Claims
- 1. The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient a medicament comprising a pharmaceutically-acceptable carrier and, as the active component thereof, a cardiotonically-effective amount of 4,5-dihydro-R-6-(4-pyridinyl)-3(2H)-pyridazinone or pharmaceutically-acceptable acid-addition salt thereof, where R is hydrogen or methyl.
- 2. The method according to claim 1 where the active component is 4,5-dihydro-6-(4-pyridinyl)-3(2H)-pyridazinone.
- 3. The method according to claim 1 where the active component is 4,5-dihydro-4-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of copending application Ser. No. 225,024, filed Jan. 14, 1981 and now abandoned, in turn, a continuation-in-part of copending application Ser. No. 71,064, filed Aug. 30, 1979 and now U.S. Pat. No. 4,298,609, issued Nov. 3, 1981, which discloses and claims 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol, its preparation and its use for lowering blood pressure.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
19987 |
Feb 1979 |
JPX |
Non-Patent Literature Citations (5)
Entry |
McEvoy and Allen, [J. Org. Chem. 38, 4044-4048 (1978); J. Med. Chem. 17, 281-286 (1974)]. |
Curran and Ross, [J. Med. Chem. 17, 273-281 (1974)]. |
Albright, McEvoy and Moran, [J. Heterocyclic Chem. 15, 881-892 (1978)]. |
McEvoy and Albright, [J. Org. Chem. 44, 4597-4603 (1979)]. |
Leete et al., [J. Org. Chem. 37, 4465-4466 (1972)]. |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
225024 |
Jan 1981 |
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Parent |
71064 |
Aug 1979 |
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