Claims
- 1. A method of inhibiting tumor growth in a mammal, said method comprising orally administering a therapeutically effective amount of a composition comprising at least one pharmaceutically acceptable carrier and a taxane having the formula
- 2. The method of claim 1 wherein X3 is 2-thienyl or 3-thienyl.
- 3. The method of claim 1 wherein X3 is 2-furyl or 3-furyl.
- 4. The method of claim 1 wherein R7a is acetoxymethyl, methoxymethyl, phenoxymethyl, ethoxymethyl or methylthiomethyl.
- 5. The method of claim 4 wherein X3 is 2-furyl or 3-furyl.
- 6. The method of claim 4 wherein X3 is 2-thienyl or 3-thienyl.
- 7. A method of inhibiting tumor growth in a mammal, said method comprising orally administering a therapeutically effective amount of a composition comprising at least one pharmaceutically acceptable carrier and a taxane having the formula
- 8. The method of claim 7 wherein R7a is methoxymethyl.
- 9. The method of claim 7 wherein X3 is 2-furyl.
- 10. The method of claim 7 wherein X3 is 2-thienyl.
- 11. A method for preparing a pharmaceutical composition comprising mixing at least one nonaqueous, pharmaceutically acceptable solvent and a taxane having the formula
- 12. The method of claim 11 wherein X3 is 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl or 4-pyridyl, C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl.
- 13. The method of claim 11 wherein R7 is R7aCOO— and R7a is a heterosubstituted methyl wherein the heteroatom is substituted to form a heterocyclo, alkoxy, alkenoxy, alkynoxy, aryloxy, hydroxy, protected hydroxy, oxy, acyloxy, nitro, amino, amido, thiol, ketal, acetal, ester or ether.
- 14. The method of claim 11 wherein X5 is —COX10 and X10 is substituted or unsubstituted phenyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl, or X5 is —COOX10 and X10 is substituted or unsubstituted C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl.
- 15. The method of claim 11 wherein X3 is 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl or 4-pyridyl, C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl, R7 is R7aCOO— and R7a is a heterosubstituted methyl wherein the heteroatom is substituted to form a heterocyclo, alkoxy, alkenoxy, alkynoxy, aryloxy, hydroxy, protected hydroxy, oxy, acyloxy, nitro, amino, amido, thiol, ketal, acetal, ester or ether.
- 16. The method of claim 11 wherein X3 is 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl or 4-pyridyl, C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl, X5 is —COX10 and X10 is substituted or unsubstituted phenyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl, or X5 is —COOX10 and X10 is substituted or unsubstituted C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl.
- 17. The method of claim 11 wherein R7 is R7aCOO—, R7a is a heterosubstituted methyl wherein the heteroatom is substituted to form a heterocyclo, alkoxy, alkenoxy, alkynoxy, aryloxy, hydroxy, protected hydroxy, oxy, acyloxy, nitro, amino, amido, thiol, ketal, acetal, ester or ether, X5 is —COX10 and X10 is substituted or unsubstituted phenyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, C1 - C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl, or X5 is —COOX10 and X10 is substituted or unsubstituted C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl.
- 18. The method of claim 11 wherein X3 is 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl, R7 is R7aCOO—, R7a is a heterosubstituted methyl wherein the heteroatom is substituted to form a heterocyclo, alkoxy, alkenoxy, alkynoxy, aryloxy, hydroxy, protected hydroxy, oxy, acyloxy, nitro, amino, amido, thiol, ketal, acetal, ester or ether, X5 is —COX10 and X10 is substituted or unsubstituted phenyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl, or X5 is —COOX10 and X10 is substituted or unsubstituted C1-C8 alkyl, C2-C8 alkenyl, or C2-C8 alkynyl.
- 19. The method of claim 13 wherein X3 is 2-furyl, 3-furyl, 2-thienyl or 3-thienyl.
- 20. The method of claim 14 wherein X3 is 2-furyl, 3-furyl, 2-thienyl or 3-thienyl.
- 21. The method of claim 19 wherein R7 is R7aCOO— and R7a is a heterosubstituted methyl wherein the heteroatom is substituted to form an alkoxy or acyloxy.
REFERENCE TO RELATED APPLICATION
[0001] This application is a continuation of U.S. Ser. No. 09/766,393 filed Feb. 2, 2001 which claims priority from U.S. provisional application Serial No. 60/179,672, filed on Feb. 2, 2000.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60179672 |
Feb 2000 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09776393 |
Feb 2001 |
US |
Child |
10720826 |
Nov 2003 |
US |