Claims
- 1) A capsule for inhalation which contains as an inhalable powder a mixture of tiotropium with at least one physiologically acceptable excipient, wherein the material forming the capsule has a TEWS or halogen drier moisture of content of less than 15%.
- 2) A capsule for inhalation according to claim 1, wherein the material forming the capsule is selected from gelatine, cellulose derivatives, starch, starch derivatives, chitosan and synthetic plastics.
- 3) A capsule for inhalation according to claim 1, wherein the material forming the capsule is a mixture of gelatine with at least one other additive selected from PEG, glycerol, sorbitol, propyleneglycol, PEO-PPO block copolymer, a polyalcohol and a polyether.
- 4) A capsule for inhalation according to claim 3, wherein the material forming the capsule contains, in addition to gelatine, PEG in an amount of 1-10% by weight.
- 5) A capsule for inhalation according to claim 3, wherein the material forming the capsule contains, in addition to gelatine, PEG in an amount of 3-8% by weight.
- 6) A capsule for inhalation according to claim 3, wherein the material forming the capsule has a TEWS or halogen drier moisture content of less than 12%.
- 7) A capsule for inhalation according to claim 3, wherein the material forming the capsule has a TEWS or halogen drier moisture content of ≦10%.
- 8) A capsule for inhalation according to claim 4, wherein the material forming the capsule has a TEWS or halogen drier moisture content of less than 12%.
- 9) A capsule for inhalation according to claim 4, wherein the material forming the capsule has a TEWS or halogen drier moisture content of ≦10%.
- 10) A capsule for inhalation according to claim 5, wherein the material forming the capsule has a TEWS or halogen drier moisture content of less than 12%.
- 11) A capsule for inhalation according to claim 5, wherein the material forming the capsule has a TEWS or halogen drier moisture content of ≦10%.
- 12) A capsule for inhalation according to claim 2, wherein the material forming the capsule is selected from hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxymethylcellulose and hydroxyethylcellulose.
- 13) A capsule for inhalation according to claim 12, wherein the material forming the capsule has a TEWS or halogen drier moisture content of less than 8%.
- 14) A capsule for inhalation according to claim 12, wherein the material forming the capsule has a TEWS or halogen drier moisture content of ≦5%.
- 15) A capsule for inhalation according to claim 2, wherein the material forming the capsule is selected from polyethylene, polycarbonate, polyester, polypropylene and polyethylene terephthalate.
- 16) A capsule for inhalation according to claim 15, wherein the material forming the capsule is selected from polyethylene, polycarbonate and polyethylene terephthalate.
- 17) A capsule for inhalation according to claim 15, wherein the material forming the capsule has a TEWS or halogen drier moisture content of less than 3%.
- 18) A capsule for inhalation according to claim 15, wherein the material forming the capsule has a TEWS or halogen drier moisture content of ≦1%.
- 19) A capsule for inhalation according to claim 16, wherein the material forming the capsule has a TEWS or halogen drier moisture content of less than 3%.
- 20) A capsule for inhalation according to claim 16, wherein the material forming the capsule has a TEWS or halogen drier moisture content of ≦1%.
- 21) A capsule for inhalation according to claim 1, wherein the inhalable powder contains a mixture of at least one physiologically acceptable excipient with 0.001 to 2% tiotropium.
- 22) A capsule for inhalation according to claim 21, wherein the excipient consists of a mixture of coarser excipient with an average particle size of 15 to 80 μm and finer excipient with an average particle size of 1 to 9 μm, the proportion of finer excipient in the total quantity of excipient being 1 to 20%.
- 23) A capsule for inhalation according to claim 22, wherein the tiotropium is in the form of its chloride, bromide, iodide, methanesulphonate, para-toluenesulphonate or methylsulphate.
- 24) An inhaler suitable for administering inhalable powders containing a capsule for inhalation according to claim 1.
- 25) A method of treating asthma or COPD in a patient in need thereof comprising administering to said patient an inhalable powder using an inhaler according to claim 24.
- 26) A method of making a capsule for inhalation according to claim 1 comprising filling an empty capsule having a TEWS or halogen drier moisture content of less than 15% with a mixture of tiotropium with at least one physiologically acceptable excipient.
Priority Claims (1)
Number |
Date |
Country |
Kind |
101 26 924.2 |
Jun 2001 |
DE |
|
RELATED APPLICATIONS
[0001] Benefit of U.S. Provisional Application Serial No. 60/304,288, filed on Jul. 9, 2001 is hereby claimed, and said application is herein incorporated by reference in its entirety.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60304288 |
Jul 2001 |
US |