Breath Analysis using Quantum Cascade Lasers

Information

  • Research Project
  • 6990641
  • ApplicationId
    6990641
  • Core Project Number
    R43HL081951
  • Full Project Number
    1R43HL081951-01
  • Serial Number
    81951
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/15/2005 - 19 years ago
  • Project End Date
    3/15/2006 - 19 years ago
  • Program Officer Name
    TAGGART, VIRGINIA
  • Budget Start Date
    9/15/2005 - 19 years ago
  • Budget End Date
    3/15/2006 - 19 years ago
  • Fiscal Year
    2005
  • Support Year
    1
  • Suffix
  • Award Notice Date
    9/13/2005 - 19 years ago
Organizations

Breath Analysis using Quantum Cascade Lasers

[unreadable] DESCRIPTION (provided by applicant): [unreadable] The analysis of components in human breath is a powerful non-invasive technique for the diagnosis and monitoring of asthma, cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The presence of elevated levels of nitric oxide (NO), carbon monoxide (CO), and ethane (C2H6) in the breath have been identified as biomarkers of these diseases, where nitric oxide and carbon monoxide are markers of airway inflammation and ethane is a marker of lipid peroxidation. The simultaneous quantification of these components of breath would be a powerful method to identify and differentiate lung diseases and their severity. Aerodyne Research, Inc. together with Harvard School of Pubic Health proposes to develop a fast response, compact, room temperature, quantum cascade laser based system for the quantitative analysis of multiple species in human breath by infrared absorption. In the Phase I study a novel room temperature cw laser will be characterized and its performance optimized for simultaneous nitric oxide and carbon dioxide monitoring in human breath. Detection limits of room temperature lasers for NO and C2H6 monitoring in a fast response system will be determined. A prototype instrument will be deployed in ongoing asthma studies collecting exhaled breath from human volunteers. These studies will answer key technical questions regarding the design of the instrument prior to more extensive Phase II studies. Relevance: The proposed breath analysis instrument will meet the need in the medical community for an instrument to allow the fast, noninvasive diagnosis and monitoring of patients with lung disease. It will also be a powerful research tool for investigating exposures that initiate and exacerbate asthma and COPD. [unreadable] [unreadable] [unreadable]

IC Name
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
  • Activity
    R43
  • Administering IC
    HL
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    99926
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    838
  • Ed Inst. Type
  • Funding ICs
    NHLBI:99926\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    AERODYNE RESEARCH, INC
  • Organization Department
  • Organization DUNS
    030817290
  • Organization City
    BILLERICA
  • Organization State
    MA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    01821
  • Organization District
    UNITED STATES