Claims
- 1. A compound of the formula ##STR12## and salts thereof, wherein R.sub.1 is imidazolyl-lower alkylene
- R.sub.2 is hydrogen or lower alkyl;
- R.sub.3 is lower alkyl or phenyl-lower alkylene;
- R.sub.4 is hydroxy, lower alkoxy or hydroxyamino; and n is 1 or 2.
- 2. A compound as in claim 1 wherein n is 1.
- 3. A compound as in claim 1 wherein R.sub.2 is hydrogen or lower alkyl; R.sub.3 is lower alkyl; and R.sub.4 is hydroxy or hydroxyamino.
- 4. A compound as in claim 1 wherein n is 2.
- 5. A compound as in claim 2 wherein R.sub.2 is hydrogen or methyl; R.sub.3 is methyl; and R.sub.4 is hydroxy or hydroxyamino.
- 6. A compound as in claim 4 wherein R.sub.2 is hydrogen or methyl; R.sub.3 is methyl; and R.sub.4 is hydroxy or hydroxyamino.
- 7. A compound as in claim 1 wherein R.sub.4 is hydroxy.
- 8. A compound as in claim 1 wherein R.sub.4 is hydroxyamino.
- 9. A compound as in claim 1 wherein R.sub.1 is 4-imidazolylmethyl.
- 10. A compound as in claim 9 wherein R.sub.2 is hydrogen; R.sub.3 is methyl; R.sub.4 is hydroxy and n is 1.
- 11. A compound as in claim 9 wherein R.sub.2 is hydrogen; R.sub.3 is methyl; R.sub.4 is hydroxyamino and n is 1.
- 12. A compound as in claim 9 wherein R.sub.2 is hydrogen; R.sub.3 is methyl; R.sub.4 is hydroxy and n is 2.
- 13. A compound as in claim 9 wherein R.sub.2 is hydrogen; R.sub.3 is methyl; R.sub.4 is hydroxyamino and n is 2.
- 14. A composition useful in reducing or relieving angiotensin related hypertension in a mammalian specie comprising about 10 to 500 mg. of a compound of claim 1 and a physiologically acceptable vehicle therefor.
Parent Case Info
This is a division, of application Ser. No. 903,288, filed May 4, 1978, which is a division of application Ser. No. 684,605, filed May 10, 1976, now U.S. Pat. No. 4,105,789.
US Referenced Citations (3)
Foreign Referenced Citations (1)
Number |
Date |
Country |
48-4783 |
Feb 1973 |
JPX |
Non-Patent Literature Citations (2)
Entry |
Vasilevskii et al., Trans. from Zh. Org. Khimii, No. 2, 236-241, 1970. |
Berse et al., J. Org. Chem. 27, 3489-3495, 1962. |
Divisions (2)
|
Number |
Date |
Country |
Parent |
903288 |
May 1978 |
|
Parent |
684605 |
May 1976 |
|