Claims
- 1. A method for treating a respiratory disease in a mammal comprising administering to said mammal a therapeutically effective amount of at least one compound, or salt or hydrate thereof, in which the at least one compound is a cannabinoid receptor modulator.
- 2. The method of claim 1 in which the at least one compound, or salt or hydrate thereof, is a CB2 receptor modulator for blocking or substantially blocking the activation of lung epithelial cells to treat the respiratory disease.
- 3. The method of claim 2, in which the respiratory disease is selected from chronic pulmonary obstructive disorder, emphysema, asthma, and bronchitis.
- 4. A method of treating a respiratory or non-respiratory leukocyte-activation associated disease in a mammal comprising administering to said mammal an effective amount of at least one cannabinoid receptor modulator having the formula (I):
- 5. The method of claim 4, in which the cannabinoid receptor modulator has the formula:
- 6. The method of claim 4, in which the cannabinoid receptor modulator has the formula:
- 7. A compound having the formula:
- 8. The compound of claim 7 having the formula:
- 9. The compound according to claim 8, having the formula:
- 10. The compound according to claim 9, or a pharmaceutically-acceptable salt or hydrate thereof, in which:
R2 is hydrogen; R5 is hydrogen, methyl, or ethyl; R14 is hydrogen; R17 is benzyl and R18 is CO2R19; or R17 and R18together form a five-to-eight membered cycloalkyl or bicycloalkyl optionally substituted with one to four C1-4alkyl; R19 is hydrogen or C1-4alkyl; and n is 1.
- 11. The compound of claim 7 having the formula (i) or (ii):
- 12. The compound of claim 11 having the formula (iii) or (iv):
- 13. The compound according to claim 7, selected from (i)
(3R)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-N-(2,2,6,6-tetramethylcyclohexyl)pyrrolo[1,2,3-de]-1,4-benzoxazine-6-carboxamide; N-[[(3R)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]carbonyl]-L-phenylalanine methyl ester; N-[[(3R)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]carbonyl]-L-tyrosine methyl ester; (3R)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)pyrrolo 1,2,3-de]-1,4-benzoxazine-6-carboxamide; N-[[(3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]carbonyl]-L-phenylalanine methyl ester; (3 S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-N-(2,2,6,6-tetramethylcyclohexyl)pyrrolo[1,2,3-de]-1,4-benzoxazine-6-carboxamide; (3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)pyrrolo[1,2,3-de]-1,4-benzoxazine-6-carboxamide; 2,3,4,5-Tetrahydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-2-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrido[4,3-b]indol-1-one; N-[[5-Fluoro-7-methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-L-phenylalanine methyl ester; 5-Fluoro-7-methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 5-Fluoro-7-methoxy-N-(2-methoxyphenyl)-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indole-3-carboxamide; N-(2-Ethylphenyl)-5-fluoro-7-methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indole-3-carboxamide; 1-[[5-Fluoro-7-methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-1,2,3,4-tetrahydroquinoline; 5,7-Dimethoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 5-Fluoro-7-methoxy-2-methyl-N-[(1R)-1-methylpropyl]-1-[2-(4-morpholinyl)ethyl]-1H-indole-3-carboxamide; 5-Fluoro-7-methoxy-2-methyl-1-[3-(4-morpholinyl)propyl]-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 6,7-Dihydro-7-(4-morpholinylmethyl)-N-[(1S,2S)-1,3,3-trimethylbicyclo [2.2.1]heptan-2-yl]-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide; (2S)-1-[[6,7-Dihydro-7-(4-morpholinylmethyl)-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl]carbonyl]-2-(methoxymethyl)pyrrolidine; N-[[7-Methoxy-2-methyl-1-[3-(4-morpholinyl)propyl]-1H-indol-3-yl]carbonyl]-L-phenylalanine methyl ester; 1-[2-(4-Morpholinyl)ethyl]-5-nitro-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide; 1-[2-(4-Morpholinyl)ethyl]-3-nitro-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-5-carboxamide; 