (1)
Entry |
"Interactions of Materials with Blood", Ch. 3, pp. 73-118, Blood Compatible Synthetic Polymers, Bruck, 1974. |