BONE REPLACEMENT MATERIAL

Abstract

A bone replacement material that is, in particular, paste-like and is characterized in that particulate calcium carbonate is suspended in an aqueous solution that contains at least one water-soluble hemostatic agent, whereby the aqueous solution contains an amount of the hemostatic agent at which it is isotonic.

Description

EXAMPLE 1

Calcium-L-lactate hydrate (Fluka) was added to and dissolved in 500 ml sterile, pyrogen-free water at 37° C. until the osmolality of the solution was 288 mOsmol as measured using an osmometer. Then, 100 ml of this solution were mixed with 65.0 g calcium carbonate (Fluka). A colorless to light-grey viscous paste was thus produced. 50 g of this paste were placed in a conventional plastic syringe. The paste was easy to dispense from this syringe by actuating the plunger.

EXAMPLE 2

Calcium acetate hydrate (Fluka) was added to and dissolved in 500 ml sterile, pyrogen-free water at 37° C. until the osmolality of the solution was 288 mOsmol as measured using an osmometer. Then, 100 ml of this solution were mixed with 60.0 g calcium carbonate (Fluka). A colorless to light-grey viscous paste was thus produced. 50 g of this paste were placed in a conventional plastic syringe. The paste was easy to dispense from this syringe by actuating the plunger.

Claims

1. Bone replacement material comprising particulate calcium carbonate suspended in an aqueous solution that comprises at least one water-soluble hemostatic agent in an amount of the hemostatic agent that renders the aqueous solution isotonic.

2. Bone replacement material according to claim 1, which comprises 55 to 67 mass percent calcium carbonate.

3. Bone replacement material according to claim 1, wherein the calcium carbonate has a particle size of from 1-50 μm.

4. Bone replacement material according to claim 1, wherein the hemostatic agent is one or more compounds selected from the group consisting of calcium chloride, calcium acetate, calcium lactate and gelatin.

5. Bone replacement material according to claim 1, which further comprises magnesium carbonate and/or magnesium oxide in addition to calcium carbonate.

6. Bone replacement material according to claim 1, which further comprises one or more antibiotics and/or other pharmaceutical agents.

7. Bone replacement material according to claim 1, which has a consistency of paste.

8. Method of repairing or replacing bone comprising apply bone replacement material according to claim 1 to an area where it is desired to repair or replace bone.