7-Methoxy-2-methyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-2-methyl-1-pentyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-2-methyl-1-[2-(4-piperidyl)ethyl]-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-1-(2-methoxyethyl)-2-methyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-2-methyl-1-(3-pyridinyl-methyl)-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-2-methyl-1-[3-(4-morpholinyl)propyl]-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 1-[2-(Dimethylamino)ethyl]-7-methoxy-2-methyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-2-methyl-1-[2-(1-pyrrolidinyl)ethyl]-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 1-(2-Cyclohexylethyl)-7-methoxy-2-methyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 1-[2-[Bis(1-methylethyl)amino]ethyl]-7-methoxy-2-methyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide 1-(2-Ethoxyethyl)-7-methoxy-2-methyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-2-methyl-1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-2-methyl-1-(2-phenoxyethyl)-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 7-Methoxy-2-methyl-1-[3-(4-methyl-1-piperazinyl)propyl]-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-indole-3-carboxamide; 5-Methoxy-1-[2-(4-morpholinyl)ethyl]-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide; 1-[2-(4-Morpholinyl)ethyl]-5-(pentyloxy)-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide; (2S)-2-(Methoxymethyl)-1-[[1-[2-(4-morpholinyl)ethyl]-5-(pentyloxy)-1H-pyrazol-3-yl]carbonyl]pyrrolidine; 2,5-Dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-2-propyl-1H-pyrido[4,3-b]indol-1-one; 2-Cyclopentyl-2,5-dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-1H-pyrido[4,3-b]indol-1-one; 2,5-Dihydro-6-methoxy-2-(2-methoxyphenyl)-5-[2-(4-morpholinyl)ethyl]-1H-pyrido[4,3-b]indol-1-one; 2,5-Dihydro-6-methoxy-2-(2-methoxyethyl)-5-[2-(4-morpholinyl)ethyl]-1H-pyrido[4,3-b]indol-1-one; 2,5-Dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-2-[(3R)-tetrahydro-3-furanyl]-1H-pyrido[4,3-b]indol-1-one; 2,5-Dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-2-[(1R)-1-methyl-2-phenylethyl]-5H-pyrido[4,3-b]indol-1-one; 2-(2,3-Dihydro-1H-inden-1-yl)-2,5-dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-H-pyrido[4,3-b]indol-1-one; 2-(Bicyclo[2.2.1]heptan-2-yl)-2,5-dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-1H-pyrido[4,3-b]indol-1-one; 2,5-Dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-2-(3,3,5-trimethylcyclo-hexanyl)-1H-pyrido[4,3-b]indol-1-one; 2,5-Dihydro-6-methoxy-3-methyl-5-[2-(4-morpholinyl)ethyl]-2-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrido [4,3-b]indol-1-one; 2-[(2-Fluorophenyl)methyl]-2,5-dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-1H-pyrido[4,3-b]indol-1-one; 2-[(2,6-Dimethylphenyl)-methyl]-2,5-dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-1H-pyrido[4,3-b]indol-1-one; 2,5-Dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-2-[(1R,2R)-1,3,3-trimethylbicyclo[2.2.1]-heptan-2-yl]-1H-pyrido[4,3-b]indol-1-one; 2,5-Dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-2-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrido[4,3-b]indol-1-one; 1,5-Dihydro-1-[2-(4-morpholinyl)ethyl]-5-[(1R,2R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-4H-pyrido[3,2-c]pyridin-4-one; 1,5-Dihydro-5-[(2-methoxyphenyl)methyl]-1-[2-(4-morpholinyl)ethyl]-4H-pyrido[3,2-c]pyridin-4-one; 2,5-Dihydro-6-methoxy-5-(phenylmethyl)-2-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrido[4,3-b]indol-1-one; 5-Butyl-2,5-dihydro-6-methoxy-2-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrido[4,3-b]indol-1-one; 4-Methyl-2,5-dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-2-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrido[4,3-b]indol-1-one; 4-Fluoro-2,5-dihydro-6-methoxy-5-[2-(4-morpholinyl)ethyl]-2-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrido[4,3-b]indol-1-one; 2-Methyl-1-[2-(4-morpholinyl)ethyl]-5-phenyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrrole-3-carboxamide; 2-Methyl-1-[2-(4-morpholinyl)ethyl]-4,5-diphenyl-N-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrrole-3-carboxamide; 1,5-Dihydro-1-[2-(4-morpholinyl)ethyl]-2-phenyl-5-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-4H-pyrido [3,2-c]pyridin-4-one; 