Cardiotoxin molecular toxicology modeling

SEQUENCE LISTING SUBMISSION ON COMPACT DISC

[0002] The Sequence Listing submitted concurrently herewith on compact disc is herein incorporated by reference in its entirety. Three copies of the Sequence Listing, one on each of three compact discs are provided. Copy 1 and Copy 2 are identical. Copies 1 and 2 are also identical to the CRF. Each electronic copy of the Sequence Listing was created on Jun. 19, 2002 with a file size of 1523 KB. The file names are as follows: Copy 1-g15090us.txt; Copy 2-g15090us.txt; and CRF-g15090us.txt.

BACKGROUND OF THE INVENTION

[0003] The need for methods of assessing the toxic impact of a compound, pharmaceutical agent or environmental pollutant on a cell or living organism has led to the development of procedures which utilize living organisms as biological monitors. The simplest and most convenient of these systems utilize unicellular microorganisms such as yeast and bacteria, since they are the most easily maintained and manipulated. In addition, unicellular screening systems often use easily detectable changes in phenotype to monitor the effect of test compounds on the cell. Unicellular organisms, however, are inadequate models for estimating the potential effects of many compounds on complex multicellular animals, as they do not have the ability to carry out biotransformations.

[0004] The biotransformation of chemical compounds by multicellular organisms is a significant factor in determining the overall toxicity of agents to which they are exposed. Accordingly, multicellular screening systems may be preferred or required to detect the toxic effects of compounds. The use of multicellular organisms as toxicology screening tools has been significantly hampered, however, by the lack of convenient screening mechanisms or endpoints, such as those available in yeast or bacterial systems.

SUMMARY OF THE INVENTION

[0005] The present invention is based, in part, on the elucidation of the global changes in gene expression in tissues or cells exposed to known toxins, in particular cardiotoxins, as compared to unexposed tissues or cells as well as the identification of individual genes that are differentially expressed upon toxin exposure.

[0006] In various aspects, the invention includes methods of predicting at least one toxic effect of a compound, predicting the progression of a toxic effect of a compound, and predicting the cardiotoxicity of a compound. The invention also includes methods of identifying agents that modulate the onset or progression of a toxic response. Also provided are methods of predicting the cellular pathways that a compound modulates in a cell. The invention also includes methods of identifying agents that modulate protein activities.

[0007] In a further aspect, the invention includes probes comprising sequences that specifically hybridize to genes in Tables 1-5I. Also included are solid supports comprising at least two of the previously mentioned probes. The invention also includes a computer system that has a database containing information identifying the expression level in a tissue or cell sample exposed to a cardiotoxin of a set of genes in Tables 1-5I.

DETAILED DESCRIPTION

[0008] Many biological functions are accomplished by altering the expression of various genes through transcriptional (e.g. through control of initiation, provision of RNA precursors, RNA processing, etc.) and/or translational control. For example, fundamental biological processes such as cell cycle, cell differentiation and cell death, are often characterized by the variations in the expression levels of groups of genes.

[0009] Changes in gene expression are also associated with the effects of various chemicals, drugs, toxins, pharmaceutical agents and pollutants on an organism or cell. Thus, changes in the expression levels of particular genes (e.g. oncogenes or tumor suppressors) may serve as signposts for the presence and progression of toxicity or other cellular responses to exposure to a particular compound.

[0010] Monitoring changes in gene expression may also provide certain advantages during drug screening and development. Often drugs are screened for the ability to interact with a major target without regard to other effects the drugs have on cells. These cellular effects may cause toxicity in the whole animal, which prevents the development and clinical use of the potential drug.

[0011] The present inventors have examined tissue from animals exposed to known cardiotoxins which induce detrimental heart effects, to identify global changes in gene expression and individual changes in gene expression induced by these compounds. These global changes in gene expression, which can be detected by the production of expression profiles (an expression level of one or more genes), provide useful toxicity markers that can be used to monitor toxicity and/or toxicity progression by a test compound. Some of these markers may also be used to monitor or detect various disease or physiological states, disease progression, drug efficacy and drug metabolism.

[0012] Identification of Toxicity Markers

[0013] To evaluate and identify gene expression changes that are predictive of toxicity, studies using selected compounds with well characterized toxicity have been conducted by the present inventors to catalogue altered gene expression during exposure in vivo and in vitro. In the present study, cyclophosphamide, ifosfamide, minoxidil, hydralazine, BI-QT, clenbuterol, isoproterenol, norepinephrine, and epinephrine were selected as known cardiotoxins.

[0014] Cyclophosphamide, an alkylating agent, is highly toxic to dividing cells and is commonly used in chemotherapy to treat non-Hodgkin's lymphomas, Burkitt's lymphoma and carcinomas of the lung, breast, and ovary (Goodman & Gilman's The Pharmacological Basis of Therapeutics 9th ed., p. 1234, 1237-1239, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). Additionally, cyclophosphamide is used as an immunosuppressive agent in bone marrow transplantation and following organ transplantation. Though cyclophosphamide is therapeutically useful, it is also associated with cardiotoxicity, nephrotoxicity, and hemorrhagic cystitis. Once in the liver, cyclophosphamide is hydroxylated by the cytochrome P450 mixed function oxidase system. The active metabolites, phosphoramide mustard and acrolein, cross-link DNA and cause growth arrest and cell death. Acrolein has been shown to decrease cellular glutathione levels (Dorr and Lagel (1994), Chem Biol Interact 93: 117-128).

[0015] The cardiotoxic effects of cyclophosphamide have been partially elucidated. One study analyzed plasma levels in 19 women with metastatic breast carcinoma who had been treated with cyclophosphamide, thiotepa, and carboplatin (Ayash et al. (1992), J Clin Oncol 10: 995-1000). Of the 19 women in the study, six developed moderate congestive heart failure. In another case study, a 10-year old boy, who had been treated with high-dose cyclophosphamide, developed cardiac arrhythmias and intractable hypotension (Tsai et al. (1990), Am J Pediatr Hematol Oncol 12: 472-476). The boy died 23 days after the transplantation.

[0016] Another clinical study examined the relationship between the amount of cyclophosphamide administered and the development of cardiotoxicity (Goldberg et al. (1986), Blood 68: 1114-1118). When the cyclophosphamide dosage was ≦1.55 g/m2/d, only 1 out of 32 patients had symptoms consistent with cyclophosphamide cardiotoxicity. Yet when the dosage was greater than 1.55 g/m2/d, 13 out of 52 patients were symptomatic. Six of the high-dose patients died of congestive heart failure.

[0017] In a related study, Braverman et al. compared the effects of once daily low-dose administration of cyclophosphamide (87+/−11 mg/kg) and twice-daily high-dose treatment (174+/−34 mg/kg) on bone marrow transplantation patients (Braverman et al. (1991), J Clin Oncol 9: 1215-1223). Within a week, the high-dose patients had an increase in left ventricular mass index. Out of five patients who developed clinical cardiotoxicity, four were in the high-dose group.

[0018] Ifosfamide, an oxazaphosphorine, is an analog of cyclophosphamide. Whereas cyclophosphamide has two chloroethyl groups on the exocyclic nitrogen, ifosfamide contains one chloroethyl group on the ring nitrogen and the other on the exocyclic nitrogen. Ifosfamide is a nitrogen mustard and alkylating agent, commonly used in chemotherapy to treat testicular, cervical, and lung cancer, as well as sarcomas and lymphomas. Like cyclophosphamide, it is activated in the liver by hydroxylation, but it reacts more slowly and produces more dechlorinated metabolites and chloroacetaldehyde. Comparatively higher doses of ifosfamide are required to match the efficacy of cyclophosphamide.

[0019] Alkylating agents can cross-link DNA, resulting in growth arrest and cell death. Despite its therapeutic value, ifosfamide is associated with nephrotoxicity (affecting the proximal and distal renal tubules), urotoxicity, venooclusive disease, myclosuppression, pulmonary fibrosis and central neurotoxicity (Goodman & Gilman's The Pharmacological Basis of Therapeutics 9th ed., p.1234-1240, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). Ifosfamide can also cause acute severe heart failure and malignant ventricular arrhythmia, which may be reversible. Death from cardiogenic shock has also been reported (Cecil Textbook of Medicine 20th ed., Bennett et al. eds., p. 331, W. B. Saunders Co., Philadelphia, 1996).

[0020] Studies of patients with advanced or resistant lymphomas or carcinomas showed that high-dose ifosfamide treatment produced various symptoms of cardiac disease, including dyspnea, tachycardia, decreased left ventricular contractility and malignant ventricular arrhythmia (Quezado et al. (1993), Ann Intern Med 118: 31-36; Wilson et al. (1992), J Clin Oncol 19: 1712-1722). Other patient studies have noted that ifosfamide-induced cardiac toxicity may be asymptomatic, although it can be detected by electrocardiogram and should be monitored (Pai et al.(2000), Drug Saf 22: 263-302).

[0021] Minoxidil is an antihypertensive medicinal agent used in the treatment of high blood pressure. It works by relaxing blood vessels so that blood may pass through them more easily, thereby lowering blood pressure. By applying minoxidil to the scalp, it has recently been shown to be effective at combating hair loss by stimulating hair growth. Once minoxidil is metabolized by hepatic sulfotransferase, it is converted to the active molecule minoxidil N—O sulfate (Goodman & Gilman's The Pharmacological Basis of Therapeutics 9th ed., pp. 796-797, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). The active minoxidil sulfate stimulates the ATP-modulated potassium channel consequently causing hyperpolarization and relaxation of smooth muscle. Early studies on minoxidil demonstrated that following a single dose of the drug, patients suffering from left ventricular failure exhibited a slightly increased heart rate, a fall in the mean arterial pressure, a fall in the systemic vascular resistance, and a slight increase in cardiac index (Franciosa and Cohn (1981) Circulation 63: 652-657).

[0022] Some common side effects associated with minoxidil treatment are an increase in hair growth, weight gain, and a fast or irregular heartbeat. More serious side effects are numbness of the hands, feet, or face, chest pain, shortness of breath, and swelling of the feet or lower legs. Because of the risks of fluid retention and reflex cardiovascular effects, minoxidil is often given concomitantly with a diuretic and a sympatholytic drug.

[0023] While minoxidil is effective at lowering blood pressure, it does not lead to a regression of cardiac hypertrophy. To the contrary, minoxidil has been shown to cause cardiac enlargement when administered to normotensive animals (Moravec et al. (1994) J Pharmacol Exp Ther 269: 290-296). Moravec et al. examined normotensive rats that had developed myocardial hypertrophy following treatment with minoxidil. The authors found that minoxidil treatment led to enlargement of the left ventricle, right ventricle, and interventricular septum.

[0024] Another rat study investigated the age- and dose-dependency of minoxidil- induced cardiotoxicity (Herman et al. (1996) Toxicology 110: 71-83). Rats ranging in age from 3 months to 2 years were given varying amounts of minoxidil over the period of two days. The investigators observed interstitial hemorrhages at all dose levels, however the hemorrhages were more frequent and severe in the older animals. The 2 year old rats had vascular lesions composed of arteriolar damage and calcification.

[0025] Hydralazine, an antihypertensive drug, causes relaxation of arteriolar smooth muscle. Such vasodilation is linked to vigorous stimulation of the sympathetic nervous system, which in turn leads to increased heart rate and contractility, increased plasma renin activity, and fluid retention (Goodman & Gilman's The Pharmacological Basis of Therapeutics 9th ed., p. 794, J. G. Hardman et al., Eds., McGraw Hill, New York, 1996). The increased renin activity leads to an increase in angiotensin II, which in turn causes stimulation of aldosterone and sodium reabsorption.

[0026] Hydralazine is used for the treatment of high blood pressure (hypertension) and for the treatment of pregnant women suffering from high blood pressure (pre-eclampsia or eclampsia). Some common side effects associated with hydralazine use are diarrhea, rapid heartbeat, headache, decreased appetite, and nausea. Hydralazine is often used concomitantly with drugs that inhibit sympathetic activity to combat the mild pulmonary hypertension that can be associated with hydralazine usage.

[0027] In one hydralazine study, rats were given one of five cardiotoxic compounds (isoproterenol, hydralazine, caffeine, cyclophosphamide, or adriamycin) by intravenous injection (Kemi et al. (1996), J Vet Med Sci 58: 699-702). At one hour and four hours post-dose, early focal myocardial lesions were observed histopathologically. Lesions were observed in the rats treated with hydralazine four hours post-dose. The lesions were found in the inner one third of the left ventricular walls including the papillary muscles.

[0028] Another study compared the effects of isoproterenol, hydralazine and minoxidil on young and mature rats (Hanton et al. (1991), Res Commun Chem Pathol Pharmacol 71: 231-234). Myocardial necrosis was observed in both age groups, but it was more severe in the mature rats. Hypotension and reflex tachycardia were also seen in the hydralazine-treated rats.

[0029] BI-QT, has been shown to induce QC prolongation in dogs and liver alterations in rats. Over a four week period, dogs treated with BI-QT exhibited sedation, decreased body weight, increased liver weight, and slightly increased levels of AST, ALP, and BUN. After three months of treatment, the dogs exhibited signs of cardiovascular effects.

[0030] Clenbuterol, a β2 adrenergic agonist, can be used therapeutically as a bronchial dilator for asthmatics. It also has powerful muscle anabolic and lipolytic effects. It has been banned in the United States but continues to be used illegally by athletes to increase muscle growth. In a number of studies, rats treated with clenbuterol developed hypertrophy of the heart and latissimus dorsi muscle (Doheny et al. (1998), Amino Acids 15: 13-25; Murphy et al. (1999), Proc Soc Exp Biol Med 221: 184-187; Petrou et al. (1995), Circulation 92: II483-II489).

[0031] In one study, mares treated with therapeutic levels of clenbuterol were compared to mares that were exercised and mares in a control group (Sleeper et al. (2002), Med Sci Sports Exerc 34: 643-650). The clenbuterol-treated mares demonstrated significantly higher left ventricular internal dimension and interventricular septal wall thickness at end diastole. In addition, the clenbuterol-treated mares had significantly increased aortic root dimensions, which could lead to an increased chance of aortic rupture.

[0032] In another study, investigators reported a case of acute clenbuterol toxicity in a human (Hoffman et al. (2001), J Toxicol 39: 339-344). A 28-year old woman had ingested a small quantity of clenbuterol, and the patient developed sustained sinus tachycardia, hypokalemia, hypophosphatemia, and hypomagnesemia.

[0033] Catecholamines are neurotransmitters that are synthesized in the adrenal medulla and in the sympathetic nervous system. Epinephrine, norepinephrine, and isoproterenol are members of the catecholamine sympathomimetic amine family (Casarett & Doull's Toxicology, The Basic Science of Poisons 6th ed., p. 618-619, C. D. Klaassen, Ed., McGraw Hill, New York, 2001). They are chemically similar by having an aromatic portion (catechol) to which is attached an amine, or nitrogen-containing group.

[0034] Isoproterenol, an antiarrhythmic agent, is used therapeutically as a bronchodilator for the treatment of asthma, chronic bronchitis, emphysema, and other lung diseases. Some side effects of usage are myocardial ischemia, arrhythmias, angina, hypertension, and tachycardia. As a β receptor agonist, isoproterenol exerts direct positive inotropic and chronotropic effects. Peripheral vascular resistance is decreased along with the pulse pressure and mean arterial pressure. However, the heart rate increases due to the decrease in the mean arterial pressure.

[0035] Norepinephrine, an α and β receptor agonist, is also known as noradrenaline. It is involved in behaviors such as attention and general arousal, stress, and mood states. By acting on β-1 receptors, it causes increased peripheral vascular resistance, pulse pressure and mean arterial pressure. Reflex bradycardia occurs due to the increase in mean arterial pressure. Some contraindications associated with norepinephrine usage are myocardial ischemia, premature ventricular contractions (PVCs), and ventricular tachycardia.

[0036] Epinephrine, a potent α and β adrenergic agonist, is used for treating bronchoconstriction and hypotension resulting from anaphylaxis as well as all forms of cardiac arrest. Injection of epinephrine leads to an increase in systolic pressure, ventricular contractility, and heart rate. Some side effects associated with epinephrine usage are cardiac arrhythmias, particularly PVCs, ventricular tachycardia, renal vascular ischemia, increased myocardial oxygen requirements, and hypokalemia.

[0037] Toxicity Prediction and Modeling

[0038] The genes and gene expression information, gene expression profiles, as well as the portfolios and subsets of the genes provided in Tables 1-5I, may be used to predict at least one toxic effect, including the cardiotoxicity of a test or unknown compound. As used, herein, at least one toxic effect includes, but is not limited to, a detrimental change in the physiological status of a cell or organism. The response may be, but is not required to be, associated with a particular pathology, such as tissue necrosis, myocarditis, arrhythmias, tachycardia, myocardial ischemia, angina, hypertension, hypotension, dyspnea, and cardiogenic shock. Accordingly, the toxic effect includes effects at the molecular and cellular level. Cardiotoxicity is an effect as used herein and includes but is not limited to the pathologies of tissue necrosis, myocarditis, arrhythmias, tachycardia, myocardial ischemia, angina, hypertension, hypotension, dyspnea, and cardiogenic shock. As used herein, a gene expression profile comprises any representation, quantitative or not, of the expression of at least one mRNA species in a cell sample or population and includes profiles made by various methods such as differential display, PCR, hybridization analysis, etc.

[0039] In general, assays to predict the toxicity or cardiotoxicity of a test agent (or compound or multi-component composition) comprise the steps of exposing a cell population to the test compound, assaying or measuring the level of relative or absolute gene expression of one or more of the genes in Tables 1-5I and comparing the identified expression level(s) to the expression levels disclosed in the Tables and database(s) disclosed herein. Assays may include the measurement of the expression levels of about 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 50, 75, 100 or more genes from Tables 1-5I.

[0040] In the methods of the invention, the gene expression level for a gene or genes induced by the test agent, compound or compositions may be comparable to the levels found in the Tables or databases disclosed herein if the expression level varies within a factor of about 2, about 1.5 or about 1.0 fold. In some cases, the expression levels are comparable if the agent induces a change in the expression of a gene in the same direction (e.g., up or down) as a reference toxin.

[0041] The cell population that is exposed to the test agent, compound or composition may be exposed in vitro or in vivo. For instance, cultured or freshly isolated heart cells, in particular rat heart cells, may be exposed to the agent under standard laboratory and cell culture conditions. In another assay format, in vivo exposure may be accomplished by administration of the agent to a living animal, for instance a laboratory rat.

[0042] Procedures for designing and conducting toxicity tests in in vitro and in vivo systems are well known, and are described in many texts on the subject, such as Loomis et al., Loomis's Essentials of Toxicology, 4th Ed., Academic Press, New York, 1996; Echobichon, The Basics of Toxicity Testing, CRC Press, Boca Raton, 1992; Frazier, editor, In Vitro Toxicity Testing, Marcel Dekker, New York, 1992; and the like.

[0043] In in vitro toxicity testing, two groups of test organisms are usually employed: One group serves as a control and the other group receives the test compound in a single dose (for acute toxicity tests) or a regimen of doses (for prolonged or chronic toxicity tests). Because, in some cases, the extraction of tissue as called for in the methods of the invention requires sacrificing the test animal, both the control group and the group receiving compound must be large enough to permit removal of animals for sampling tissues, if it is desired to observe the dynamics of gene expression through the duration of an experiment.

[0044] In setting up a toxicity study, extensive guidance is provided in the literature for selecting the appropriate test organism for the compound being tested, route of administration dose ranges, and the like. Water or physiological saline (0.9% NaCl in water) is the solute of choice for the test compound since these solvents permit administration by a variety of routes. When this is not possible because of solubility limitations, vegetable oils such as corn oil or organic solvents such as propylene glycol may be used.

[0045] Regardless of the route of administration, the volume required to administer a given dose is limited by the size of the animal that is used. It is desirable to keep the volume of each dose uniform within and between groups of animals. When rats or mice are used, the volume administered by the oral route generally should not exceed about 0.005 ml per gram of animal. Even when aqueous or physiological saline solutions are used for parenteral injection the volumes that are tolerated are limited, although such solutions are ordinarily thought of as being innocuous. The intravenous LD50 of distilled water in the mouse is approximately 0.044 ml per gram and that of isotonic saline is 0.068 ml per gram of mouse. In some instances, the route of administration to the test animal should be the same as, or as similar as possible to, the route of administration of the compound to man for therapeutic purposes.

[0046] When a compound is to be administered by inhalation, special techniques for generating test atmospheres are necessary. The methods usually involve aerosolization or nebulization of fluids containing the compound. If the agent to be tested is a fluid that has an appreciable vapor pressure, it may be administered by passing air through the solution under controlled temperature conditions. Under these conditions, dose is estimated from the volume of air inhaled per unit time, the temperature of the solution, and the vapor pressure of the agent involved. Gases are metered from reservoirs. When particles of a solution are to be administered, unless the particle size is less than about 2 μm the particles will not reach the terminal alveolar sacs in the lungs. A variety of apparatuses and chambers are available to perform studies for detecting effects of irritant or other toxic endpoints when they are administered by inhalation. The preferred method of administering an agent to animals is via the oral route, either by intubation or by incorporating the agent in the feed.

[0047] When the agent is exposed to cells in vitro or in cell culture, the cell population to be exposed to the agent may be divided into two or more subpopulations, for instance, by dividing the population into two or more identical aliquots. In some preferred embodiments of the methods of the invention, the cells to be exposed to the agent are derived from heart tissue. For instance, cultured or freshly isolated rat heart cells may be used.

[0048] The methods of the invention may be used generally to predict at least one toxic response, and, as described in the Examples, may be used to predict the likelihood that a compound or test agent will induce various specific heart pathologies, such as tissue necrosis, myocarditis, arrhythmias, tachycardia, myocardial ischemia, angina, hypertension, hypotension, dyspnea, cardiogenic shock, or other pathologies associated with at least one of the toxins herein described. The methods of the invention may also be used to determine the similarity of a toxic response to one or more individual compounds. In addition, the methods of the invention may be used to predict or elucidate the potential cellular pathways influenced, induced or modulated by the compound or test agent due to the similarity of the expression profile compared to the profile induced by a known toxin (see Tables 5-5I).

[0049] Diagnostic Uses for the Toxicity Markers

[0050] As described above, the genes and gene expression information or portfolios of the genes with their expression information as provided in Tables 1-5I may be used as diagnostic markers for the prediction or identification of the physiological state of a tissue or cell sample that has been exposed to a compound or to identify or predict the toxic effects of a compound or agent. For instance, a tissue sample such as a sample of peripheral blood cells or some other easily obtainable tissue sample may be assayed by any of the methods described above, and the expression levels from a gene or genes from Tables 5-5I may be compared to the expression levels found in tissues or cells exposed to the toxins described herein. These methods may result in the diagnosis of a physiological state in the cell, may be used to diagnose toxin exposure or may be used to identify the potential toxicity of a compound, for instance a new or unknown compound or agent that the subject has been exposed to. The comparison of expression data, as well as available sequence or other information may be done by researcher or diagnostician or may be done with the aid of a computer and databases as described below.

[0051] In another format, the levels of a gene(s) of Tables 5-5I, its encoded protein(s), or any metabolite produced by the encoded protein may be monitored or detected in a sample, such as a bodily tissue or fluid sample to identify or diagnose a physiological state of an organism. Such samples may include any tissue or fluid sample, including urine, blood and easily obtainable cells such as peripheral lymphocytes.

[0052] Use of the Markers for Monitoring Toxicity Progression

[0053] As described above, the genes and gene expression information provided in Tables 5-5I may also be used as markers for the monitoring of toxicity progression, such as that found after initial exposure to a drug, drug candidate, toxin, pollutant, etc. For instance, a tissue or cell sample may be assayed by any of the methods described above, and the expression levels from a gene or genes from Tables 5-5I may be compared to the expression levels found in tissue or cells exposed to the cardiotoxins described herein. The comparison of the expression data, as well as available sequence or other information may be done by a researcher or diagnostician or may be done with the aid of a computer and databases.

[0054] Use of the Toxicity Markers for Drug Screening

[0055] According to the present invention, the genes identified in Tables 1-5I may be used as markers or drug targets to evaluate the effects of a candidate drug, chemical compound or other agent on a cell or tissue sample. The genes may also be used as drug targets to screen for agents that modulate their expression and/or activity. In various formats, a candidate drug or agent can be screened for the ability to stimulate the transcription or expression of a given marker or markers or to down-regulate or counteract the transcription or expression of a marker or markers. According to the present invention, one can also compare the specificity of a drug's effects by looking at the number of markers which the drug induces and comparing them. More specific drugs will have less transcriptional targets. Similar sets of markers identified for two drugs may indicate a similarity of effects.

[0056] Assays to monitor the expression of a marker or markers as defined in Tables 1-5I may utilize any available means of monitoring for changes in the expression level of the nucleic acids of the invention. As used herein, an agent is said to modulate the expression of a nucleic acid of the invention if it is capable of up- or down-regulating expression of the nucleic acid in a cell.

[0057] In one assay format, gene chips containing probes to one, two or more genes from Tables 1-5I may be used to directly monitor or detect changes in gene expression in the treated or exposed cell. Cell lines, tissues or other samples are first exposed to a test agent and in some instances, a known toxin, and the detected expression levels of one or more, or preferably 2 or more of the genes of Tables 1-5I are compared to the expression levels of those same genes exposed to a known toxin alone. Compounds that modulate the expression patterns of the known toxin(s) would be expected to modulate potential toxic physiological effects in vivo. The genes in Tables 1-5I are particularly appropriate markers in these assays as they are differentially expressed in cells upon exposure to a known cardiotoxin. Tables 1 and 2 disclose those genes that are differentially expressed upon exposure to the named toxins and their corresponding GenBank Accession numbers. Table 3 discloses the human homologues and the corresponding GenBank Accession numbers of the differentially expressed genes of Tables 1 and 2.

[0058] In another format, cell lines that contain reporter gene fusions between the open reading frame and/or the transcriptional regulatory regions of a gene in Tables 1-5I and any assayable fusion partner may be prepared. Numerous assayable fusion partners are known and readily available including the firefly luciferase gene and the gene encoding chloramphenicol acetyltransferase (Alam et al. (1990), Anal Biochem 188: 245-254). Cell lines containing the reporter gene fusions are then exposed to the agent to be tested under appropriate conditions and time. Differential expression of the reporter gene between samples exposed to the agent and control samples identifies agents which modulate the expression of the nucleic acid.

[0059] Additional assay formats may be used to monitor the ability of the agent to modulate the expression of a gene identified in Tables 5-5I. For instance, as described above, mRNA expression may be monitored directly by hybridization of probes to the nucleic acids of the invention. Cell lines are exposed to the agent to be tested under appropriate conditions and time, and total RNA or mRNA is isolated by standard procedures such those disclosed in Sambrook et al. (Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989).

[0060] In another assay format, cells or cell lines are first identified which express the gene products of the invention physiologically. Cells and/or cell lines so identified would be expected to comprise the necessary cellular machinery such that the fidelity of modulation of the transcriptional apparatus is maintained with regard to exogenous contact of agent with appropriate surface transduction mechanisms and/or the cytosolic cascades. Further, such cells or cell lines may be transduced or transfected with an expression vehicle (e.g., a plasmid or viral vector) construct comprising an operable non-translated 5′-promoter containing end of the structural gene encoding the gene products of Tables 1-5I fused to one or more antigenic fragments or other detectable markers, which are peculiar to the instant gene products, wherein said fragments are under the transcriptional control of said promoter and are expressed as polypeptides whose molecular weight can be distinguished from the naturally occurring polypeptides or may further comprise an immunologically distinct or other detectable tag. Such a process is well known in the art (see Sambrook et al., supra).

[0061] Cells or cell lines transduced or transfected as outlined above are then contacted with agents under appropriate conditions; for example, the agent comprises a pharmaceutically acceptable excipient and is contacted with cells comprised in an aqueous physiological buffer such as phosphate buffered saline (PBS) at physiological pH, Eagles balanced salt solution (BSS) at physiological pH, PBS or BSS comprising serum or conditioned media comprising PBS or BSS and/or serum incubated at 37° C. Said conditions may be modulated as deemed necessary by one of skill in the art. Subsequent to contacting the cells with the agent, said cells are disrupted and the polypeptides of the lysate are fractionated such that a polypeptide fraction is pooled and contacted with an antibody to be further processed by immunological assay (e.g., ELISA, immunoprecipitation or Western blot). The pool of proteins isolated from the agent-contacted sample is then compared with the control samples (no exposure and exposure to a known toxin) where only the excipient is contacted with the cells and an increase or decrease in the immunologically generated signal from the agent-contacted sample compared to the control is used to distinguish the effectiveness and/or toxic effects of the agent.

[0062] Use of Toxicity Markers to Identify Agents that Modulate Protein Activity or Levels

[0063] Another embodiment of the present invention provides methods for identifying agents that modulate at least one activity of a protein(s) encoded by the genes in Tables 1-5I. Such methods or assays may utilize any means of monitoring or detecting the desired activity.

[0064] In one format, the relative amounts of a protein (Tables 1-5I) between a cell population that has been exposed to the agent to be tested compared to an unexposed control cell population and a cell population exposed to a known toxin may be assayed. In this format, probes such as specific antibodies are used to monitor the differential expression of the protein in the different cell populations. Cell lines or populations are exposed to the agent to be tested under appropriate conditions and time. Cellular lysates may be prepared from the exposed cell line or population and a control, unexposed cell line or population. The cellular lysates are then analyzed with the probe, such as a specific antibody.

[0065] Agents that are assayed in the above methods can be randomly selected or rationally selected or designed. As used herein, an agent is said to be randomly selected when the agent is chosen randomly without considering the specific sequences involved in the association of a protein of the invention alone or with its associated substrates, binding partners, etc. An example of randomly selected agents is the use a chemical library or a peptide combinatorial library, or a growth broth of an organism.

[0066] As used herein, an agent is said to be rationally selected or designed when the agent is chosen on a nonrandom basis which takes into account the sequence of the target site and/or its conformation in connection with the agent's action. Agents can be rationally selected or rationally designed by utilizing the peptide sequences that make up these sites. For example, a rationally selected peptide agent can be a peptide whose amino acid sequence is identical to or a derivative of any functional consensus site.

[0067] The agents of the present invention can be, as examples, peptides, small molecules, vitamin derivatives, as well as carbohydrates. Dominant negative proteins, DNAs encoding these proteins, antibodies to these proteins, peptide fragments of these proteins or mimics of these proteins may be introduced into cells to affect function. “Mimic” used herein refers to the modification of a region or several regions of a peptide molecule to provide a structure chemically different from the parent peptide but topographically and functionally similar to the parent peptide (see G. A. Grant in: Molecular Biology and Biotechnology, Meyers, ed., pp. 659-664, VCH Publishers, New York, 1995). A skilled artisan can readily recognize that there is no limit as to the structural nature of the agents of the present invention.

