Claims
- 1. A method of treating cancer susceptible to compounds of the following formula, in mammals in need of such treatment, comprising administering to said mammal a therapeutically effective amount of a compound of the formula: or a pharmaceutically acceptable salt, or hydrate, wherein:R1 is —COY1 wherein Y1 is hydroxy, (C1-C3)alkoxy, phenoxy, benzyloxy, amino, (C1-C4)alkanoylamino, (C1-C4)alkanesulfonylamino, benzenesulfonylamino, naphthalenesulfonylamino, di[(C1-C4)]aminosulfonylamino or one of the foregoing groups mono- or disubstituted with (C1-C3)alkyl, trifluoromethyl, hydroxy, (C1-C3)alkoxy, fluoro or chloro; R2 and R3 are independently selected from hydrogen, (C1-C10)alkyl, and phenyl; X is O; Y is N; Z is S-methyl, S-propyl or S-octyl; n is one; r is an integer ranging from one to five, the moiety (CH2)r optionally including one or more carbon-carbon double or triple bond when r is an integer of from two to five; and s is an integer of from one to five, the moiety (CH2)s optionally including one or more carbon-carbon double or triple bond when s is an integer of from 2 to 5.
- 2. The method of claim 1, wherein R1 is —COOH.
- 3. The method of claim 1, wherein r is zero, R2 is phenyl and R3 is H.
- 4. The method of claim 1, wherein the compound of formula I is a compound of the formula: wherein Z and n are as defined for formula I.
- 5. The method of claim 4, wherein the compound of formula III is selected from:3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-2-octylsulfanyl-propionic acid; 3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-2-propylsulfanyl-proponic acid.
- 6. A method of treating cancer in mammals in need of such treatment, comprising administering to said mammal a therapeutically effective amount of 3-[2-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-2-octylsulfanyl-propionic acid or a pharmaceutically acceptable salt, or hydrate thereof, wherein said cancer is brain, squamous cell, bladder, gastric, pancreatic, breast, head, neck, oesophageal, prostate, colorectal, lung, renal, gynecological or thyroid cancer.
Parent Case Info
This application is based upon co-pending provisional application No. 60/151,138 filed Aug. 27, 1999.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5089514 |
Hulin |
Feb 1992 |
A |
Non-Patent Literature Citations (1)
Entry |
B. Hulin, J. Med. Chem., 1996, vol. 39: 3897-3907. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/151138 |
Aug 1999 |
US |