Claims
- 1. A process for preparing carboxylic acid derivatives of the formula I ##STR3## where X is OR.sup.2 or NH.sub.2,
- R.sup.1 is C.sub.1 -C.sub.20 -alkyl, C.sub.1 -C.sub.20 -hydroxyalkyl, C.sub.3 -C.sub.12 -cycloalkyl, C.sub.4 -C.sub.12 -alkylcycloalkyl, C.sub.4 -C.sub.12 -cycloalkylalkyl, C.sub.5 -C.sub.20 -alkylcycloalkylalkyl, aryl, C.sub.7 -C.sub.20 -aralkyl, C.sub.7 -C.sub.20 -alkylaryl, a heteroaliphatic or heteroaromatic ring with 5 to 8 carbon atoms and
- R.sup.2 is C.sub.1 -C.sub.20 -alkyl,
- from carbonitriles of the general formula II
- R.sup.1 --C.tbd.N (II),
- where R.sup.1 has the abovementioned meanings, and alcohols of the formula III
- R.sup.2 --OH (III),
- where R.sup.2 has the abovementioned meanings, at from 50 to 300.degree. C. under from 0.1 to 350 bar in the presence of titanium dioxide as a heterogeneous catalyst, wherein the reaction is carried out in liquid phase.
- 2. The process of claim 1, wherein anatase, rutile or mixtures thereof is used as titanium dioxide.
- 3. The process of claim 1, wherein the reaction is carried out at from 100 to 290.degree. C.
- 4. The process of claim 1, wherein the reaction is carried out at from 140 to 270.degree. C.
- 5. The process of claim 1, wherein the reaction is carried out in liquid phase under from 1 to 200 bar.
- 6. The process of claim 1, wherein the reaction is carried out under from 30 to 140 bar.
- 7. The process of claim 1, wherein R.sup.1 is 3-pyridyl, 1-methyl-1-hydroxyethyl, 1-hydroxyethyl or 2-hydroxyethyl.
Priority Claims (1)
Number |
Date |
Country |
Kind |
195 18 474 |
May 1995 |
DEX |
|
Parent Case Info
This application is a 371 of PCT/EP96/01890 filed May 7, 1996
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/EP96/01890 |
5/7/1996 |
|
|
11/10/1997 |
11/10/1997 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO96/36592 |
11/21/1996 |
|
|
US Referenced Citations (4)
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2714767 |
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9616039 |
May 1996 |
WOX |
Non-Patent Literature Citations (1)
Entry |
Chem. Abst., vol. 78, No. 5, 1973. |