BPN14770 Phase 1 Single Ascending Dose Clinical Trial in Healthy Subjects

Information

• Research Project
• 9077367

• ApplicationId

  9077367

• Core Project Number

  U01NS078034

• Full Project Number

  3U01NS078034-04S1

• Serial Number

  078034

• FOA Number

  PA-14-077

• Sub Project Id

• Project Start Date

  9/1/2015 - 9 years ago

• Project End Date

  5/31/2016 - 8 years ago

• Program Officer Name

  CYWIN, CHARLES L

• Budget Start Date

  9/1/2015 - 9 years ago

• Budget End Date

  5/31/2016 - 8 years ago

• Fiscal Year

  2015

• Support Year

  04

• Suffix

  S1

• Award Notice Date

  9/19/2015 - 9 years ago

Organizations

• TETRA DISCOVERY PARTNERS, INC.

DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is an increasing medical burden due to the aging demographics of the US population. The most common form of dementia among older adults, AD affects parts of the brain important for memory formation and retrieval, seriously impairing a person's ability to live independently and cope with daily activities. In collaboration with the NIH Blueprint Neurotherapeutics Program, we seek to develop phosphodiesterase Type 4 (PDE4) allosteric modulators for improving cognition in accordance with the Target Product Profile below. Ideally, the therapeutic will improve cognition in MCI patients and impact AD pathophysiology, thereby slowing conversion to probable AD. Drug PropertiesMinimum Acceptable ResultIdeal ResultPrimary Drug IndicationImprovement of cognition in persons with Mild Cognitive Impairment (MCI) due to probable ADSlowing of conversion from MCI to probable ADPatient PopulationPatients with MCI due to probable AD according to the NIAA/AA working group criteriaPatients with MCI due to probable AD according to the NIAA/AA working group criteriaDelivery ModeOralOralTreatment DurationChronicChronicRegimenOral, once dailyOral, once daily

IC Name

• Activity

  U01

• Administering IC

  NS

• Application Type

  3

• Direct Cost Amount

  676223

• Indirect Cost Amount

  18480

• Total Cost

  694703

• Sub Project Total Cost

• ARRA Funded

  False

• CFDA Code

  853

• Ed Inst. Type

• Funding ICs

  NIA:347351\NINDS:347352\

• Funding Mechanism

  Non-SBIR/STTR RPGs

• Study Section

• Study Section Name

• Organization Name

  TETRA DISCOVERY PARTNERS, INC.

• Organization Department

• Organization DUNS

  967529939

• Organization City

  GRAND RAPIDS

• Organization State

  MI

• Organization Country

  UNITED STATES

• Organization Zip Code

  495033314

• Organization District

  UNITED STATES