Claims
- 1. A method of increasing cardiac contractility in a mammal comprising administering to a mammal in need of such treatment a pharmaceutical composition comprising an effective amount of a compound having the structural formula ##STR30## wherein (A) X is
- (1) H, CH.sub.2 OH, F, Cl, Br, CN;
- (2) CO.sub.2 R.sub.1 where R.sub.1 is hydrogen, alkyl of from one to six carbon atoms, or a pharmaceutically metal or amine cation;
- (3) CONR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 are independently hydrogen or alkyl of from one to six carbon atoms; or
- (4) NR.sub.4 R.sub.5 where R.sub.4 and R.sub.5 are independently hydrogen or alkyl of from one to six carbon atoms;
- (B) W and Y are independently hydrogen or alkyl of from one to six carbon atoms;
- (C) Z is ##STR31## wherein A is a direct bond to the phenyl ring, (CH.sub.2).sub.n or O(CH.sub.2).sub.n+1 where n is an integer of from 1 to 4 and R.sub.11 and R.sub.12 are attached to the same carbon atom of the piperidine ring, which may be carbon number three or four, and wherein when R.sub.11 is hydrogen, R.sub.12 is
- (a) phenyl;
- (b) hydroxy; or
- (c) alkoxy of from one to six carbon atoms, and
- when R.sub.11 is not hydrogen, R.sub.11 and R.sub.12 taken together are ethylenedioxy;
- or a pharmaceutically acceptable salt thereof.
CROSS-REFERENCE TO RELATED APPLICATIONS
This is a division of application Ser. No. 515,799 filed July 22, 1983, now U.S. Pat. No. 4,503,061, which is a continuation-in-part of application Ser. No. 410,803 filed Aug. 23, 1982, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3951982 |
Goel |
Apr 1976 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
515799 |
Jul 1983 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
410803 |
Aug 1982 |
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