Claims
- 1. A pharmaceutical composition suitable for oral administration comprising a pharmaceutically acceptable carrier and an effective blood sugar lowering amount of an oral hypoglycemic agent, said agent being a compound selected from the group consisting of carboxylic acids of the formula: ##STR6## and the lower alkyl esters and unsubstituted amide derivatives thereof, and the base salts of said acids with pharmacologically acceptable cations, wherein
- W is --CH.sub.2 -- or --CH(CH.sub.3)--;
- X is hydrogen or lower alkyl; and
- X.sup.1 is hydrogen, lower alkyl, lower alkoxy or lower phenylalkoxy, with the proviso that when X.sup.1 is other than lower alkyl, X is hydrogen.
- 2. The composition as claimed in claim 1 wherein X and X.sup.1 are each hydrogen and W is --CH.sub.2 --.
- 3. The composition as claimed in claim 1 wherein X is hydrogen, X.sup.1 is lower alkoxy and W is --CH.sub.2 --.
- 4. The composition as claimed in claim 1 wherein X is hydrogen, X.sup.1 is lower phenylalkoxy and W is --CH.sub.2 --.
- 5. The composition as claimed in claim 1 wherein X and X.sup.1 are each hydrogen and W is --CH(CH.sub.3)--.
- 6. The composition as claimed in claim 3 wherein the hypoglycemic agent is 6-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid.
- 7. The composition as claimed in claim 3 wherein the hypoglycemic agent is 6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid.
- 8. The composition as claimed in claim 3 wherein the hypoglycemic agent is 6-ethoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid.
- 9. The composition as claimed in claim 4 wherein the hypoglycemic agent is 6-benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid.
- 10. A method for lowering blood sugar in the treatment of a diabetic host, which comprises orally administering to said host an effective blood sugar lowering amount of a compound selected from the group consisting of carboxylic acids of the formula: ##STR7## and the lower alkyl esters and unsubstituted amide derivatives thereof, and the base salts of said acids with pharmacologically acceptable cations, wherein
- W is --CH.sub.2 -- or --CH(CH.sub.3)--;
- X is hydrogen or lower alkyl; and
- X.sup.1 is hydrogen, lower alkyl, lower alkoxy or lower phenylalkoxy, with the proviso that when X.sup.1 is other than lower alkyl, X is hydrogen.
- 11. The method as claimed in claim 10 wherein the compound administered is 4-methyl-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid.
- 12. The method as claimed in claim 10 wherein the compound administered is 6-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid.
- 13. The method as claimed in claim 10 wherein the compound administered is 6-ethoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid.
- 14. The method as claimed in claim 10 wherein the compound administered is 6-benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid.
Parent Case Info
This is a division of application Ser. No. 199,153, filed on Oct. 21, 1980 now U.S. Pat. No. 4,305,955.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3565904 |
Juby et al. |
Feb 1971 |
|
Non-Patent Literature Citations (2)
Entry |
G. A. Stewart, "Pharmacological Studies on Oral Hypoglycemic Agents," Dtsch.-Eng. Med. Rundsch. (Anglo-German Medical Review), vol. 1, p. 334, (1962). |
S. Ch. Lahiri et al., "Studies on Indan Acids as Potential Oral Hypoglycemic Agents," Journal of the Indian Chemical Society, vol. 53, p. 1041, (1976). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
199153 |
Oct 1980 |
|