[0068] Nucleic Acid Assay Formats

[0069] As previously discussed, the genes identified as being differentially expressed upon exposure to a known cardiotoxin (Tables 1-5I) may be used in a variety of nucleic acid detection assays to detect or quantify the expression level of a gene or multiple genes in a given sample. The genes described in Tables 1-5I may also be used in combination with one or more additional genes whose differential expression is associate with toxicity in a cell or tissue. In preferred embodiments, the genes in Tables 5-5I may be combined with one or more of the genes described in prior and related applications 60/303,819; 60/305,623; 60/369,351; 60/377,611; 09/917,800; 10/060,087; and 10/152,319, all of which are incorporated by reference on page 1 of this application.

[0070] Any assay format to detect gene expression may be used. For example, traditional Northern blotting, dot or slot blot, nuclease protection, primer directed amplification, RT- PCR, semi- or quantitative PCR, branched-chain DNA and differential display methods may be used for detecting gene expression levels. Those methods are useful for some embodiments of the invention. In cases where smaller numbers of genes are detected, amplification based assays may be most efficient. Methods and assays of the invention, however, may be most efficiently designed with hybridization-based methods for detecting the expression of a large number of genes.

[0071] Any hybridization assay format may be used, including solution-based and solid support-based assay formats. Solid supports containing oligonucleotide probes for differentially expressed genes of the invention can be filters, polyvinyl chloride dishes, particles, beads, microparticles or silicon or glass based chips, etc. Such chips, wafers and hybridization methods are widely available, for example, those disclosed by Beattie (WO 95/11755).

[0072] Any solid surface to which oligonucleotides can be bound, either directly or indirectly, either covalently or non-covalently, can be used. A preferred solid support is a high density array or DNA chip. These contain a particular oligonucleotide probe in a predetermined location on the array. Each predetermined location may contain more than one molecule of the probe, but each molecule within the predetermined location has an identical sequence. Such predetermined locations are termed features. There may be, for example, from 2, 10, 100, 1000 to 10,000, 100,000, 400,000 or 1,000,000 or more of such features on a single solid support. The solid support, or the area within which the probes are attached may be on the order of about a square centimeter. Probes corresponding to the genes of Tables 5-5I or from the related applications described above may be attached to single or multiple solid support structures, e.g., the probes may be attached to a single chip or to multiple chips to comprise a chip set.

[0073] Oligonucleotide probe arrays for expression monitoring can be made and used according to any techniques known in the art (see for example, Lockhart et al. (1996), Nat Biotechnol 14: 1675-1680; McGall et al. (1996), Proc Nat Acad Sci USA 93: 13555-13460). Such probe arrays may contain at least two or more oligonucleotides that are complementary to or hybridize to two or more of the genes described in Tables 5-5I. For instance, such arrays may contain oligonucleotides that are complementary to or hybridize to at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 50, 70, 100 or more of the genes described herein. Preferred arrays contain all or nearly all of the genes listed in Tables 1-5I, or individually, the gene sets of Tables 5-5I. In a preferred embodiment, arrays are constructed that contain oligonucleotides to detect all or nearly all of the genes in any one of or all of Tables 1-5I on a single solid support substrate, such as a chip.

[0074] The sequences of the expression marker genes of Tables 1-5I are in the public databases. Table 1 provides the GenBank Accession Number or NCBI RefSeq ID for each of the sequences (see www.ncbi.nlm.nih.gov/) as well as a corresponding SEQ ID NO. in the sequence listing filed with this application. Table 3 provides the LocusLink and Unigene names and descriptions for the human homologues of the genes described in Tables 1 and 2. The sequences of the genes in GenBank and/or RefSeq are expressly herein incorporated by reference in their entirety as of the filing date of this application, as are related sequences, for instance, sequences from the same gene of different lengths, variant sequences, polymorphic sequences, genomic sequences of the genes and related sequences from different species, including the human counterparts, where appropriate. These sequences may be used in the methods of the invention or may be used to produce the probes and arrays of the invention. In some embodiments, the genes in Tables 1-5I that correspond to the genes or fragments previously associated with a toxic response may be excluded from the Tables.

[0075] As described above, in addition to the sequences of the GenBank Accession Numbers or NCBI RefSeq ID's disclosed in the Tables 1-5I, sequences such as naturally occurring variants or polymorphic sequences may be used in the methods and compositions of the invention. For instance, expression levels of various allelic or homologous forms of a gene disclosed in Tables 1-5I may be assayed. Any and all nucleotide variations that do not significantly alter the functional activity of a gene listed in the Tables 1-5I, including all naturally occurring allelic variants of the genes herein disclosed, may be used in the methods and to make the compositions (e.g., arrays) of the invention.

[0076] Probes based on the sequences of the genes described above may be prepared by any commonly available method. Oligonucleotide probes for screening or assaying a tissue or cell sample are preferably of sufficient length to specifically hybridize only to appropriate, complementary genes or transcripts. Typically the oligonucleotide probes will be at least about 10, 12, 14, 16, 18, 20 or 25 nucleotides in length. In some cases, longer probes of at least 30, 40, or 50 nucleotides will be desirable.

[0077] As used herein, oligonucleotide sequences that are complementary to one or more of the genes described in Tables 1-5I refer to oligonucleotides that are capable of hybridizing under stringent conditions to at least part of the nucleotide sequences of said genes, their encoded RNA or mRNA, or amplified versions of the RNA such as cRNA. Such hybridizable oligonucleotides will typically exhibit at least about 75% sequence identity at the nucleotide level to said genes, preferably about 80% or 85% sequence identity or more preferably about 90% or 95% or more sequence identity to said genes.

[0078] “Bind(s) substantially” refers to complementary hybridization between a probe nucleic acid and a target nucleic acid and embraces minor mismatches that can be accommodated by reducing the stringency of the hybridization media to achieve the desired detection of the target polynucleotide sequence.

[0079] The terms “background” or “background signal intensity” refer to hybridization signals resulting from non-specific binding, or other interactions, between the labeled target nucleic acids and components of the oligonucleotide array (e.g., the oligonucleotide probes, control probes, the array substrate, etc.). Background signals may also be produced by intrinsic fluorescence of the array components themselves. A single background signal can be calculated for the entire array, or a different background signal may be calculated for each target nucleic acid. In a preferred embodiment, background is calculated as the average hybridization signal intensity for the lowest 5% to 10% of the probes in the array, or, where a different background signal is calculated for each target gene, for the lowest 5% to 10% of the probes for each gene. Of course, one of skill in the art will appreciate that where the probes to a particular gene hybridize well and thus appear to be specifically binding to a target sequence, they should not be used in a background signal calculation. Alternatively, background may be calculated as the average hybridization signal intensity produced by hybridization to probes that are not complementary to any sequence found in the sample (e.g. probes directed to nucleic acids of the opposite sense or to genes not found in the sample such as bacterial genes where the sample is mammalian nucleic acids). Background can also be calculated as the average signal intensity produced by regions of the array that lack any probes at all.

[0080] The phrase “hybridizing specifically to” or “specifically hybridizes” refers to the binding, duplexing, or hybridizing of a molecule substantially to or only to a particular nucleotide sequence or sequences under stringent conditions when that sequence is present in a complex mixture (e.g., total cellular) DNA or RNA.

[0081] Assays and methods of the invention may utilize available formats to simultaneously screen at least about 100, preferably about 1000, more preferably about 10,000 and most preferably about 1,000,000 different nucleic acid hybridizations.

[0082] As used herein a “probe” is defined as a nucleic acid, capable of binding to a target nucleic acid of complementary sequence through one or more types of chemical bonds, usually through complementary base pairing, usually through hydrogen bond formation. As used herein, a probe may include natural (i.e., A, G, U, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, the bases in probes may be joined by a linkage other than a phosphodiester bond, so long as it does not interfere with hybridization. Thus, probes may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages.

[0083] The term “perfect match probe” refers to a probe that has a sequence that is perfectly complementary to a particular target sequence. The test probe is typically perfectly complementary to a portion (subsequence) of the target sequence. The perfect match (PM) probe can be a “test probe”, a “normalization control” probe, an expression level control probe and the like. A perfect match control or perfect match probe is, however, distinguished from a “mismatch control” or “mismatch probe.”

[0084] The terms “mismatch control” or “mismatch probe” refer to a probe whose sequence is deliberately selected not to be perfectly complementary to a particular target sequence. For each mismatch (MM) control in a high-density array there typically exists a corresponding perfect match (PM) probe that is perfectly complementary to the same particular target sequence. The mismatch may comprise one or more bases.

[0085] While the mismatch(es) may be located anywhere in the mismatch probe, terminal mismatches are less desirable as a terminal mismatch is less likely to prevent hybridization of the target sequence. In a particularly preferred embodiment, the mismatch is located at or near the center of the probe such that the mismatch is most likely to destabilize the duplex with the target sequence under the test hybridization conditions.

[0086] The term “stringent conditions” refers to conditions under which a probe will hybridize to its target subsequence, but with only insubstantial hybridization to other sequences or to other sequences such that the difference may be identified. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. Generally, stringent conditions are selected to be about 5° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH.

[0087] Typically, stringent conditions will be those in which the salt concentration is at least about 0.01 to 1.0 M Na+ ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes (e.g., 10 to 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide.

[0088] The “percentage of sequence identity” or “sequence identity” is determined by comparing two optimally aligned sequences or subsequences over a comparison window or span, wherein the portion of the polynucleotide sequence in the comparison window may optionally comprise additions or deletions (i.e., gaps) as compared to the reference sequence (which does not comprise additions or deletions) for optimal alignment of the two sequences. The percentage is calculated by determining the number of positions at which the identical submit (e.g. nucleic acid base or amino acid residue) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the window of comparison and multiplying the result by 100 to yield the percentage of sequence identity. Percentage sequence identity when calculated using the programs GAP or BESTFIT (see below) is calculated using default gap weights.

[0089] Probe Design

[0090] One of skill in the art will appreciate that an enormous number of array designs are suitable for the practice of this invention. The high density array will typically include a number of test probes that specifically hybridize to the sequences of interest. Probes may be produced from any region of the genes identified in the Tables and the attached representative sequence listing. In instances where the gene reference in the Tables is an EST, probes may be designed from that sequence or from other regions of the corresponding full-length transcript that may be available in any of the sequence databases, such as those herein described. See WO 99/32660 for methods of producing probes for a given gene or genes. In addition, any available software may be used to produce specific probe sequences, including, for instance, software available from Molecular Biology Insights, Olympus Optical Co. and Biosoft International. In a preferred embodiment, the array will also include one or more control probes.

[0091] High density array chips of the invention include “test probes.” Test probes may be oligonucleotides that range from about 5 to about 500, or about 7 to about 50 nucleotides, more preferably from about 10 to about 40 nucleotides and most preferably from about 15 to about 35 nucleotides in length. In other particularly preferred embodiments, the probes are 20 or 25 nucleotides in length. In another preferred embodiment, test probes are double or single strand DNA sequences such as cDNA fragments. DNA sequences are isolated or cloned from natural sources or amplified from natural sources using native nucleic acid as templates. These probes have sequences complementary to particular subsequences of the genes whose expression they are designed to detect. Thus, the test probes are capable of specifically hybridizing to the target nucleic acid they are to detect.

[0092] In addition to test probes that bind the target nucleic acid(s) of interest, the high density array can contain a number of control probes. The control probes may fall into three categories referred to herein as 1) normalization controls; 2) expression level controls; and 3) mismatch controls.

[0093] Normalization controls are oligonucleotide or other nucleic acid probes that are complementary to labeled reference oligonucleotides or other nucleic acid sequences that are added to the nucleic acid sample to be screened. The signals obtained from the normalization controls after hybridization provide a control for variations in hybridization conditions, label intensity, “reading” efficiency and other factors that may cause the signal of a perfect hybridization to vary between arrays. In a preferred embodiment, signals (e.g., fluorescence intensity) read from all other probes in the array are divided by the signal (e.g., fluorescence intensity) from the control probes thereby normalizing the measurements.

[0094] Virtually any probe may serve as a normalization control. However, it is recognized that hybridization efficiency varies with base composition and probe length. Preferred normalization probes are selected to reflect the average length of the other probes present in the array, however, they can be selected to cover a range of lengths. The normalization control(s) can also be selected to reflect the (average) base composition of the other probes in the array, however in a preferred embodiment, only one or a few probes are used and they are selected such that they hybridize well (i.e., no secondary structure) and do not match any target-specific probes.

[0095] Expression level controls are probes that hybridize specifically with constitutively expressed genes in the biological sample. Virtually any constitutively expressed gene provides a suitable target for expression level controls. Typically expression level control probes have sequences complementary to subsequences of constitutively expressed “housekeeping genes” including, but not limited to the actin gene, the transferrin receptor gene, the GAPDH gene, and the like.

[0096] Mismatch controls may also be provided for the probes to the target genes, for expression level controls or for normalization controls. Mismatch controls are oligonucleotide probes or other nucleic acid probes identical to their corresponding test or control probes except for the presence of one or more mismatched bases. A mismatched base is a base selected so that it is not complementary to the corresponding base in the target sequence to which the probe would otherwise specifically hybridize. One or more mismatches are selected such that under appropriate hybridization conditions (e.g., stringent conditions) the test or control probe would be expected to hybridize with its target sequence, but the mismatch probe would not hybridize (or would hybridize to a significantly lesser extent). Preferred mismatch probes contain a central mismatch. Thus, for example, where a probe is a 20 mer, a corresponding mismatch probe will have the identical sequence except for a single base mismatch (e.g., substituting a G, a C or a T for an A) at any of positions 6 through 14 (the central mismatch).

[0097] Mismatch probes thus provide a control for non-specific binding or cross hybridization to a nucleic acid in the sample other than the target to which the probe is directed. For example, if the target is present the perfect match probes should be consistently brighter than the mismatch probes. In addition, if all central mismatches are present, the mismatch probes can be used to detect a mutation, for instance, a mutation of a gene in the accompanying Tables 1-5I. The difference in intensity between the perfect match and the mismatch probe provides a good measure of the concentration of the hybridized material.

[0098] Nucleic Acid Samples

[0099] Cell or tissue samples may be exposed to the test agent in vitro or in vivo. When cultured cells or tissues are used, appropriate mammalian cell extracts, such as liver cell extracts, may also be added with the test agent to evaluate agents that may require biotransformation to exhibit toxicity.

[0100] The genes which are assayed according to the present invention are typically in the form of mRNA or reverse transcribed mRNA. The genes may or may not be cloned. The genes may or may not be amplified and cRNA produced. The cloning and/or amplification do not appear to bias the representation of genes within a population. In some assays, it may be preferable, however, to use polyA+ RNA as a source, as it can be used with less processing steps.

[0101] As is apparent to one of ordinary skill in the art, nucleic acid samples used in the methods and assays of the invention may be prepared by any available method or process. Methods of isolating total mRNA are well known to those of skill in the art. For example, methods of isolation and purification of nucleic acids are described in detail in Chapter 3 of Laboratory Techniques in Biochemistry and Molecular Biology, Vol. 24, Hybridization With Nucleic Acid Probes: Theory and Nucleic Acid Probes, P. Tijssen, Ed., Elsevier Press, New York, 1993. Such samples include RNA samples, but also include cDNA synthesized from a mRNA sample isolated from a cell or tissue of interest. Such samples also include DNA amplified from the cDNA, and RNA transcribed from the amplified DNA (cRNA). One of skill in the art would appreciate that it is desirable to inhibit or destroy RNase present in homogenates before homogenates are used.

[0102] Biological samples may be of any biological tissue or fluid or cells from any organism as well as cells raised in vitro, such as cell lines and tissue culture cells. Frequently the sample will be a tissue or cell sample that has been exposed to a compound, agent, drug, pharmaceutical composition, potential environmental pollutant or other composition. In some formats, the sample will be a “clinical sample” which is a sample derived from a patient. Typical clinical samples include, but are not limited to, sputum, blood, blood-cells (e.g., white cells), tissue or fine needle biopsy samples, urine, peritoneal fluid, and pleural fluid, or cells therefrom. Biological samples may also include sections of tissues, such as frozen sections or formalin fixed sections taken for histological purposes.

[0103] Forming High Density Arrays

[0104] Methods of forming high density arrays of oligonucleotides with a minimal number of synthetic steps are known. The oligonucleotide analogue array can be synthesized on a single or on multiple solid substrates by a variety of methods, including, but not limited to, light-directed chemical coupling, and mechanically directed coupling (see Pirrung, U.S. Pat. No. 5,143,854).

[0105] In brief, the light-directed combinatorial synthesis of oligonucleotide arrays on a glass surface proceeds using automated phosphoramidite chemistry and chip masking techniques. In one specific implementation, a glass surface is derivatized with a silane reagent containing a functional group, e.g., a hydroxyl or amine group blocked by a photolabile protecting group. Photolysis through a photolithographic mask is used selectively to expose functional groups which are then ready to react with incoming 5′ photoprotected nucleoside phosphoramidites. The phosphoramidites react only with those sites which are illuminated (and thus exposed by removal of the photolabile blocking group). Thus, the phosphoramidites only add to those areas selectively exposed from the preceding step. These steps are repeated until the desired array of sequences have been synthesized on the solid surface. Combinatorial synthesis of different oligonucleotide analogues at different locations on the array is determined by the pattern of illumination during synthesis and the order of addition of coupling reagents.

[0106] In addition to the foregoing, additional methods which can be used to generate an array of oligonucleotides on a single substrate are described in PCT Publication Nos. WO 93/09668 and WO 01/23614. High density nucleic acid arrays can also be fabricated by depositing pre-made or natural nucleic acids in predetermined positions. Synthesized or natural nucleic acids are deposited on specific locations of a substrate by light directed targeting and oligonucleotide directed targeting. Another embodiment uses a dispenser that moves from region to region to deposit nucleic acids in specific spots.

[0107] Hybridization

[0108] Nucleic acid hybridization simply involves contacting a probe and target nucleic acid under conditions where the probe and its complementary target can form stable hybrid duplexes through complementary base pairing. See WO 99/32660. The nucleic acids that do not form hybrid duplexes are then washed away leaving the hybridized nucleic acids to be detected, typically through detection of an attached detectable label. It is generally recognized that nucleic acids are denatured by increasing the temperature or decreasing the salt concentration of the buffer containing the nucleic acids. Under low stringency conditions (e.g., low temperature and/or high salt) hybrid duplexes (e.g., DNA:DNA, RNA:RNA, or RNA:DNA) will form even where the annealed sequences are not perfectly complementary. Thus, specificity of hybridization is reduced at lower stringency. Conversely, at higher stringency (e.g., higher temperature or lower salt) successful hybridization tolerates fewer mismatches. One of skill in the art will appreciate that hybridization conditions may be selected to provide any degree of stringency.

[0109] In a preferred embodiment, hybridization is performed at low stringency, in this case in 6×SSPET at 37° C. (0.005% Triton X-100), to ensure hybridization and then subsequent washes are performed at higher stringency (e.g., 1×SSPET at 37° C.) to eliminate mismatched hybrid duplexes. Successive washes may be performed at increasingly higher stringency (e.g., down to as low as 0.25×SSPET at 37° C. to 50° C.) until a desired level of hybridization specificity is obtained. Stringency can also be increased by addition of agents such as formamide. Hybridization specificity may be evaluated by comparison of hybridization to the test probes with hybridization to the various controls that can be present (e.g., expression level control, normalization control, mismatch controls, etc.).

[0110] In general, there is a tradeoff between hybridization specificity (stringency) and signal intensity. Thus, in a preferred embodiment, the wash is performed at the highest stringency that produces consistent results and that provides a signal intensity greater than approximately 10% of the background intensity. Thus, in a preferred embodiment, the hybridized array may be washed at successively higher stringency solutions and read between each wash. Analysis of the data sets thus produced will reveal a wash stringency above which the hybridization pattern is not appreciably altered and which provides adequate signal for the particular oligonucleotide probes of interest.

[0111] Signal Detection

[0112] The hybridized nucleic acids are typically detected by detecting one or more labels attached to the sample nucleic acids. The labels may be incorporated by any of a number of means well known to those of skill in the art. See WO 99/32660.

[0113] Databases

[0114] The present invention includes relational databases containing sequence information, for instance, for the genes of Tables 1-5I, as well as gene expression information from tissue or cells exposed to various standard toxins, such as those herein described (see Tables 5-5I). Databases may also contain information associated with a given sequence or tissue sample such as descriptive information about the gene associated with the sequence information (see Tables 1 and 2), or descriptive information concerning the clinical status of the tissue sample, or the animal from which the sample was derived. The database may be designed to include different parts, for instance a sequence database and a gene expression database. Methods for the configuration and construction of such databases and computer-readable media to which such databases are saved are widely available, for instance, see U.S. Pat. No. 5,953,727, which is herein incorporated by reference in its entirety.

[0115] The databases of the invention may be linked to an outside or external database such as GenBank (www.ncbi.nlm.nih.gov/entrez.index.html); KEGG (www.genome.ad.jp/kegg); SPAD (www.grt.kyushu-u.acjp/spad/index.html); HUGO (www.gene.ucl.ac.uk/hugo); Swiss-Prot (www.expasy.ch.sprot); Prosite (www.expasy.ch/tools/scnpsitl.html); OMIM (www.ncbi.nlm.nih.gov/omim); and GDB (www.gdb.org). In a preferred embodiment, as described in Tables 1-5I, the external database is GenBank and the associated databases maintained by the National Center for Biotechnology Information (NCBI) (www.ncbi.nlm.nih.gov).

[0116] Any appropriate computer platform, user interface, etc. may be used to perform the necessary comparisons between sequence information, gene expression information and any other information in the database or information provided as an input. For example, a large number of computer workstations are available from a variety of manufacturers, such has those available from Silicon Graphics. Client/server environments, database servers and networks are also widely available and appropriate platforms for the databases of the invention.

[0117] The databases of the invention may be used to produce, among other things, electronic Northerns that allow the user to determine the cell type or tissue in which a given gene is expressed and to allow determination of the abundance or expression level of a given gene in a particular tissue or cell.

[0118] The databases of the invention may also be used to present information identifying the expression level in a tissue or cell of a set of genes comprising one or more of the genes in Tables 5-5I, comprising the step of comparing the expression level of at least one gene in Tables 5-5I in a cell or tissue exposed to a test agent to the level of expression of the gene in the database. Such methods may be used to predict the toxic potential of a given compound by comparing the level of expression of a gene or genes in Tables 5-5I from a tissue or cell sample exposed to the test agent to the expression levels found in a control tissue or cell samples exposed to a standard toxin or cardiotoxin such as those herein described. Such methods may also be used in the drug or agent screening assays as described herein.

[0119] Kits

[0120] The invention further includes kits combining, in different combinations, high- density oligonucleotide arrays, reagents for use with the arrays, protein reagents encoded by the genes of the Tables, signal detection and array-processing instruments, gene expression databases and analysis and database management software described above. The kits may be used, for example, to predict or model the toxic response of a test compound, to monitor the progression of heart disease states, to identify genes that show promise as new drug targets and to screen known and newly designed drugs as discussed above.

[0121] The databases packaged with the kits are a compilation of expression patterns from human or laboratory animal genes and gene fragments (corresponding to the genes of Tables 1-5I). In particular, the database software and packaged information that may contain the databases saved to a computer-readable medium include the expression results of Tables 1-5I that can be used to predict toxicity of a test agent by comparing the expression levels of the genes of Tables 1-5I induced by the test agent to the expression levels presented in Tables 5-5I. In another format, database and software information may be provided in a remote electronic format, such as a website, the address of which may be packaged in the kit.

[0122] Databases and software designed for use with microarrays is discussed in PCT/US99/20449, filed Sep. 8, 1999, Genomic Knowledge Discovery, PCT/IB00/00863, filed Jun. 28, 2000, Biological Data Processing, and in Balaban et al., U.S. Pat. No. 6,229,911, a computer-implemented method for managing information, stored as indexed tables, collected from small or large numbers of microarrays, and U.S. Pat. No. 6,185,561, a computer-based method with data mining capability for collecting gene expression level data, adding additional attributes and reformatting the data to produce answers to various queries. Chee et al., U.S. Pat. No. 5,974,164, disclose a software-based method for identifying mutations in a nucleic acid sequence based on differences in probe fluorescence intensities between wild type and mutant sequences that hybridize to reference sequences.

[0123] The kits may used in the pharmaceutical industry, where the need for early drug testing is strong due to the high costs associated with drug development, but where bioinformatics, in particular gene expression informatics, is still lacking. These kits will reduce the costs, time and risks associated with traditional new drug screening using cell cultures and laboratory animals. The results of large-scale drug screening of pre-grouped patient populations, pharmacogenomics testing, can also be applied to select drugs with greater efficacy and fewer side-effects. The kits may also be used by smaller biotechnology companies and research institutes who do not have the facilities for performing such large-scale testing themselves.

[0124] Without further description, it is believed that one of ordinary skill in the art can, using the preceding description and the following illustrative examples, make and utilize the compounds of the present invention and practice the claimed methods. The following working examples therefore, specifically point out the preferred embodiments of the present invention, and are not to be construed as limiting in any way the remainder of the disclosure.

EXAMPLES

Example 1

Identification of Toxicity Markers

[0125] The cardiotoxins cyclophosphamide, ifosfamide, minoxidil, hydralazine, BI-QT, clenbuterol, isoproterenol, norepinephrine, and epinephrine and control compositions were administered to male Sprague-Dawley rats at various timepoints using administration diluents, protocols and dosing regimes as previously described in the art and previously described in the priority applications discussed above. The low and high dose level for each compound are provided in the chart below.

1Heart ToxinLow Dose (mg/kg)High Dose (mg/kg)cyclophosphamide20200ifosfamide5100minoxidil 12 mg/L 120 mg/Lhydralazine2.525BI-QT1050clenbuterol0.44isoproterenol0.050.5norepinephrine0.050.5epinephrine0.11

[0126] After administration, the dosed animals were observed and tissues were collected as described below:

[0127] Observation of Animals

[0128] 1. Clinical Observations—Twice daily: mortality and moribundity check. Cage Side Observations—skin and fur, eyes and mucous membrane, respiratory system, circulatory system, autonomic and central nervous system, somatomotor pattern, and behavior pattern.

[0129] Potential signs of toxicity, including tremors, convulsions, salivation, diarrhea, lethargy, coma or other a typical behavior or appearance, were recorded as they occurred and included a time of onset, degree, and duration.

[0130] 2. Physical Examinations—Prior to randomization, prior to initial treatment, and prior to sacrifice.

[0131] 3. Body Weights—Prior to randomization, prior to initial treatment, and prior to sacrifice.

[0132] Clinical Pathology

[0133] 1. Frequency Prior to necropsy.

[0134] 2. Number of animals All surviving animals.

[0135] 3. Bleeding Procedure Blood was obtained by puncture of the orbital sinus while under 70% CO2/30% O2 anesthesia.

[0136] 4. Collection of Blood Samples Approximately 0.5 mL of blood was collected into EDTA tubes for evaluation of hematology parameters. Approximately 1 mL of blood was collected into serum separator tubes for clinical chemistry analysis. Approximately 200 uL of plasma was obtained and frozen at ˜−80° C. for test compound/metabolite estimation. An additional ˜2 mL of blood was collected into a 15 mL conical polypropylene vial to which ˜3 mL of Trizol was immediately added. The contents were immediately mixed with a vortex and by repeated inversion. The tubes were frozen in liquid nitrogen and stored at ˜−80° C.

[0137] Termination Procedures

[0138] Terminal Sacrifice

[0139] Approximately 3, 6, 24, 48, 144, 168, 192, 336, and/or 360 hours after the initial dose, rats were weighed, physically examined, sacrificed by decapitation, and exsanguinated. The animals were necropsied within approximately five minutes of sacrifice. Separate sterile, disposable instruments were used for each animal, with the exception of bone cutters, which were used to open the skull cap. The bone cutters were dipped in disinfectant solution between animals.

[0140] Necropsies were conducted on each animal following procedures approved by board-certified pathologists.

[0141] Animals not surviving until terminal sacrifice were discarded without necropsy (following euthanasia by carbon dioxide asphyxiation, if moribund). The approximate time of death for moribund or found dead animals was recorded.

[0142] Postmortem Procedures

[0143] Fresh and sterile disposable instruments were used to collect tissues. Gloves were worn at all times when handling tissues or vials. All tissues were collected and frozen within approximately 5 minutes of the animal's death. The liver sections and kidneys were frozen within approximately 3-5 minutes of the animal's death. The time of euthanasia, an interim time point at freezing of liver sections and kidneys, and time at completion of necropsy were recorded. Tissues were stored at approximately −80° C. or preserved in 10% neutral buffered formalin.

[0144] Tissue Collection and Processing

[0145] Liver

[0146] 1. Right medial lobe—snap frozen in liquid nitrogen and stored at ˜−80° C.

[0147] 2. Left medial lobe—Preserved in 10% neutral-buffered formalin (NBF) and evaluated for gross and microscopic pathology.

[0148] 3. Left lateral lobe—snap frozen in liquid nitrogen and stored at ˜−80° C.

[0149] Heart

[0150] A sagittal cross-section containing portions of the two atria and of the two ventricles was preserved in 10% NBF. The remaining heart was frozen in liquid nitrogen and stored at ˜−80° C.

[0151] Kidneys (Both)

[0152] 1. Left—Hemi-dissected; half was preserved in 10% NBF and the remaining half was frozen in liquid nitrogen and stored at ˜−80° C.

[0153] 2. Right—Hemi-dissected; half was preserved in 10% NBF and the remaining half was frozen in liquid nitrogen and stored at ˜−80° C.

[0154] Testes (Both)

[0155] A sagittal cross-section of each testis was preserved in 10% NBF. The remaining testes were frozen together in liquid nitrogen and stored at ˜−80° C.

[0156] Brain (Whole)

[0157] A cross-section of the cerebral hemispheres and of the diencephalon was preserved in 10% NBF, and the rest of the brain was frozen in liquid nitrogen and stored at ˜−80° C.

[0158] Microarray sample preparation was conducted with minor modifications, following the protocols set forth in the Affymetrix GeneChip Expression Analysis Manual. Frozen tissue was ground to a powder using a Spex Certiprep 6800 Freezer Mill. Total RNA was extracted with Trizol (GibcoBRL) utilizing the manufacturer's protocol. The total RNA yield for each sample was 200-500 μg per 300 mg tissue weight. mRNA was isolated using the Oligotex mRNA Midi kit (Qiagen) followed by ethanol precipitation. Double stranded cDNA was generated from mRNA using the SuperScript Choice system (GibcoBRL). First strand cDNA synthesis was primed with a T7-(dT24) oligonucleotide. The cDNA was phenol-chloroform extracted and ethanol precipitated to a final concentration of 1μg/ml. From 2 μg of cDNA, cRNA was synthesized using Ambion's T7 MegaScript in vitro Transcription Kit.

