Claims
- 1. A carbostyril compound represented by the formula (I): ##STR55## wherein R.sub.1 represents a hydrogen atom, R.sub.2 represents a hydrogen atom, a phenylalkyl group selected from the group consisting of monophenylalkyl and diphenylalkyl groups having a straight or branched chain alkyl group having 1 to 6 carbon atoms in the alkyl moiety, an alkoxyalkyl group having a straight or branched chain alkoxy group of 1 to 6 carbon atoms in the alkoxy moiety thereof and a straight or branched chain alkylene group of 1 to 6 carbon atoms in the alkyl moiety thereof, a mono hydroxyalkyl group having a straight or branched chain alkyl group of 1 to 6 carbon atoms, an alkylcarbonyl group having a straight or branched chain alkyl group of 1 to 6 carbon atoms in the alkyl moiety thereof, or a straight or branched chain alkynyl group having 2 to 7 carbon atoms, R.sub.3 represents a hydrogen atom, and R.sub.4 represents a pyrrolidinoalkyl group having a straight or branched alkylene group of 1 to 6 carbon atoms, a piperazinoalkyl group having a straight or branched alkylene group of 1 to 6 carbon atoms, or a morpholinoalkyl group having a straight or branched alkylene group of 1 to 6 carbon atoms, or R.sub.3 and R.sub.4 can form, when taken together with the nitrogen atom to which they are attached, a piperidino group, a morpholino group, a pyrrolidino group or a piperazino group, said phenylalkyl, pyrrolidinoalkyl, piperazinoalkyl, morpholinoalkyl, piperidino, morpholino, pyrrolidino or piperazino group optionally containing 1 to 3 substituents selected from the class contsisting of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, an alkylenedioxy group of 1 to 2 carbon atoms, a carbamoyl group and a phenyl group, the 3,4-bond of the carbostyril nucleus represents a single bond, and the pharmaceutically acceptable acid additional salts thereof.
- 2. 8-Benzyloxy-5-[2-hydroxy-3-(4-phenylpiperazino)propoxy]-3,4-dihydrocarbostyril according to claim 1.
- 3. 8-Benzyloxy-5-{2-hydroxy-3-[4-(3-chlorophenyl)piperazino]propoxy}-3,4-dihydrocarbostyril according to claim 1.
- 4. 8-(2-Propynyloxy)-5-(2-hydroxy-3-morpholinopropoxy)3,4-dihydrocarbostyril according to claim 1.
- 5. 8-(2-Propynyloxy)-5-(3-pyrrolidino-2-hydroxypropoxy)-3,4-dihydrocarbostyril according to claim 1.
- 6. 8-(2-Propynyloxy)-5-[2-hydroxy-3-(3-morpholinopropylamino)propoxy]-3,4-dihydrocarbostyril according to claim 1.
- 7. 8-(2-Propynyloxy)-5-(2-hydroxy-3-piperidinopropoxy)-3,4-dihydrocarbostyril according to claim 1.
- 8. 8-(2-Propynyloxy)-5-[2-hydroxy-3-(4-phenylpiperazino)propoxy]-3,4-dihydrocarbostyril according to claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
51/28957 |
Mar 1976 |
JPX |
|
51/52498 |
May 1976 |
JPX |
|
CROSS-REFERENCE TO RELATED APPLICATION
This is a Continuation-in-Part Application of the Applicants' Application Ser. No. 778,537 filed Mar. 17, 1977, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4072683 |
Nakagawa et al. |
Feb 1978 |
|
4147869 |
Nakagawa et al. |
Apr 1979 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
778537 |
Mar 1977 |
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