Claims
- 1. A method to treat a condition selected from the group consisting of pain, stroke, epilepsy, anxiety and depression in a subject, which method comprises administering to a subject in need of such treatment an amount of a compound of formula (1) effective to treat said condition wherein said compound of formula (1) is:
- 2. The method of claim 1 wherein each of R1, R2, R4 and R5 is independently halo, or is optionally heteroatom containing and/or optionally substituted alkyl, alkenyl, aryl, arylalkyl, arylalkenyl, or phenoxy.
- 3. The method of claim 1 wherein R1 and R2 and/or R4 and R5 form a bridge of 1-3 members.
- 4. The method of claim 1 wherein R3 is COOH or an alkyl ester thereof.
- 5. The method of claim 1 wherein all of n1-n5 are 0.
- 6. The method of claim 1 wherein one of n1-n5 is 1 and the other n are 0.
- 7. The method of claim 1 wherein one of n1-n5 is 2 and the other n are 0.
- 8. The method of claim 1 wherein one of n1-n5 is 3 and the other n are 0.
- 9. The method of claim 1 which is compound P1-P36 in FIG. 1 or a salt thereof.
- 10. The method of claim 1 wherein the condition is pain.
- 11. The method of claim 1 wherein the condition is stroke.
- 12. The method of claim 1 wherein the condition is epilepsy.
- 13. The method of claim 1 wherein the condition is anxiety or depression.
- 14. The method of claim 5 wherein the condition is pain.
- 15. The method of claim 5 wherein the condition is stroke.
- 16. The method of claim 5 wherein the condition is epilepsy.
- 17. The method of claim 5 wherein the condition is anxiety or depression.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation-in-part of U.S. Ser. No. 10/060,900 filed 29 Jan. 2002, which is a continuation of U.S. Ser. No. 09/476,927 filed 30 Dec. 1999, now U.S. Pat. No. 6,387,897; which is a continuation-in-part of U.S. Ser. No. 09/401,699, filed 23 Sep. 1999, now U.S. Pat. No. 6,294,533; which is a continuation-in-part of U.S. Ser. No. 09/107,037 filed 30 Jun. 1998, now U.S. Pat. No. 6,011,035. The contents of these applications are incorporated herein by reference.
Continuations (2)
|
Number |
Date |
Country |
Parent |
10409763 |
Apr 2003 |
US |
Child |
10746932 |
Dec 2003 |
US |
Parent |
09476927 |
Dec 1999 |
US |
Child |
10060900 |
Jan 2002 |
US |
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
10060900 |
Jan 2002 |
US |
Child |
10409763 |
Apr 2003 |
US |
Parent |
09401699 |
Sep 1999 |
US |
Child |
09476927 |
Dec 1999 |
US |
Parent |
09107037 |
Jun 1998 |
US |
Child |
09401699 |
Sep 1999 |
US |