[0159] To biotin label the cRNA, nucleotides Bio-11-CTP and Bio-16-UTP (Enzo Diagnostics) were added to the reaction. Following a 37° C. incubation for six hours, impurities were removed from the labeled cRNA following the RNeasy Mini kit protocol (Qiagen). cRNA was fragmented (fragmentation buffer consisting of 200 mM Tris-acetate, pH 8.1, 500 mM KOAc, 150 mM MgOAc) for thirty-five minutes at 94° C. Following the Affymetrix protocol, 55 μg of fragmented cRNA was hybridized on the Affymetrix rat array set for twenty-four hours at 60 rpm in a 45° C. hybridization oven. The chips were washed and stained with Streptavidin Phycoerythrin (SAPE) (Molecular Probes) in Affymetrix fluidics stations. To amplify staining, SAPE solution was added twice with an anti-streptavidin biotinylated antibody (Vector Laboratories) staining step in between. Hybridization to the probe arrays was detected by fluorometric scanning (Hewlett Packard Gene Array Scanner). Data was analyzed using Affymetrix GeneChip® version 2.0 and Expression Data Mining (EDMT) software (version 1.0), Gene Logic's GeneExpress® 2000 software and S-Plus™ software.

[0160] Tables 1 and 2 disclose those genes that are differentially expressed upon exposure to the named toxins and their corresponding GenBank Accession and Sequence Identification numbers, the identities of the metabolic pathways in which the genes function, the gene names if known, and the unigene cluster titles. The model code represents the various toxicity state that each gene is able to discriminate as well as the individual toxin type associated with each gene. The codes are defined in Table 4. The GLGC ID is the internal Gene Logic identification number.

[0161] Table 3 discloses those genes that are the human homologues of those genes in Tables 1 and 2 that are differentially expressed upon exposure to the named toxins. The corresponding GenBank Accession and Sequence Identification numbers, the gene names if known, and the unigene cluster titles of the human homologues are listed.

[0162] Table 4 defines the comparison codes used in Tables 1, 2, 3, and 5.

[0163] Tables 5-5I disclose the summary statistics for each of the comparisons performed. Each of these tables contains a set of predictive genes and creates a model for predicting the cardiotoxicity of an unknown, i.e., untested compound. Each gene is identified by its Gene Logic identification number and can be cross-referenced to a gene name and representative SEQ ID NO. in Tables 1 and 2. For each comparison of gene expression levels between samples in the toxicity group (samples affected by exposure to a specific toxin) and samples in the non-toxicity group (samples not affected by exposure to that same specific toxin), the tox mean (for toxicity group samples) is the mean signal intensity, as normalized for the various chip parameters that are being assayed. The non-tox mean represents the mean signal intensity, as normalized for the various chip parameters that are being assayed, in samples from animals other than those treated with the high dose of the specific toxin. These animals were treated with a low dose of the specific toxin, or with vehicle alone, or with a different toxin. Samples in the toxicity groups were obtained from animals sacrificed at the timepoint(s) indicated in the Table 5-5I headings, while samples in the non-toxicity groups were obtained from animals sacrificed at all time points in the experiments. For individual genes, an increase in the tox mean compared to the non-tox mean indicates up-regulation upon exposure to a toxin. Conversely, a decrease in the tox mean compared to the non-tox mean indicates down-regulation.

[0164] The mean values are derived from Average Difference (AveDiff) values for a particular gene, averaged across the corresponding samples. Each individual Average Difference value is calculated by integrating the intensity information from multiple probe pairs that are tiled for a particular fragment. The normalization multiplies each expression intensity for a given experiment (chip) by a global scaling factor. The intent of this normalization is to make comparisons of individual genes between chips possible. The scaling factor is calculated as follows:

[0165] 1. From all the unnormalized expression values in the experiment, delete the largest 2% and smallest 2% of the values. That is, if the experiment yields 10,000 expression values, order the values and delete the smallest 200 and largest 200.

[0166] 2. Compute the trimmed mean, which is equal to the mean of the remaining values.

[0167] 3. Compute the scale factor SF=100/(trimmed mean)

[0168] The value of 100 used here is the standard target valued used. Some AveDiff values may be negative due to the general noise involved in nucleic acid hybridization experiments. Although many conclusions can be made corresponding to a negative value on the GeneChip platform, it is difficult to assess the meaning behind the negative value for individual fragments. Our observations show that, although negative values are observed at times within the predictive gene set, these values reflect a real biological phenomenon that is highly reproducible across all the samples from which the measurement was taken. For this reason, those genes that exhibit a negative value are included in the predictive set. It should be noted that other platforms of gene expression measurement may be able to resolve the negative numbers for the corresponding genes. The predictive ability of each of those genes should extend across platforms, however. Each mean value is accompanied by the standard deviation for the mean. The linear discriminant analysis score (discriminant score), as disclosed in the tables, measures the ability of each gene to predict whether or not a sample is toxic. The discriminant score is calculated by the following steps:

[0169] Calculation of a discriminant score

[0170] Let Xi represent the AveDiff values for a given gene across the non-tox samples, i=1 . . . n.

[0171] Let Yi represent the AveDiff values for a given gene across the tox samples, i=1 . . . t.

[0172] The calculations proceed as follows:

[0173] 1. Calculate mean and standard deviation for Xi's and Yi's, and denote these by mX, mY, sX,sY.

[0174] 2. For all Xi's and Yi's, evaluate the function f(z)=((1/sY)*exp(−0.5*((z−mY)/sY)2))/(((1/sY)*exp(−0.5*((z−mY)/sY)2))+((1/sX)*exp(−0.5*((z−mX)/sX)2))).

[0175] 3. The number of correct predictions, say P, is then the number of Yi's such that f(Yi)>0.5 plus the number of Xi's such that f(Xi )<0.5.

[0176] 4. The discriminant score is then P/(n+t).

[0177] Linear discriminant analysis uses both the individual measurements of each gene and the calculated measurements of all combinations of genes to classify samples. For each gene a weight is derived from the mean and standard deviation of the toxic and nontox groups. Every gene is multiplied by a weight and the sum of these values results in a collective discriminate score. This discriminant score is then compared against collective centroids of the tox and nontox groups. These centroids are the average of all tox and nontox samples respectively. Therefore, each gene contributes to the overall prediction. This contribution is dependent on weights that are large positive or negative numbers if the relative distances between the tox and nontox samples for that gene are large and small numbers if the relative distances are small. The discriminant score for each unknown sample and centroid values can be used to calculate a probability between zero and one as to the group in which the unknown sample belongs.

Example 2

General Toxicity Modeling

[0178] Samples were selected for grouping into tox-responding and non-tox-responding groups by examining each study individually with Principal Components Analysis (PCA) to determine which treatments had an observable response. Only groups where confidence of their tox-responding and non-tox-responding status was established were included in building a general tox model (Tables 5-5I).

[0179] Linear discriminant models were generated to describe toxic and non-toxic samples. The top discriminant genes and/or EST's were used to determine toxicity by calculating each gene's contribution with homo and heteroscedastic treatment of variance and inclusion or exclusion of mutual information between genes. Prediction of samples within the database exceeded 80% true positives with a false positive rate of less than 5%. It was determined that combinations of genes and/or EST's generally provided a better predictive ability than individual genes and that the more genes and/or EST used the better predictive ability. Although the preferred embodiment includes fifty or more genes, many pairings or greater combinations of genes and/or EST can work better than individual genes. All combinations of two or more genes from the selected list (Tables 5-5I) could be used to predict toxicity. These combinations could be selected by pairing in an agglomerate, divisive, or random approach. Further, as yet undetermined genes and/or EST's could be combined with individual or combination of genes and/or EST's described here to increase predictive ability. However, the genes and/or EST's described here would contribute most of the predictive ability of any such undetermined combinations.

[0180] Other variations on the above method can provide adequate predictive ability. These include selective inclusion of components via agglomerate, divisive, or random approaches or extraction of loading and combining them in agglomerate, divisive, or random approaches. Also the use of composite variables in logistic regression to determine classification of samples can also be accomplished with linear discriminate analysis, neural or Bayesian networks, or other forms of regression and classification based on categorical or continual dependent and independent variables.

Example 3

Modeling Methods

[0181] The above modeling methods provide broad approaches of combining the expression of genes to predict sample toxicity. One could also provide no weight in a simple voting method or determine weights in a supervised or unsupervised method using agglomerate, divisive, or random approaches. All or selected combinations of genes may be combined in ordered, agglomerate, or divisive, supervised or unsupervised clustering algorithms with unknown samples for classification. Any form of correlation matrix may also be used to classify unknown samples. The spread of the group distribution and discriminate score alone provide enough information to enable a skilled person to generate all of the above types of models with accuracy that can exceed discriminate ability of individual genes. Some examples of methods that could be used individually or in combination after transformation of data types include but are not limited to: Discriminant Analysis, Multiple Discriminant Analysis, logistic regression, multiple regression analysis, linear regression analysis, conjoint analysis, canonical correlation, hierarchical cluster analysis, k-means cluster analysis, self-organizing maps, multidimensional scaling, structural equation modeling, support vector machine determined boundaries, factor analysis, neural networks, bayesian classifications, and resampling methods.

Example 4

Individual Compound Markers

[0182] The mechanism of action of a particular compound's induced toxicity, as exhibited by gene expression, may differ from all other compounds' mechanisms of induced toxicity. Therefore, markers of toxicity were identified that separated a specific compound's mode of toxicity from all other modes of toxicity exhibited by all other compounds in the database. These markers were identified for each of the cardiotoxins. The top 10, 25, 50, 100 genes based on individual discriminate scores were used in a model to ensure that combination of genes provided a better prediction than individual genes. As described above, all combinations of two or more genes from this list could potentially provide better prediction than individual genes when selected in any order or by ordered, agglomerate, divisive, or random approaches. In addition, combining these genes with other genes could provide better predictive ability, but most of this predictive ability would come from the genes listed herein.

[0183] Samples may be considered toxic if they score positive in any individual compound represented here or in any modeling method mentioned under general toxicology models based on combination of individual time and dose grouping of individual toxic compounds obtainable from the data. Most logical groupings with one or more genes and one or more sample dose and time points should produce better predictions of general toxicity or similarity to known toxicant than individual genes.

[0184] Although the present invention has been described in detail with reference to examples above, it is understood that various modifications can be made without departing from the spirit of the invention. Accordingly, the invention is limited only by the following claims. All cited patents, patent applications and publications referred to in this application are herein incorporated by reference in their entirety.

