Claims
- 1. A carboxymethylmannoglucan derivative comprising tetrasaccharide units represented by the following general formula (III) or salt thereof: ##STR10## wherein R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22, R.sup.23 and R.sup.24 which may be the same or different each represent a hydrogen atom, CH.sub.2 COOH, CH.sub.2 CONR.sup.*1 R.sup.*2 wherein NR.sup.*1 R.sup.*2 represents a residue formed by removing one hydrogen atom from an amino group of a drug which has an amino group and is represented by the general formula HNR.sup.*1 R.sup.*2, CE.sub.2 COOR.sup.*3 wherein OR.sup.*3 represents a residue formed by removing a hydrogen atom from an alcoholic hydroxyl group of a drug which has an alcoholic hydroxyl group and is represented by the general formula HOR.sup.*3, or �CH.sub.2 COO.multidot.1/2�Pt(NH.sub.3).sub.2 ! wherein Pt represents a divalent platinum,
- with the proviso that at least one of R.sup.13 to R.sup.24 in the molecule represents CH.sub.2 CONR.sup.*1 R.sup.*2, CH.sub.2 COOR.sup.*3 or �CH.sub.2 COO.multidot.1/2�Pt(NH.sub.3).sub.2 !.
- 2. A carboxymethylmannoglucan derivative or salt thereof according to claim 1, which has a molecular weight of 10,000 to 2,000,000.
- 3. A carboxymethylmannoglucan derivative or salt thereof according to claim 1 or 2, which has a degree of substitution, defined as the number of carboxymethyl groups per saccaride residue of 0.01 to 3.0.
- 4. A process for preparing a carboxymethylmannoglucan derivative or salt thereof according to any one of claims 1 or 2, comprising reacting a compound or salt thereof of the formula ##STR11## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11 and R.sup.12 may be the same or different, each representing a hydrogen atom or CH.sub.2 COOH, with HNR.sup.*1 R.sup.*2, HOR.sup.*3 or Pt(NH.sub.3).sub.2 (NO.sub.3).sub.2.
- 5. A process for preparing a carboxymethylmannoglucan derivative or salt thereof according to claim 3, comprising reacting a carboxymethylmannoglucan comprising tetrasaccharide units represented by the following general formula (I) or salt thereof, ##STR12## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11 and R.sup.12, which may the same or different, each represent a hydrogen atom or CH.sub.2 COOH, with HNR.sup.*1 R.sup.*2, HOR.sup.*3 or Pt(NH.sub.3).sub.2 (NO.sub.3).sub.2.
- 6. A method for transferring a drug to a tumor in a mammal, comprising the step of administering a carboxymethylmannoglucan derivative comprising tetrasaccharide units represented by the following general formula (III) or salt thereof: ##STR13## wherein R.sup.13, R.sup.14, R.sup.15, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21, R.sup.22, R.sup.23 and R.sup.24, which may be the same or different, each represent a hydrogen atom, CH.sub.2 COOH, CH.sub.2 CONR.sup.*1 R.sup.*2, wherein NR.sup.*1 R.sup.*2* represents a residue formed by removing one hydrogen atom from an amino group of a drug which has an amino group and is represented by the general formula HNR.sup.*1 R.sup.*2, CH.sub.2 COOR.sup.*3, wherein OR.sup.*3 represents a residue formed by removing a hydrogen atom from an alcoholic hydroxyl group of a drug which has an alcoholic hydroxyl group and is represented by the general formula HOR.sup.*3, or, wherein Pt represents a divalent platinum,
- with the proviso that at least one of R.sup.13 to R.sup.24 in the molecule represents CH.sub.2 CONR.sup.*1 R.sup.*2, CH.sub.2 COOR.sup.*3 or, to said mammal.
Priority Claims (2)
Number |
Date |
Country |
Kind |
3-27544 |
Feb 1991 |
JPX |
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3-360395 |
Dec 1991 |
JPX |
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Parent Case Info
This is a divisional application of Ser. No. 08/397,560, filed Mar. 2, 1995, now U.S. Pat. No. 5,567,690, which is a continuation of abandoned Ser. No. 08/136,039, filed Oct. 14, 1993, which is a divisional of abandoned Ser. No. 07/934,501, filed Oct. 21, 1992, which is a 371 of PCT/JP92/00184, filed Feb. 21, 1992.
US Referenced Citations (11)
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Entry |
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Divisions (2)
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Date |
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397560 |
Mar 1995 |
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Parent |
934501 |
Oct 1992 |
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Continuations (1)
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136039 |
Oct 1993 |
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