Claims
- 1. A compound of the formula ##STR12## and salts thereof, wherein R.sub.1 is hydrogen, lower alkyl, phenyl-lower alkylene, hydroxy-lower alkylene, hydroxyphenyl-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylmercapto-lower alkylene or carbamoyl-lower alkylene;
- R.sub.2 is hydrogen or lower alkyl;
- R.sub.3 is lower alkyl or phenyl-lower alkylene;
- R.sub.4 is hydroxyamino; and n is 1 or 2.
- 2. A compound as in claim 1 wherein n is 1.
- 3. A compound as in claim 1 wherein R.sub.1 is guanidino-lower alkylene, amino-lower alkylene or phenyl-lower alkylene; R.sub.2 is hydrogen or lower alkyl; and R.sub.3 is lower alkyl.
- 4. A compound as in claim 3 wherein n is 2.
- 5. A compound as in claim 2 wherein R.sub.1 is guanidino-propyl, amino-C.sub.3 -C.sub.4 -lower alkylene or phenylmethyl; R.sub.2 is hydrogen or methyl; and R.sub.3 is methyl.
- 6. A compound as in claim 2 wherein R.sub.1 is phenylmethyl; R.sub.2 is hydrogen or methyl; and R.sub.3 is methyl.
- 7. A compound as in claim 6 wherein R.sub.2 is hydrogen.
- 8. A compound as in claim 2 wherein R.sub.1 is aminobutyl; R.sub.2 is hydrogen or methyl; and R.sub.3 is methyl.
- 9. A compound as in claim 8 wherein R.sub.2 is hydrogen.
- 10. A compound as in claim 2 wherein R.sub.1 is guanidinopropyl; R.sub.2 is hydrogen or methyl; and R.sub.3 is methyl.
- 11. A compound as in claim 10 wherein R.sub.2 is hydrogen.
- 12. A compound as in claim 1 wherein n is 2.
- 13. A compound as in claim 1 wherein R.sub.1 is hydroxyphenyl-lower alkylene.
- 14. A compound as in claim 13 wherein R.sub.2 is hydrogen or methyl; and R.sub.3 is methyl.
- 15. A compound as in claim 1 wherein R.sub.1 is p-hydroxyphenylmethyl; R.sub.2 is hydrogen, and R.sub.3 is methyl.
- 16. A compound as in claim 15 wherein n is 2.
- 17. A composition comprising about 10 to 500 mg. of a compound of claim 1 and a physiologically acceptable vehicle therefor.
- 18. A composition comprising about 10 to 500 mg. of the compound of claim 9 and a physiologically acceptable vehicle therefor.
Parent Case Info
This is a division, of application Ser. No. 684,605, filed May 10, 1976, now U.S. Pat. No. 4,105,789.
US Referenced Citations (4)
Divisions (1)
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Number |
Date |
Country |
Parent |
684605 |
May 1976 |
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