2TABLE 1Attorney Docket No. 44921-5090US Document No. 1828250.1Seq.GenBankModelID No.IdentifierAcc. No.Gene NameUnigene Cluster TitleCode116130J01435unknown Glu-Pro dipeptideunknown Glu-Pro dipeptide repeata, c, f,repeat proteinproteinGeneral125319J01435unknown Glu-Pro dipeptideunknown Glu-Pro dipeptide repeata, c, frepeat proteinprotein125050J01435unknown Glu-Pro dipeptideunknown Glu-Pro dipeptide repeatc, f, grepeat proteinprotein225051J01436a, c325439M35826a, c, f, g416132AA850885unknown Glu-Pro dipeptideunknown Glu-Pro dipeptide repeata, crepeat proteinprotein56153AA875531procollagen, type I, alpha 2Rattus norvegicus CDK110 mRNA,eprocollagen, type I, alpha 2615666AA892248a, f719421AA945152NG, NG dimethylarginineNG, NG dimethylargininea, cdimethylaminohydrolasedimethylaminohydrolase814981AI103396Rattus norvegicus CDK110 mRNAa, c, f914982AI171355Rattus norvegicus CDK110 mRNAa, f1014983AI179150Rattus norvegicus CDK110 mRNAa, c, f1121152X14848golgi SNAP receptor complexgolgi SNAP receptor complexa, b, c, f, gmember 1member 11215511NM_012498Rattus norvegicus AldehydeAldehyde reductase 1 (low Kmhreductase 1 (low Km aldosealdose reductase) (5.8 kb Pstlreductase) (5.8 kb Pstl fragment,fragment, probably the functionalprobably the functional gene)gene)(Akr1b1), mRNA. Length = 1339137063NM_012495Rattus norvegicus Aldolase A,Aldolase A, fructose-bisphosphatecfructose-bisphosphate (Aldoa),mRNA. Length = 1442147427NM_012515Rattus norvegicusBenzodiazepin receptor (peripheral)hBenzodiazepin receptor(peripheral) (Bzrp), mRNA.Length = 7811515741NM_012520Rattus norvegicus CatalaseCatalasec, g(Cat), mRNA. Length = 2495164468NM_012529Rattus norvegicus CreatineCreatine kinase, brainekinase, brain (Ckb), mRNA.Length = 11461723869NM_012551Rattus norvegicus Early growthEarly growth response 1Generalresponse 1 (Egr1), mRNA.Length = 31121819408NM_012554Rattus norvegicus Enolase 1,Enolase 1, alphahalpha (Eno1), mRNA. Length =1725196477NM_012559Rattus norvegicus Fibrinogen,Fibrinogen, gamma polypeptideggamma polypeptide (Fgg),mRNA. Length = 13582016080NM_012580Rattus norvegicus HemeHeme oxygenaseGeneraloxygenase (Hmox1), mRNA.Length = 8702120313NM_012585Rattus norvegicus 5-5-Hydroxytryptamine (serotonin)GeneralHydroxytryptamine (serotonin)receptor 1Areceptor 1A (Htr1a), mRNA.Length = 12692215098NM_012588Rattus norvegicus Insulin-likeInsulin-like growth factor-bindingcgrowth factor-binding proteinprotein (IGF-BP3)(IGF-BP3) (Igfbp3), mRNA.Length = 23522324716NM_012589Rattus norvegicus Interleukin 6Interleukin 6 (interferon, beta 2)General(interferon, beta 2) (II6), mRNA.Length = 1046242629NM_012603Rattus norvegicus AvianAvian myelocytomatosis viral (v-Generalmyelocytomatosis viral (v-myc)myc) oncogene homologoncogene homolog (Myc),mRNA. Length = 21682523523NM_012615Rattus norvegicus OrnitineOrnitine decarboxylaseGeneraldecarboxylase (Odc1), mRNA.Length = 24422620589NM_012618Rattus norvegicus S100 calcium-Protein 9 Ka homologous toGeneralbinding protein A4 (S100a4),calcium-binding proteinmRNA. Length = 4872715540NM_012620Rattus norvegicus serine (orPlasminogen activator inhibitorGeneralcysteine) proteinase inhibitor,clade E (nexin, plasminogenactivator inhibitor type 1),member 1 (Serpine1), mRNA.Length = 30532818725NM_012645Rattus norvegicus RT1 class IbRattus norvegicus MHC class Ibcgene (RT1Aw2), mRNA. Length =RT1.S3 (RT1.S3) mRNA, partial1540cds2818726NM_012645Rattus norvegicus RT1 class IbRattus norvegicus MHC class IbGeneralgene (RT1Aw2), mRNA. Length =RT1.S3 (RT1.S3) mRNA, partial1540cds299423NM_012649Rattus norvegicusRyudocan/syndecan 4GeneralRyudocan/syndecan 4 (Sdc4),mRNA. Length = 2462299424NM_012649Rattus norvegicusRyudocan/syndecan 4GeneralRyudocan/syndecan 4 (Sdc4),mRNA. Length = 24623016224NM_012656Rattus norvegicus SecretedSecreted acidic cystein-richcacidic cystein-rich glycoproteinglycoprotein (osteonectin)(osteonectin) (Sparc), mRNA.Length = 2025311514NM_012678Rattus norvegicus TropomyosinTropomycin 4c, h,4 (Tpm4), mRNA. Length = 900General3220776NM_012680Rattus norvegicus TuberousTuberous sclerosis 2, (renalGeneralsclerosis 2, (renal carcinoma)carcinoma)(Tsc2), mRNA. Length = 55733325650NM_012736Rattus norvegicus Glycerol-3-fphosophate dehydrogenase 2(mitochondrial) (Gpd2), mRNA.Length = 240034344NM_012747Rattus norvegicus SignalSignal transducer and activator ofbtransducer and activator oftranscription 3transcription 3 (Stat3), mRNA.Length = 2924358829NM_012749Rattus norvegicus NucleolinNucleolinh, General(Ncl), mRNA. Length = 2142363601NM_012751Rattus norvegicus solute carrierGlucose transporter 4, insuline-dfamily 2 (facilitated glucoseresponsivetransporter), member 4 (Glut4),mRNA. Length = 25063715174NM_012756Rattus norvegicus Insulin-likeInsulin-like growth factor 2 receptorbgrowth factor 2 receptor (Igf2r),mRNA. Length = 8810381349NM_012776Rattus norvegicus adrenergicG-protein-linked receptor kinaseGeneralreceptor kinase, beta 1 (Adrbk1),(beta adrenergic receptor kinase 1)mRNA. Length = 268339449NM_012786Rattus norvegicus Cytochrome cCytochrom c oxidase subunit VIII-Ha, boxidase subunit VIII-H(heart/muscle)(heart/muscle) (Cox8h), mRNA.Length = 33040961NM_012796Rattus norvegicus glutathione S-glutathione S-transferase, theta 2etransferase, theta 2 (Gstt2),mRNA. Length = 12584115032NM_012816Rattus norvegicus alpha-Methylacyl-CoA racemase alphag, imethylacyl-CoA racemase(Amacr), mRNA. Length = 15044218109NM_012823Rattus norvegicus Annexin A3ESTs, Weakly similar to LURT3General(Anx3), mRNA. Length = 1454annexin III - rat [R. norvegicus]4311137NM_012839Rattus norvegicus CytochromeCytochrome C, expressed ingC, expressed in somatic tissuessomatic tissues(Cycs), mRNA. Length = 3184417541NM_012844Rattus norvegicus EpoxideEpoxide hydrolase 1 (microsomala, c,hydrolase 1 (microsomalxenobiotic hydrolase)Generalxenobiotic hydrolase) (Ephx1),mRNA. Length = 12424517305NM_012876Rattus norvegicus RibosomalRibosomal protein S29b, e, gprotein S29 (Rps29), mRNA.Length = 318461748NM_012889Rattus norvegicus Vascular cellVascular cell adhesion molecule 1a, Generaladhesion molecule 1 (Vcam1),mRNA. Length = 30074716721NM_012891Rattus norvegicus Acyl-CoaAcyl-Coa dehydrogenase, Very longGeneraldehydrogenase, Very long chainchain(Acadvl), mRNA. Length = 21174816274NM_012898Rattus norvegicus alpha 2 HS-alpha 2 HS-glycoprotein alpha 2aglycoprotein alpha 2 (fetuin)(fetuin)(Ahsg), mRNA. Length = 14644924783NM_012914Rattus norvegicus ATPase,ATPase, Ca++ transporting,h, GeneralCa++ transporting, ubiquitousubiquitous(Atp2a3), mRNA. Length = 44725018695NM_012931Rattus norvegicus v-crk-v-crk-associated tyrosine kinaseb, Generalassociated tyrosine kinasesubstratesubstrate (Crkas), mRNA.Length = 3335512555NM_012967Rattus norvegicus IntercellularIntercellular adhesion molecule 1Generaladhesion molecule 1 (Icam1),mRNA. Length = 26025224528NM_012973Rattus norvegicus PotassiumPotassium (K+) channel protein,h(K+) channel protein, slowlyslowly activating (Isk)activating (Isk) (Kcne1), mRNA.Length = 58553956NM_012976Rattus norvegicus Lectin,Lectin, galactose binding, soluble 9a, Generalgalactose binding, soluble 5(Galectin-9)(Galectin-5) (Lgals5), mRNA.Length = 87254958NM_012977Rattus norvegicus Lectin,Lectin, galactose binding, soluble 9Generalgalactose binding, soluble 9(Galectin-9)(Galectin-9) (Lgals9), mRNA.Length = 15455517394NM_012992Rattus norvegicusNucleoplasmin-related proteinGeneralNucleoplasmin-related protein(Nuclear protein B23(Nuclear protein B23 (Npm1),mRNA. Length = 12325619392NM_012998Rattus norvegicus ProteinProtein disulfide isomerase (Prolylidisulfide isomerase(Prolyl 4-4-hydroxylase, beta polypeptide)hydroxylase, beta polypeptide)(P4hb), mRNA. Length = 24605724264NM_012999Rattus norvegicus Subtilisin - likeSubtilisin - like endoproteaseeendoprotease (Pace4), mRNA.Length = 4153583405NM_013011Rattus norvegicus Tyrosine 3-Tyrosine 3-i, Generalmonooxygenase/tryptophan 5-monooxygenase/tryptophan 5-monooxygenase activationmonooxygenase activation protein,protein, zeta polypeptidezeta polypeptide(Ywhaz), mRNA. Length = 16875920229NM_013018Rattus norvegicus Ras-relatedRas-related small GTP bindingGeneralsmall GTP binding protein 3Aprotein 3A(Rab3a), mRNA. Length = 743601606NM_013039Rattus norvegicus ATP-bindingSulfonylurea receptorgcassette, sub-family C(CFTR/MRP), member 8(Abcc8), mRNA. Length = 509961730NM_013040Rattus norvegicus ATP-bindingSulfonylurea receptor 2hcassette, sub-family C(CFTR/MRP), member 9(Abcc9), mRNA. Length = 50006217401NM_013043Rattus norvegicus TransformingTransforming growth factor betag, Generalgrowth factor beta stimulatedstimulated clone 22clone 22 (Tgfb1i4), mRNA.Length = 16666311114NM_013046Rattus norvegicus ThyrotropinThyrotropin releasing hormonef, Generalreleasing hormone (Trh), mRNA.Length = 7686311113NM_013046Rattus norvegicus ThyrotropinThyrotropin releasing hormonefreleasing hormone (Trh), mRNA.Length = 7686416924NM_013069Rattus norvegicus CD74 antigenCD74 antigen (invariantb(invariant polpypeptide of majorpolpypeptide of majorhistocompatibility class II antigen-histocompatibility class II antigen-associated) (Cd74), mRNA.associated)Length = 11506425676NM_013069Rattus norvegicus CD74 antigenb(invariant polpypeptide of majorhistocompatibility class II antigen-associated) (Cd74), mRNA.Length = 11506416925NM_013069Rattus norvegicus CD74 antigenCD74 antigen (invariantb(invariant polpypeptide of majorpolpypeptide of majorhistocompatibility class II antigen-histocompatibility class II antigen-associated) (Cd74), mRNAassociated)Length = 115065357NM_013086Rattus norvegicus CAMPCAMP responsive elementGeneralresponsive element modulatormodulator(Crem), mRNA. Length = 607661521NM_013091Rattus norvegicus TumorTumor necrosis factor receptorinecrosis factor receptorsuperfamily, member 1a (Tnfr1),mRNA. Length = 2130671684NM_013096Rattus norvegicus Hemoglobin,Hemoglobin, alpha 1a, balpha 1 (Hba1), mRNA. Length =5566726150NM_013096Rattus norvegicus Hemoglobin,a, balpha 1 (Hba1), mRNA. Length =556671689NM_013096Rattus norvegicus Hemoglobin,Hemoglobin, alpha 1a, b,alpha 1 (Hba1), mRNA. Length =General556671685NM_013096Rattus norvegicus Hemoglobin,Hemoglobin, alpha 1aalpha 1 (Hba1), mRNA. Length =556671688NM_013096Rattus norvegicus Hemoglobin,Hemoglobin, alpha 1a, balpha 1 (Hba1), mRNA. Length =556681321NM_013098Rattus norvegicus Glucose-6-Glucose-6-phosphataseaphosphatase (G6pc), mRNA.Length = 22376919949NM_013106Rattus norvegicus GuanineGuanine nucleotide binding, protein,Generalnucleotide binding, protein, alphaalpha inhibiting polypeptide 3inhibiting polypeptide 3 (Gnai3),mRNA. Length = 30727023709NM_013113Rattus norvegicus ATPaseATPase Na+/K+ transporting beta 1gNa+/K+ transporting beta 1polypeptidepolypeptide (Atp1b1), mRNA.Length = 2528712005NM_013127Rattus norvegicus CD38 antigenCD38 antigen (ADP-ribosyl cyclase/c(ADP-ribosyl cyclase/cycliccyclic ADP-ribose hydrolase)ADP-ribose hydrolase) (Cd38),mRNA. Length = 22487214299NM_013129Rattus norvegicus Interleukin 15Interleukin 15General(II15), mRNA. Length = 13137316982NM_013144Rattus norvegicus Insulin-likeInsulin-like growth factor bindingGeneralgrowth factor binding protein 1protein 1(Igfbp1), mRNA. Length = 15007421683NM_013154Rattus norvegicusCCAAT/enhancerbinding, proteinGeneralCCAAT/enhancerbinding, protein(C/EBP) delta(C/EBP) delta (Cebpd), mRNA.Length = 12007421682NM_013154Rattus norvegicusCCAAT/enhancerbinding, proteinGeneralCCAAT/enhancerbinding, protein(C/EBP) delta(C/EBP) delta (Cebpd), mRNA.Length = 12007524867NM_013155Rattus norvegicus Very lowVery low density lipoproteinGeneraldensity lipoprotein receptorreceptor(Vldlr), mRNA. Length = 29527625567NM_013156Rattus norvegicus Cathepsin Ld, General(Ctsl), mRNA. Length = 1386763431NM_013156Rattus norvegicus Cathepsin LCathepsin LGeneral(Ctsl), mRNA. Length = 1386763430NM_013156Rattus norvegicus Cathepsin LCathepsin Ld, General(Ctsl), mRNA. Length = 1386771714NM_013187Rattus norvegicusPhospholipase C, gamma 1g, i,Phospholipase C, gamma 1General(Plcg1), mRNA. Length = 51067816448NM_013197Rattus norvegicusAminolevulinate synthase 2, deltaa, b,Aminolevulinate synthase 2,Generaldelta (Alas2), mRNA. Length =18997920826NM_013218Rattus norvegicus adenylateadenylate kinase 3hkinase 3 (Ak3), mRNA. Length =10618018313NM_013220Rattus norvegicus cardiaccardiac ankyrin repeat proteinf, g, i,ankyrin repeat protein (AIrp),GeneralmRNA. Length = 174981815NM_013224Rattus norvegicus ribosomalribosomal protein S26e, Generalprotein S26 (Rps26), mRNA.Length = 4358215239NM_016989Rattus norvegicus adenylateR. norvegicus (Sprague Dawley)hcyclase activating polypeptide 1ribosomal protein L15 mRNA(Adcyap1), mRNA. Length =2681833202NM_017039Rattus norvegicus ProteinProtein phosphatase 2 (formerlyhphosphatase 2 (formerly 2A),2A), catalytic subunit, alpha isoformcatalytic subunit, alpha isoform(Ppp2ca), mRNA. Length = 1804833203NM_017039Rattus norvegicus ProteinProtein phosphatase 2 (formerlyhphosphatase 2 (formerly 2A),2A), catalytic subunit, alpha isoformcatalytic subunit, alpha isoform(Ppp2ca), mRNA. Length = 18048424596NM_017040Rattus norvegicus ProteinProtein phosphatase 2 (formerlyhphosphatase 2 (formerly 2A),2A), catalytic subunit, beta isoformcatalytic subunit, beta isoform(Ppp2cb), mRNA. Length = 1843856654NM_017068Rattus norvegicus Lysosomal-Lysosomal-associated membraneaassociated membrane protein 2protein 2(Lamp2), mRNA. Length = 15488611152NM_017073Rattus norvegicus GlutamineGlutamine synthetase (glutamate-Generalsynthetase (glutamate-ammoniaammonia ligase)ligase) (Glul), mRNA. Length =27938611153NM_017073Rattus norvegicus GlutamineGlutamine synthetase (glutamate-Generalsynthetase (glutamate-ammoniaammonia ligase)ligase) (Glul), mRNA. Length =27938722552NM_017087Rattus norvegicus SmallSmall proteoglycan I (biglycan),Generalproteoglycan I (biglycan), bonebone (BSPG1) (bone/cartilage(BSPG1) (bone/cartilageproteclycan 1 precursor)proteclycan 1 precursor) (Bgn),mRNA. Length = 2446888888NM_017090Rattus norvegicus guanylateGuanylate cyclase, soluble, alpha 1Generalcyclase 1, soluble, alpha 3(GTP pyrophosphate - lyase)(Gucy1a3), mRNA. Length =4775891435NM_017125Rattus norvegicus Cd63 antigenCd63 antigeng, General(Cd63), mRNA. Length = 8609021663NM_017126Rattus norvegicus ferredoxin 1ferredoxin 1General(Fdx1), mRNA. Length = 8389124886NM_017138Rattus norvegicus lamininlaminin receptor 1Generalreceptor 1 (Lamr1), mRNA.Length = 10189224106NM_017141Rattus norvegicus DNADNA polymerase betacpolymerase beta (Polb), mRNA.Length = 32989224107NM_017141Rattus norvegicus DNADNA polymerase betaGeneralpolymerase beta (Polb), mRNA.Length = 32989320859NM_017144Rattus norvegicus troponin I,troponin I, cardiaca, b, fcardiac (Tnni3), mRNA. Length =8309415365NM_017147Rattus norvegicus cofilin 1, non-cofilin 1, non-muscleg, h,muscle (Cfl1), mRNA. Length =General1039955351NM_017150Rattus norvegicus ribosomalribosomal protein L29Generalprotein L29 (Rpl29), mRNA.Length = 6309616953NM_017151Rattus norvegicus ribosomalribosomal protein S15e, hprotein S15 (Rps15), mRNA.Length = 4879721975NM_017154Rattus norvegicus xanthinexanthine dehydrogenaseGeneraldehydrogenase (Xdh), mRNA.Length = 41989817104NM_017160Rattus norvegicus ribosomalribosomal protein S6Generalprotein S6 (Rps6), mRNA.Length = 8019817107NM_017160Rattus norvegicus ribosomalribosomal protein S6Generalprotein S6 (Rps6), mRNA.Length = 8019919031NM_017180Rattus norvegicus T-cell deathT-cell death associated geneGeneralassociated gene (Tdag), mRNA.Length = 135310015434NM_017187Rattus norvegicus high mobilityhigh mobility group protein 2fgroup box 2 (Hmgb2), mRNA.Length = 107210114696NM_017202Rattus norvegicus cytochrome ccytochrome c oxidase, subunit IVeoxidase, subunit IVa (Cox4a),mRNA. Length = 6961025005NM_017209Rattus norvegicus nuclearnuclear receptor binding factor 1Generalreceptor binding factor 1 (Nrbf1),mRNA. Length = 130210320193NM_017232Rattus norvegicus prostaglandin-prostaglandin-endoperoxideGeneralendoperoxide synthase 2synthase 2(Ptgs2), mRNA. Length = 182710420482NM_017240Rattus norvegicus myosin heavymyosin heavy chain, cardiacechain, cardiac muscle, fetalmuscle, fetal(Myh7), mRNA. Length = 59251043780NM_017240Rattus norvegicus myosin heavyESTechain, cardiac muscle, fetal(Myh7), mRNA. Length = 592510420484NM_017240Rattus norvegicus myosin heavymyosin heavy chain, cardiaca, c, e, fchain, cardiac muscle, fetalmuscle, fetal(Myh7), mRNA. Length = 592510517563NM_017245Rattus norvegicus eukaryoticeukaryotic translation elongationg, Generaltranslation elongation factor 2factor 2(Eef2), mRNA. Length = 262610615301NM_017259Rattus norvegicus B-cellB-cell translocation gene 2, anti-Generaltranslocation gene 2, anti-proliferativeproliferative (Btg2), mRNA.Length = 251910615299NM_017259Rattus norvegicus B-cellB-cell translocation gene 2, anti-Generaltranslocation gene 2, anti-proliferativeproliferative (Btg2), mRNA.Length = 251910615300NM_017259Rattus norvegicus B-cellB-cell translocation gene 2, anti-Generaltranslocation gene 2, anti-proliferativeproliferative (Btg2), mRNA.Length = 25191073254NM_017282Rattus norvegicus proteasomeproteasome (prosome, macropain)h(prosome, macropain) subunit,subunit, alpha type 5alpha type 5 (Psma5), mRNA.Length = 97010882NM_017297Rattus norvegicus potassiumpotassium inwardly-rectifyingiinwardly-rectifying channel,channel, subfamily J, member 5subfamily J, member 5 (Kcnj5),mRNA. Length = 31561091894NM_017320Rattus norvegicus cathepsin Scathepsin SGeneral(Ctss), mRNA. Length = 1330110356NM_017334Rattus norvegicus transcriptionalCAMP responsive elementGeneralrepressor CREM (CREM),modulatormRNA. Length = 436110355NM_017334Rattus norvegicus transcriptionalGeneralrepressor CREM (CREM),mRNA. Length = 43611120848NM_017343Rattus norvegicus myosinRat mRNA for myosin regulatoryc, gregulatory light chain (MRLCB),light chain (RLC)mRNA. Length = 1139112460NM_019131Rattus norvegicus TropomyosinTropomyosin 1 (alpha)a1 (alpha) (Tpm1), mRNA.Length = 10041135622NM_019143Rattus norvegicus Fibronectin 1Fibronectin 1General(Fn1), mRNA. Length = 832911417066NM_019170Rattus norvegicus carbonylcarbonyl reductaseereductase (Cbr), mRNA.Length = 10181151174NM_019184Rattus norvegicus CytochromeCytochrome P450, subfamily IICbP450, subfamily IIC(mephenytoin 4-hydroxylase)(mephenytoin 4-hydroxylase)(Cyp2c), mRNA. Length = 185611618569NM_019212Rattus norvegicus actin, alpha 1,actin, alpha 1, skeletal muscleGeneralskeletal muscle (Acta1), mRNA.Length = 113411720433NM_019232Rattus norvegicusserum/glucocorticoid regulatedb, Generalserum/glucocorticoid regulatedkinasekinase (Sgk), mRNA. Length =243511817908NM_019242Rattus norvegicus interferon-interferon-related developmentalcrelated developmental regulatorregulator 11 (lfrd1), mRNA. Length = 173611911218NM_019247Rattus norvegicus paired-likepaired-like homeodomainGeneralhomeodomain transcriptiontranscription factor 3factor 3 (Pitx3), mRNA. Length =125312023419NM_019257Rattus norvegicus splicing factor,splicing factor, arginine/serine-rich 5darginine/serine-rich 5 (SRp40,(SRp40, HRS)HRS) (Sfrs5), mRNA. Length =278112121443NM_019262Rattus norvegicus complementcomplement component 1, qGeneralcomponent 1, q subcomponent,subcomponent, beta polypeptidebeta polypeptide (C1qb), mRNA.Length = 113612220735NM_019283Rattus norvegicus solute carrierantigen identified by monoclonala, d,family 3 (activators of dibasicantibodies 4F2Generaland neutral amino acidtransport), member 2 (Slc3a2),mRNA. Length = 194012220734NM_019283Rattus norvegicus solute carrierantigen identified by monoclonaldfamily 3 (activators of dibasicantibodies 4F2and neutral amino acidtransport), member 2 (Slc3a2),mRNA. Length = 194012310016NM_019289Rattus norvegicus Actin-relatedActin-related protein complex 1biprotein complex 1b (Arpc1b),mRNA. Length = 143012415056NM_019291Rattus norvegicus carboniccarbonic anhydrase 2Generalanhydrase 2 (Ca2), mRNA.Length = 145912520750NM_019301Rattus norvegicus ComplementComplement receptor relatedhreceptor related protein (Cr1),proteinmRNA. Length = 181112652NM_019335Rattus norvegicus ProteinProtein kinase, interferon-inducibleekinase, interferon-inducibledouble stranded RNA dependentdouble stranded RNA dependent(Prkr), mRNA. Length = 380812722675NM_019358Rattus norvegicus glycoproteinglycoprotein 38General38 (Gp38), mRNA. Length =185412820057NM_019370Rattus norvegicus alkalinealkaline phosphodiesterasegphosphodiesterase (LOC54410),mRNA. Length = 27771291324NM_019371Rattus norvegicus factor-factor-responsive smooth muscleGeneralresponsive smooth muscleproteinprotein (SM-20), mRNA.Length = 282513022727NM_019383Rattus norvegicus ATP synthaseATP synthase subunit disubunit d (Atp5jd), mRNA.Length = 58113116NM_019386Rattus norvegicus tissue-typetissue-type transglutaminaseGeneraltransglutaminase (Tgm2),mRNA. Length = 339313117NM_019386Rattus norvegicus tissue-typetissue-type transglutaminaseGeneraltransglutaminase (Tgm2),mRNA. Length = 3393132574NM_019905Rattus norvegicus calpactin IRattus norvegicus clone BB.1.4.1g, i,heavy chain (Anxa2), mRNA.unknown Glu-Pro dipeptide repeatGeneralLength = 1395protein mRNA, completecds, calpactin I heavychain, hydroxyacid oxidase 3(medium-chain)13318713NM_020075Rattus norvegicus eukaryoticeukaryotic initiation factor 5 (elF-5)Generalinitiation factor 5 (elF-5) (Eif5),mRNA. Length = 350413318715NM_020075Rattus norvegicus eukaryoticeukaryotic initiation factor 5 (elF-5)Generalinitiation factor 5 (elF-5) (Eif5),mRNA. Length = 350413419696NM_021699Rattus norvegicusserine/threonine kinaseGeneralserine/threonine kinase(LOC60328), mRNA. Length =257213519710NM_021744Rattus norvegicus CD14 antigenCD14 antigeni, General(Cd14), mRNA. Length = 159113620035NM_021754Rattus norvegicus Nopp140Nopp140 associated proteinGeneralassociated protein (Nap65),mRNA. Length = 198013714397NM_021909Rattus norvegicus FXYD domain-FXYD domain-containing iong, Generalcontaining ion transport regulatortransport regulator 55 (Fxyd5), mRNA. Length = 94013817100NM_022179Rattus norvegicus Hexokinase 3Hexokinase 3h, General(Hk3), mRNA. Length = 369213817101NM_022179Rattus norvegicus Hexokinase 3Hexokinase 3General(Hk3), mRNA. Length = 369213920204NM_022196Rattus norvegicus leukemialeukemia inhibitory factori, Generalinhibitory factor (Lif), mRNA.Length = 60914020385NM_022229Rattus norvegicus heat shockheat shock protein 60 (liver)hprotein 60 (liver) (Hsp60),mRNA. Length = 21751416263NM_022251Rattus norvegicusRattus norvegicus aminopeptidasebaminopeptidase A (Enpep),A short variant mRNA, partial cdsmRNA. Length = 40751426585NM_022266Rattus norvegicus connectiveconnective tissue growth factori, Generaltissue growth factor (Ctgf),mRNA. Length = 234514317161NM_022298Rattus norvegicus alpha-tubulinalpha-tubuling, General(Tuba1), mRNA. Length = 161714413480NM_022390Rattus norvegicus quinoidquinoid dihydropteridine reductasefdihydropteridine reductase(Qdpr), mRNA. Length = 130714522415NM_022392Rattus norvegicus growthgrowth response protein (CL-6)Generalresponse protein (CL-6)(LOC64194), mRNA. Length =241014623705NM_022396Rattus norvegicus guanineguanine nucleotide binding proteinhnucleotide binding proteingamma subunit 11gamma subunit 11 (Gng11),mRNA. Length = 55714723300NM_022398Rattus norvegicus 2-oxoglutarate2-oxoglutarate carrierhcarrier (LOC64201), mRNA.Length = 94614824536NM_022399Rattus norvegicus calreticulincalreticulinc(Calr), mRNA. Length = 188214920915NM_022407Rattus norvegicus Aldehydealdehyde dehydrogenase family 1,Generaldehydrogenase 1, subfamily A1subfamily A1(Aldh1a1), mRNA. Length =20121508212NM_022500Rattus norvegicus ferritin lightferritin light chain 1Generalchain 1 (Ftl1), mRNA. Length =5521511867NM_022510Rattus norvegicus ribosomalribosomal protein L4Generalprotein L4 (Rpl4), mRNA.Length = 13871524242NM_022521Rattus norvegicus ornithineornithine aminotransferasefaminotransferase (Oat), mRNA.Length = 19381536100NM_022531Rattus norvegicus desmin (Des),desminf, GeneralmRNA. Length = 21691548598NM_022538Rattus norvegicus phosphatidatephosphatidate phosphohydrolasefphosphohydrolase type 2type 2(Ppap2), mRNA. Length = 8711548597NM_022538Rattus norvegicus phosphatidatephosphatidate phosphohydrolaseb, Generalphosphohydrolase type 2type 2(Ppap2), mRNA. Length = 87115511039NM_022543Rattus norvegicus steroidsteroid sensitive gene-1 proteinGeneralsensitive gene-1 protein (Ssg1),mRNA. Length = 371915620925NM_022594Rattus norvegicus enoylenoyl hydratase-like protein,ehydratase-like protein,peroxisomalperoxisomal (Ech1), mRNA.Length = 109715720944NM_022597Rattus norvegicus cathepsin Bcathepsin Bf, General(Ctsb), mRNA. Length = 190415821211NM_022607Rattus norvegicus MIPP65MIPP65 proteinb, hprotein (Mipp65), mRNA.Length = 14681592250NM_022643Rattus norvegicus Testis-specificESTs, Highly similar to 0506206Ahhistone 2b (Th2b), mRNA.histone H2B [R. norvegicus]Length = 47016012542NM_022647Rattus norvegicus histone 2bESTs, Highly similar to 0506206Af(H2b), mRNA. Length = 378histone H2B [R. norvegicus]16115727NM_022953Rattus norvegicus Slit1 (Slit1),Slit1GeneralmRNA. Length = 495016215729NM_022955Rattus norvegicus MEGF6MEGF6General(Egfl3), mRNA. Length = 552316321239NM_024125Rattus norvegicus LiverLiver activating protein (LAP, alsoc, Generalactivating protein (LAP, also NF-NF-IL6, nuclear factor-IL6,IL6, nuclear factor-IL6,previously designated TCF5)previously designated TCF5)(Cebpb), mRNA. Length = 1408164353NM_024127Rattus norvegicus DNA-damage-DNA-damage-inducible transcript 1iinducible transcript 1 (Gadd45a),mRNA. Length = 71116517226NM_024131Rattus norvegicus D-D-dopachrome tautomeraseGeneraldopachrome tautomerase (Ddt),mRNA. Length = 62816624634NM_024137Rattus norvegicus humanhuman immunodeficiency virus typeGeneralimmunodeficiency virus type II enhancer-binding protein 2enhancer-binding protein 2(Hivep2), mRNA. Length = 973116624632NM_024137Rattus norvegicus humanhuman immunodeficiency virus typeaimmunodeficiency virus type II enhancer-binding protein 2enhancer-binding protein 2(Hivep2), mRNA. Length = 973116722NM_024388Rattus norvegicus immediateimmediate early gene transcriptionbearly gene transcription factorfactor NGFI-BNGFI-B (Nr4a1), mRNA.Length = 24881689929NM_024392Rattus norvegicus peroxisomalperoxisomal multifunctional enzymegmultifunctional enzyme type IItype II(Hsd17b4), mRNA. Length =25351693582NM_024396Rattus norvegicus ATP-bindingATP-binding cassette, sub-family Aacassette, sub-family A (ABC1),(ABC1), member 2member 2 (Abca2), mRNA.Length = 804017022626NM_024400Rattus norvegicus a disintegrina disintegrin and metalloproteinaseGeneraland metalloproteinase withwith thrombospondin motifs 1thrombospondin motifs 1(ADAMTS-1)(ADAMTS-1) (Adamts1), mRNA.Length = 487817113633NM_024403Rattus norvegicus activatingactivating transcription factor ATF-4Generaltranscription factor ATF-4 (Atf4),mRNA. Length = 117317113634NM_024403Rattus norvegicus activatingactivating transcription factor ATF-4Generaltranscription factor ATF-4 (Atf4),mRNA. Length = 117317217917NM_024488Rattus norvegicus CDK5CDK5 activator-binding protein C53a, bactivator-binding proteinC53(C53), mRNA. Length = 186517326164NM_030836Rattus norvegicus leucyl-specificleucyl-specific aminopeptidaseiaminopeptidase PILS (APPILS),PILSmRNA. Length = 50421741221NM_030845Rattus norvegicus gro (Gro1),groGeneralmRNA. Length = 92917517342NM_030873Rattus norvegicus profilin IIprofilin IId(Pfn2), mRNA. Length = 196617623109NM_031000Rattus norvegicus aldo-ketoaldo-keto reductase family 1,c, f, hreductase family 1, member A1member A1 (aldehyde reductase)(aldehyde reductase) (Akr1a1),mRNA. Length = 112417721165NM_031005Rattus norvegicus non-musclenon-muscle alpha-actinin 1Generalalpha-actinin 1 (Actn1), mRNA.Length = 29561781845NM_031010Rattus norvegicus arachidonatearachidonate 12-lipoxygenasea, b,12-lipoxygenase (Alox12),GeneralmRNA. Length = 204817825517NM_031010Rattus norvegicus arachidonatearachidonate 12-lipoxygenasea, b,12-lipoxygenase (Alox12),GeneralmRNA. Length = 204817915886NM_031035Rattus norvegicus GTP-bindingGTP-binding protein (G-alpha-i2)c, fprotein (G-alpha-i2) (Gnai2),mRNA. Length = 174818015957NM_031050Rattus norvegicus lumicanlumicanh(Lum), mRNA. Length = 174018111849NM_031065Rattus norvegicus ribosomalribosomal protein L10ah, Generalprotein L10a (Rpl10a), mRNA.Length = 71018212639NM_031099Rattus norvegicus ribosomalribosomal protein L5e, Generalprotein L5 (Rpl5), mRNA.Length = 106918320812NM_031100Rattus norvegicus ribosomalribosomal protein L10eprotein L10 (Rpl10), mRNA.Length = 76918423854NM_031101Rattus norvegicus ribosomalribosomal protein L13Generalprotein L13 (Rpl13), mRNA.Length = 72218516938NM_031103Rattus norvegicus ribosomalribosomal protein L19eprotein L19 (Rpl19), mRNA.Length = 70318622205NM_031105Rattus norvegicus large subunitlarge subunit ribosomal proteinhribosomal protein L36a (Rpl36a),L36amRNA. Length = 44418716847NM_031109Rattus norvegicus ribosomalribosomal protein S10g, Generalprotein S10 (Rps10), mRNA.Length = 61018810878NM_031110Rattus norvegicus ribosomalribosomal protein S11e, Generalprotein S11 (Rps11), mRNA.Length = 53418920839NM_031113Rattus norvegicus ribosomalribosomal protein S27aGeneralprotein S27a (Rps27a), mRNA.Length = 55219022749NM_031116Rattus norvegicus smallsmall inducible cytokine A5binducible cytokine A5 (RANTES)(RANTES)(Scya5), mRNA. Length = 2791911580NM_031117Rattus norvegicus small nuclearsmall nuclear ribonucleoparticle-hribonucleoparticle-associatedassociated protein (snRNP) mRNA,protein (snRNP) mRNA, cloneclone Sm51Sm51 (Snrpn), mRNA. Length =142819213929NM_031131Rattus norvegicus TGF beta 2TGF beta 2 proteinGeneralprotein (Tgfb2), mRNA. Length =288019315185NM_031140Rattus norvegicus vimentinvimentinc, General(Vim), mRNA. Length = 17961941638NM_031143Rattus norvegicus diacylglyceroldiacylglycerol kinaseGeneralkinase (Dgkz), mRNA. Length =356019521624NM_031144Rattus norvegicus cytoplasmiccytoplasmic beta-actingbeta-actin (Actx), mRNA.Length = 112819615277NM_031237Rattus norvegicus ubiquitin-ubiquitin-conjugating enzyme E2D 3g, i,conjugating enzyme E2D 3(homologous to yeast UBC4/5)General(homologous to yeast UBC4/5)(Ube2d3), mRNA. Length = 153119718597NM_031325Rattus norvegicus UDP-glucoseUDP-glucose dehydrogeanseGeneraldehydrogeanse (Ugdh), mRNA.Length = 231819811258NM_031327Rattus norvegicus cysteine richcysteine rich protein 61Generalprotein 61 (Cyr61), mRNA.Length = 187119918654NM_031358Rattus norvegicus potassiumpotassium inwardly-rectifyingi, Generalinwardly-rectifying channel,channel, subfamily J, member 11subfamily J, member 11(Kcnj11), mRNA. Length = 222720012581NM_031514Rattus norvegicus Janus kinaseJanus kinase 2 (a protein tyrosinei, General2 (a protein tyrosine kinase)kinase)(Jak2), mRNA. Length = 373120120449NM_031530Rattus norvegicus SmallSmall inducible gene JEg, Generalinducible gene JE (Scya2),mRNA. Length = 78020120448NM_031530Rattus norvegicus SmallSmall inducible gene JEginducible gene JE (Scya2),mRNA. Length = 780202445NM_031535Rattus norvegicus B cellB cell lymphoma 2 like, ESTs,blymphoma 2 like (Bcl2l), mRNA.Moderately similar to acetolactateLength = 1748synthase homolog [H. sapiens]2034011NM_031543Rattus norvegicus CytochromeCytochrome P450, subfamily 2e1aP450, subfamily 2e1 (ethanol-(ethanol-inducible)inducible) (Cyp2e1), mRNA.Length = 162420418389NM_031545Rattus norvegicus BrainBrain natriuretic factori, Generalnatriuretic factor (Nppb), mRNA.Length = 628205692NM_031557Rattus norvegicus ProstaglandinProstaglandin I2 (prostacyclin)hI2 (prostacyclin) synthasesynthase(Ptgis), mRNA. Length = 161820618318NM_031561Rattus