1,5-Dihydro-1-[2-(4-morpholinyl)ethyl]-2,3-diphenyl-5-[(1S,2S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-4H-pyrido [3,2-c]pyridin-4-one; 7-Methoxy-1-[2-(4-morpholinyl)ethyl]-N-(2,2,6,6-tetramethylcyclohexyl)-1H-indazole-3-carboxamide; 7-Methoxy-1-[2-(4-morpholinyl)ethyl]-N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-1H-indazole-3-carboxamide; 7-Methoxy-1-[2-(4-morpholinyl)ethyl]-N-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl]-1H-indazole-3-carboxamide; 7-Methoxy-N-[(1S)-1-(2-methyl-2H-tetrazol-5-yl)-2-phenylethyl]-1-[2-(4-morpholinyl)ethyl]-1H-indazole-3-carboxamide; N-[(1S)-1-(Aminocarbonyl)-2-phenylethyl]-7-methoxy-1-[2-(4-morpholinyl)ethyl]-1H-indazole-3-carboxamide; 7-Methoxy-N-[(2-methoxyphenyl)methyl]-1-[2-(4-morpholinyl)ethyl]-1H-indazole-3-carboxamide; 7-Methoxy-N-(2-methoxyphenyl)-1-[2-(4-morpholinyl)ethyl]-1H-indazole-3-carboxamide; 7-Methoxy-N-(2-methoxy-5-methylphenyl)-1-[2-(4-morpholinyl)ethyl]-1H-indazole-3-carboxamide; N-(5-Chloro-2-methoxyphenyl)-7-methoxy-1-[2-(4-morpholinyl)ethyl]-1H-indazole-3-carboxamide; N-(4-Fluorophenyl)-7-methoxy-1-[2-(4-morpholinyl)ethyl]-1H-indazole-3-carboxamide; 7-Methoxy-N-methyl-N-(3-methylphenyl)-1-[2-(4-morpholinyl)ethyl]-1H-indazole-3-carboxamide; N-[[5-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-L-phenylalanine methyl ester; N-[[6-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-L-phenylalanine methyl ester; N-[[7-Hydroxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-L-phenylalaninamide; N-[[2,7-Dimethyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-L-phenylalanine methyl ester; N-[[7-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-L-tyrosine methyl ester; N-[[7-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-3-methyl-L-valine methyl ester; N2-[[7-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-N,N-dimethyl-L-phenylalaninamide; (1S)-N-[1-(Hydroxymethyl)-2-phenylethyl]-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indole-3-carboxamide; N-[[2-Methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-L-phenylalanine methyl ester; N-[[7-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-L-phenylalanine methyl ester; 7-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-indole-3-carboxamide; (αS)-α-[[[7-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]amino]-2-thiophenepropanoic acid methyl ester; N-[[7-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-6-aza-1H-indol-3-yl]carbonyl]-L-phenylalanine methyl ester; N-[[7-Methoxy-1-[2-(4-morpholinyl)ethyl]-1H-indazol-3-yl]carbonyl]-L-phenylalanine methyl ester; 7-Methoxy-1-[2-(4-morpholinyl)ethyl]-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-indazol-3-carboxamide; N-[[7-Methoxy-1-[2-(4-morpholinyl)ethyl]-1H-indazol-3-yl]carbonyl]-R-amphetamide; (αS)-α-[[[7-Methoxy-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]amino]-2-thiazolepropanoic acid methyl ester; 7-Methoxy-2-methyl-N-[(1S)-1-(3-methyl)-tetrazolyl)-2-phenylethyl]-1-[2-(4-morpholinyl)ethyl]-1H-indole-3-carboxamide; 7-Methoxy-2-methyl-N-[(1S)-1-(2-methyl) -tetrazolyl)-2-phenylethyl]-1-[2-(4-morpholinyl)ethyl]-1H-indole-3-carboxamide; N-[[7-Methoxy-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]carbonyl]-L-phenylalanine methyl ester; N-[[7-Methoxy-1-[2-(4-morpholinyl)ethyl]-1H-indazol-3-yl]carbonyl]-1-naphthyl amide; 7-Methoxy-1-[2-(4-morpholinyl)ethyl]-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-indole-3-carboxamide; 2-Methyl-1-[2-(4-morpholinyl)ethyl]-N-(1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-pyrrole-3-carboxamide; 2,5-Dimethyl-N-[(1R)-1-methyl-2-phenylethyl]-1-[2-(4-morpholinyl)ethyl]-1H-pyrrole-3-carboxamide; N-[[2,5-Dimethyl-1-[2-(4-morpholinyl)ethyl]-1H-pyrrol-3-yl]carbonyl]-L-phenylalanine methyl ester; N-[[2-Methyl-1-[2-(4-morpholinyl)ethyl]-1H-pyrrol-3-yl]carbonyl]-L-phenylalanine methyl ester; 2-Methyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenylethyl]-1-[2-(4-morpholinyl)ethyl]-1H-pyrrole-3-carboxamide; N-[[1-[2-(4-Morpholinyl)ethyl]-1H-imidazol-4-yl]carbonyl]-L-phenylalanine methyl ester; N-[[1-(2-Phenoxyethyl)-1H-imidazol-4-yl]carbonyl]-L-phenylalanine methyl ester; and N-[(1-Pentyl-1H-imidazol-4-yl)carbonyl]-L-phenylalanine methyl ester; and (ii) a pharmaceutically-acceptable salt or hydrate thereof.
