Claims
- 1. A pharmaceutical composition for use in treating aggression or psychosis or both which comprises an effective non-toxic antiaggression amount or an effective non-toxic antipsychosis, or an effective amount for treating both aggression and psychosis of a compound 9-[3-(3,5-cis-dimethylpiperazino)propyl] carbazole, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate of a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.
- 2. The pharmaceutical composition of claim 1 wherein the amount of the compound in the composition, calculated as base, is 10 to 300 mg.
- 3. The pharmaceutical composition of claim 1 wherein the amount of the compound present is an effective nontoxic antiaggression amount and the composition is for use in treating aggression.
- 4. A pharmaceutical composition of claim 1 wherein the amount of the compound present is an effective nontoxic antipsychotic amount and is for use in treating psychosis.
- 5. The pharmaceutical composition of claim 4 wherein the amount of the compound in the composition, calculated as base, is 10 to 300 mg.
- 6. The pharmaceutical composition of claim 4 wherein the amount of the compound present is an effective nontoxic antiaggression amount.
- 7. The pharmaceutical composition of claim 1 in which the compound is the mono or dihydrochloride salt.
- 8. The composition of claim 1 in a form for oral administration.
- 9. The composition of claim 1 in which the salt comprises anions selected from the class consisting of hydrochloride, sulphate, tosylate, lactic methanesulphonate, tartrate and maleate.
- 10. The composition of claim 1 in which the salt is the dihydrochloride, succinate, lactate, maleate, and hydrochloride.
- 11. The composition of claim 1 in which the composition comprises said salt and said carrier therefor.
- 12. A pharmaceutical preparation in dosage unit form adapted for administration to obtain an anti-aggressive effect or an anti-psychosis effect, comprising per dosage unit, an anti-aggressive or anti-psychosis effective nontoxic amount of a compound 9-[3-(3,5-cis-dimethylpiperazino) propyl] carbazole, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate of a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent.
- 13. A pharmaceutical preparation in accordance with claim 12 in which the amount is 10 to 900 mg calculated as base.
- 14. A pharmaceutical preparation in accordance with claim 12 in a form adapted for oral or parenteral administration.
- 15. A pharmaceutical preparation in accordance with claim 13 in a form adapted for oral or parenteral administration.
- 16. A pharmaceutical preparation in accordance with claim 12 in the form of a tablet or capsule.
- 17. A pharmaceutical preparation in accordance with claim 13 in the form of a tablet or capsule.
- 18. A pharmaceutical composition in accordance with claim 12 in which the dihydrochloride salt of the compound is the active ingredient.
- 19. A pharmaceutical composition in accordance with claim 13 in which the dihydrochloride salt of the compound is the active ingredient.
- 20. A pharmaceutical composition in dosage unit form adapted for administration to a human to obtain a therapeutic effect comprising from about 10 to 900 mg of a compound 9-[3-(3,5-cis-dimethylpiperazino)propyl] carbazole, or a pharmaceutically acceptable salt thereof and a pharmaceutical diluent.
- 21. The preparation in accordance with claim 20 in which the dihydrochloride salt of the compound is the active ingredient.
- 22. The method of treating aggression in a human which has been identified as exhibiting aggressive symptoms which comprises administering to said human an effective nontoxic antiaggression amount of 9-[3-(3,5-cis-dimethylpiperazino)propyl]-carbazole, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of a pharmaceutically acceptable salt thereof.
- 23. The method of claim 22 in which the amount is 1 to 30 mg/kg of bodyweight calculated as base.
- 24. The method of claim 23 in which the amount is 2 to 5 mg/kg of bodyweight calculated as base.
- 25. The method of claim 22, 23 or 24 in which 9-[3-(3,5-cis-dimethylpiperazino)propyl]carbazole dihydrochloride hemihydrate is administered.
- 26. The method of treating psychosis in a human which has been identified as exhibiting psychotic symptoms which comprises administering to said human an effective nontoxic antipsychotic amount of 9-[3-(3,5-cis-dimethylpiperazino)propyl]carbazole, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of a pharmaceutically acceptible salt thereof.
- 27. The method of claim 26 in which the amount is 1 to 30 mg/kg of bodyweight calculated as base.
- 28. The method of claim 27 in which the amount is 2 to 5 mg/kg of bodyweight calculated as base.
- 29. The method of claim 26 in which the psychosis is schizophrenia and the amount is a nontoxic effective schizophrenia amount.
- 30. The method of claim 27 or 28 in which the psychosis is schizophrenia.
- 31. The method of claim 22 in which the compound is the mono or di-hydrochloride salt.
- 32. The method of claim 22 in which the salt is the dihydrochloride, succinate, lactate, maleate or hydrochloride.
- 33. The method of claim 22 in which an acid addition salt is administered in a pharmaceutically acceptable carrier.
- 34. The method of claim 33 in which the salt is the dihydrochloride salt.
- 35. The method of claim 26 in which an acid addition salt is administered in a pharmaceutically acceptable carrier.
- 36. The method of claim 35 in which the salt is the dihydrochloride salt.
- 37. The method of claim 26 in which the psychosis is mania.
- 38. The method of claim 26 in which the psychosis is senile psychosis.
Priority Claims (1)
Number |
Date |
Country |
Kind |
42845/78 |
Nov 1978 |
GBX |
|
Parent Case Info
This is a division, of application Ser. No. 016,914 filed Mar. 2, 1979.
Foreign Referenced Citations (2)
Number |
Date |
Country |
201630 |
Jan 1956 |
AUX |
1167510 |
Nov 1958 |
FRX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
16914 |
Mar 1979 |
|