norvegicus CD36 antigenCD36 antigen (collagen type Ih(collagen type I receptor,receptor, thrombospondin receptor)thrombospondin receptor)(Cd36), mRNA. Length = 243620724219NM_031579Rattus norvegicus proteinprotein tyrosine phosphatase 4a1Generaltyrosine phosphatase 4a1(Ptp4a1), mRNA. Length = 263820824235NM_031614Rattus norvegicus thioredoxinthioredoxin reductase 1Generalreductase 1 (Txnrd1), mRNA.Length = 3360209567NM_031628Rattus norvegicus nuclearnuclear receptor subfamily 4, groupGeneralreceptor subfamily 4, group A,A, member 3member 3 (Nr4a3), mRNA.Length = 4400210211NM_031664Rattus norvegicus solute carriersolute carrier family 28 (sodium-cfamily 28 (sodium-coupledcoupled nucleoside transporter),nucleoside transporter), membermember 22 (Slc28a2), mRNA. Length =288121118403NM_031677Rattus norvegicus four and a halffour and a half LIM domains 2gLIM domains 2 (Fhl2), mRNA.Length = 84021220743NM_031684Rattus norvegicus solute carriersolute carrier family 29 (nucleosidef, g,family 29 (nucleosidetransporters), member 1Generaltransporters), member 1(Slc29a1), mRNA. Length = 176621321575NM_031698Rattus norvegicus ribophorin IIribophorin IIb(Rpn2), mRNA. Length = 223421416918NM_031709Rattus norvegicus ribosomalribosomal protein S12e, Generalprotein S12 (Rps12), mRNA.Length = 49921519050NM_031719Rattus norvegicus chloridechloride channel current inducerGeneralchannel, nucleotide-sensitive, 1A(Clns1a), mRNA. Length = 139921519048NM_031719Rattus norvegicus chloridechloride channel current inducerfchannel, nucleotide-sensitive, 1A(Clns1a), mRNA. Length = 13992163549NM_031723Rattus norvegicus signalsignal peptidase complex (18 kD)hpeptidase complex (18 kD)(Spc18), mRNA. Length = 64321714184NM_031776Rattus norvegicus guanineguanine deaminaseGeneraldeaminase (Gda), mRNA.Length = 156821714185NM_031776Rattus norvegicus guanineguanine deaminaseGeneraldeaminase (Gda), mRNA.Length = 15682181169NM_031789Rattus norvegicus NF-E2-relatedNF-E2-related factor 2afactor 2 (Nfe2l2), mRNA.Length = 230721917195NM_031814Rattus norvegicus G protein-G protein-coupled receptor kinase-gcoupled receptor kinase-associated ADP ribosylation factorassociated ADP ribosylationGTPase-activating protein (GIT1)factor GTPase-activating protein(GIT1) (Git1), mRNA. Length =323622017535NM_031816Rattus norvegicusretinoblastoma binding protein 7hretinoblastoma binding protein 7(Rbbp7), mRNA. Length = 194722115840NM_031817Rattus norvegicus osteomodulinosteomodulin (osteoadherin)g, General(osteoadherin) (Omd), mRNA.Length = 15362222655NM_031821Rattus norvegicus serum-serum-inducible kinaseiinducible kinase (Snk), mRNA.Length = 27812233251NM_031825Rattus norvegicus fibrillin-1fibrillin-1b(Fbn1), mRNA. Length = 89422233252NM_031825Rattus norvegicus fibrillin-1fibrillin-1c(Fbn1), mRNA. Length = 894222422321NM_031832Rattus norvegicus IgE bindingIgE binding proteing, Generalprotein (Lgals3), mRNA.Length = 9482254749NM_031834Rattus norvegicusminoxidil sulfotransferasec, dsulfotransferase family 1A,phenol-preferring, member 1(Sult1a1), mRNA. Length = 122722615603NM_031851Rattus norvegicus ProhibitinProhibitini(Phb), mRNA. Length = 168822722300NM_031967Rattus norvegicus development-development-related proteincrelated protein (AF045564),mRNA. Length = 271822817735NM_031970Rattus norvegicus Heat shock 27ESTs, Heat shock 27 kDa proteing, i,kDa protein (Hsp27),GeneralmRNA. Length = 78722817734NM_031970Rattus norvegicus Heat shock 27ESTs, Heat shock 27 kDa proteing, i,kDa protein (Hsp27),GeneralmRNA. Length = 78722817736NM_031970Rattus norvegicus Heat shock 27ESTs, Heat shock 27 kDa proteinf, g, ikDa protein (Hsp27),GeneralmRNA. Length = 78722918500NM_031984Rattus norvegicus cerebellar Ca-cerebellar Ca-binding protein, spotcbinding protein, spot 35 protein35 protein(Calb1), mRNA. Length = 228023018899NM_031985Rattus norvegicus S6 kinaseS6 kinasea(Rps6kb1), mRNA. Length =228723119768NM_031986Rattus norvegicus synteninsyntenini(Sdcbp), mRNA. Length = 207723217829NM_033234Rattus norvegicus Hemoglobin,Rat major beta-globin mRNA,a, cbeta (Hbb), mRNA. Length = 620complete cds23225468NM_033234Rattus norvegicus Hemoglobin,a, bbeta (Hbb), mRNA. Length = 62023225469NM_033234Rattus norvegicus Hemoglobin,a, b,beta (Hbb), mRNA. Length = 620General23217832NM_033234Rattus norvegicus Hemoglobin,Rat major beta-globin mRNA,a, b,beta (Hbb), mRNA. Length = 620complete cdsGeneral23312364NM_033351Rattus norvegicus Fc receptor,Rat MHC class I lgG Fc regionGenerallgG, alpha chain transporterreceptor large subunit p51 (FcRn)(Fcgrt), mRNA. Length = 1552mRNA, complete cds23411714NM_033352Rattus norvegicus ATP-bindingESTsGeneralcassette, sub-family D (ALD),member 2 (Abcd2), mRNA.Length = 553123515867NM_053289Rattus norvegicus Pancreatitis-ESTs, Weakly similar to T15062Generalassociated protein 1 (Pap1),hypothetical protein R02D3.2 -mRNA. Length = 781Caenorhabditis elegans[C. elegans], Rattus norvegicuspancreatitis-associated proteinprecursor (pap) mRNA, completecds2364093NM_053290Rattus norvegicusR. norvegicus phosphoglycerateGeneralPhosphoglycerate mutase 1mutase B isozyme (PGAM) mRNA,(Pgam1), mRNA. Length = 1754complete cds23716886NM_053291Rattus norvegicusESTs, Highly similar to PGK2 RATcphosphoglycerate kinase 1PHOSPHOGLYCERATE KINASE,(Pgk1), mRNA. Length = 1675TESTIS SPECIFIC [R. norvegicus]23814928NM_053330Rattus norvegicus ribosomalRattus norvegicus ribosomal proteine, hprotein L21 (Rpl21), mRNA.L21 mRNA, complete cdsLength = 5542391609NM_053338Rattus norvegicus Ras-relatedRattus norvegicus ras-relatedc, Generalassociated with diabetes (Rrad),protein (rad) mRNA, complete cdsmRNA. Length = 14212409353NM_053347Rattus norvegicus nuclearRattus norvegicus LIS1-interactingGeneraldistribution gene E homologprotein NUDE1 (Nude1) mRNA,(Aspergillus) (Nude), mRNA.complete cdsLength = 21532416155NM_053356Rattus norvegicus procollagen,procollagen, type I, alpha 2etype I, alpha 2 (Col1a2), mRNA.Length = 44742416156NM_053356Rattus norvegicus procollagen,procollagen, type I, alpha 2etype I, alpha 2 (Col1a2), mRNA.Length = 447424216017NM_053401Rattus norvegicus brainbrain expressed X-linked 3iexpressed X-linked 3 (Bex3),mRNA. Length = 5192432242NM_053433Rattus norvegicus flavin-flavin-containing monooxygenase 3d, Generalcontaining monooxygenase 3(Fmo3), mRNA. Length = 20372448085NM_053453Rattus norvegicus regulator of G-regulator of G-protein signalingGeneralprotein signaling protein 2protein 2(Rgs2), mRNA. Length = 162924511403NM_053464Rattus norvegicus spermidinespermidine synthaseGeneralsynthase (Srm), mRNA.Length = 126824623276NM_053467Rattus norvegicus integralintegral membrane protein Tmp21-IGeneralmembrane protein Tmp21-I (p23)(p23)(Tmp21), mRNA. Length = 131424715556NM_053483Rattus norvegicus karyopherinkaryopherin (importin) alpha 2General(importin) alpha 2 (Kpna2),mRNA. Length = 188624816394NM_053485Rattus norvegicus calciumcalcium binding protein A6Generalbinding protein A6 (calcyclin)(calcyclin)(S100a6), mRNA. Length = 29124918826NM_053523Rattus norvegicus homocysteine-Rattus norvegicus SUP mRNA,cinducible, endoplasmic reticulumcomplete cdsstress-inducible, ubiquitin-likedomain member 1 (Herpud1),mRNA. Length = 185725014380NM_053536Rattus norvegicus Kruppel-likeRattus norvegicus mRNA forGeneralfactor 15 (kidney) (KIf15), mRNA.Kruppel-like transcription factor,Length = 2458complete cds25115708NM_053565Rattus norvegicus cytokineRattus norvegicus suppressor ofGeneralinducible SH2-containing proteincytokine signaling-3 (SOCS-3)3 (Cish3), mRNA. Length = 863mRNA, complete cds2523050NM_053582Rattus norvegicus glucocorticoid-Rattus norvegicus gis5 mRNA ford, Generalinducible protein (gis5), mRNA.glucocorticoid-inducible protein,Length = 1869complete cds2523049NM_053582Rattus norvegicus glucocorticoid-Rattus norvegicus gis5 mRNA ford, Generalinducible protein (gis5), mRNA.glucocorticoid-inducible protein,Length = 1869complete cds25321709NM_053596Rattus norvegicus endothelin-Rat mRNA for endothelin-Generalconverting enzyme 1 (Ece1),converting enzyme, complete cdsmRNA. Length = 44692542103NM_053597Rattus norvegicus ribosomalRattus norvegicus ribosomal proteine, hprotein S27 (Rps27), mRNA.S271 (S27-1) mRNA, complete cdsLength = 3362557580NM_053603Rattus norvegicus chlorideRattus norvegicus chlorideGeneralintracellular channel 5 (Clic5),intracellular channel 5 mRNA,mRNA. Length = 2140complete cds25620243NM_053615Rattus norvegicus casein kinaseRattus norvegicus casein kinase 1h1, alpha 1 (Csnk1a1), mRNA.alpha (CKIa) mRNA, complete cdsLength = 97825713005NM_053623Rattus norvegicus fatty acid-Rattus norvegicus mRNA for Acyl-GeneralCoenzyme A ligase, long chain 4CoA synthetase, complete cds(Facl4), mRNA. Length = 486225818644NM_053648Rattus norvegicus beta-caroteneRattus norvegicus mRNA for beta-c15, 15′-dioxygenase (Bcdo),carotene 15, 15′-dioxygenase,mRNA. Length = 2207complete cds2596684NM_053703Rattus norvegicus mitogen-Rattus norvegicus mitogen-Generalactivated protein kinase kinase 6activated protein kinase kinase 6(Map2k6), mRNA. Length = 1690(Mkk6) mRNA, complete cds26025379NM_053713Rattus norvegicus Kruppel-liked, Generalfactor 4 (gut) (Klf4), mRNA.Length = 239326022411NM_053713Rattus norvegicus Kruppel-likeESTsdfactor 4 (gut) (Klf4), mRNA.Length = 23932611218NM_053748Rattus norvegicusRattus norvegicus mRNA fore, Generaldipeptidylpeptidase III (Dpp3),dipeptidyl peptidase III, completemRNA. Length = 2632cds2629059NM_053783Rattus norvegicus interferonRattus norvegicus interferon-g, Generalgamma receptor (Ifngr), mRNA.gamma receptor mRNA, completeLength = 1860cds26315103NM_053814Rattus norvegicus RhoRattus norvegicus P116RIP mRNA,hinteracting protein 3 (Rhoip3),complete cdsmRNA. Length = 328626415002NM_053819Rattus norvegicus tissue inhibitorRattus norvegicus tissue inhibitor off, g,of metalloproteinase 1 (Timp1),metalloproteinase-1 (TIMP1),GeneralmRNA. Length = 740mRNA, complete cds26415003NM_053819Rattus norvegicus tissue inhibitorRattus norvegicus tissue inhibitor off, g,of metalloproteinase 1 (Timp1),metalloproteinase-1 (TIMP1),GeneralmRNA. Length = 740mRNA, complete cds26517155NM_053835Rattus norvegicus clathrin, lightRat clathrin light chain (LCB2)epolypeptide (Lcb) (Cltb), mRNA.mRNA, complete cds, Rat clathrinLength = 982light chain (LCB3) mRNA, completecds26620868NM_053843Rattus norvegicus Fc receptor,Rat Fc-gamma receptor mRNA,GeneralIgG, low affinity III (Fcgr3),complete cdsmRNA. Length = 131826620869NM_053843Rattus norvegicus Fc receptor,Rat Fc-gamma receptor mRNA,GeneralIgG, low affinity III (Fcgr3),complete cdsmRNA. Length = 13182671571NM_053857Rattus norvegicus eukaryoticRattus norvegicus Sprague/Dawleyd, Generaltranslation initiation factor 4EPHAS-I mRNA, complete cdsbinding protein 1 (Eif4ebp1),mRNA. Length = 84326818358NM_053864Rattus norvegicus valosin-Rattus norvegicus transitionalhcontaining protein (Vcp), mRNA.endoplasmic reticulum ATPaseLength = 2870mRNA, complete cds26917728NM_053867Rattus norvegicus tumor protein,Rattus norvegicus lens epitheliala, btranslationally-controlled 1protein mRNA, complete cds(Tpt1), mRNA. Length = 79427019781NM_053883Rattus norvegicus dualRattus norvegicus dual-specificityGeneralspecificity phosphatase 6protein tyrosine phosphatase(Dusp6), mRNA. Length = 2104(rVH6) mRNA, complete cds271385NM_053885Rattus norvegicus arginine-Rattus norvegicus atrophin-1i, Generalglutamic acid dipeptide (RE)related protein (rARP) mRNA,repeats (Rere), mRNA. Length =complete cds66592721288NM_053949Rattus norvegicus potassiumRattus norvegicus mRNA forGeneralvoltage-gated channel, subfamilypotassium channel r-ERGH (eag-related), member 2(Kcnh2), mRNA. Length = 388927319774NM_053961Rattus norvegicus endoplasmicESTs, Moderately similar to S12207aretuclum protein 29 (Erp29),hypothetical protein [M. musculus]mRNA. Length = 452927416546NM_053965Rattus norvegicus solute carrierR. norvegicus mRNA forGeneralfamily 25 (carnitine/acylcarnitinecarnitine/acylcarnitine carriertranslocase), member 20protein(Slc25a20), mRNA. Length =123127519544NM_053982Rattus norvegicus ribosomalEST, Moderately similar toGeneralprotein S15a (Rps15a), mRNA.RS1A_HUMAN 40S RIBOSOMALLength = 449PROTEIN S15A [R. norvegicus]27615642NM_053985Rattus norvegicus H3 histone,R. norvegicus mRNA for histoneGeneralfamily 3B (H3f3b), mRNA.H3.3Length = 110727717739NM_053995Rattus norvegicus 3-Sprague-Dawley D-beta-ehydroxybutyrate dehydrogenasehydroxybutyrate dehydrogenase(heart, mitochondrial) (Bdh),mRNA, complete cdsmRNA. Length = 142027817329NM_054008Rattus norvegicus Rgc32 proteinRattus norvegicus RGC-32 (RGC-General(Rgc32), mRNA. Length = 88932) mRNA, complete cds27919658NM_057103Rattus norvegicus A kinaseRattus norvegicus PKC bindingGeneral(PRKA) anchor protein (gravin)protein and substrate mRNA,12 (Akap12), mRNA. Length =complete cds5236280968NM_057133Rattus norvegicus nuclearRattus norvegicus mRNA for smallhreceptor subfamily 0, group B,heterodimer partner homolog,member 2 (Nr0b2), mRNA.complete cdsLength = 11112812413NM_057141Rattus norvegicusRattus norvegicus mRNA for dC-e, hheterogeneous nuclearstretch binding protein (CSBP),ribonucleoprotein K (Hnrpk),complete cdsmRNA. Length = 25632812416NM_057141Rattus norvegicusRattus norvegicus mRNA for dC-dheterogeneous nuclearstretch binding protein (CSBP),ribonucleoprotein K (Hnrpk),complete cdsmRNA. Length = 25632821892NM_057144Rattus norvegicus cysteine-richR. norvegicus mRNA for muscle LIMg, i,protein 3 (Csrp3), mRNA.proteinGeneralLength = 85328317477NM_057194Rattus norvegicus phospholipidRattus norvegicus phospholipidg, Generalscramblase 1 (Plscr1), mRNA.scramblase PLSCR mRNA,Length = 1569complete cds28414126NM_057208Rattus norvegicus tropomyosinRattus norvegicus tropomyosin non-g3, gamma (Tpm3), mRNA.muscle isoform NM1 (TPM-gamma)Length = 1101mRNA, complete cds, Rattusnorvegicus tropomyosin non-muscleisoform NM3 (TPM-gamma) mRNA,complete cds2858641NM_057211Rattus norvegicus Kruppel-likeRattus norvegicus mRNA for BTEcfactor 9 (Klf9), mRNA. Length =binding protein, complete cds272128610498NM_078617Rattus norvegicus ribosomalR. norvegicus (Sprague-Dawley)e, fprotein S23 (Rps23), mRNA.ribosomal protein S23 mRNALength = 43228720392NM_080477Rattus norvegicus 6-R. norvegicus mRNA for 6-GeneralPhosphofructo-2-kinase/fructose-phosphofructo-2-kinase/6-2,6-bisphosphatase 2 (heart)phosphofructo-2-kinase exons(Pfkfb2), mRNA. Length = 25371a′, 1b, 1c, 1d28823033NM_080888Rattus norvegicusESTs, Highly similar to NIPLb, GeneralBCL2/adenovirus E1B 19 kDa-MOUSE BCL2/ADENOVIRUS E1Binteracting protein 3-like (Bnip3l),19-KDA PROTEIN-INTERACTINGmRNA. Length = 3219PROTEIN 3 LIKE [M. musculus]28915843NM_080910Rattus norvegicusRat AIRC mRNA for AIRhphosphoribosylaminoimidazolecarboxylase-SAICAR synthetase,carboxylase,complete cdsphosphoribosylaminoribosylaminoimidazole succinocarboxamidesynthetase (Paics), mRNA.Length = 132929021391NM_130416Rattus norvegicus annexin A7ESTs, Weakly similar to ANX4 RATGeneral(Anxa7), mRNA. Length = 2912ANNEXIN IV [R. norvegicus]29125094X77117c29211663AA800803ESTs, Weakly similar toGeneralYNP5_CAEEL HYPOTHETICAL28.3 KD PROTEIN T05G5.5 INCHROMOSOME III [C. elegans]29325717X61296i2945292AI171607ESTsd, General29523998AI230578ESTsGeneral2965186AA925674ESTsd, General2971754AA817837ESTsGeneral2986438AA819269ESTsGeneral2996059AI178245ESTs, Moderately similar tob, GeneralC17orf1 protein [H. sapiens]30018663U95052ESTs, Weakly similar to S49172htranslation initiation factor elF-4gamma [H. sapiens]3017414AI137586ESTs, Highly similar tog, GeneralIMB3_HUMANIMPORTIN BETA-3SUBUNIT [H. sapiens]30210019AI178756ESTsd, h3036226AA818521ESTsGeneral30415571M27207R. norvegicus mRNA for collagene, halpha1 type I30515089AI009752ESTsg30617214AI639008ESTsa3076073AA818818ESTa30817781AI175474ESTsa30922386AA800844ESTs, Moderately similar to LYOXeRAT PROTEIN-LYSINE 6-OXIDASE PRECURSOR[R. norvegicus]31024765AA900050ESTs, Highly similar tohR37A_HUMAN 60S RIBOSOMALPROTEIN L37 [R. norvegicus]31120984D90109Acyl CoA synthetase, long chainAcyl CoA synthetase, long chainh31222873AA923945ESTs, Weakly similar toi, Generalprocollagen-lysine 5-dioxygenase[R. norvegicus]3132341AI012144ESTsa, General3144861AA901290ESTsGeneral31522796AI072213ESTsGeneral31615935AA866345ESTsGeneral31716038AI177372ESTs, Moderately similar to MPL3hRAT MICROTUBULE-ASSOCIATED PROTEINS 1A/1BLIGHT CHAIN 3 [R. norvegicus]31815212AI229753ADP-ribosylation factor 2ADP-ribosylation factor 2d, General31923157AI172489ESTs, Moderately similar to STRIaRAT STRIATIN [R. norvegicus]3204710AI168973ESTs, Weakly similar to phosducin-Generallike protein [R. norvegicus]32122697AA945996ESTsb, General32215892AI179988ESTsa, General32311404AI237002spermidine synthasespermidine synthaseg, General32423596AI105435HMm: glutaryl-Coenzyme AESTs, Highly similar to GCDHc, GeneraldehydrogenaseMOUSE GLUTARYL-COADEHYDROGENASE PRECURSOR[M. musculus]32515841AI103465ESTs, Moderately similar tod, g,ribonuclease P protein subunit p29General[H. sapiens]3267220AI013098ESTsd32720647AI639402ESTsb32810829AI044467ESTc, f32922043AA943738ESTsf3302936AI229843ESTs, Highly similar to TNF-Generalinduced protein GG2-1 [H. sapiens]33126133AI009950e3325867AA858953HHs: asparaginyl-tRNAESTs, Highly similar toGeneralsynthetaseSYN_HUMAN ASPARAGINYL-TRNA SYNTHETASE,CYTOPLASMIC [H. sapiens]3333278AI008988ESTs, Highly similar to breakpointGeneralcluster region protein [H. sapiens]33421101AI175789smooth muscle alpha-actinsmooth muscle alpha-acting33512613H31620ESTs, Highly similar to hypotheticalGeneralprotein [H. sapiens]3366927AI010542ESTsh3378789AI070073ESTsh33822995AI232047ESTsGeneral3395129AA925335ESTsd34012462AI175421ESTsGeneral3411760U25281Rattus norvegicus SH3 domainGeneralbinding protein (CR16) mRNA,complete cds34224521AA945636ESTs, Highly similar to 60S ACIDICeRIBOSOMAL PROTEIN P1[R. norvegicus]34325354L13025e34424272AA955948Rattus norvegicusGeneraldeoxyribonuclease II mRNA,complete cds34518160AA799448ESTsh34611738AI104213ESTsGeneral34715644AI010256R. norvegicus mRNA for histoneGeneralH3.334810971AI073212ESTse34923578AA955042ESTs, Weakly similar to folateGeneralbinding protein [R. norvegicus]3506217AI230381ESTsGeneral35121514AA851660ESTsGeneral35216909AA942704ESTs, Moderately similar to SUR2eMOUSE SURFEIT LOCUSPROTEIN 2 [M. musculus]35321284AI170842ESTs, Weakly similar to CARPGeneral[R. norvegicus]35423645AI144653Rattus norvegicus G protein-bindingGeneralprotein CRFG (Crfg) mRNA,complete cds3558230AI059117ESTsGeneral3569720AI071727ESTg35724012AA957335ESTsa, i35814737AI008416ESTsg, General3597308AA818407ESTsb, General3606102AI228335ESTsGeneral36119728AI170394ESTsc3626568AA817891ESTsGeneral36320891AI169337ESTs, Highly similar to CGI-117Generalprotein [H. sapiens]36411375AI237594ESTs, Weakly similar to G01614b, Generalzinc finger protein 127 [H. sapiens]3651483U34843Rattus norvegicus cell cycleiprogression related D123 mRNA,complete cds36620684H32977ESTsGeneral3673959AA901338ESTs, Highly similar tog, GeneralIF2B_HUMAN EUKARYOTICTRANSLATION INITIATIONFACTOR 2 BETA SUBUNIT[H. sapiens]36819518AA800817ESTsa36922445AA944530ESTs, Highly similar to AF134238 1fPL6 protein [M. musculus]37016312AA875032ESTsc, General37119255M15562Rat (diabetic BB) MHC class IIb, Generalalpha chain RT1.D alpha (u)3724048AA851814Rattus norvegicus osteoactivinGeneralmRNA, complete cds3737471AI012379ESTsGeneral37421351AA945932Annexin III (Lipocortin III)Annexin III (Lipocortin III)d, General37523963AA957139ESTsGeneral3769658AA943748ESTsd, General37714384AI177096HMm: adenine phosphoribosylRat adeninectransferasephosphoribosyltransferase (APRT)gene, complete cds3785531AI145859ESTsd3793324AA997981ESTse38013083H31665ESTsd38118400AA799991ESTsa, f,General38215281D13623ESTsGeneral38322578AA924105ESTs, Weakly similar to SY03 RATgSMALL INDUCIBLECYTOKINE A3PRECURSOR [R. norvegicus]38412752AI012146ESTsGeneral3856606AI012308ESTsf, g,General38611936AI228030ESTs, Highly similar to SAP18h[M. musculus]3872539AI111960ESTs, Weakly similar to FKB5GeneralMOUSE 51 KDA FK506-BINDINGPROTEIN [M. musculus]3886353AI008442PCTAIRE-1 protein kinase,PCTAIRE-1 protein kinase,falternatively splicedalternatively spliced38915786AI013924ESTsGeneral39016596AI102486ESTs, Weakly similar to S37583GeneralRING finger protein rfp - mouse[M. musculus]39118581AI176160ESTsGeneral3924948AA924428ESTsh39312098AI237075ESTsd39420073AI639152EST, Weakly similar to A1AT RATb, GeneralALPHA-1-ANTIPROTEINASEPRECURSOR [R. norvegicus]39518456D00688ESTs, Highly similar to 1903159AGeneralmonoamine oxidase A[R. norvegicus]39611208AI237586ESTs, Moderately similar to INIBGeneralRAT INTERFERON-INDUCIBLEPROTEIN [R. norvegicus]3978314AI059386ESTsGeneral3981893X51529phospholipase A2, group IIAphospholipase A2, group IIAGeneral(platelets, synovial fluid)(platelets, synovial fluid)39910821AI043999ESTse40020983AI044900Acyl CoA synthetase, long chainAcyl CoA synthetase, long chainGeneral40118472AI168975ESTsGeneral40221592AI102065ESTs, Highly similar to AF117613 1Generalheme-binding protein [M. musculus]4038665AI071965Heat shock protein 70-1ESTs, Moderately similar to T17342Generalhypothetical proteinDKFZp586K1924.1[H. sapiens], Heat shock protein 70-140411066AI071602ESTsh40519452AA964500ESTe, f4066509AI232361ESTsGeneral40722266AA945601ESTsa4082742AI070173ESTsg, i,General409244U38376EST, Weakly similar to actin-Generalfilament binding protein Frabin[R. norvegicus], Rattus norvegicuscytosolic phospholipase A2 mRNA,complete cds4104238AI234816ESTs, Highly similar tobY103_HUMAN HYPOTHETICALPROTEIN KIAA0103 [H. sapiens]4119970AI045198ESTsGeneral4126550AA817947ESTsh4135193AA925693ESTGeneral41422175AA818999ESTs, Highly similar to zinc fingerGeneralprotein [H. sapiens]41516538AA799449ESTs, Weakly similar tohnucleosome assembly protein[R. norvegicus]4161830AI009002Rat mRNA for cdc25B, completea, bcds41717485AI012352ESTsGeneral4183982AI175100ESTsGeneral4193965AI112118ESTsGeneral4205969AI102520ESTs, Moderately similar toc, GeneralAF161588 1 GABA-A receptor-associated protein [R. norvegicus]42115088AI232613ESTs, Highly similar to AF151886 1GeneralCGI-128 protein [H. sapiens]42225691X53504e4232984AA997015ESTsGeneral42411708AI171807ESTsGeneral42523187AI144591ESTsGeneral42616818AI072906ESTsa42719298AI236338ESTs, Weakly similar to NHPX RATGeneralNHP2/RS6 FAMILY PROTEINYEL026W HOMOLOG[R. norvegicus]42814345AA944773ESTse42910109X58465Ribosomal protein S5Ribosomal protein S5e4305596AI044747ESTse, General43114989AI177366Integrin, beta 1Integrin, beta 1f, i, General43217320AI178069ESTsGeneral43313646X62166ESTs, Highly similar to RL3 RATGeneral60S RIBOSOMAL PROTEIN L3[R. norvegicus]43418611X58200ribosomal protein L23ESTs, Highly similar toe, GeneralRL23_HUMAN 60S RIBOSOMALPROTEIN L23 [R. norvegicus]43521671AA900295Rattus norvegicus placenta growthGeneralfactor (PIGF) mRNA, complete cds4369452AA955206ESTsGeneral43720901AA942706ESTsd43821985AA943273ESTsa4397168AI012739ESTsGeneral44012195AA899121ESTs, Weakly similar to RanBPMGeneral[H. sapiens]44115929AA849740ESTs, Highly similar to CGI-126Generalprotein [H. sapiens]44216322AA866240ESTc44318047AI171359ESTsc44415966AA923994ESTs, Highly similar tobDRG2_HUMANDEVELOPMENTALLYREGULATED GTP-BINDINGPROTEIN 2 [H. sapiens]44513251AI179264ESTs, Moderately similar to LZIP-1Generaland LZIP-2 [M. musculus]44618095AI177482SH-PTP2 protein tyrosineSH-PTP2 protein tyrosinei, Generalphosphatase, non-receptor typephosphatase, non-receptor type 111144716053AI228596ESTs, Weakly similar to T16757Generalhypothetical protein R144.3 -Caenorhabditis elegans [C. elegans]44810684AA849687ESTs, Weakly similar toe, fALZHEIMER'S DISEASEAMYLOID A4 PROTEINHOMOLOG PRECURSOR[R. norvegicus]44922691AI177967ESTs, Weakly similar to TGFB RATGeneralLATENT TRANSFORMINGGROWTH FACTOR BETABINDING PROTEIN 1PRECURSOR [R. norvegicus]45015438AI179399collagen type V, alpha 2collagen type V, alpha 2e45120975AA799599ESTsf, General45215048M24542HHs: ubiquinol-cytochrome cRat Rieske iron-sulfur proteinc, ireductase, Rieske iron-sulfurmRNA, complete cdspolypeptide 145319379AI102711ESTs, Moderately similar to RL3GeneralRAT 60S RIBOSOMAL PROTEINL3 [R. norvegicus]45412583AI234251ESTsGeneral45519480AA944442ESTs, Weakly similar to DRALc[R. norvegicus]4567700AI105383ESTs, Weakly similar to T19707Generalhypothetical protein C34C6.5 -Caenorhabditis elegans [C. elegans]45721996AA946036ESTsf45826148AI013396General4599551AI013558ESTsd46023632AI237273ESTsd, f,General46115292AF012714multiple inositol polyphosphatemultiple inositol polyphosphatechistidine phosphatase 1histidine phosphatase 14626632AI235277ESTsGeneral46318406AI236168ESTsGeneral46411865AA866383ESTsGeneral46520461AI639350ESTsI, General46611728AI007884ESTsd4676562AI177734ESTsd, General4683046AA997706ESTsh46925730X63369General47023166AA859954ESTsGeneral4713271AI010303ESTse4724626AI104744ESTsGeneral4736430AI232319ESTs, Highly similar to JC5221Generalstomatin - mouse [M. musculus]4746262AI177125ESTsGeneral4758786AA996993EST, Moderately similar to Prerdprotein [H. sapiens], ESTs, Highlysimilar to rer [M. musculus]47612946AI228291ESTsGeneral47723015AI227724ESTsf, General47815949AA963780ESTsi4795458AI009756ALG-2 interacting protein 1ALG-2 interacting protein 1g, i,General48011726AA849518ESTsd48122197AI178527ESTsGeneral48221311AI178688ESTsGeneral48316092AI009012ESTs, Highly similar to Wdr1g, i,protein [M. musculus]General48415283AA858548ESTsi, General48523601AA955126EST, Moderately similar to MYBBfMOUSE MYB-RELATEDPROTEINB [M. musculus]4862418AI013790ESTs, Moderately similar to T08802ehypothetical proteinDKFZp586D0623.1 [H. sapiens]4873214AI235483ESTsGeneral48820056AI639504ESTs, Weakly similar to T13607Generalhypothetical protein EG: 87B1.3 -fruit fly [D.melanogaster]4896431AA859085ESTsGeneral49017145M38566Serine protease inhibitorSerine protease inhibitori49115492AA892376ESTsh49223687AI137958ESTse49317224AI179883ESTs, Moderately similar tocSid393p [M. musculus]4943682AA998964ESTsc49521818AF036537Rattus norvegicus homocysteinecrespondent protein HCYP2 mRNA,complete cds4963434AI232014ESTsGeneral49715084AA799397ESTsa49823013AI230743actin-related protein 3actin-related protein 3General42925702X58465e4993817AA926328Tyrosine 3-Tyrosine 3-Generalmonooxygenase/tryptophan 5-monooxygenase/tryptophan 5-monooxygenase activationmonooxygenase activation protein,protein, zeta polypeptidezeta polypeptide5003669AA957535ESTsg, i,General50111331AI145556ESTsd50215558AA875537ESTs, Weakly similar to A46241Generalinterferon response element-bindingfactor IREBF-2 - mouse[M. musculus]50323409AA956294ESTsGeneral5044652AA899642ESTsGeneral50514117AI171350ESTsGeneral50618744AI170407ESTsGeneral50711561AI233182ESTsGeneral50822711AA946072ESTsGeneral5093941AI011598ESTs, Moderately similar to LMA5d, i,MOUSE LAMININGeneralALPHA-5 CHAIN[M. musculus]51023464AA925876ESTsGeneral511168AA924985calsequestrin 2calsequestrin 2h51214944AA925364ESTse51324228AA800318ESTs, Weakly similar to A1AT RATbALPHA-1-ANTIPROTEINASEPRECURSOR [R. norvegicus]51423822AA943114ESTsGeneral51512988AI137070ESTsb, General5164499AA892511EST, Weakly similar to CA22 RATeCALCIUM-BINDINGPROTEIN P22[R. norvegicus]51712274AA964306ESTsGeneral5186094AA818911ESTsd51919257AI030775Rat (diabetic BB) MHC class IIbalpha chain RT1.D alpha (u)52017847AI178214ESTsGeneral52118887AA892860ESTsGeneral52220740S69874Rattus norvegicus Sprague-Dawleyc, d,lipid-binding protein mRNA,Generalcomplete cds5234770AI235915ESTsf52421705AA900684ESTs, Moderately similar tofY064_HUMAN HYPOTHETICALPROTEIN KIAA0064 [H. sapiens]52518797AI236618ESTs, Weakly similar to KIAA0597Generalprotein [H. sapiens]52622212AI236294ESTs, Highly similar to translationGeneralinitiation factor eIF6 [M. musculus]5272153U75404ESTsGeneral52821654U53184estrogen-responsive uterineestrogen-responsive uterinei, Generaltranscripttranscript5293191AI013075ESTs, Weakly similar to T03454GeneralALR protein [H. sapiens]53016613AA874784ESTse, f,General5315482AI180252ESTsGeneral53214337AI180414ESTs, Moderately similar to SPA1GeneralMOUSE GTPASE-ACTIVATINGPROTEIN SPA-1 [M. musculus]53323471AA955162ESTsGeneral5344098AI008642ESTs, Weakly similar to LANP RATi, GeneralLEUCINE-RICHACIDIC NUCLEARPROTEIN [R. norvegicus]53523372AI031002ESTsh53618217AA858930ESTsGeneral5373905AI103403polypyrimidine tract bindingpolypyrimidine tract binding proteinGeneralprotein53824375AI104979ESTs, Moderately similar toGeneralnucleolar protein p40 [H. sapiens]53914256AI176845ESTs, Weakly similar to cornichonGeneral[M. musculus]54018349AA799744ESTsGeneral5412310AI029969ESTsGeneral5423437AA892897ESTsGeneral543806AI169231ESTs, Highly similar to GENE 33GeneralPOLYPEPTIDE [R. norvegicus]54411531AA799773ESTs, Highly similar to gamma-g, h, i,filamin [H. sapiens]General54515181AI235234ESTsi54622689AA945962ESTsGeneral5479084AA893717ESTsf5485307AA893529ESTs, Weakly similar tobselenocysteine tRNA genetranscription activating factor[M. musculus]54925663X05472e55018278AI105080ESTs, Moderately similar toGeneralSCOT_HUMANSUCCINYL-COA: 3-KETOACID-COENZYME ATRANSFERASE PRECURSOR[H. sapiens]5516044AI011285ESTsa, General55217361AA859114ESTsi, General55322464AI009713ESTsd5548137AA800749ESTse55516426X70369procollagen, type III, alpha 1procollagen, type III, alpha 1c, e55624237AA817726ESTsGeneral55717950AI236590ESTsGeneral55818172AI058364ESTs, Weakly similar to G02313d, g,CDC37 homolog [H. sapiens]General55922614AI031004ESTs, Highly similar to SX17dMOUSE TRANSCRIPTIONFACTOR SOX-17 [M. musculus]56023005AA942770ESTsGeneral56117285J02827Branched chain alpha-ketoacidBranched chain alpha-ketoacidGeneraldehydrogenase subunit E1 alphadehydrogenase subunit E1 alpha56215885AA965207ESTs, Highly similar to KIAA0958dprotein [H. sapiens]5635461AI044338ESTsGeneral56422677AA942718ESTsGeneral56518507AI175551ESTs, Moderately similar toGeneralAF145050 1 translation elongationfactor 1-delta subunit[R. norvegicus]5668012AI058330decay-accelarating factordecay-accelarating factorGeneral56713310AI177119ESTs, Weakly similar to C1QB RATb, GeneralCOMPLEMENT C1QSUBCOMPONENT, B CHAINPRECURSOR [R. norvegicus]5686548AI072658ESTsd, General5697941AI043958ESTsg, i,General57013619AI179464ESTsGeneral5713207AA997466ESTsGeneral57220582AA859688ESTs, Weakly similar to I37195 AU-f, Generalspecific RNA-binding protein/enoyl-CoA hydratase homolog [H. sapiens]57321796AI012221ESTs, Weakly similar to S70484g, GeneralRS43 protein - rat (fragment)[R. norvegicus]57419071AA850524ESTs, Highly similar to I49257fNF2d9 - mouse [M. musculus]57524200AI012356ESTsGeneral57624246AA963703ESTs, Highly similar to cell cycleg, Generalprotein p38-2G4 homolog[H. sapiens]5776133AA866234ESTs, Highly similar tocEFTU_HUMAN ELONGATIONFACTOR TU, MITOCHONDRIALPRECURSOR [H. sapiens]57821632AI009167ESTs, Highly similar to BAG-familyGeneralmolecular chaperone regulator-2[H. sapiens]57913772AA851926ESTs, Weakly similar to A57514GeneralRNA helicase HEL117 - rat[R. norvegicus]58022247AA943537Rattus norvegicus zyxin mRNA,i, Generalpartial cds58123732AA957653ESTs, Weakly similar to RNB6General[R. norvegicus]58222385AA859805ESTs, Moderately similar to LYOXeRAT PROTEIN-LYSINE 6-OXIDASE PRECURSOR[R. norvegicus]5832459AA964755ESTsi58423964AI234748ESTsg, General5854074AI175990ESTsg58617204AI171844HMm: RIKEN cDNA 2410043G19Rattus norvegicus F1-ATPasee, ggeneepsilon subunit mRNA, nucleargene encoding mitochondrialprotein, complete cds5876560AI230440ESTsd58817883M11851Rat heart myosin light chain 2a, b(MLC2) mRNA, 3′ end58922937AA850290ESTsi5904944AA924405ESTs, Moderately similar tog, GeneralNO56_HUMAN NUCLEOLARPROTEIN NOP56 [H. sapiens]5913822AA900863ESTs, Weakly similar to nuclearg, GeneralRNA helicase [R. norvegicus]5922729AI170363ESTsd59319282AA955123ESTGeneral59421740AI176810ESTsGeneral59523773AA956476ESTsGeneral5966843AI009768ESTsf59714840AI237698ESTsGeneral59820038AA899797ESTc, General59918541X14671ESTs, Highly similar to RL26 RATe, h60S RIBOSOMAL PROTEIN L26[R. norvegicus]60013966AI231421ESTsd, General60117234AI102741Tissue inhibitor ofTissue inhibitor ofhmetalloproteinase 3metalloproteinase 360222544AA851245ESTs, Weakly similar to KIAA0926Generalprotein [H. sapiens]60313023AI233740ESTs, Weakly similar to ALDR RATGeneralALDOSE REDUCTASE[R. norvegicus]60424209AI172423ESTsi, General60523626AA955540ESTsGeneral6064670AI233714ESTsh60718215AA943367ESTsh6083014AI176362ESTsc, General60916756AA818089ESTs, Highly similar to glycyl-tRNAGeneralsynthetase [H. sapiens]61022605AA859447ESTsi6115283AF090113Rattus norvegicus glutamatehreceptor interacting protein 2(GRIP2) mRNA, complete cds6126043AI059588ESTs, Weakly similar to 54TMpg[H. sapiens]61321474AA851361ESTsd61423038AA900881branched chainbranched chain aminotransferase 1,Generalaminotransferase 1, cytosoliccytosolic61513336AI237070ESTs, Weakly similar toa, b,dJ1042K10.4 [H. sapiens]General6163988AI008546proteasome (prosome,proteasome (prosome, macropain)dmacropain) subunit, alpha type 3subunit, alpha type 361720823AI176302ESTs, Highly similar to A47416dubiquitin-like protein/ribosomalprotein S30 - rat [R. norvegicus]61823044AF034218hyaluronidase 2hyaluronidase 2General61919013AI639256ESTsa62016124AI176963Rattus norvegicus transcriptioncfactor MRG1 mRNA, complete cds62117848AA900460ESTs, Weakly similar to TCPA RATGeneralT-COMPLEX PROTEIN 1, ALPHASUBUNIT [R. norvegicus]62219074AI009391ESTsf6233615AI237645transferrin receptortransferrin receptord, General62411387AA891677ESTsGeneral62525765X89706General62621653AI237535estrogen-responsive uterineestrogen-responsive uterineGeneraltranscripttranscript6275228AI233311ESTs, Highly similar to cytokine-likeGeneralfactor-1 precursor [H. sapiens]6287299AI013911ESTs, Weakly similar to CIRPc, d,[R. norvegicus]General6292093AI102097ESTsGeneral6309166AI137406ESTsi, General63119723AA818761ESTsGeneral6322741AA963077ESTGeneral63322667AA945069ESTsGeneral63417687AA799531ESTs, Weakly similar to T23793a, ehypothetical protein M18.3 -Caenorhabditis elegans [C. elegans]63523217AI235953ESTsGeneral63612135AI176418ESTsc63719894AA859581Rattus norvegicus late gestationdlung protein 1 (Lgl1) mRNA,complete cds63815345AI171587ESTsh63923165AI231799ESTs, Moderately similar to I68673Generalgene X123 protein [H. sapiens]6403391AA998197ESTGeneral64116215AA874999ESTs, Moderately similar toGeneralAF133910 1 ARL-6 interactingprotein-3 [M. musculus]64219086AA892598ESTsGeneral6434725AA900290ESTs, Highly similar to ALPHA-2-d, GeneralMACROGLOBULIN PRECURSOR[R. norvegicus]6446727AI233213ESTsa, g64521816AI231217ESTs, Highly similar to S61A RATh, GeneralPROTEIN TRANSPORT PROTEINSEC61 ALPHA SUBUNIT[R. norvegicus]6462069AI103616ESTs, Weakly similar to RhoAg, i,[R. norvegicus]General64722717AI235948ESTs, Highly similar to entactine, g[R. norvegicus]64811205AI172057ESTsGeneral64922498AA944806ESTsc6507192AI178530ESTsc6518058AA818475ESTsGeneral65218800AI178504ESTsGeneral65312376AI103939ESTsi65412695AI170948ESTs, Moderately similar to S68207i, GeneralG protein-coupled receptor 6C.1[H. sapiens]6555227AA925924ESTs, Highly similar to cytokine-likef, i, Generalfactor-1 precursor [H. sapiens]6567936AA875495ESTsi, General6574491AA818798Rattus norvegicus mRNA forGeneralcathepsin Y, partial cds65813647AA892367ESTs, Highly similar to RL3 RATGeneral60S RIBOSOMAL PROTEIN L3[R. norvegicus]65925716X61295e66010547AA800186ESTGeneral6617760AI030806ESTsb, General66216687AI013553ESTsa66324040AA957422ESTs, Highly similar to HIGHGeneralAFFINITY IMMUNOGLOBULINEPSILON RECEPTOR GAMMA-SUBUNIT PRECURSOR[R. norvegicus]66416154AI009661ESTs, Moderately similar to AF1qi[M. musculus]66514390AI232385ESTsg66614651AI235919ESTsGeneral66717289AA891785HMm: isocitrate dehydrogenase 2ESTs, Weakly similar to IDHC RATb(NADP+), mitochondrialISOCITRATE DEHYDROGENASE[R. norvegicus]66812609AA997486ESTsd, i,General66921657X61381Rattus norvegicus interferon-b, i,inducible protein variant 10 mRNA,Generalcomplete cds6705384AA891041jun B proto-oncogenejun B proto-oncogeneGeneral6715613AI044850ESTsb67216136AI103983unknown Glu-Pro dipeptideRattus norvegicus clone BB.1.4.1Generalrepeat proteinunknown Glu-Pro dipeptide repeatprotein mRNA, complete cds67323270AI179601ESTsGeneral67414464AI104848ESTsGeneral6756053AA818655ESTd67619067AA859663ESTsGeneral67722877AI178819ESTs, Moderately similar to CGI-General137 protein [H. sapiens]67814257AI230460ESTse6795132AA925342ESTs, Highly similar to SKLMGeneralMOUSE SKELEMIN [M. musculus]6802706AA965083ESTsGeneral68122615AA945643ESTsf, General68213460AI175375ESTsGeneral6838707AI059707ESTsi, General68417948AA944581ESTs, Highly similar to RAB/RipGeneralprotein [M. musculus]68513082AI136848ESTs, Weakly similar to T34013a, bhypothetical protein Y4C6B.5 -Caenorhabditis elegans [C. elegans]68616074AA874874ESTs, Highly similar to ADHX RATfALCOHOL DEHYDROGENASECLASS III [R. norvegicus]6878861AI070306ESTsGeneral6888594AI012932ESTsGeneral68922311AI176007ESTs, Highly similar toGeneralPM5P_HUMAN PROTEIN PM5PRECURSOR [H. sapiens]69024268AI172281ESTse6919073AA892273ESTsa, b69222423AA893164ESTsb6935550AI044628ESTs, Weakly similar to unknownGeneral[H. sapiens]6943895AA894029ESTsb69519069AA943737endothelial differentiationendothelial differentiationGeneralsphingolipid G-protein-coupledsphingolipid G-protein-coupledrecepreceptor 169622666AA900974ESTsd, General6972852AI177059ESTse, General69812108AA848963ESTs, Moderately similar to DNA-aREPAIR PROTEINCOMPLEMENTING XP-C CELLSHOMOLOG [M. musculus]69923240AA893939ESTs, Highly similar to Method:iconceptual translation supplied byauthor [M. musculus]7004161AI112141ESTs, Weakly similar to A55169Generalpre-T-cell receptor alpha chainprecursor - mouse [M. musculus]70118272AA799294ESTs, Highly similar to KIAA0740c, e,protein [H. sapiens]General70223612AI170751ESTsGeneral7034790AA900875Rattus norvegicus transcriptionGeneralfactor MRG2 mRNA, complete cds70416168AA893280ESTs, Moderately similar toGeneraladipophilin [H. sapiens]70511644AI235282ESTs, Moderately similar to AM2Generalreceptor [M. musculus]70619057AI235094cortactin isoform Bcortactin isoform BGeneral7079501AI638949ESTs, Weakly similar to S44893aZK1236.7 protein - Caenorhabditiselegans [C. elegans]70824310AA924578ESTse, General7091283U61729Rattus norvegicus proline rich.Generalprotein mRNA, complete cds7107681AI030449ESTs, Moderately similar toGeneralmethyltransferase related protein[M. musculus]7111439U57391Rattus norvegicus FceRI gamma-Generalchain interacting protein SH2-B(SH2-B) mRNA, complete cds71220872X51707ribosomal protein S19ESTs, Highly similar to RS19 RATf40S RIBOSOMAL PROTEIN S19[R. norvegicus]71321660AI169751Rattus norvegicus interferon-b, Generalinducible protein variant 10 mRNA,complete cds71419454AA998888ESTs, Weakly similar to T09013fRING finger protein Fxy - mouse[M. musculus]71512979AI169177ESTs, Highly similarGeneralto RADIATION-INDUCIBLE IMMEDIATE-EARLYGENE IEX-1 [M. musculus]7165675AI045026ESTsGeneral71717903AI231083ESTs, Moderately similar tod, GeneralAF155103 1 NY-REN-25 antigen[H. sapiens]7186743AI231219ESTsd, General71923538AI102727solute carrier family 20solute carrier family 20 (phosphateGeneral(phosphate transporter), member 1transporter), member 172020617X53581e72119416AA850244ESTsGeneral72216191AA874982ESTsc7238745AI069939ESTsd72414494AI234222ESTsg72522681AA944413ESTsGeneral72621579AI103572ESTsGeneral72723978AA925352ESTsh, General72825742X80130a, b, c72914458AI145095ESTsGeneral7306172AA819646ESTs, Highly similar to AF055084 1Generalvery large G-protein coupledreceptor-1 [H. sapiens]7311998AA817864ESTsb73225545S77900c73312999AI176276ESTs, Highly similar todUAP1_HUMAN UDP-N-ACETYLHEXOSAMINEPYROPHOSPHORYLASE[H. sapiens]7341159AA891949ESTsg, General73518907AI178971Rattus norvegicus alpha-globina, b,(GloA) gene, complete cdsGeneral73625647U83119e73717892AI228438ESTsa73818447AA849939ESTsb, General40118473AI168975ESTsGeneral7394222AA860024ESTs, Highly similar toGeneralEF1G_HUMAN ELONGATIONFACTOR 1-GAMMA [H. sapiens]74015197AI105444ESTsGeneral74122958AI171374ESTs, Moderately similar tod, Generalmeningioma-expressed antigen 11[H. sapiens]7429111AI073176ESTs, Weakly similar to G01614Generalzinc finger protein 127 [H. sapiens]74323110AI169640ESTs, Weakly similar todAR20_CAEEL PROBABLE ARP2/3COMPLEX 20 KDASUBUNIT (P20-ARC) [C. elegans]74420998AA799803ESTs, Weakly similar to serineGeneralprotease [R. norvegicus]74523184AI176554ESTsd74614149AA998172platelet-activating factorplatelet-activating factoriacetylhydrolase alpha 2 subunitacetylhydrolase alpha 2 subunit(PAF-(PAF-AH alpha 2)74723816AA956596ESTse7488494AI059968ESTsi, General74921841AA996499ESTs, Weakly similar to C1QB RATb, GeneralCOMPLEMENT C1QSUBCOMPONENT, B CHAINPRECURSOR [R. norvegicus]75019765AI230945ESTs, Highly similar to AF151862 1dCGI-104 protein [H. sapiens]7516002AA818101ESTb75221945AI104132ESTse7534496AA892400ESTsi75412921AI112636ESTs, Moderately similar toGeneralUDP_HUMAN URIDINEPHOSPHORYLASE [H. sapiens]75514516AI013197ESTs, Weakly similar to codingesequence of pol [R. norvegicus]75611504AI171652ESTsGeneral7573698AI172193ESTse7585886AI045807ESTsGeneral7594154AI009467ESTsGeneral7604330AA818747ESTsc, General39016597AI102486ESTs, Weakly similar to S37583GeneralRING finger protein rfp - mouse[M. musculus]76115191AI176456Rat metallothionein-2 andGeneralmetallothionein-1 genes, completecds76210654AI235991Rattus norvegicus enhancer-of-splitfand hairy-related protein 2 (SHARP-2) mRNA, complete cds76314341AI227596ESTsGeneral76422915AI228299ESTs, Highly similar to p97a, c,homologous protein [H. sapiens]General7656638AI137579ESTsc, General76625250D10706h76724072AI231093ESTse76815628AI230338ESTs, Highly similar toGeneralRS16_HUMAN 40S RIBOSOMALPROTEIN S1 [R. norvegicus]76918831AI104357ESTs, Highly similar to ATRTCc, h,actin beta - rat [R. norvegicus]General7708343AI059502ESTsi7717749AA848804ESTs, Highly similar to BTF3GeneralMOUSE TRANSCRIPTIONFACTOR BTF3 [M. musculus]7729984AA955536ESTs, Weakly similar to ELLGeneralMOUSE RNA POLYMERASE IIELONGATION FACTOR ELL[M. musculus]77317264D25233Retinoblastoma 1 (includingRetinoblastoma 1 (includingGeneralosteosarcoma)osteosarcoma)7745356AI177813ESTs, Moderately similar to S27962Generalmodulator recognition factor 1[H. sapiens]7758626AI059449ESTsGeneral7762522AA964957ESTsa7776291AI144797ESTsh64219085AA892598ESTsGeneral77818366AA799442ESTsGeneral7791686AI179971Hemoglobin, alpha 1Hemoglobin, alpha 1b, General78020004AI031036ESTsc7814969AI113008ESTs, Moderately similar tof, g,megakaryocyte stimulating factorGeneral[H. sapiens]7826697AI045340ESTsGeneral78313420AA892042ESTsd, h,General78421527AA851733ESTsf78522017AA944209ESTs, Moderately similar to PIM1GeneralRAT PROTO-ONCOGENESERINE/THREONINE-PROTEINKINASE PIM-1 [R. norvegicus]7869388AA894173ESTsb78723197AI172159ESTsGeneral7883518AA944584ESTsb, f42218606X53504ESTs, Highly similar to 60Se, GeneralRIBOSOMAL PROTEIN L12[R. norvegicus]78923123AA924794ESTsg, General7903081AA999171Signal transducer and activatorSignal transducer and activator ofhof transcription 1transcription 179117358AI179147ESTs, Highly similar toe, hETFB_HUMAN ELECTRONTRANSFER FLAVOPROTEINBETA-SUBUNIT [H. sapiens]7922435AI639411ESTs, Highly similar to dJ149A16.6h[H. sapiens]79324651M83678RAB13RAB13b79417675AI137597ESTsf7954407H33528ESTsGeneral7964874AA923850ESTsGeneral79716001AA866452actin, alpha, cardiacactin, alpha, cardiaca, b, c, g,General79818883AA799992ESTsGeneral79910972AI233956ESTsGeneral8001114AI029917Rat brain neuron-specific enolasefmRNA, complete cds80115382AI172302ESTs, Weakly similar to S43056Generalhypothetical protein - mouse[M. musculus]80215568AI010257ESTsGeneral80310532AI009602ESTsg, General80411873AI232326ESTsGeneral80513161AI138093ESTse80611485AI235348ESTs, Weakly similar to polycomb-fgroup protein [R. norvegicus]80725689X52815g, General8081831AI071137Rat mRNA for cdc25B, completea, b,cdsGeneral80925846AI638988General81020086AI013260laminlaming81120041AI112161ESTsi, General81218867D88250Rattus norvegicus mRNA for serinea, b,protease, complete cdsGeneral8137615AI030163ESTsd81423833AI113026ESTs, Highly similar to AGP2_RATGeneralANGIOPOIETIN-2 (ANG-2)[R. norvegicus]81523731AA894004ESTs, Weakly similar to AF099929f, g,1 pervin [R. norvegicus]General81621400M36410sepiapterin reductasesepiapterin reductaseGeneral81720763AA925516ESTsb81815218AI102495ESTs, Moderately similar to purineGeneralnucleoside phosphorylase[M. musculus]8193088AI013369ESTsc82010317AI172339ESTs, Weakly similar to T21860Generalhypothetical protein F36F2.1 -Caenorhabditis elegans [C. elegans]82117468AA892545ESTs, Highly similar to multi-dmembrane spanning polyspecifictransporter [M. musculus]82223566AA955482ESTs, Moderately similar toGeneralAF132950 1 CGI-16 protein[H. sapiens]82315510AA875428ESTsg, General82417408AA818971ESTsh82516608AA996840ESTsh82615308AI072896ESTs, Weakly similar to neuralhplakophilin related arm-repeatprotein [M. musculus]8277397AI104244Rattus norvegicus mRNA forholigomycin sensitivity conferringprotein, complete cds82818542AA893493ESTs, Highly similar to RL26 RATe60S RIBOSOMAL PROTEIN L26[R. norvegicus]82919094AI232021ESTs, Highly similar to HumaneTranslation Initiation Factor Eif1,Nmr, 29 Structures [H. sapiens]83014449AI234152ESTsGeneral83112096AA819415ESTsi8326135AA819065ESTsd83321785AI177312ESTsg, General83418454AI231776ESTs, Highly similar to mRNAGeneralcleavage factor I 25 kDa subunit[H. sapiens]83521581AA944828ESTsc, General83615383AA955358ESTsGeneral83716071AA997821ESTsGeneral83816533AA998174ESTsg, General8395950AI169266ESTs, Moderately similar toGeneralAR16_HUMANARP2/3 COMPLEX16 KDA SUBUNIT [H. sapiens]84015004AI235224Rattus norvegicus tissue inhibitor off, g,metalloproteinase-1 (TIMP1),GeneralmRNA, complete cds79818881AA799992ESTsa, General84121185AI170056ESTsGeneral8425049D10655dihydrolipoamidedihydrolipoamide acetyltransferaseeacetyltransferase84317810AA799778Rat F-0-ATPase subunit b mRNA,icomplete cds84410071AI639058ESTs, Moderately similar toi, GeneraldJ718J7.1 [H. sapiens]8452913AI232272ESTs, Weakly similar to T25417Generalhypothetical protein T28D6.9 -Caenorhabditis elegans [C. elegans]8465703AI045136ESTsi, General8473143AI232408ESTsGeneral84810780AI136555Rattus norvegicus mRNA forg, GeneralCastration Induced ProstaticApoptosis Related protein-1 (CIPAR-1)8495357AI179507ESTsb, General85018909AA849426ESTs, Weakly similar toGeneralYLC4_CAEEL HYPOTHETICAL81.0 KD PROTEIN C35D10.4 INCHROMOSOME III [C. elegans]32122696AA945996ESTsGeneral8519815AA848218ESTsGeneral85220761AA900331ESTsGeneral85318686D00729dodecenoyl-Coenzyme A deltaRat mRNA for delta3, delta2-enoyl-e, hisomerase (3, 2 trans-enoyl-CoA isomerase, dodecenoyl-Coenyme ACoenzyme A delta isomerase (3, 2trans-enoyl-Coenyme A isomerase)8542378AA964501ESTsd85517307H32747ESTsh85610837AI072144ESTsGeneral8574130AA800298ESTse, f,General85818529AI230716ESTsg, General8597362AI029026ESTsGeneral8602730AI012962ESTs, Weakly similar to putativeGeneralprenylated protein [H. sapiens]86121766AA850916ESTsGeneral86213240AI169311ESTsd, General86312664AA999110ESTs, Weakly similar toGeneralMAPE_HUMAN MELANOMAANTIGEN PREFERENTIALLYEXPRESSED IN TUMORS[H. sapiens]86424520L20869Rat pancreatitis associated proteinGeneralIII (PAPIII0) mRNA, complete cds86510549AA801255ESTsGeneral8668737AI071926ESTsh86712674AI235358ESTs, Highly similar to UCR2 RATa, cUBIQUINOL-CYTOCHROME CREDUCTASE COMPLEX COREPROTEIN 2 PRECURSOR[R. norvegicus]8688032AI058398ESTsf8692587AI232103ESTsGeneral87013547M63983Hypoxanthine phosphoribosylESTs, Moderately similar to ICA2itransferaseMOUSE INTERCELLULARADHESION MOLECULE-2PRECURSOR[M. musculus], Hypoxanthinephosphoribosyl transferase8712135AI010195ESTsGeneral8726881AI010169ESTsGeneral8735494AI044425ESTsGeneral87416834AA963324ESTsd8755699AI045128ESTs, Moderately similar to T50615Generalhypothetical proteinDKFZp761G1515.1 [H. sapiens]8766282AA819523ESTsc87718598AI070775ESTsGeneral8785297AI170379ESTsGeneral8797867AI043695HHs: phosphoribosylRattus norvegicus mRNA fordpyrophosphate amidotransferaseamidophosphoribosyltransferase8806097AA818929ESTsGeneral88110115AI058890ESTsd8823738AA998256ESTsGeneral8839770AI060016ESTsGeneral88418830AA964496ESTs, Highly similar to ATRTCg, h,actin beta - rat [R. norvegicus]General8857161AI233407ESTs, Weakly similar to S44853GeneralK12H4.3 protein - Caenorhabditiselegans [C. elegans]88619729AA818910ESTsGeneral88715524D13124HMm: RIKEN cDNARattus norvegicus P2 mRNA forb1810041M08 geneATP synthase subunit c, completecds88816679AI105268ESTsd88919184AI178025ESTs, Highly similar to TGIFGeneralMOUSE 5′-TG-3′ INTERACTINGFACTOR [M. musculus]8906015AA818158ESTsf89121659AI010584Rattus norvegicus interferon-Generalinducible protein variant 10 mRNA,complete cds89218612AI228624ESTs, Highly similar toGeneralRL23_HUMAN 60S RIBOSOMALPROTEIN L23 [R. norvegicus]89319291AA963933ESTGeneral73221583S77900ESTsc, General8947888AI233583HHs: arginyl-tRNA synthetaseESTs, Moderately similar tohSYR_HUMAN ARGINYL-TRNASYNTHETASE [H. sapiens]89521079AA800245ESTs, Weakly similar to T09013fRING finger protein Fxy - mouse[M. musculus]89617949AI011480ESTs, Highly similar to RAB/Ripg, iprotein [M. musculus]8974089AI180251ESTsd8983823AI233147ESTs, Weakly similar to nuclearGeneralRNA helicase [R. norvegicus]89917506AI070068ESTs, Weakly similar to 2104282AGeneralGadd45 gene [R. norvegicus]90021667AI013773ESTsGeneral9018919AI103388ESTs, Weakly similar tog, i,ARF6_HUMAN ADP-GeneralRIBOSYLATION FACTOR 6[R. norvegicus]90224064AA957480ESTsh9035902AI045871ESTs, Moderately similar toiinhibitor of MyoD family-a[M. musculus]9047913AI043849ESTs, Weakly similar to ELLGeneralMOUSE RNA POLYMERASE IIELONGATION FACTOR ELL[M. musculus]9052980AI177761ESTs, Weakly similar to LMP1 RATbLYSOSOME-ASSOCIATEDMEMBRANE GLYCOPROTEIN 1PRECURSOR [R. norvegicus]9068477AI179167ESTsGeneral90711203AA892554ESTs, Highly similar to ras-GTPase-Generalactivating protein SH3-domainbinding protein [M. musculus]90822150AA893607ESTsGeneral90910185H33426ESTsg91015626X17665ESTs, Highly similar tof, h,RS16_HUMAN 40S RIBOSOMALGeneralPROTEIN S1 [R. norvegicus]9112096AI233801ESTsh9121809AA946503Rat mRNA for alpha-2u globulin-frelated protein91323501AA955251ESTsGeneral91423927AA957007glutathione S-transferase, mu 5glutathione S-transferase, mu 5e9156205AI104907TEMOTEMOe9168822AI070158ESTs, Moderately similar to AD08iMOUSE ADAM 8 PRECURSOR[M. musculus]9175754AA850738ESTsGeneral91821822AI228642ESTs, Highly similar to sevenhtransmembrane domain protein[H. sapiens]91919075AI236473ESTs, Moderately similar toGeneralcysteine-rich hydrophobic 1[M. musculus]9202361AA875512R. norvegicus epsilon 3 globin genea9214420AI171916ESTsg, General9223819AI176209Tyrosine 3-Tyrosine 3-Generalmonooxygenase/tryptophan 5-monooxygenase/tryptophan 5-monooxygenase activationmonooxygenase activation protein,protein, zeta polypeptidezeta polypeptide92322042AA946476ESTsi, General9243016AA818069Rat mRNA for polyubiquitin (foura, frepetitive ubiquitins in tandem),complete cds92522487AI102578ESTs, Highly similar to I49523GeneralMouse primary response gene B94mRNA, 3′end - mouse [M. musculus]9265507AI176584Rattus norvegicus insulin-likeGeneralgrowth factor binding protein 5mRNA, 3′ UTR92722077AI177099ESTs, Highly similar to serineGeneralprotease [H. sapiens]92825386L37970b92913930AA800613Rattus norvegicus gene for TIS11,Generalcomplete cds93011484AI179612ESTs, Moderately similar to MY16GeneralMOUSE MYELOIDDIFFERENTIATION PRIMARYRESPONSE PROTEIN MYD116[M. musculus], Rattus norvegicusprogression elevated gene 3 proteinmRNA, complete cds9313417AI012337ESTs, Highly similar to NHPX RATg, GeneralNHP2/RS6 FAMILY PROTEINYEL026W HOMOLOG[R. norvegicus]93214677AI234620ESTc9332134AA894212ESTs, Weakly similar to T20899ahypothetical protein F14F3.3 -Caenorhabditis elegans [C. elegans]58617203AI171844HMm: RIKEN cDNA 2410043G19Rattus norvegicus F1-ATPaseb, egeneepsilon subunit mRNA, nucleargene encoding mitochondrialprotein, complete cds93413291AI137286ESTsGeneral93522899AA956555ESTsGeneral93619913AI639155ESTsGeneral9371097AF016296Rattus norvegicus neuropilinGeneralmRNA, complete cds9384594Y07704Rattus norvegicus mRNA Best5e, Generalprotein93922146AA893980ESTsGeneral94013382AI101527ESTs, Highly similar toa, gSR19_HUMAN SIGNALRECOGNITION PARTICLE 19 KDPROTEIN [H. sapiens]9412399AI030247ESTsGeneral94217644AA924036ESTsGeneral943895AI009614ESTsGeneral9441802AA817841ESTsc9453003AA997330ESTsd, General9469757AI170693ESTsc94723583AI234819ESTsGeneral9488886AI233766ESTs, Weakly similar to proteasef, General[R. norvegicus]94924185AA893708ESTs, Highly similar to T00333hhypothetical protein KIAA0560[H. sapiens]95022929AI071578ESTs, Moderately similar toGeneralNEURONAL PROTEIN 3.1[M. musculus]95118271AA925267ESTs, Highly similar to KIAA0740eprotein [H. sapiens]9523773AA998356ESTs, Weakly similar toGeneralBCL3_HUMAN B-CELLLYMPHOMA 3-ENCODEDPROTEIN [H. sapiens]95318108X62528R.rattus mRNA for ribonucleasefinhibitor9546176AA819657ESTa95514250AA799729Phosphodiesterase 4B, cAMP-ESTs, Phosphodiesterase 4B,Generalspecific (dunce (Drosophila)-cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4)homolog phosphodiesterase E4)95622948AI105421ESTsd95710991AI104342ESTsb95811563AI102560ESTsa95925669X07314a, b9609277AI072424ESTs, Highly similar to AF155568 1iNSAP1 protein [H. sapiens]96113467AI138034UDP-glucose: ceramideUDP-glucose: ceramideGeneralglycosyltransferaseglycosyltransferase96211516AI103962ESTsh96320110AF071204stem cell factor KL-1 precursorstem cell factor KL-1 precursorb96419320AA891666melanoma antigen, family D, 1melanoma antigen, family D, 1i96513029AI179391ESTsd, General96610348AI069934ESTe9678495AI059971ESTs, Weakly similar to TNRCd, g, i,MOUSE LYMPHOTOXIN-BETAGeneralRECEPTOR PRECURSOR[M. musculus]96814968K02815Rat mRNA for RT1.B-1(alpha) chainGeneralof integral membrane protein96919358AI009675ESTa, b,General9704031AI176989ESTsa97119005AI175875ESTsd97221661AI176479Rattus norvegicus interferon-b, f,inducible protein variant 10 mRNA,Generalcomplete cds97313596U90261SH3 domain-containing adapterSH3 domain-containing adapterc, hproteinprotein97411724AI102812ESTsa, b,General9752042AI101921ESTsGeneral97625632U75405e97710227AI102248ESTsh, General9787224AI009820ESTsh9792131AI171091ESTs, Weakly similar to T19999hhypothetical protein C47D12.2 -Caenorhabditis elegans [C. elegans]98020055AI230762ESTs, Weakly similar to CLP3 RATGeneralCALPONIN, ACIDIC ISOFORM[R. norvegicus]98118897AA875207Rat major beta-globin mRNA,dcomplete cds98218468AA859966ESTs, Weakly similar to Edp1Generalprotein [M. musculus]98322820AA848315HMm: inosine 5′-phosphateESTs, Weakly similar to guanosineGeneraldehydrogenase 2monophosphate reductase[R. norvegicus]98417901AA944355ESTs, Moderately similar toGeneralAF155103 1 NY-REN-25 antigen[H. sapiens]9858305AI111695ESTsa98614842AI237724ESTsGeneral26167AI044866General98710097AI639425ESTsf, General9886861AI176970ESTsh98918859AA799467ESTsg99021510AA851620ESTsGeneral9913561AB020504Rattus norvegicus mRNA forGeneralPMF31, complete cds99222898AA901107ESTsGeneral99314668AI012185ESTsc99423035AA945712ESTsd9956330AI170426ESTsb9963808AI008643ESTs, Weakly similar to heat shockGeneralprotein hsp40-3 [M. musculus]99710334AI060295ESTs, Moderately similar to smallaGTP-binding protein rab5[R. norvegicus]99822762D89730ESTs, Weakly similar to AF137350c, General1 embryonic vascular EGF repeat-containing protein EVEC[R. norvegicus]99915837AI010411ESTs, ESTs, Moderately similar togNADH-ubiquinone oxidoreductaseB14.5B subunit [H. sapiens]10004169AI009669ESTs, Weakly similar to HIGHGeneralAFFINITY IMMUNOGLOBULINEPSILON RECEPTOR BETA-SUBUNIT [R. norvegicus]100122596AA955298ESTsGeneral100211483AF020618ESTs, Moderately similar to MY16GeneralMOUSE MYELOIDDIFFERENTIATION PRIMARYRESPONSE PROTEIN MYD116[M. musculus], Rattus norvegicusprogression elevated gene 3 proteinmRNA, complete cds100317540AA955914EST, EST, Moderately similar toGeneralFBRL MOUSE FIBRILLARIN[M. musculus], ESTs, Highly similarto FBRL MOUSE FIBRILLARIN[M. musculus]100426030M34331e100515569Z78279R. norvegicus mRNA for collagenc, ealpha 1 type I100622378AA944212ESTsGeneral100723155AA926016ESTs, Weakly similar to RINGifinger protein terf [R. norvegicus]10084832AA800190ESTs, Highly similar to glycogenGeneralphosphorylase [R. norvegicus]100918774AI010279ESTsa, i101021798AA926365ESTs, Moderately similar tobAF151827 1 CGI-69 protein[H. sapiens]10113392AA998205ESTsd10129796AI071990Rattus norvegicus pEachy mRNA,Generalcomplete cds101316314AA859348ESTsGeneral10142757AA997851ESTsc, General10154636AA899491HMm: tryptophanyl-tRNAESTs, Highly similar to SYWisynthetaseMOUSE TRYPTOPHANYL-TRNASYNTHETASE [M. musculus]101621644AI179609ESTsGeneral48011727AA849518ESTsd1017345AI059916Signal transducer and activatorSignal transducer and activator offof transcription 3transcription 3101822773AA859885ESTsc10192767AA963201ESTsGeneral102022036AI070141ESTs, Highly similar to CD97Generalprotein [M. musculus]10218580AI060314ESTc10229362AI102706ESTsGeneral102310659AI103059ESTsGeneral102416549AA892270ESTsa10252254AI235325ESTsh, General102612366AI232088ESTsGeneral102720897AI175812ESTs, Highly similar to CopaGeneralprotein [M. musculus]102813270AI228760ESTsd102912031AA893860HHs: threonyl-tRNA synthetaseESTs, Moderately similar toGeneralSYTC_HUMANTHREONYL-TRNASYNTHETASE, CYTOPLASMIC[H. sapiens]103016859AI236753ESTsGeneral10316982AI170793ESTs, Highly similar to titin-likeGeneralprotein [H. sapiens]103215518AI072945ESTsGeneral10338612AI058527ESTsa, b,General103414289AA891838ESTs, Highly similar to musclebprotein 684 [M. musculus]58022248AA943537Rattus norvegicus zyxin mRNA,Generalpartial cds103512303AA944786ESTsd103617632AI102472ESTsc103719722AI013508Rattus norvegicus Hsp70 bindingGeneralprotein HspBP mRNA, completecds103815051AI236332ESTs, Highly similar to ATDAGeneralMOUSE DIAMINEACETYLTRANSFERASE[M. musculus]10397273AI234712ESTsf104015879AI228313ESTsGeneral104110020AI045632ESTsf, General104222432AI171263ESTs, Highly similar to FBRLg, GeneralMOUSE FIBRILLARIN[M. musculus]104325705X59375General10444696AI237009ESTsc104518673AA849028ESTs, Highly similar to PRC8 RATdPROTEASOME COMPONENT C8[R. norvegicus]104613166AI178736ESTsb104724128AA849766ESTs, Highly similar to hypotheticalcprotein [H. sapiens]104824042AI230002ESTsGeneral10499339AI101160ESTs, Weakly similar to S46930Generalteg292 protein - mouse[M. musculus]105015190AI102562Rat metallothionein-i (mt-1) mrnaGeneral10513433AI030339ESTsGeneral10524459AA891721ESTsGeneral105319012AI172056ESTsGeneral10542802D85435Rattus norvegicus mRNA for proteinckinase C delta-bindig protein,complete cds105514763AA944481ESTs, Weakly similar to FIBA RATGeneralFIBRINOGEN ALPHA/ALPHA-ECHAIN PRECURSOR[R. norvegicus]10569583AI071185ESTsd, General105710394AA943564ESTs, Weakly similar to T27118Generalhypothetical protein Y53C10A.5 -Caenorhabditis elegans [C. elegans]105816821AA999042ESTsGeneral10593718AI229643ESTsGeneral10608022AI058357ESTsGeneral106119840AA899197Rattus norvegicus mRNA forg, Generalpoly(A) binding protein (pabp1gene)106215215AI060260ESTsd10638053AI175033ESTsGeneral106412086AA801116ESTsc106521447AI009608ESTs, Highly similar to orfd[M. musculus]10664232AI012958ESTsGeneral106712978X96437ESTs, Highly similarGeneralto RADIATION-INDUCIBLE IMMEDIATE-EARLYGENE IEX-1 [M. musculus]10681031AA892863ESTsd106918682AI059499ESTs, Highly similar to chaperoninhcontaining TCP-1 theta subunit[M. musculus]107025806E00898g10714432AI101851ESTsd10722997AI030545ESTsi, General10736936AI010593ESTsd107411684AI010917ESTsg, General1075804AI169756ESTs, Highly similar to GENE 33GeneralPOLYPEPTIDE [R. norvegicus]107615192AI101099Rat metallothionein-2 andGeneralmetallothionein-1 genes, completecds107719145AA964613ESTsf10783887AA893307ESTa107913539AI177280ESTs, Moderately similar to A45304Generalgranulocyte/macrophage colony-stimulating factor receptor, lowaffinity, precursor - mouse[M. musculus]10805258AA926089ESTs, Highly similar to similar todhuman DNA-binding protein 5[H. sapiens]108117380AA799612ubiquitin conjugating enzymeubiquitin conjugating enzymeh54411530AA799773ESTs, Highly similar to gamma-ifilamin [H. sapiens]10828541AI112310ESTs, Highly similar to hypotheticaldprotein [H. sapiens]108315876AA892582ESTs, Highly similar toe, hRL8_HUMAN 60S RIBOSOMALPROTEIN L [R. norvegicus]10847806AA818421ESTsGeneral108519011AI102618ESTsGeneral10868938AI070590ESTsGeneral108713266AI172326ESTsGeneral108822765AI176265ESTsGeneral108922196U21719ESTsGeneral10906789AA998207ESTsi, General10911287AI172299ESTsf, General109213985AA819429ESTe10935887AI179099ESTs, Moderately similar to Vanin-1b[M. musculus]109415189M11794General1095657AI010262Rattus norvegicus mRNA forGeneralinetrleukin-4 receptor (membrane-bound form), complete cds109614554U48828R. norvegicus H1SHR mRNA, Rattusf, i, Generalnorvegicus retroviral-like ovarianspecific transcript 30-1 mRNA109723096AA924352ESTs, Weakly similar to Prostatica, bAcid Phosphatase [R. norvegicus]10987120AI012393ESTs, Weakly similar to RINGa, bfinger protein terf [R. norvegicus]109913033AI113076ESTsc110012745AI011799ESTsa, General11018759AI237646ESTsGeneral95022930AI071578ESTs, Moderately similar toeNEURONAL PROTEIN 3.1[M. musculus]11024490AA851184Rattus norvegicus mRNA forGeneralcathepsin Y, partial cds1103600AA800222ESTsc, e7791687AI179971Hemoglobin, alpha 1Hemoglobin, alpha 1a, b,General110423139AI180040ESTsd, f110511876AI009321ESTs, Highly similar to similar toGeneralhuman DNA-binding protein 5[H. sapiens]110613568AA800169ESTsGeneral110725671X07686e11082410AA964589ESTGeneral110923230AI236146ESTsd76615134D10706ESTs, Highly similar to OAZ RATcORNITHINE DECARBOXYLASEANTIZYME [R. norvegicus]11106166AI136516ESTsGeneral111112066AA800566ESTsc68417947AA944581ESTs, Highly similar to RAB/Ripiprotein [M. musculus]37119256M15562Rat (diabetic BB) MHC class IIf, Generalalpha chain RT1.D alpha (u)111223210H31420ESTsh11135844AA944367ESTs, Highly similar to N-Generalacetylglucosamine-phosphatemutase [H. sapiens]11142992AI171776ESTsGeneral11158515AA849917ESTsa, b111621974AA945769ESTs, Highly similar to T43483atranslation initiation factor IF-2homolog [H. sapiens]111711896AA997845ESTs, Highly similar to proteinakinase Dyrk2 [H. sapiens]111810820AI009411ESTs, Highly similar to RS3e, GeneralMOUSE 40S RIBOSOMALPROTEIN S3 [R. norvegicus]11196532AI234105ESTsGeneral11206274AA819206ESTsGeneral112123099AI112365ESTs, Highly similar to mm-MagoGeneral[M. musculus]112212898AI105049ESTsGeneral112322011AI176212ESTs, Weakly similar to T25165Generalhypothetical protein T23D8.3 -Caenorhabditis elegans [C. elegans]112414693AI234830ESTs, Weakly similar toGeneralYK61_YEAST HYPOTHETICAL39.6 KDA PROTEIN IN MTD1-NUP133 INTERGENIC REGION[S. cerevisiae]112512107AI172460ESTsd11263799AF002281Rattus norvegicus alpha-actinin-2f, Generalassociated LIM protein mRNA,complete cds112714955AA945750ESTsd112814862AI236048ESTf11299317AI029174ESTsh113024028AI180239ESTsGeneral113116081AI179610Heme oxygenaseHeme oxygenaseGeneral113225918AI639204e113315042AI179422ESTsGeneral113411242AI179260ESTsGeneral113518018D12771Rattus norvegicus mRNA forimitochondrial adenine nuleotidetranslocator11366655AA850688ESTsf113710182AI176185ESTs, Highly similar to P55-C-FOSGeneralPROTO-ONCOGENE PROTEIN[R. norvegicus]113820990AI176509ESTs, Weakly similar toiKPCN_HUMANPROTEIN KINASEC, NU TYPE (NPKC-NU)(PROTEIN KINASE EPK2)[H. sapiens]113912118AA892775LysozymeLysozymeg11404355AI103410ESTsGeneral

