Claims
- 1. A method of producing a porous calcium phosphate material, comprising:
forming a mixture of calcium ions and phosphate ions having a calcium to phosphorus ratio of 0.1 to 1.67; heating said mixture to an appropriate reaction temperature; and cooling the reaction mixture, such that a porous calcium phosphate material is produced.
- 2. The method of claim 1, wherein said appropriate reaction temperature is about 5° C. to 150° C. below the melting point of the mixture.
- 3. The method of claim 1, further comprising preheating said mixture to 400° C. to 760° C. for at least 1 second.
- 4. The method of claim 3, wherein said mixture is preheated to 400° C. to 760° C. for at least 1 second two or more times.
- 5. The method of claim 1, further comprising compressing said mixture to a pressure of 10,000 psi.
- 6. The method of claim 1, wherein said ratio of calcium to phosphate ions is about 0.40 to about 0.60.
- 7. A surgical implant comprising a calcium phosphate material produced by the method of claim 1.
- 8. A calcium phosphate material produced by the method of claim 1.
- 9. A method of producing a porous calcium phosphate material comprising:
forming a mixture of calcium ions and phosphate ions; adding a gas-generating material to said mixture; heating said mixture an appropriate reaction temperature; and cooling said mixture such that a solid, porous calcium phosphate material, is produced.
- 10. The method of claim 9, wherein said gas-generating material is a source of ammonium ions selected from the group consisting of ammonium carbonate, ammonium bicarbonate, ammonium acetate, ammonium hydroxide, ammonium nitrates, ammonium sulfates, ammonium hydrogenphosphate, ammonium dihydrogenphosphate, ammonium fluorophosphates, ammonium citrate, ammonium hydrogencitrate, ammonium hydrogen difluoride, ammonium hydrogen oxalate hemihydrate, ammonium halides, ammonium salts, ammonia anhydride, ammonia solutions, and combinations thereof.
- 11. A surgical implant comprising a calcium phosphate material produced by the method of claim 9.
- 12. A calcium phosphate material produced by the method of claim 9.
- 13. A method of producing a porous calcium phosphate material comprising:
mixing a gas-generating material and a calcium phosphate ceramic precursor; heating said mixture to below the sintering temperature to generate a gas; and sintering the calcium phosphate ceramic precursors to make solid ceramic materials, such that a porous calcium phosphate material is produced.
- 14. The method of claim 13, wherein said calcium phosphate ceramic precursor is monocalcium phosphate hydrate (MCP), dicalcium phosphate hydrate (DCPD), dicalcium phosphate anhydrous (DCPA), octacalcium phosphate pentahydrate (OCP), tricalcium phosphate (TCP), alpha and beta from (hydroxyapatite), pentacalcium hydroxylphosphate (HAP), tetracalcium phosphate monoxide (TCPM), calcium pyrophosphate, calcium metaphosphates, polycalcium metaphospates, or combinations thereof.
- 15. A method of producing a porous calcium phosphate material comprising subliming a chemical in a reactive calcium phosphate mixture precursor, and reacting the reactive calcium phosphate mixture, to produce a porous calcium phosphate material.
- 16. A method of producing a porous calcium phosphate material comprising subliming a chemical in one or more calcium phosphate ceramic precursor and sintering the calcium phosphate precursor, to produce a porous calcium phosphate material.
- 17. A calcium phosphate material, wherein said material is synthetic and comprises pores, wherein said pores have an average size between about 20 μm and about 200 μm.
- 18. The calcium phosphate material of claim 17, wherein said material has a bulk density of about 1.0 gm/cm3 to about 2.5 gm/cm3.
- 19. The calcium phosphate material of claim 17, wherein said material has a porosity of about between about 20% and about 80%.
- 20. The calcium phosphate material of claim 17, wherein said material has interconnected pores.
- 21. The calcium phosphate material of claim 17, wherein said material has a compression strength of about 10,000 psi or greater.
- 22. A method of treating a bone disorder in a subject, comprising applying a calcium phosphate material, to a bone of said subject, such that said bone disorder of said subject is treated, wherein said material is porous and synthetic.
- 23. A calcium phosphate material, comprising the calcium salt of:
RELATED APPLICATIONS
[0001] This application claims priority to U.S. Provisional Application Serial No.: 60/342,622, filed Dec. 21, 2001, entitled “Calcium Phosphate Bone Replacement Materials and Methods of Use Thereof.” The entire contents of the aforementioned application are hereby incorporated herein by reference in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
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60342622 |
Dec 2001 |
US |