Claims
- 1. A calcium phosphate cement comprising calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
- 2. The calcium phosphate cement according to claim 1, wherein said calcium phosphate particles have a diameter of 0.2 to 80 microns.
- 3. The calcium phosphate cement according to claim 1, wherein said whiskers or fine crystals have a width ranging from 2 to 70 nm and a length ranging from 5 to 800 nm.
- 4. The calcium phosphate cement according to claim 3, wherein said calcium phosphate particles have a diameter of 0.5 to 50 microns.
- 5. The calcium phosphate cement according to claim 4, wherein said whiskers or fine crystals have a length ranging from 10 to 700 nm.
- 6. The calcium phosphate cement according to claim 1, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.5 to 2.5.
- 7. The calcium phosphate cement according to claim 3, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.5 to 2.5.
- 8. The calcium phosphate cement according to claim 4, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.5 to 2.5.
- 9. The calcium phosphate cement according to claim 5, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.5 to 2.5.
- 10. The calcium phosphate cement according to claim 3, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.8 to 2.3.
- 11. The calcium phosphate cement according to claim 4, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.8 to 2.3.
- 12. The calcium phosphate cement according to claim 5, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.8 to 2.3.
- 13. The calcium phosphate cement according to claim 3, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 1.0 to 2.2.
- 14. The calcium phosphate cement according to claim 4, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 1.0 to 2.2.
- 15. The calcium phosphate cement according to claim 5, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 1.0 to 2.2.
- 16. A method of treating a born or a tooth having a defect in a patient, comprising mixing a calcium phosphate cement and a hardening-promoter-containing aqueous solution to form a paste, and a) injecting said paste into a bone defect or a bone cavity of said patient or b) shaping said paste and implanting the resulting shaped paste into a bone defect or a bone cavity of said patient, wherein said calcium phosphate cement comprises calcium phosphate particles having a diameter of 0.05 to 100 microns, and said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
- 17. The method according to claim 16, wherein said hardening-promoter-containing aqueous solution is an aqueous solution comprising phosphate ions, calcium ions, fluorine ions, or phosphate ions together with fluorine ions as a hardening promoter.
- 18. The method according to claim 17, wherein said hardening-promoter-containing aqueous solution has 1 mM -3 M of said hardening promoter.
- 19. The method according to claim 18, wherein said hardening-promoter-containing aqueous has 10 mM -1 M of said hardening promoter.
- 20. The method according to claim 16, wherein said calcium phosphate particles have a diameter of 0.2 to 80 microns, and said whiskers or fine crystals have a width ranging from 2 to 70 nm and a length ranging from 5 to 800 nm.
- 21. The method according to claim 20, wherein said calcium phosphate particles have a diameter of 0.5 to 50 microns, and said whiskers or fine crystals have a length ranging from 10 to 700 nm.
- 22. The method according to claim 20, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.5 to 2.5.
- 23. The method according to claim 21, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.5 to 2.5.
- 24. The method according to claim 22, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.8 to 2.3.
- 25. The method according to claim 23, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.8 to 2.3.
- 26. The method according to claim 24, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 1.0 to 2.2.
- 27. The method according to claim 25, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 1.0 to 2.2.
- 28. A process for preparing a calcium phosphate cement comprising mixing a calcium phosphate powder or small pieces of calcium phosphate with a wetting agent, and controlling growth of whiskers or fine crystals on surfaces of said calcium phosphate powder or small pieces of calcium phosphate by a controlling treatment.
- 29. The process according to claim 28 further comprising grinding the resulting product from the controlling treatment to form calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said whiskers or fine crystals have a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
- 30. The process according to claim 29, wherein said calcium phosphate particles have a diameter of 0.2 to 80 microns, and said whiskers or fine crystals have a width ranging from 2 to 70 nm and a length ranging from 5 to 800 nm.
- 31. The process according to claim 30, wherein said calcium phosphate particles have a diameter of 0.5 to 50 microns, and said whiskers or fine crystals have a length ranging from 10 to 700 nm.
- 32. The process according to claim 28, wherein said wetting agent is an aqueous solution containing more than 20 ppm of phosphoric acid or phosphate.
- 33. The process according to claim 32, wherein said wetting agent is an aqueous solution containing more than 50 ppm of phosphoric acid or phosphate.
- 34. The process according to claim 33, wherein said wetting agent is an aqueous solution containing more than 100 ppm of phosphoric acid or phosphate.
- 35. The process according to claim 28, wherein said controlling treatment is a vacuuming treatment, an organic solvent treatment, a microwave treatment or a heating treatment.
- 36. The process according to claim 32, wherein said controlling treatment is a vacuuming treatment, an organic solvent treatment, a microwave treatment or a heating treatment.
- 37. The process according to claim 33, wherein said controlling treatment is a vacuuming treatment, an organic solvent treatment, a microwave treatment or a heating treatment.
- 38. The process according to claim 34, wherein said controlling treatment is a vacuuming treatment, an organic solvent treatment, a microwave treatment or a heating treatment.
- 39. The process according to claim 38, wherein said calcium phosphate powder or said small pieces of calcium phosphate are soaked with said wetting agent, and said controlling treatment is a heating treatment comprising drying the resulting soaked calcium phosphate powder or soaked small pieces of calcium phosphate at a temperature higher than 45° C.
- 40. The process according to claim 38, wherein said calcium phosphate powder or said small pieces of calcium phosphate are soaked with said wetting agent, and said controlling treatment is a vacuuming treatment comprising drying the resulting soaked calcium phosphate powder or soaked small pieces of calcium phosphate under vacuum.
- 41. The process according to claim 38, wherein said calcium phosphate powder or said small pieces of calcium phosphate are soaked with said wetting agent, and said controlling treatment is a microwave treatment comprising drying the resulting soaked calcium phosphate powder or soaked small pieces of calcium phosphate by microwave heating.
- 42. The process according to claim 38, wherein said controlling treatment is an organic solvent treatment comprising mixing the mixture of said wetting agent and said calcium phosphate powder or small pieces of calcium phosphate with a water miscible organic solvent, and drying the resulting mixture under vacuum.
- 43. The process according to claim 29, wherein said calcium phosphate particles have a molar ratio of calcium to phosphate ranging from 0.5 to 2.5.
- 44. The method according to claim 16, wherein said calcium phosphate cement further comprises a growth factor, a bone morphology protein or a pharmaceutical carrier.
- 45. The method according to claim 17, wherein said hardening-promoter-containing aqueous solution further comprises a growth factor, a bone morphology protein or a pharmaceutical carrier.
RELATED APPLICATION
[0001] This application is a continuation-in-part and claims the benefit of priority under 35 USC §120 of U.S. application Ser. No. 09/615,384, filed Jul. 13, 2000. The disclosure of the prior application is considered part of and is incorporated by reference in the disclosure of this application.
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09615384 |
Jul 2000 |
US |
Child |
10414582 |
Apr 2003 |
US |