[0185]

3

TABLE 2

Attorney Docket No. 44921-5090US Document No. 1828250.1

Seq. ID

GenBank

Model

No.
Identifier
Acc. No.
Pathways
Code

894
7888
AI233583
Aminoacyl-tRNA biosynthesis, Arginine and
h

proline metabolism

1029
12031
AA893860
Aminoacyl-tRNA biosynthesis, Glycine, serine
General

and threonine metabolism

1015
4636
AA899491
Aminoacyl-tRNA biosynthesis, Tryptophan
i

metabolism

138
17100
NM_022179
Aminosugars metabolism, Fructose and
h, General

mannose metabolism, Galactose

metabolism, Glycolysis/

Gluconeogenesis, Starch and sucrose

metabolism

138
17101
NM_022179
Aminosugars metabolism, Fructose and
General

mannose metabolism, Galactose

metabolism, Glycolysis/

Gluconeogenesis, Starch and sucrose

metabolism

168
9929
NM_024392
Androgen and estrogen metabolism
g

56
19392
NM_012998
Arginine and proline metabolism
i

149
20915
NM_022407
Arginine and proline metabolism, Ascorbate and
General

aldarate metabolism, Bile acid

biosynthesis, Butanoate metabolism, Fatty acid

metabolism, Glycerolipid metabolism, Histidine

metabolism, Lysine degradation, Propanoate

metabolism, Pyruvate metabolism, Tryptophan

metabolism, Valine, leucine and isoleucine

degradation, beta-Alanine metabolism

16
4468
NM_012529
Arginine and proline metabolism, Urea cycle and
e

metabolism of amino groups

25
23523
NM_012615
Arginine and proline metabolism, Urea cycle and
General

metabolism of amino groups

152
4242
NM_022521
Arginine and proline metabolism, Urea cycle and
f

metabolism of amino groups

13
7063
NM_012495
Carbon fixation, Fructose and mannose
c

metabolism, Glycolysis/

Gluconeogenesis, Inositol metabolism, Pentose

phosphate cycle

667
17289
AA891785
Citrate cycle (TCA cycle), Glutathione
b

metabolism, Reductive carboxylate cycle (CO2

fixation)

92
24106
NM_017141
DNA polymerase, Purine metabolism, Pyrimidine
c

metabolism

92
24107
NM_017141
DNA polymerase, Purine metabolism, Pyrimidine
General

metabolism

200
12581
NM_031514
epo, ifn_gamma, il3, il6, interact6-1, pdgf, tpo
i, General

257
13005
NM_053623
Fatty acid metabolism
General

311
20984
D90109
Fatty acid metabolism
h

400
20983
AI044900
Fatty acid metabolism
General

853
18686
D00729
Fatty acid metabolism
e, h

324
23596
AI105435
Fatty acid metabolism, Lysine
c, General

degradation, Tryptophan metabolism

115
1174
NM_019184
Fatty acid metabolism, Tryptophan metabolism
b

203
4011
NM_031543
Fatty acid metabolism, Tryptophan metabolism
a

144
13480
NM_022390
Folate biosynthesis
f

816
21400
M36410
Folate biosynthesis
General

12
15511
NM_012498
Fructose and mannose metabolism, Galactose
h

metabolism, Glycerolipid metabolism, Pentose

and glucuronate interconversions, Pyruvate

metabolism

68
1321
NM_013098
Galactose metabolism, Glycolysis/
a

Gluconeogenesis, Starch and sucrose

metabolism

86
11152
NM_017073
Glutamate metabolism, Nitrogen metabolism
General

86
11153
NM_017073
Glutamate metabolism, Nitrogen metabolism
General

879
7867
AI043695
Glutamate metabolism, Purine metabolism
d

40
961
NM_012796
Glutathione metabolism
e

914
23927
AA957007
Glutathione metabolism
e

194
1638
NM_031143
Glycerolipid metabolism
General

746
14149
AA998172
Glycerolipid metabolism
i

176
23109
NM_031000
Glycerolipid metabolism, Glycolysis/
c, f, h

Gluconeogenesis, Pentose and glucuronate

interconversions

398
1893
X51529
Glycerolipid metabolism, Phospholipid
General

degradation, Prostaglandin and leukotriene

metabolism

78
16448
NM_013197
Glycine, serine and threonine metabolism
a, b,

General

236
4093
NM_053290
Glycolysis/Gluconeogenesis
General

18
19408
NM_012554
Glycolysis/Gluconeogenesis, Phenylalanine,
h

tyrosine and tryptophan biosynthesis

213
21575
NM_031698
Glycoprotein biosynthesis
b

132
574
NM_019905
Glyoxylate and dicarboxylate metabolism
g, i

General

23
24716
NM_012589
il6, interact6-1
General

163
21239
NM_024125
il6, interact6-1
c, General

77
1714
NM_013187
Inositol phosphate metabolism
g, i,

General

15
15741
NM_012520
Methane metabolism, Tryptophan metabolism
c, g

71
2005
NM_013127
Nicotinate and nicotinamide metabolism
c

124
15056
NM_019291
Nitrogen metabolism
General

197
18597
NM_031325
Nucleotide sugars metabolism, Pentose and
General

glucuronate interconversions, Starch and

sucrose metabolism

39
449
NM_012786
Oxidative phosphorylation
a, b

101
14696
NM_017202
Oxidative phosphorylation
e

452
15048
M24542
Oxidative phosphorylation
c, i

130
22727
NM_019383
Oxidative phosphorylation, Type III protein
i

secretion system

586
17204
AI171844
Oxidative phosphorylation, Type III protein
e, g

secretion system

887
15524
D13124
Oxidative phosphorylation, Type III protein
b

secretion system

586
17203
AI171844
Oxidative phosphorylation, Type III protein
b, e

secretion system

614
23038
AA900881
Pantothenate and CoA biosynthesis, Valine,
General

leucine and isoleucine biosynthesis, Valine,

leucine and isoleucine degradation

20
16080
NM_012580
Porphyrin and chlorophyll metabolism
General

1131
16081
AI179610
Porphyrin and chlorophyll metabolism
General

103
20193
NM_017232
Prostaglandin and leukotriene metabolism
General

114
17066
NM_019170
Prostaglandin and leukotriene metabolism
e

178
1845
NM_031010
Prostaglandin and leukotriene metabolism
a, b,

General

178
25517
NM_031010
Prostaglandin and leukotriene metabolism
a, b,

General

205
692
NM_031557
Prostaglandin and leukotriene metabolism
h

107
3254
NM_017282
Proteasome
h

616
3988
AI008546
Proteasome
d

88
8888
NM_017090
Purine metabolism
General

97
21975
NM_017154
Purine metabolism
General

217
14184
NM_031776
Purine metabolism
General

217
14185
NM_031776
Purine metabolism
General

289
15843
NM_080910
Purine metabolism
h

377
14384
AI177096
Purine metabolism
c

870
13547
M63983
Purine metabolism
i

955
14250
AA799729
Purine metabolism
General

983
22820
AA848315
Purine metabolism
General

79
20826
NM_013218
Pyrimidine metabolism
h

208
24235
NM_031614
Pyrimidine metabolism
General

561
17285
J02827
Valine, leucine and isoleucine degradation
General

[0186]

4

TABLE 3

Attorney Docket No. 44921-5090US Document No. 1828250.1

Seq. ID

GenBank
Homologous Human

Model

No.
Identifier
Acc. No.
Genes
Homologous Human Cluster Title
Code

1
25319
J01435

EST, Moderately similar to 0806162C protein
a, c, f

COI [M. musculus], EST, Moderately similar to

810024C cytochrome oxidase I [H. sapiens],

ESTs, Moderately similar to 0806162C protein

COI [M. musculus], ESTs, Moderately similar to

810024C cytochrome oxidase I [H. sapiens]

1
25050
J01435

EST, Moderately similar to 0806162C protein
c, f, g

COI [M. musculus], EST, Moderately similar to

810024C cytochrome oxidase I [H. sapiens],

ESTs, Moderately similar to 0806162C protein

COI [M. musculus], ESTs, Moderately similar to

810024C cytochrome oxidase I [H. sapiens]

2
25051
J01436

a, c

3
25439
M35826

a, c, f, g

4
16132
AA850885

EST, Moderately similar to 0806162C protein
a, c

COI [M. musculus], EST, Moderately similar to

810024C cytochrome oxidase I [H. sapiens],

ESTs, Moderately similar to 0806162C protein

COI [M. musculus], ESTs, Moderately similar to

810024C cytochrome oxidase I [H. sapiens]

5
6153
AA875531
collagen, type I, alpha 2,
EST, Moderately similar to 0806162B
e

procollagen, type I, alpha 2
cytochrome b [M. musculus], EST, Moderately

similar to 810024B cytochrome b [H. sapiens],

EST, Weakly similar to 0806162B cytochrome

b [M. musculus], EST, Weakly similar to

0812187A cytochrome b [R. norvegicus], EST,

Weakly similar to 810024M URF 6 [H. sapiens],

EST, Weakly similar to [Segment 1 of 2]

COLLAGEN ALPHA 1(I) CHAIN [R. norvegicus],

ESTs, Weakly similar to CA1F_HUMAN

COLLAGEN ALPHA 1(XVI) CHAIN

PRECURSO [H. sapiens], Mus musculus,

Similar to RIKEN cDNA 1700051I12 gene,

clone MGC: 28741 IMAGE: 4481590, mRNA,

complete cds, RIKEN cDNA 1700051I12 gene,

chordin, collagen, type XVI, alpha 1, expressed

sequence AI835009, hypothetical protein

FLJ14547, procollagen, type II, alpha 1

6
15666
AA892248

a, f

7
19421
AA945152
dimethylarginine
EST, Moderately similar to 0806162A ATPase
a, c

dimethylaminohydrolase 1
6 [M. musculus], EST, Weakly similar to

0806162A ATPase 6 [M. musculus], ESTs,

Moderately similar to DDH1 RAT NG, NG-

DIMETHYLARGININE

DIMETHYLAMINOHYDROLASE 1

[R. norvegicus], ESTs, Weakly similar to DDH1

RAT NG, NG-DIMETHYLARGININE

DIMETHYLAMINOHYDROLASE 1

[R. norvegicus], dimethylarginine

dimethylaminohydrolase 1

8
14981
AI103396

EST, Moderately similar to 0806162B
a, c, f

cytochrome b [M. musculus], EST, Moderately

similar to 810024B cytochrome b [H. sapiens],

EST, Weakly similar to 0806162B cytochrome

b [M. musculus], EST, Weakly similar to

0812187A cytochrome b [R. norvegicus], EST,

Weakly similar to 810024M URF 6 [H. sapiens]

9
14982
AI171355

EST, Moderately similar to 0806162B
a, f

cytochrome b [M. musculus], EST, Moderately

similar to 810024B cytochrome b [H sapiens],

EST, Weakly similar to 0806162B cytochrome

b [M. musculus], EST, Weakly similar to

0812187A cytochrome b [R. norvegicus], EST,

Weakly similar to 810024M URF 6 [H. sapiens]

10
14983
AI179150

EST, Moderately similar to 0806162B
a, c, f

cytochrome b [M. musculus], EST, Moderately

similar to 810024B cytochrome b [H. sapiens],

EST, Weakly similar to 0806162B cytochrome

b [M. musculus], EST, Weakly similar to

0812187A cytochrome b [R. norvegicus], EST,

Weakly similar to 810024M URF 6 [H. sapiens]

11
21152
X14848
golgi SNAP receptor

Homo sapiens
, Similar to golgi SNAP receptor
a, b, c,

complex member 1
complex member 1, clone MGC: 13657
f, g

IMAGE: 4250494, mRNA, complete cds, golgi

SNAP receptor complex member 1

12
15511
NM_012498
aldo-keto reductase

h

family 1, member B1

(aldose reductase), aldo-

keto reductase family 1,

member B3 (aldose

reductase)

13
7063
NM_012495
aldolase 1, A isoform,
EST, Moderately similar to ADHUA fructose-
c

aldolase A, fructose-
bisphosphate aldolase [H. sapiens], EST,

bisphosphate
Weakly similar to ADHUA fructose-

bisphosphate aldolase [H. sapiens], EST,

Weakly similar to I39435 fructose-bisphosphate

aldolase [H. sapiens], ESTs, Moderately similar

to aldolase A [M. musculus], Homo sapiens,

aldolase 1, A isoform, clone MGC: 18171

IMAGE: 4155253, mRNA, complete cds, RIKEN

cDNA 4933425L11 gene, aldolase 1, A isoform,

aldolase 3, C isoform, aldolase A, fructose-

bisphosphate

14
7427
NM_012515
benzodiazapine receptor
Human DNA sequence from clone 34B21 on
h

(peripheral),
chromosome 6p12.1-21.1. Contains part of a

benzodiazepine receptor,
gene for a novel protein with ZU5 domain

peripheral
similar to part of Tight Junction Protein ZO1

(TJP1) and UNC5 Homologs, the gene for a

novel BZRP (peripheral benzodiazapine

receptor (MBR, PBR, PBKS, IBP, Isoquinoline-

binding protein)) LIKE protein, the gene for a

novel protein similar to part of APOBEC1

(Phorbolin 1, Apolipoprotein B mRNA editing

protein), and the NFYA gene for nuclear

transcription factor Y, alpha (CCAAT-Binding

transcription factor subunit B, CBF-B, CAAT-

Box DNA binding protein subunit A). Contains

ESTs, STSs, GSSs, two putative CpG islands

and a ca repeat polymorphism, RIKEN cDNA

25127D2 gene, benzodiazapine receptor

(peripheral), benzodiazepine receptor,

peripheral

15
15741
NM_012520
catalase, catalase 1

Homo sapiens
cDNA FLJ1272 fis, clone
c, g

HEMBB12371, catalase, catalase 1

16
4468
NM_012529
creatine kinase, brain
EST, Moderately similar to CREATINE
e

KINASE, B CHAIN [R. norvegicus], EST,

Weakly similar to KIHUCB creatine kinase

[H. sapiens], creatine kinase, brain

17
23869
NM_012551
early growth response 1
ESTs, Weakly similar to 153869 zinc finger
General

protein - mouse [M. musculus], early growth

response 1, repressor of GATA, testis zinc

finger protein

18
19408
NM_012554
enolase 1, (alpha),
EST, Moderately similar to ALPHA ENOLASE
h

enolase 1, alpha non-
[R. norvegicus], EST, Weakly similar to A2917

neuron
phosphopyruvate hydratase [H. sapiens], Homo

sapiens
cDNA FLJ12774 fis, clone

NT2RP21663, moderately similar to ENOLASE

(EC 4.2.1.11), enolase 1, (alpha), enolase 1,

alpha non-neuron, enolase alpha, lung-specific,

expressed sequence AI42712

19
6477
NM_012559
fibrinogen, gamma
EST, Moderately similar to FGHUGB fibrinogen
g

polypeptide
gamma-B chain precursor [H. sapiens], EST,

Moderately similar to Recombinant Human

Gamma-Fibrinogen Carboxyl Terminal

Fragment [H. sapiens], ESTs, Weakly similar to

FIBG RAT FIBRINOGEN GAMMA-A/-B CHAIN

PRECURSOR [R. norvegicus], RIKEN cDNA

1117F23 gene, expressed sequence AI33526,

fibrinogen, gamma polypeptide, fibrinogen-like

1, ficolin A, ficolin B

20
16080
NM_012580
heme oxygenase
heme oxygenase (decycling) 1
General

(decycling) 1

21
20313
NM_012585
5-hydroxytryptamine
5-hydroxytryptamine (serotonin) receptor 1A,
General

(serotonin) receptor 1A
protein “A”

22
15098
NM_012588
insulin-like growth factor
insulin-like growth factor binding protein 3,
c

binding protein 3
protease, serine, 11 (lgf binding)

23
24716
NM_012589
interleukin 6, interleukin 6
interleukin 6, interleukin 6 (interferon, beta 2)
General

(interferon, beta 2)

24
2629
NM_012603
myelocytomatosis
RIKEN cDNA 292K7 gene, myelocytomatosis
General

oncogene, v-myc avian
oncogene, v-myc avian myelocytomatosis viral

myelocytomatosis viral
oncogene homolog

oncogene homolog

25
23523
NM_012615
ornithine decarboxylase
ESTs, Weakly similar to A Chain A, Crystal
General

1, ornithine
Structure Ornithine Decarboxylase From

decarboxylase, structural
Mouse, Truncated 37 Residues From The C-

Terminus, To 1.6 Angstrom Resolution

[M. musculus], ESTs, Weakly similar to

ORNITHINE DECARBOXYLASE

[R. norvegicus], ornithine decarboxylase 1,

ornithine decarboxylase antizyme inhibitor,

ornithine decarboxylase, structural, ornithine

decarboxylase-like protein

26
20589
NM_012618
S1 calcium binding
S1 calcium binding protein A3, S1 calcium-
General

protein A4, S1 calcium-
binding protein A2, S1 calcium-binding protein

binding protein A4
A3, S1 calcium-binding protein A4, S1 calcium-

(calcium protein,
binding protein A4 (calcium protein, calvasculin,

calvasculin, metastasin,
metastasin, murine placental homolog)

murine placental

homolog)

27
15540
NM_012620
serine (or cysteine)
serine (or cysteine) proteinase inhibitor, clade E
General

proteinase inhibitor, clade
(nexin, plasminogen activator inhibitor type 1),

E (nexin, plasminogen
member 1

activator inhibitor type 1),

member 1

28
18725
NM_012645

c

28
18726
NM_012645

General

29
9423
NM_012649
syndecan 4, syndecan 4
syndecan 4, syndecan 4 (amphiglycan,
General

(amphiglycan, ryudocan)
ryudocan)

29
9424
NM_012649
syndecan 4, syndecan 4
syndecan 4, syndecan 4 (amphiglycan,
General

(amphiglycan, ryudocan)
ryudocan)

30
16224
NM_012656
secreted acidic cysteine
EST, Moderately similar to SPARC
c

rich glycoprotein,
PRECURSOR [R. norvegicus], SPARC-like 1

secreted protein, acidic,
(mast9, hevin), secreted acidic cysteine rich

cysteine-rich
glycoprotein, secreted protein, acidic, cysteine-

(osteonectin)
rich (osteonectin)

31
1514
NM_012678

ESTs, Highly similar to S7282 tropomyosin
c, h,

TM3-pl, fibroblast [H. sapiens], ESTs,
General

Moderately similar to alpha-tropomyosin slow

[M. musculus], RIKEN cDNA 18159A23 gene,

tropomyosin 4

32
20776
NM_012680
tuberous sclerosis 2
DKFZp566D133 protein, EST, Moderately
General

similar to TSC2_HUMAN TUBERIN

[H. sapiens], Homo sapiens cDNA FLJ12339 fis,

clone MAMMA1225, KIAA1272 protein, tuberin-

like protein 1, tuberous sclerosis 2

33
25650
NM_012736
glycerol phosphate
expressed sequence AA48484, expressed
f

dehydrogenase 1,
sequence AI448216, glycerol phosphate

mitochondrial, glycerol-3-
dehydrogenase 1, mitochondrial, glycerol-3-

phosphate
phosphate dehydrogenase 2 (mitochondrial)

dehydrogenase 2

(mitochondrial)

34
344
NM_012747

Signal transducer and activator of transcription
b

1, signal transducer and activator of

transcription 1, signal transducer and activator

of transcription 1, 91 kD, signal transducer and

activator of transcription 3, signal transducer

and activator of transcription 3 (acute-phase

response factor)

35
8829
NM_012749

h, General

36
3601
NM_012751

ESTs, Highly similar to GTR4_HUMAN
d

GLUCOSE TRANSPORTER TYPE 4, INSULIN-

RESPONSIV [H. sapiens], solute carrier family

2 (facilitated glucose transporter), member 1,

solute carrier family 2 (facilitated glucose

transporter), member 4, solute carrier family 2

(facilitated glucose transporter), member 6

37
15174
NM_012756

ESTs, Highly similar to 1312358A IGF II
b

receptor [H. sapiens], expressed sequence

AI661837, insulin-like growth factor 2 receptor

38
1349
NM_012776
adrenergic receptor
G protein-coupled receptor kinase 2, groucho
General

kinase, beta 1,
gene related (Drosophila), G protein-coupled

adrenergic, beta, receptor
receptor kinase 5, G protein-coupled receptor

kinase 1
kinase 6, adrenergic, beta, receptor kinase 1,

rhodopsin kinase

39
449
NM_012786

EST, Moderately similar to CYTOCHROME C
a, b

OXIDASE POLYPEPTIDE VIII-HEART

PRECURSOR [R. norvegicus], EST, Weakly

similar to COXQ MOUSE CYTOCHROME C

OXIDASE POLYPEPTIDE VIII-HEART

PRECURSOR [M. musculus], cytochrome c

oxidase subunit VIII, cytochrome c oxidase,

subunit VIIIb

40
961
NM_012796
glutathione S-transferase
ESTs, Highly similar to GTT2 RAT
e

theta 2, glutathione S-
GLUTATHIONE S-TRANSFERASE YRS-YRS

transferase, theta 2
[R. norvegicus], Homo sapiens mRNA; cDNA

DKFZp762N226 (from clone DKFZp762N226),

expressed sequence AI266894, glutathione S-

transferase theta 2, glutathione S-transferase,

theta 2, hypothetical protein

41
15032
NM_012816

alpha-methylacyl-CoA racemase, hypothetical
g, i

protein FLJ1188

42
18109
NM_012823

EST, Weakly similar to ANXA_HUMAN
General

ANNEXIN XI [H. sapiens], annexin A1, annexin

A3

43
11137
NM_012839
cytochrome c,
ESTs, Highly similar to 63485A cytochrome c
g

cytochrome c, somatic
[H. sapiens], ESTs, Weakly similar to

CYTOCHROME C, SOMATIC [M. musculus],

Homo sapiens
pseudogene for cytochrome c-

like protein, clone pHGC4E1, Human DNA

sequence from clone RP11-169O17 on

chromosome 13 Contains ESTs, GSSs, STSs

and four CpG islands. Contains a novel protein

similar to cytochrome c, part of a novel gene

similar to TPTE encoding a transmembrane

phosphatase with tensin homology and the

ADPRTL1 gene encoding ADP-

ribosyltransferase (NAD+; poly (ADP-ribose)

polymerase)-like protein 1 (vault protein,

KIAA177), cytochrome c, cytochrome c,

somatic

44
17541
NM_012844
epoxide hydrolase 1,
EST, Moderately similar to HYEP_HUMAN
a, c,

microsomal, epoxide
EPOXIDE HYDROLASE 1 [H. sapiens], ESTs,
General

hydrolase 1, microsomal
Highly similar to HYEP_HUMAN EPOXIDE

(xenobiotic)
HYDROLASE 1 [H. sapiens], epoxide hydrolase

1, microsomal, epoxide hydrolase 1,

microsomal (xenobiotic)

45
17305
NM_012876
ribosomal protein S29
EST, Highly similar to 4S RIBOSOMAL
b, e, g

