Claims
- 1. A method for treating osteoporosis comprising administering an effective amount of a steroid having the formula: ##STR3## wherein R.sub.1 represents O, (H,OH), or two hydrogen atoms;
- R.sub.2 is hydroxy an ether or an ester;
- R.sub.3 is (2-6 C) alkynyl or (2-6 C) alkynyl substituted with hydroxy;
- R.sub.4 is a hydrocarbon group selected from the group consisting of (1-6 C) alkyl, (1-6 C) alkoxy, (2-6 C) alkenyl, (2-6 C) alkynyl, and (2-6 C) alkylidene, said hydrocarbon group being substituted with fluorine with the proviso that R.sub.4 is not difluoro methyl; and
- R.sub.5 is hydrogen or (1-6 C) alkyl.
- 2. A steroid having the formula: ##STR4## wherein R.sub.1 is O;
- R.sub.2 is hydroxy;
- R.sub.3 is ethynyl;
- R.sub.4 is 2-fluoroethyl or 2-fluoroethenyl; and
- R.sub.5 is hydrogen.
- 3. (7.alpha.,11E,17.alpha.)-11-ethylidene-17-hydroxy-7-methyl-19-norpregn-4-en-20-yn-3-one.
Priority Claims (1)
Number |
Date |
Country |
Kind |
93200332 |
Feb 1993 |
WOX |
|
Parent Case Info
This is a division of U.S. Ser. No. 08/791,084, now Pat. No. 5,710,144 filed Jan. 29, 1997, which is a continuation of U.S. Ser. No. 08/464,845, filed Sep. 26, 1995, now abandoned, which is a U.S. National Phase Application of PCT/EP94/00348, filed Feb. 4, 1994.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3325520 |
Baran et al. |
Jun 1967 |
|
3465010 |
Baran et al. |
Sep 1969 |
|
3983144 |
Leemhuis et al. |
Sep 1976 |
|
4292251 |
Overbeek |
Sep 1981 |
|
Foreign Referenced Citations (11)
Number |
Date |
Country |
0136011 |
Apr 1985 |
EPX |
0145493 |
Jun 1985 |
EPX |
0337938 |
Oct 1989 |
EPX |
0461290 |
Dec 1991 |
EPX |
0474374 |
Mar 1992 |
EPX |
3702383 |
Aug 1988 |
DEX |
7216767 |
Dec 1972 |
NLX |
7701384 |
Aug 1978 |
NLX |
8502571 |
Apr 1987 |
NLX |
1190240 |
Nov 1967 |
GBX |
2058564 |
Apr 1981 |
GBX |
Non-Patent Literature Citations (4)
Entry |
A.J. van den Broeck et al., Rec. Trav. Chim. Pays-Bas, 94:2:35-39, 1975. |
J.S. Baran et al., Experientia, 26/7:762-763, 1970. |
H.O. Hoppen et al., Acta Endocrinologica, 115:406-412, 1967. |
E.W. Bergink et al., Journal of Steroid Biochem, 14:175-183, 1980. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
791084 |
Jan 1997 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
464845 |
|
|