Claims
- 1. A compound having the formula Z--B--Y--B'--Z .nHA wherein Y is a bivalent organic radical selected from the group consisting of C.sub.2 -C.sub.12 alkylene, C.sub.5 -C.sub.12 cycloalkylene, C.sub.5 -C.sub.12 cycloalkylenebis(loweralkyl), C.sub.6 -C.sub.12 arylene and loweralkylarylene, C.sub.7 -C.sub.12 aryleneloweralkyl, and C.sub.8 -C.sub.12 arylenebis(loweralkyl); B is a carbamylguanidino group; B' is B; and Z is selected from the group consisting of C.sub.1 -C.sub.12 alkyl; C.sub.3 -C.sub.12 alkenyl; C.sub.3 -C.sub.12 alkynyl; C.sub.3 -C.sub.12 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl; and pharmacologically acceptable addition salts of these compounds with acids represented by nHA wherein n=0, 1/3, 1/2, 2/3, 1, and 2 and HA is an inorganic or organic acid.
- 2. A compound according to claim 1 wherein Y is selected from the group consisting of C.sub.4 -C.sub.8 alkylene, C.sub.5 -C.sub.8 cycloalkylene, C.sub.5 -C.sub.8 cycloalkylenebis(loweralkyl), C.sub.6 -C.sub.8 arylene and loweralkylarylene, C.sub.7 -C.sub.8 aryleneloweralkyl, and C.sub.8 arylenebis(loweralkyl) radicals.
- 3. A compound according to claim 1 wherein Z is selected from the group consisting of C.sub.4 -C.sub.10 alkyl, C.sub.5 -C.sub.9 cycloalkyl, and C.sub.6 -C.sub.9 cycloalkylalkyl radicals.
- 4. A compound according to claim 1 having the formula: ##STR18##
- 5. A compound according to claim 1 having the formula: ##STR19##
- 6. A compound according to claim 5 wherein Y is selected from the group consisting of C.sub.4 -C.sub.8 alkylene, C.sub.5 -C.sub.8 cycloalkylene, C.sub.5 -C.sub.8 cycloalkylenebis(loweralkyl), C.sub.6 -C.sub.8 arylene and loweralkylarylene, C.sub.7 -C.sub.8 aryleneloweralkyl, and C.sub.8 arylenebis(loweralkyl) radicals.
- 7. A compound according to claim 5 wherein Z is selected from the group consisting of C.sub.4 -C.sub.10 alkyl, C.sub.5 -C.sub.9 cycloalkyl, and C.sub.6 -C.sub.9 cycloalkylalkyl radicals.
- 8. A compound according to claim 5 wherein Y is selected from the group consisting of C.sub.4 -C.sub.8 alkylene, C.sub.5 -C.sub.8 cycloalkylene, C.sub.5 -C.sub.8 cycloalkyenebis(loweralkyl), C.sub.6 -C.sub.8 arylene and loweralkylarylene, C.sub.7 -C.sub.8 aryleneloweralkyl, and C.sub.8 arylenebis (loweralkyl) radicals, and Z is selected from the group consisting of C.sub.4 -C.sub.10 alkyl, C.sub.5 -C.sub.9 cycloalkyl, and C.sub.6 -C.sub.9 cycloalkylalkyl radicals.
- 9. A compound according to claim 8 wherein Y is selected from the group consisting of pentamethylene, hexamethylene, heptamethylene, 1,4-cyclohexylenedimethyl, and .alpha.,.alpha.'-m-xylylene radicals and Z is selected from the group consisting of 2-ethylhexyl, 1,3-dimethylpentyl, 1,4-dimethylpentyl, 1,5-dimethylhexyl, and cyclohexylmethyl radicals.
- 10. A compound according to claim 8 wherein Y is C.sub.5 -C.sub.7 polymethylene and Z is 2-ethylhexyl.
- 11. A compound according to claim 1 wherein said acid, HA, is selected from the group consisting of hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid, acetic acid, glycolic acid, 2,3-dihydroxypropionic acid, saccharic acid, gluconic acid, lactobionic acid, maleic acid, fumaric acid, lactic acid, citric acid, malic acid, methanesulfonic acid, and ethanesulfonic acid.
- 12. 1,6-Bis(2-ethylhexylcarbamylguanidino)hexane and pharmacologically acceptable acid addition salts.
- 13. 1,6-Bis(1-adamantylcarbamylguanidino)hexane and pharmacologically acceptable acid addition salts.
- 14. 1,6-Bis(cyclohexylmethylcarbamylguanidino)hexane and pharmacologically acceptable acid addition salts.
RELATED APPLICATIONS
This application is a division of Assignee's copending application Ser. No. 546,549, filed Feb. 3, 1975 now U.S. Pat. No. 4,022,962.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3564041 |
Farrissey et al. |
Feb 1971 |
|
3798269 |
Cutler |
Mar 1974 |
|
4022834 |
Gundersen |
May 1977 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
546549 |
Feb 1975 |
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