Claims
- 1. A method for treating a mammal having a condition which presents with low bone mass comprising administering to a mammal having a condition which presents with low bone mass a therapeutically effective amount of a compound of Formula I ##STR29## or a pharmaceutically-acceptable cationic salt thereof wherein Ar is 3-thienyl, 5(C.sub.1 -C.sub.4 alkyl)-2-thienyl, 5(C.sub.1 -C.sub.4 alkyl)-3-thienyl, .alpha.-napthyl, .beta.-napthyl, tropyl, 3,4-methylenedioxyphenyl;
- R is H or methyl;
- W is a single bond or a cis double bond;
- Z is a single bond or a trans double bond; and
- M and Q are each independently carbonyl, ##STR30##
- 2. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- W is a single bond;
- Z is a single bond;
- Q is ##STR31## and Ar is 3,4-methylenedioxyphenyl.
- 3. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- W is a single bond;
- Z is s trans double bond;
- Q is ##STR32## and Ar is 3,4-methylenedioxyphenyl.
- 4. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- W is s cis double bond;
- Z is a single bond;
- Q is ##STR33## and Ar is 3,4-methylenedioxyphenyl.
- 5. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- W is a cis double bond;
- Z is a trans double bond;
- Q is ##STR34## and Ar is 3,4-methylenedioxyphenyl.
- 6. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- W is a single bond;
- Z is a single bond;
- Q is ##STR35## and Ar is 3,4-methylenedioxyphenyl.
- 7. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- W is a single bond;
- Z is a trans double bond;
- Q is ##STR36## and Ar is 3,-methylenedioxyphenyl.
- 8. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- W is a cis double bond;
- Z is a single bond;
- Q is ##STR37## and Ar is 3,4-methylenedioxyphenyl.
- 9. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- W is a cis double bond;
- Z is a trans double bond;
- Q is ##STR38## and Ar is 3,4-methylenedioxyphenyl.
- 10. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- Q is ##STR39## and Ar is 3-thienyl.
- 11. A method as recited in claim 1 wherein
- R is H;
- W is a cis double bond;
- Z is a trans double bond;
- M is carbonyl;
- Q is ##STR40## and Ar is 3-thienyl.
- 12. A method as recited in claim 1 wherein
- R is H;
- M is carbonyl;
- Q is ##STR41## and Ar is 3-thienyl.
- 13. A method as recited in claim 1 wherein
- R is H;
- W is a cis double bond;
- Z is a trans double bond;
- M is carbonyl;
- Q is ##STR42## and Ar is 3-thienyl.
- 14. A method as recited in claim 1 wherein the condition is osteoporosis.
- 15. A method as recited in claim 1 wherein about 0.001 to 100 mg/kg/day of the Formula I compound is administered.
- 16. A method as recited in claim 15 wherein about 0.01 to 10 mg/kg/day of the Formula I compound is administered.
Parent Case Info
This claims the benefit of provisional application U.S. Ser. No. 60/012,413 filed Feb. 28, 1996, the benefit of which is hereby claimed under 37 C.F.R. .sctn.1.78(a)(3).
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3932389 |
Johnson et al. |
Jan 1976 |
|
4097601 |
Schaaf |
Jun 1978 |
|
4621100 |
Lund et al. |
Nov 1986 |
|