Patent Application
20240381800
Genus/species: Cannabis sativa.
Variety denomination: ‘PTC8506V’.
Cannabis plants contain over a hundred known cannabinoids, which bind to endogenous endocannabinoid receptors. Varinolic cannabinoids, as known as varins, are a type of cannabinoid compounds having three carbon atoms in their alkyl side chain instead of the five carbon atom alkyl side chains more commonly associated with cannabinoids. Two such varins are tetrahydrocannabivarin (THCV) and cannabidivarin (CBDV), which are homologues of tetrahydrocannabinol (THC) and cannabidiol (CBD), respectively. Each varin has a unique pharmacological profile and distinct molecular targets.
THCV and CBDV have potential benefits across a broad set of applications. Cannabis plants or extracts with high THCV levels, for example, can be used as an agent for anticonvulsant activity, obesity-associated glucose intolerance, appetite suppression, anxiety management for PTSD, diabetic neuropathy, and major neuropathic and pain related pathologies. Another THCV application is that of an appetite suppressing compound. CBDV has been shown to have anti-epileptic and anticonvulsant activity.
Research and development as well as the sale of varin products has been limited due to low commonly occurring levels of varins in Cannabis flower. The ability to produce Cannabis with high varin levels will create a platform for a new Cannabinoid category with differentiated, high margin products in both medical and recreational markets. The present application solves these problems by providing a novel Cannabis plant having high THCV and low THC levels, which is referred to by the variety name ‘PTC8506V’.
The new variety of Cannabis sativa was created by sourcing Cannabis plants that produce THCV and THC. Crosses were conducted to elevate further THCV, THC and/or other varins. All breeding, cultivation, and chemotype analyses were conducted in Hillsboro, Oregon. ‘PTC8506V’ resulted from the cross of a high THC pollen receiver plant (‘21GAQ-1271’, unpatented) and a high THCV pollen donor plant (‘21VLP5-1-102’, unpatented). ‘21GAQ-1271’ is a clonal variety with a THC content of 22.2%, and a THCV content below the limit of detection (LOD). ‘21VLP5-1-102’ had a THC content of 1.2%, and THCV content of 5.66%. A clone of ‘21VLP5-1-102’ was crossed onto a clone of ‘21GAQ-1271’ in 2021. 32 of the resulting F1 seed were sown. ‘PTC8506V’ was discovered and selected as a single plant from this F1 seed and was subsequently propagated clonally in Hillsboro, OR. ‘PTC8506V’ was asexually reproduced by apical and sub-apical semi-herbaceous stem cuttings in Hillsboro, Oregon for eight cycles. Asexual reproduction has demonstrated that ‘PTC8506V’ reproduces true to type with all of the characteristics, as herein described, and firmly fixed and retained through successive generations of asexual propagation.
The new variety is named ‘PTC8506V’ and is characterized as having elevated levels of THCV and THC.
The following is a detailed description of the new Cannabis variety ‘PTC8506V’.
All breeding, cultivation, and chemotype analyses were conducted in Hillsboro, Oregon.
Cannabis plants having elevated THCV or THC levels were sourced and obtained, and crosses were conducted to produce new varieties to further elevate THCV and THC levels. The plants were crossed to produce new varieties having elevated THCV and THC levels. Plant variety ‘PTC8506V’ was selected and asexually reproduced.
Table 1 describes the general characteristics of ‘PTC8506V’ at 55 days after lighting was changed to 12 hours on/12 hours off.
Table 2 describes the leaf/foliage of ‘PCT8506V’. Color codes are hex color codes.
Table 3 describes the stem of ‘PTC8506V’.
Table 4 describes the inflorescence of ‘PTC8506V’.
Table 5 describes other characteristics of ‘PTC8506V’
Chemical analyses were conducted using High Performance Liquid Chromatography to detect the cannabinoids described herein. Table 6 describes a chemotype analysis of ‘PTC8506V’, which was chemotyped by taking a sample from the main cola at day 56 after initiation of the 12:12 light cycle, which initiates flowering. Trichomes were 70% cloudy and 5% amber, indicative of full maturity at sampling.
