Claims
- 1. A compound of the formula ##STR559## or a non-toxic pharmaceutically acceptable salt thereof, wherein D is a residue of the formula ##STR560## is a radical of the formula ##STR561## wherein the dotted line indicates the presence of a double bond in either the 4- or 5-position of the dihydropyridine ring; n is zero, one or two; and each R is independently selected from the group consisting of halo, C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.7 alkoxy, C.sub.2 -C.sub.8 alkoxycarbonyl, C.sub.2 -C.sub.8 alkanoyloxy, C.sub.1 -C.sub.7 haloalkyl, C.sub.1 -C.sub.7 alkylthio, C.sub.1 -C.sub.7 alkylsulfinyl, C.sub.1 -C.sub.7 alkylsulfonyl, --CH.dbd.NOR'" wherein R'" is H or C.sub.1 -C.sub.7 alkyl, and --CONR'R", wherein R' and R", which can be the same or different, are each H or C.sub.1 -C.sub.7 alkyl.
- 2. A compound according to claim 1, wherein D is a residue of the formula ##STR562##
- 3. A compound according to claim 1, wherein n is one and R is located in the 3-position of the diihydropyridine ring.
- 4. A compound according to claim 3, wherein R is --CONH.sub.2.
- 5. The compound according to claim 1, having the formula ##STR563##
- 6. A pharmaceutical composition comprising an effective antidepressant amount of a compound of the formula ##STR564## or a non-toxic pharmaceutically acceptable salt thereof, wherein D is a residue of the formula ##STR565## is a radical of the formula ##STR566## wherein the dotted line indicates the presence of a double bond in either the 4- or 5-position of the dihydropyridine ring; n is zero, one or two; and each R is independently selected from the group consisting of halo, C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.7 alkoxy, C.sub.2 -C.sub.8 alkoxycarbonyl, C.sub.2 -C.sub.8 alkanoyloxy, C.sub.1 -C.sub.7 haloalkyl, C.sub.1 -C.sub.7 alkythio, C.sub.1 -C.sub.7 alkylsulfinyl, C.sub.1 -C.sub.7 alkylsulfonyl, --CH.dbd.NOR'" wherein R'" is H or C.sub.1 -C.sub.7 alkyl, and --CONR'R", wherein R' and R", which can be the same or different, are each H or C.sub.1 -C.sub.7 alkyl; and a non-toxic pharmaceutically acceptable carrier therefor.
- 7. A pharmaceutical composition according to claim 6, formulated as a pharamaceutically acceptable sustained release composition.
- 8. A pharamaceutical composition according to claim 6 wherein, in the compound of formula (I), D is a residue of the formula ##STR567##
- 9. A pharamaceutical composition according to claim 6 wherein, in the compound of formula (I), n is one and R is located in the 3-position of the dihydropyridine ring.
- 10. A pharmaceutical composition according to claim 9 wherein, in the compound of formula (I), R is --CONH.sub.2.
- 11. A pharmaceutical composition according to claim 6, wherein the compound of formula (I) has the formula ##STR568##
- 12. A method for eliciting an antidepressant response in an animal in need thereof, comprising administering to said animal an effective antidepressant amount of a compound of the formula ##STR569## or a non-toxic pharmaceutically acceptable salt thereof, wherein D is a residue of the formula ##STR570## is a radical of the formula ##STR571## wherein the dotted line indicates the presence of a double bond in either the 4- or 5-position of the dihydropyridine ring; n is zero, one or two; and each R is independently selected from the group consisting of halo, C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.7 alkoxy, C.sub.2 -C.sub.8 alkoxycarbonyl, C.sub.2 -C.sub.8 alkanoyloxy, C.sub.1 -C.sub.7 haloalkyl, C.sub.1 -C.sub.7 alkylthio, C.sub.1 -C.sub.7 alkylsulfinyl, C.sub.1 -C.sub.7 alkylsulfonyl, --CH.dbd.NOR'" wherein R'" is H or C.sub.1 -C.sub.7 alkyl, and --CONR'R", wherein R' and R", which can be the same or different, are each H or C.sub.1 -C.sub.7 alkyl.
- 13. A method according to claim 12 wherein, in the compound of formula (I), D is a residue of the formula ##STR572##
- 14. A method according to claim 12 wherein, in the compound of formula (I), n is one and R is located in the 3-position of the dihydropyridine ring.
- 15. A method according to claim 14 wherein, in the compound of formula (I), R is --CONH.sub.2.
- 16. A method according to claim 12, wherein the compound of formula (I) has the formula ##STR573##
Parent Case Info
This application is a divisional of application Ser. No. 07/505,910, filed Apr. 4, 1990, now U.S. Pat. No. 5,082,853, which is divisional of application Ser. No. 07/208,872, filed Jun. 20, 1988, now U.S. Pat. No. 4,933,438, which is a divisional of application Ser. No. 06/785,903, filed Aug. 29, 1985, now U.S. Pat. No. 4,771,059, which is the U.S. national phase of PCT/US85/00236, filed Feb. 15, 1985 and a continuation-in-part of application Ser. No. 06/584,800, filed Feb. 29, 1984, now abandoned.
Non-Patent Literature Citations (1)
Entry |
Thiel, et al., "Chemical Abstracts", vol. 59, 1963, Col. 6389e-6391a. |
Divisions (3)
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Number |
Date |
Country |
Parent |
505910 |
Apr 1990 |
|
Parent |
208872 |
Jun 1988 |
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Parent |
785903 |
Aug 1985 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
584800 |
Feb 1984 |
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