- 14. A compound having the formula:
- 15. The compound according to claim 14, or a pharmaceutically-acceptable salt thereof, in which
R1 is —CHR17R18; R2 is hydrogen, methyl, ethyl, propyl, or phenyl; R17 and R18 (i) independently of each other are (CH2)s—(CR21R22)v—(CH2)t—W, or (ii) together form a three-to-eight membered cycloalkyl or bicycloalkyl optionally substituted with one to four groups selected from C1-4alkyl, C1-4alkoxy, aryl, cycloalkyl, and heteroaryl, or together form optionally substituted napthyl, tetrahydronapthyl, acenapthyl, dihydroindenyl, pyrazolyl, or benzodioxapinyl; W at each occurrence is selected from —CH3, C1-4alkylthio, C1-4alkoxy, hydroxy, cyano, —CO2H, —CO2C1-4alkyl, —C(═O)N(C1-4alkyl)2, —C(═O)NH(C1-4alkyl), —C(═O)NH(cycloalkyl), —C(═O)H, —C(═O)NH2, —C(═O)C1-4alkyl, —C(═O)N(C1-4alkyl)O(C1-4alkyl), —NH(C═O)C1-4alkyl, —N(C1-4alkyl)(phenyl), —NH(C═O)phenyl, phenyl, imidazole, biphenyl, diphenylC1-4alkyl, pyridine, pyrrolidine, thiophene, pyrazole, imidazole, tetrazole, oxazole, oxadiazole, and napthyl, wherein said group W is optionally substituted with one to four C1-4alkyl, hydroxy, halogen, cyano, C1-4alkoxy, keto, trifluoromethyl, amino, acetylamino, five-or-six membered heterocyclo, three-to-eight membered cycloalkyl, benzyl, or aryl; and R21 and R22 are lower alkyl, hydroxy, or hydroxyalkyl.
- 16. The compound according to claim 14, or a pharmaceutically-acceptable salt thereof, having the formula:
- 17. The compound according to claim 14, or a pharmaceutically-acceptable salt thereof, having the formula:
- 18. A pharmaceutical composition adapted for treating a respiratory disease or non-respiratory leukocyte-activation associated disease in a mammal comprising a therapeutically-effective amount of at least one cannabinoid receptor modulator according to claim 7 and a pharmaceutically-acceptable carrier or diluent.
- 19. A pharmaceutical composition for treating a respiratory disease or non-respiratory leukocyte-activation associated disease in a mammal comprising (i) one or more compounds according to claim 7; (ii) one or more second compounds effective for treating a leukocyte-activation associated disease in a mammal; and (iii) a pharmaceutically-acceptable carrier or diluent.
- 20. A process of preparing a compound according to claim 7 having the formula (Ij):
- 21. A process of producing a compound according to claim 7 having the formula (Ik):
- 22. A process of producing a compound according to claim 7 having the formula (In):
RELATED APPLICATIONS
[0001] This application is related to, and pursuant to 35 U.S.C. § 119(e) claims the benefit of priority of, U.S. application Ser. No. 60/181,818, filed Feb. 11, 2000, the entire contents of which is incorporated herein by refernece.
Provisional Applications (1)
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Number |
Date |
Country |
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60181818 |
Feb 2000 |
US |