Claims
- 1. A carboxymethyl ring-opened mannoglucan or derivative thereof comprising units represented by the formula (XI) or salt thereof: ##STR10## wherein R.sup.35, R.sup.36, R.sup.37, R.sup.38, Y.sup.313, Y.sup.314, Y.sup.315, Y.sup.413, Y.sup.414 and Y.sup.415, which may be the same or different, each represents a hydrogen atom, CH.sub.2 COOH or CH.sub.2 CONR*.sup.1 R*.sup.2, wherein the NR*.sup.1 R*.sup.2 represents a residue formed by removing one hydrogen atom from an amino group of daunorubicin or mitomycin C, or CH.sub.2 COO.multidot.1/2[Pt(NH.sub.3).sub.2 ], wherein Pt represents divalent platinum;
- wherein the degree of substitution is defined as the number of CH.sub.2 COOH and CH.sub.2 CONR*.sup.1 R*.sup.2 groups in the molecule per saccharide residue and is in the range of 0.4 to 1.0.
- 2. The carboxymethyl ring-opened opening-mannoglucan or derivative or salt thereof according to claim 1, which has a molecular weight of 10,000 to 2,000,000.
- 3. The process for preparing a carboxymethyl ring-opened-mannoglucan or derivative or salt thereof according to claim 1, comprising the steps of reacting a mannoglucan comprising tetrasaccharide units represented by the formula (II): ##STR11## wherein R.sup.10 represents a hydrogen atom or CH.sub.2 COOH, with periodic acid or its salt; reacting the reaction product with sodium borohydride and reacting the reaction product with a halogenoacetic acid, and reacting the reaction product with daunorubicin, mitomycin C or CH.sub.2 COO.multidot.1/2[Pt(NH.sub.3).sub.2 ], where Pt represents divalent platinum, and recovering said ring opened mannoglucan or derivative or salt thereof.
- 4. The process for preparing a carboxymethyl ring-opened-mannoglucan or derivative or salt thereof according to claim 2, comprising the steps of reacting a mannoglucan comprising tetrasaccharide units represented by the formula (II): ##STR12## wherein R.sup.10 represents a hydrogen atom or CH.sub.2 COOH, with periodic acid or its salt; reacting the reaction product with sodium borohydride and reacting the reaction product with a halogenoacetic acid, and reacting the reaction product with daunorubicin, mitomycin C or CH.sub.2 COO.multidot.1/2[Pt(NH.sub.3).sub.2 ], where Pt represents divalent platinum, and recovering said ring-opened mannoglucan or derivative or salt thereof.
- 5. A method for transferring a drug to tumor in a mammal, comprising the step of administering a carboxymethyl ring-opened mannoglucan or derivative thereof according to claim 1 to said mammal.
Priority Claims (2)
Number |
Date |
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Kind |
3-27544 |
Feb 1991 |
JPX |
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3-360395 |
Dec 1991 |
JPX |
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Parent Case Info
This application is a continuation of now abandoned application, Ser. No. 08/136,039, filed Oct. 14, 1993, now abandoned; which is a divisional of Ser. No. 07/934,501, filed Oct. 21, 1992, now abandoned, which is a 371 of PCT/JP92/00184, filed Feb. 21, 1992.
US Referenced Citations (10)
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Jul 1989 |
EPX |
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Entry |
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Divisions (1)
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Number |
Date |
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Parent |
934501 |
Oct 1992 |
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Continuations (1)
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Number |
Date |
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Parent |
136039 |
Oct 1993 |
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