Cannabinergic Receptor Antagonists for Nicotine Addiction

Information

  • Research Project
  • 8713752
  • ApplicationId
    8713752
  • Core Project Number
    R43DA036982
  • Full Project Number
    1R43DA036982-01A1
  • Serial Number
    036982
  • FOA Number
    PA-13-234
  • Sub Project Id
  • Project Start Date
    7/1/2014 - 9 years ago
  • Project End Date
    12/31/2015 - 8 years ago
  • Program Officer Name
    SHIH, MING L
  • Budget Start Date
    7/1/2014 - 9 years ago
  • Budget End Date
    12/31/2015 - 8 years ago
  • Fiscal Year
    2014
  • Support Year
    01
  • Suffix
    A1
  • Award Notice Date
    5/30/2014 - 10 years ago
Organizations

Cannabinergic Receptor Antagonists for Nicotine Addiction

DESCRIPTION (provided by applicant): Existing evidence in animals and man indicates that blockade of the CB1 receptor may offer an effective approach for combating nicotine addiction. Early studies in humans have documented these effects. This Phase I application proposes studies to design advanced CB1 pyrrolidinone antagonists toward the development of medications for smoking cessation. Our intention is to: 1) develop CB1 antagonists with limited inverse agonist or neutral antagonist activity and 2) to characterize their ability to attenuate th effects of nicotine in behavioral screening assays in rats that can be conducted within the limits of a Phase I program. We expect to forward the most successful compounds from Phase I into Phase II studies, in which we shall pursue a more detailed lead optimization program, characterize compounds for side-effect liability, and evaluate their ability to reduce addiction-related effects of nicotine in established, addiction-related, self- administration studies in nonhuman primates. Such Phase II studies should lead to one pre-clinical candidate and 2-3 back-ups.

IC Name
NATIONAL INSTITUTE ON DRUG ABUSE
  • Activity
    R43
  • Administering IC
    DA
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    221844
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    279
  • Ed Inst. Type
  • Funding ICs
    NIDA:221844\
  • Funding Mechanism
    SBIR-STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    MAKSCIENTIFIC, LLC
  • Organization Department
  • Organization DUNS
    155844017
  • Organization City
    Watertown
  • Organization State
    MA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    024710188
  • Organization District
    UNITED STATES