Claims
- 1. A method of making a biodegradable porous bone grafting matrix which maintains physical integrity for a period of at least about 3 days after implant and its porosity for about 7-14 days after implant into a physiological environments in which bone replacement is occurring, comprising the steps of:(a) forming a dispersion comprising a biodegradable water-insoluble biopolymer, a water-soluble binder, and particulate calcium phosphate mineral immobilized by said binder or biopolymer; (b) forming said dispersion into a porous matrix; (c) cross-linking said porous matrix.
- 2. A method according to claim 1 wherein said step (b) comprises lyophilizing said dispersion.
- 3. A method according to claim 1 wherein said dispersion further comprises leachable particles and said step (b) comprises drying said dispersion and leaching said particles to form said matrix.
- 4. A method according to claim 1 wherein said dispersion further comprises sublimable particles and said step (b) comprises drying said dispersion and subliming said particles to form said matrix.
- 5. A method according to claim 1 wherein said biodegradable water-insoluble biopolymer comprises mineralized collagen fibrils containing about 30-80% by weight of collagen.
- 6. A method according to claim 1 wherein said binder comprises soluble collagen.
- 7. A method according to claim 1 wherein said mineral comprises hydroxyapatite.
- 8. A method according to claim 1 wherein said mineral consists of particles of a diameter of about five microns or less.
Parent Case Info
This is a divisional of U.S. application Ser. No. 08/633,554, filed Apr. 17, 1996 now U.S. Pat. No. 5,776,193.
The priority is claimed of U.S. provisional application Ser. No. 60/005,523, filed Oct. 16, 1995.
US Referenced Citations (29)
Foreign Referenced Citations (12)
Number |
Date |
Country |
1 271 763 |
Apr 1970 |
GB |
WO 8904646 |
Jun 1989 |
WO |
WO 9001955 |
Mar 1990 |
WO |
WO 9010018 |
Sep 1990 |
WO |
WO 9118558 |
Dec 1991 |
WO |
WO 9220371 |
Nov 1992 |
WO |
WO 9304710 |
Mar 1993 |
WO |
WO 9305808 |
Apr 1993 |
WO |
WO 9305823 |
Apr 1993 |
WO |
WO 9400145 |
Jan 1994 |
WO |
WO 9415653 |
Jul 1994 |
WO |
WO 9508304 |
Mar 1995 |
WO |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/005523 |
Oct 1995 |
US |