PROTEIN S29 [R. norvegicus], EST,

Moderately similar to RS29_HUMAN 4S

RIBOSOMAL PROTEIN S29 [M. musculus],

EST, Weakly similar to 4S RIBOSOMAL

PROTEIN S29 [R. norvegicus], ESTs, Highly

similar to RS29_HUMAN 4S RIBOSOMAL

PROTEIN S29 [H. sapiens], ESTs, Weakly

similar to RS29_HUMAN 4S RIBOSOMAL

PROTEIN S29 [H. sapiens], ribosomal protein

S29

46
1748
NM_012889
vascular cell adhesion
immunoglobulin superfamily, member 1, mRNA
a, General

molecule 1
for 1-gicerin/MUC18, mucosal vascular

addressin cell adhesion molecule 1, vascular

cell adhesion molecule 1

47
16721
NM_012891
acyl-Coenzyme A
EST, Weakly similar to ACYL-COA
General

dehydrogenase, very long
DEHYDROGENASE, VERY-LONG-CHAIN

chain
SPECIFIC PRECURSOR [R. norvegicus],

ESTs, Weakly similar to ACYL-COA

DEHYDROGENASE, VERY-LONG-CHAIN

SPECIFIC PRECURSOR [R. norvegicus], NPD2

protein, RIKEN cDNA 2617P15 gene, acyl

Coenzyme A dehydrogenase, very long chain

48
16274
NM_012898
alpha-2-HS-glycoprotein
alpha-2-HS-glycoprotein
a

49
24783
NM_012914
ATPase, Ca++
ATPase, Ca++ transporting, cardiac muscle,
h, General

transporting, ubiquitous
fast twitch 1, ATPase, Ca++ transporting,

cardiac muscle, slow twitch 2, ATFase, Ca++

transporting, ubiquitous, expressed sequence

AW61228

50
18695
NM_012931

CD2-associated protein, HEF like Protein,
b, General

Homo sapiens
cDNA FLJ14854 fis, clone

PLACE1972, breast cancer anti-estrogen

resistance 1, enhancer of filamentation 1 (cas-

like docking; Crk-associated substrate related),

neural precursor cell expressed,

developmentally down-regulated gene 9, v-crk-

associated tyrosine kinase substrate

51
2555
NM_012967
intercellular adhesion

Homo sapiens
mRNA; cDNA DKFZp434E516
General

molecule, intercellular
(from clone DKFZp434E516), intercellular

adhesion molecule 1
adhesion molecule, intercellular adhesion

(CD54), human rhinovirus
molecule 1 (CD54), human rhinovirus receptor,

receptor
intercellular adhesion molecule 3, intercellular

adhesion molecule 5, telencephalin

52
24528
NM_012973
potassium voltage-gated
potassium voltage-gated channel, lsk-related
h

channel, lsk-related
family, member 1, potassium voltage-gated

family, member 1,
channel, lsk-related subfamily, member 1

potassium voltage-gated

channel, lsk-related

subfamily, member 1

53
956
NM_012976

ESTs, Highly similar to LEG9 RAT GALECTIN-
a, General

9 [R. norvegicus], ESTs, Highly similar to

LEG9_HUMAN GALECTIN-9 [H. sapiens],

ESTs, Weakly similar to LEG9 RAT GALECTIN-

9 [R. norvegicus], expressed sequence

AI265545, lectin, galactose binding, soluble 12,

lectin, galactose binding, soluble 9, lectin,

galactoside-binding, soluble, 9 (galectin 9)

54
958
NM_012977

ESTs, Highly similar to LEG9 RAT GALECTIN-
General

9 [R. norvegicus], ESTs, Highly similar to

LEG9_HUMAN GALECTIN-9 [H. sapiens],

ESTs, Weakly similar to LEG9 RAT GALECTIN-

9 [R. norvegicus], expressed sequence

AI265545, lectin, galactose binding, soluble 12,

lectin, galactose binding, soluble 9, lectin,

galactoside-binding, soluble, 9 (galectin 9)

55
17394
NM_012992
nucleophosmin (nucleolar
ESTs, Moderately similar to NPM_HUMAN
General

phosphoprotein B23,
NUCLEOPHOSMIN [H. sapiens], ESTs, Weakly

numatrin), nucleophosmin 1
similar to NPM_HUMAN NUCLEOPHOSMIN

[H. sapiens], nucleophosmin (nucleolar

phosphoprotein B23, numatrin), nucleophosmin

1, nucleophosmin/nucleoplasmin 3,

nucleoplasmin 3

56
19392
NM_012998
procollagen-proline, 2-
RIKEN cDNA 177B13 gene, RIKEN cDNA
i

oxoglutarate 4-
18141F13 gene, RIKEN cDNA 18147B9 gene,

dioxygenase (proline 4-
expressed sequence AI661267, procollagen-

hydroxylase), beta
proline, 2-oxoglutarate 4-dioxygenase (proline 4

polypeptide (protein
hydroxylase), beta polypeptide (protein disulfide

disulfide isomerase;
isomerase; thyroid hormone binding protein

thyroid hormone binding
p55)

protein p55), prolyl 4-

hydroxylase, beta

polypeptide

57
24264
NM_012999
paired basic amino acid
EST, Highly similar to PAC4 RAT SUBTILISIN-
e

cleaving system 4,
LIKE PROTEASE PACE4 PRECURSOR

proprotein convertase
[R. norvegicus], Homo sapiens clone 1

subtilisin/kexin type 6
thrombospondin mRNA, complete cds, RIKEN

cDNA A9329K19 gene, paired basic amino acid

cleaving system 4, proprotein convertase

subtilisin/kexin type 6

58
3405
NM_013011

EST, Weakly similar to 143B_HUMAN 14-3-3
i, General

PROTEIN BETA/ALPHA [H. sapiens], ESTs,

Highly similar to A Chain A, 14-3-3

ZetaPHOSPHOPEPTIDE COMPLEX

[H. sapiens], makorin, ring finger protein, 3,

stratifin, tyrosine 3-monooxgenase/tryptophan 5

monooxgenase activation protein, beta

polypeptide, tyrosine 3-

monooxygenase/tryptophan 5-monooxygenase

activation protein, zeta polypeptide

59
20229
NM_013018
RAB3A, member RAS

Homo sapiens
, clone MGC: 4711
General

oncogene family
IMAGE: 3534915, mRNA, complete cds,

RAB3A, member RAS oncogene family,

RAB3C, member RAS oncogene family, RIKEN

cDNA 261528C18 gene

60
1606
NM_013039
ATP-binding cassette,
ATP-binding cassette, sub-family C
g

sub-family C
(CFTR/MRP), member 8, ATP-binding

(CFTR/MRP), member 8
cassette, sub-family C (CFTR/MRP), member

9, EST, Moderately similar to ACC8 RAT

SULFONYLUREA RECEPTOR 1

[R. norvegicus], EST, Weakly similar to MRP5

MOUSE MULTIDRUG RESISTANCE-

ASSOCIATED PROTEIN 5 [M. musculus],

ESTs, Highly similar to ACC8_HUMAN

SULFONYLUREA RECEPTOR 1 [H. sapiens],

ESTs, Weakly similar to T42728 sulfonylurea

receptor 2, isoform B - mouse [M. musculus],

Mus musculus
adult male pituitary gland cDNA,

RIKEN full-length enriched library,

clone: 533439B14, full insert sequence

61
730
NM_013040
ATP-binding cassette,
ATP-binding cassette, sub-family C
h

sub-family C
(CFTR/MRP), member 8, ATP-binding

(CFTR/MRP), member 9
cassette, sub-family C (CFTR/MRP), member

9, ESTs, Highly similar to ACC8_HUMAN

SULFONYLUREA RECEPTOR 1 [H. sapiens],

ESTs, Weakly similar to T42728 sulfonylurea

receptor 2, isoform B - mouse [M. musculus],

Mus musculus
adult male pituitary gland cDNA,

RIKEN full-length enriched library,

clone: 533439B14, full insert sequence

62
17401
NM_013043
transforming growth factor
ESTs, Moderately similar to DIP_HUMAN DIP
g, General

beta 1 induced transcript
PROTEIN [H. sapiens], delta sleep inducing

4, transforming growth
peptide, immunoreactor, glucocorticoid-induced

factor beta-stimulated
leucine zipper, transforming growth factor beta

protein TSC-22
1 induced transcript 4, transforming growth

factor beta-stimulated protein TSC-22

63
11114
NM_013046
thyrotropin releasing
thyrotropin releasing hormone, thyrotropin-
f, General

hormone, thyrotropin-
releasing hormone

releasing hormone

63
11113
NM_013046
thyrotropin releasing

f

hormone, thyrotropin-

releasing hormone

64
16924
NM_013069

CD74 antigen (invariant polypeptide of major
b

histocompatibility complex, class II antigen-

associated), la-associated invariant chain,

KIAA275 gene product, sparc/osteonectin,

cwcv and kazal-like domains proteoglycan

(testican), sparc/osteonectin, cwcv and kazal-

like domains proteoglycan 1, sparc/osteonectin,

cwcv and kazal-like domains proteoglycan 2

64
25676
NM_013069

b

64
16925
NM_013069

CD74 antigen (invariant polypeptide of major
b

histocompatibility complex, class II antigen-

associated), la-associated invariant chain,

KIAA275 gene product, sparc/osteonectin,

cwcv and kazal-like domains proteoglycan

(testican), sparc/osteonectin, cwcv and kazal-

like domains proteoglycan 1, sparc/osteonectin,

cwcv and kazal-like domains proteoglycan 2

65
357
NM_013086

General

66
1521
NM_013091

tumor necrosis factor receptor superfamily,
i

member 12, tumor necrosis factor receptor

superfamily, member 12 (translocating chain-

association membrane protein), tumor necrosis

factor receptor superfamily, member 1A, tumor

necrosis factor receptor superfamily, member

1a, tumor necrosis factor receptor superfamily,

member 1a-like 1, tumor necrosis factor

receptor superfamily, member 1a-like 2

67
1684
NM_013096
hemoglobin alpha, adult
EST, Moderately similar to HART1 hemoglobin
a, b

chain 2, hemoglobin,
alpha-1 chain - rat [R. norvegicus], ESTs,

alpha 1
Moderately similar to HART1 hemoglobin alpha-

1 chain - rat [R. norvegicus], RIKEN cDNA

25142H12 gene, hemoglobin alpha, adult chain

1, hemoglobin, alpha 1, hemoglobin, alpha 2

67
26150
NM_013096

a, b

67
1689
NM_013096
hemoglobin alpha, adult
EST, Moderately similar to HART1 hemoglobin
a, b,

chain 2, hemoglobin,
alpha-1 chain - rat [R. norvegicus], ESTs,
General

alpha 1
Moderately similar to HART1 hemoglobin alpha-

1 chain - rat [R. norvegicus], RIKEN cDNA

25142H12 gene, hemoglobin alpha, adult chain

1, hemoglobin, alpha 1, hemoglobin, alpha 2

67
1685
NM_013096
hemoglobin alpha, adult

a

chain 2, hemoglobin,

alpha 1

67
1688
NM_013096
hemoglobin alpha, adult

a, b

chain 2, hemoglobin,

alpha 1

68
1321
NM_013098

ESTs, Weakly similar to G6PT RAT GLUCOSE-
a

6-PHOSPHATASE [R. norvegicus], Homo

sapiens
, clone IMAGE: 35476, mRNA, partial

cds, RIKEN cDNA 711K1 gene, expressed

sequence AW545836, glucose-6-phosphatase,

catalytic, glucose-6-phosphatase, catalytic

(glycogen storage disease type I, von Gierke

disease), glucose-6-phosphatase, catalytic,

related sequence, islet-specific glucose-6-

phosphatase catalytic subunit-related protein

69
19949
NM_013106
guanine nucleotide
guanine nucleotide binding protein (G protein),
General

binding protein (G
alpha inhibiting activity polypeptide 3, guanine

protein), alpha inhibiting
nucleotide binding protein, alpha inhibiting 3

activity polypeptide 3,

guanine nucleotide

binding protein, alpha

inhibiting 3

70
23709
NM_013113

ATPase, Na+/K+ transporting, beta 1
g

polypeptide

71
2005
NM_013127

CD38 antigen, CD38 antigen (p45), Homo
c

sapiens
cDNA: FLJ22754 fis, clone KAIA615

72
14299
NM_013129
interleukin 15
interleukin 15
General

73
16982
NM_013144

insulin-like growth factor binding protein 1,
General

protease, serine, 11 (IGF binding)

74
21683
NM_013154
CCAAT/enhancer binding
CCAAT/enhancer binding protein (C/EBP),
General

protein (C/EBP), delta
delta

74
21682
NM_013154
CCAAT/enhancer binding
CCAAT/enhancer binding protein (C/EBP),
General

protein (C/EBP), delta
delta

75
24867
NM_013155

EST, Weakly similar to LDVR RAT VERY LOW-
General

DENSITY LIPOPROTEIN RECEPTOR

PRECURSOR [R. norvegicus], ESTs, Weakly

similar to LDVR RAT VERY LOW-DENSITY

LIPOPROTEIN RECEPTOR PRECURSOR

[R. norvegicus], low density lipoprotein receptor-

related protein 8, apolipoprotein e receptor,

very low density lipoprotein receptor

76
25567
NM_013156

d, General

76
3431
NM_013156
cathepsin L
ESTs, Weakly similar to CATHEPSIN L
General

PRECURSOR [M. musculus], RIKEN cDNA

23151M13 gene, RIKEN cDNA 493486L24

gene, cathepsin 7, cathepsin F, cathepsin L,

cathepsin L2, cathepsin O

76
3430
NM_013156
cathepsin L
ESTs, Weakly similar to CATHEPSIN L
d, General

PRECURSOR [M. musculus], RIKEN cDNA

23151M13 gene, RIKEN cDNA 493486L24

gene, cathepsin 7, cathepsin F, cathepsin L,

cathepsin L2, cathepsin O

77
1714
NM_013187

Homo sapiens
, Similar to cortactin isoform B,
g, i,

clone MGC: 3591 IMAGE: 3637586, mRNA,
General

complete cds, cell differentiation and embryonic

development, ems1 sequence (mammary

tumor and squamous cell carcinoma-associated

(p8/85 src substrate), expressed sequence

AI89414, phospholipase C, gamma 1 (formerly

subtype 148)

78
16448
NM_013197

EST, Highly similar to HEM RAT 5-
a, b,

AMINOLEVULINIC ACID SYNTHASE,
General

ERYTHROID-SPECIFIC, MITOCHONDRIAL

PRECURSOR [R. norvegicus], ESTs, Highly

similar to SYHUAE 5-aminolevulinate synthase

[H. sapiens], aminolevulinate, delta-, synthase 2

(sideroblastic/hypochromic anemia),

aminolevulinic acid synthase 1, aminolevulinic

acid synthase 2, erythroid, glycine C-

acetyltransferase (2-amino-3-ketobutyrate

coenzyme A ligase), glycine C-

acetyltransferase (2-amino-3-ketobutyrate-

coenzyme A ligase)

79
20826
NM_013218

ESTs, Weakly similar to KAD3_HUMAN
h

GTP: AMP PHOSPHOTRANSFERASE

MITOCHONDRIAL [H. sapiens], RIKEN cDNA

1718L2 gene, adenylate kinase 3 alpha like

80
18313
NM_013220
ankyrin-like repeat
ESTs, Highly similar to A44437 regenerating
f, g, i,

protein, cardiac ankyrin
liver inhibitory factor RL/IF-1 - rat
General

repeat protein
[R. norvegicus], ESTs, Highly similar to A57291

cytokine inducible nuclear protein C193

[H. sapiens], ESTs, Weakly similar to A57291

cytokine inducible nuclear protein C193

[H. sapiens], ESTs, Weakly similar to I-kappa B

alpha chain [M. musculus], RIKEN cDNA

11158D9 gene, RIKEN cDNA 169D24 gene,

RIKEN cDNA 493539L19 gene, ankyrin repeat

domain 2 (stretch responsive muscle), cardiac

ankyrin repeat protein, expressed sequence

AA489, nuclear factor of kappa light chain gene

enhancer in B-cells inhibitor, alpha, nuclear

factor of kappa light polypeptide gene enhancer

in B-cells inhibitor, alpha

81
815
NM_013224

ESTs, Highly similar to RS26_HUMAN 4S
e, General

RIBOSOMAL PROTEIN S26 [H. sapiens],

Homo sapiens
, clone IMAGE: 41953, mRNA,

Human DNA sequence from PAC 384D21 on

chromosome X contains ribosomal protein S26

pseudogene, STS, polymerase (RNA) II (DNA

directed) polypeptide D, ribosomal protein S26

82
15239
NM_016989

EST, Weakly similar to RL15 RAT 6S
h

RIBOSOMAL PROTEIN L15 [R. norvegicus],

ESTs, Highly similar to RL15_HUMAN 6S

RIBOSOMAL PROTEIN L15 [H. sapiens],

ESTs, Moderately similar to RL15 RAT 6S

RIBOSOMAL PROTEIN L15 [R. norvegicus],

RIKEN cDNA 2518H7 gene, ribosomal protein

L15

83
3202
NM_017039
protein phosphatase 2

h

(formerly 2A), catalytic

subunit, alpha isoform,

protein phosphatase 2a,

catalytic subunit, alpha

isoform

83
3203
NM_017039
protein phosphatase 2
protein phosphatase 2 (formerly 2A), catalytic
h

(formerly 2A), catalytic
subunit, alpha isoform, protein phosphatase 2a,

subunit, alpha isoform,
catalytic subunit, alpha isoform

protein phosphatase 2a,

catalytic subunit, alpha

isoform

84
24596
NM_017040
protein phosphatase 2

Mus musculus
adult female placenta cDNA,
h

(formerly 2A), catalytic
RIKEN full-length enriched library,

subunit, beta isoform,
clone: 1617J22, full insert sequence, RIKEN

protein phosphatase 2a,
cDNA 2313C1 gene, expressed sequence

catalytic subunit, beta
AI115466, protein phosphatase 2 (formerly 2A),

isoform
catalytic subunit, beta isoform, protein

phosphatase 2a, catalytic subunit, beta isoform,

protein phosphatase 4, catalytic subunit

85
6654
NM_017068
lysosomal membrane
CD68 antigen, ESTs, Highly similar to LMP2
a

glycoprotein 2, lysosomal-
RAT LYSOSOME-ASSOCIATED MEMBRANE

associated membrane
GLYCOPROTEIN 2 PRECURSOR

protein 2
[R. norvegicus], ESTs, Weakly similar to A4842

lysosomal membrane glycoprotein lamp-2

homolog [H. sapiens], lysosomal membrane

glycoprotein 2, lysosomal-associated

membrane protein 2

86
11152
NM_017073
glutamate-ammonia
glutamate-ammonia ligase (glutamine
General

ligase (glutamine
synthase), glutamine synthetase

synthase), glutamine

synthetase

86
11153
NM_017073
glutamate-ammonia
glutamate-ammonia ligase (glutamine
General

ligase (glutamine
synthase), glutamine synthetase

synthase), glutamine

synthetase

87
22552
NM_017087
biglycan
ESTs, Weakly similar to BONE/CARTILAGE
General

PROTEOGLYCAN I PRECURSOR

[R. norvegicus], ESTs, Weakly similar to

PGS1_HUMAN BONE/CARTILAGE

PROTEOGLYCAN I PRECURSOR [H. sapiens],

asporin, asporin (LRR class 1), biglycan, opticin

88
8888
NM_017090
guanylate cyclase 1,
ESTs, Weakly similar to ANPA MOUSE
General

soluble, alpha 3
ATRIAL NATRIURETIC PEPTIDE RECEPTOR

A PRECURSOR [M. musculus], ESTs, Weakly

similar to GUANYLATE CYCLASE SOLUBLE,

ALPHA-1 CHAIN [R. norvegicus], guanylate

cyclase 1, soluble, alpha 2, guanylate cyclase

1, soluble, alpha 3, guanylate cyclase 1,

soluble, beta 3, natriuretic peptide receptor 1,

soluble guanylyl cyclase alpha2 subunit

89
1435
NM_017125
CD63 antigen (melanoma
CD63 antigen (melanoma 1 antigen), Cd63
g, General

1 antigen), Cd63 antigen
antigen, DNA segment, Chr 14, ERATO Doi

226, expressed, EST, Weakly similar to CD63

ANTIGEN [R. norvegicus], EST, Weakly similar

to I3816 melanoma-associated antigen CD63

[H. sapiens], ESTs, Weakly similar to A46493

metastasis suppressor KAI1 [H. sapiens], Homo

sapiens
cDNA FLJ221 fis, clone COLF121,

RIKEN cDNA 131A2 gene, RIKEN cDNA

22121G21 gene, transmembrane 4 superfamily

member 2

90
21663
NM_017126
ferredoxin 1
ESTs, Moderately similar to AXHU adrenodoxin
General

precursor [H. sapiens], Homo sapiens, Similar

to RIKEN cDNA B23118G17 gene, clone

MGC: 1964 IMAGE: 3622817, mRNA, complete

cds, RIKEN cDNA 136N24 gene, RIKEN cDNA

B23118G17 gene, ferredoxin 1

91
24886
NM_017138
laminin receptor 1 (67 kD,
EST, Moderately similar to 4S RIBOSOMAL
General

ribosomal protein SA)
PROTEIN SA [R. norvegicus], ESTs, Highly

similar to A31233 ribosomal protein RS.4K,

cytosolic [H. sapiens], ESTs, Highly similar to

A5688 laminin receptor, 67 K [H. sapiens],

ESTs, Moderately similar to A29395 ribosomal

protein RS.4 K - mouse [M. musculus], ESTs,

Weakly similar to 14534A protein 4 kD

[M. musculus], Homo sapiens laminin receptor-

like protein LAMRL5 mRNA, complete cds,

laminin receptor 1 (67 kD, ribosomal protein SA)

92
24106
NM_017141
DNA polymerase beta,
EST, Weakly similar to A27112 DNA-directed
c

polymerase (DNA
DNA polymerase [R. norvegicus], Mus

directed), beta

musculus
, Similar to DNA polymerase beta,

clone MGC: 6386 IMAGE: 3581916, mRNA,

complete cds, polymerase (DNA directed),

beta, polymerase (DNA directed), lambda

92
24107
NM_017141
DNA polymerase beta,
EST, Weakly similar to A27112 DNA-directed
General

polymerase (DNA
DNA polymerase [R. norvegicus], Mus

directed), beta

musculus
, Similar to DNA polymerase beta,

clone MGC: 6386 IMAGE: 3581916, mRNA,

complete cds, polymerase (DNA directed),

beta, polymerase (DNA directed), lambda

93
20859
NM_017144
troponin I, cardiac
EST, Moderately similar to TROPONIN I,
a, b, f

CARDIAC MUSCLE [R. norvegicus], troponin I,

cardiac, troponin I, skeletal, slow 1

94
15365
NM_017147
cofilin 1 (non-muscle),
EST, Moderately similar to COF1_HUMAN
g, h,

cofilin 1, non-muscle
COFILIN, NON-MUSCLE ISOFOR [H. sapiens],
General

ESTs, Highly similar to DEST_HUMAN

DESTRIN [H. sapiens], ESTs, Moderately

similar to COF1 RAT COFILIN, NON-MUSCLE

ISOFORM [R. norvegicus], ESTs, Moderately

similar to COF1_HUMAN COFILIN, NON-

MUSCLE ISOFOR [H. sapiens], cofilin 1 (non-

muscle), cofilin 1, non-muscle, cofilin 2

(muscle), cofilin 2, muscle, destrin

95
5351
NM_017150
ribosomal protein L29
EST, Moderately similar to 6S RIBOSOMAL
General

PROTEIN L29 [R. norvegicus], EST, Weakly

similar to S65784 ribosomal protein L29,

cytosolic [H. sapiens], ESTs, Highly similar to

S65784 ribosomal protein L29, cytosolic

[H. sapiens], ESTs, Weakly similar to 6S

RIBOSOMAL PROTEIN L29 [M. musculus],

Human DNA sequence from clone RP4-595K12

on chromosome 1p31.2-31.3 Contains a

pseudogene similar to 6S RPL29 (ribosomal

protein L29 (cell surface heparin binding protein

HIP)), a chromosome 1 specific mRNA

(KIAA499), a novel mRNA (KIAA433), ESTs,

STSs, GSSs and a CpG Island, ribosomal

protein L29

96
16953
NM_017151
ribosomal protein S15
EST, Moderately similar to R3HU15 ribosomal
e, h

protein S15, cytosolic [H. sapiens], EST,

Weakly similar to 4S RIBOSOMAL PROTEIN

S15 [R. norvegicus], ESTs, Highly similar to

R3HU15 ribosomal protein S15, cytosolic

[H. sapiens], Homo sapiens, clone

IMAGE: 44798, mRNA, partial cds, ribosomal

protein S15

97
21975
NM_017154
xanthene dehydrogenase,
EST, Weakly similar to XDH RAT XANTHINE
General

xanthine dehydrogenase
DEHYDROGENASE/OXIDASE [R. norvegicus],

RIKEN cDNA 1211D3 gene, RIKEN cDNA

2313G12 gene, aldehyde oxidase (female

form), aldehyde oxidase 1, xanthene

dehydrogenase, xanthine dehydrogenase

98
17104
NM_017160
ribosomal protein S6
EST, Moderately similar to R3HU6 ribosomal
General

protein S6, cytosolic [H. sapiens], EST, Weakly

similar to 4S RIBOSOMAL PROTEIN S6

[R. norvegicus], ESTs, Moderately similar to 4S

RIBOSOMAL PROTEIN S6 [M. musculus],

Homo sapiens
cDNA: FLJ23534 fis, clone

LNG6974, highly similar to HUMRPS6A Human

ribosomal protein S6 mRNA, RIKEN cDNA

58345M2 gene, ribosomal protein S6

98
17107
NM_017160
ribosomal protein S6
EST, Moderately similar to R3HU6 ribosomal
General

protein S6, cytosolic [H. sapiens], EST, Weakly

similar to 4S RIBOSOMAL PROTEIN S6

[R. norvegicus], ESTs, Moderately similar to 4S

RIBOSOMAL PROTEIN S6 [M. musculus],

Homo sapiens
cDNA: FLJ23534 fis, clone

LNG6974, highly similar to HUMRPS6A Human

ribosomal protein S6 mRNA, RIKEN cDNA

58345M2 gene, ribosomal protein S6

99
19031
NM_017180
T-cell death associated
ESTs, Weakly similar to S58222 PQ-rich
General

gene, pleckstrin
protein [H. sapiens], MARCKS-like protein, Mus

homology-like domain,

musculus
8 days embryo cDNA, RIKEN full-

family A, member 1
length enriched library, clone: 573519L1, full

insert sequence, Myristoylated alanine-rich

protein kinase C substrate, myristoylated

alanine rich protein kinase C substrate,

myristoylated alanine-rich protein kinase C

substrate (MARCKS, 8K-L), pleckstrin

homology-like domain, family A, member 1,

pleckstrin homology-like domain, family A,

member 3, tumor suppressing subtransferable

candidate 3

100
15434
NM_017187

EST, Moderately similar to HMG2 RAT HIGH
f

MOBILITY GROUP PROTEIN HMG2

[R. norvegicus], EST, Weakly similar to HMG2

RAT HIGH MOBILITY GROUP PROTEIN

HMG2 [R. norvegicus], ESTs, Weakly similar to

21363A high mobility group protein 2

[H. sapiens], ESTs, Weakly similar to HMG2

RAT HIGH MOBILITY GROUP PROTEIN

HMG2 [R. norvegicus], Human DNA sequence

from clone RP3-527B1 on

chromosome 6q25.1-25.3

Contains a pseudogene similar to HMG

(high mobility group) protein, STSs and GSSs,

Human DNA sequence from clone RP5-17G16

on chromosome 1p34.2-35.3. Contains part of

the gene for a novel CUB and Sushi (SCR

repeat) domain protein, a novel high-mobility

group (nonhistone chromosomal) protein 2

(HMG2) like protein (pseudo) gene, a heat

shock 6 kD protein 1 (chaperonin) (HSPD1)

pseudogene, ESTs, STSs and GSSs, RIKEN

cDNA 26121J1 gene, expressed sequence

AI326135, expressed sequence C8539, high

mobility group box 2, high-mobility group

(nonhistone chromosomal) protein 2

101
14696
NM_017202

e

102
5005
NM_017209

Alcohol dehydrogenase 3, CGI-63 protein,
General

ESTs, Weakly similar to QOR MOUSE

QUINONE OXIDOREDUCTASE [M. musculus],

Homo sapiens
, clone MGC: 183

IMAGE: 3897118, mRNA, complete cds,

KIAA1576 protein, RIKEN cDNA 22147J23

gene, alcohol dehydrogenase 1, complex,

alcohol dehydrogenase 1C (class I), gamma

polypeptide, crystallin, zeta, expressed

sequence AI194826, membrane protein of

cholinergic synaptic vesicles

103
20193
NM_017232
prostaglandin-
prostaglandin-endoperoxide synthase 2,
General

endoperoxide synthase 2,
prostaglandin-endoperoxide synthase 2

prostaglandin-
(prostaglandin G/H synthase and

endoperoxide synthase 2
cyclooxygenase)

(prostaglandin G/H

synthase and

cyclooxygenase)

104
20482
NM_017240
myosin heavy chain,
EST, Highly similar to MYOSIN HEAVY CHAIN,
e

cardiac muscle, adult,
CARDIAC MUSCLE BETA ISOFORM

myosin heavy chain,
[R. norvegicus], EST, Moderately similar to

cardiac muscle, fetal,
MYOSIN HEAVY CHAIN, CARDIAC MUSCLE

myosin, heavy
BETA ISOFORM [R. norvegicus], ESTs, Highly

polypeptide 6, cardiac
similar to MYOSIN HEAVY CHAIN, CARDIAC

muscle, alpha
MUSCLE BETA ISOFORM [R. norvegicus],

(cardiomyopathy,
ESTs, Highly similar to MYSA MOUSE

hypertrophic 1), myosin,
MYOSIN HEAVY CHAIN, CARDIAC MUSCLE

heavy polypeptide 7,
ALPHA ISOFORM [M. musculus], KIAA1512

cardiac muscle, beta
protein, myosin heavy chain, cardiac muscle,

adult, myosin heavy chain, cardiac muscle,

fetal, myosin, heavy polypeptide 2, skeletal

muscle, adult, myosin, heavy polypeptide 7,

cardiac muscle, beta, tuftelin 1

104
3780
NM_017240

e

104
20484
NM_017240
myosin heavy chain,
EST, Highly similar to MYOSIN HEAVY CHAIN,
a, c, e, f

cardiac muscle, adult,
CARDIAC MUSCLE BETA ISOFORM

myosin heavy chain,
[R. norvegicus], EST, Moderately similar to

cardiac muscle, fetal,
MYOSIN HEAVY CHAIN, CARDIAC MUSCLE

myosin, heavy
BETA ISOFORM [R. norvegicus], ESTs, Highly

polypeptide 6, cardiac
similar to MYOSIN HEAVY CHAIN, CARDIAC

muscle, alpha
MUSCLE BETA ISOFORM [R. norvegicus],

(cardiomyopathy,
ESTs, Highly similar to MYSA MOUSE

hypertrophic 1), myosin,
MYOSIN HEAVY CHAIN, CARDIAC MUSCLE

heavy polypeptide 7,
ALPHA ISOFORM [M. musculus], KIAA1512

cardiac muscle, beta
protein, myosin heavy chain, cardiac muscle,

adult, myosin heavy chain, cardiac muscle,

fetal, myosin, heavy polypeptide 2, skeletal

muscle, adult, myosin, heavy polypeptide 7,

cardiac muscle, beta, tuftelin 1

105
17563
NM_017245
eukaryotic translation
EST, Weakly similar to EFHU2 translation
g, General

elongation factor 2
elongation factor eEF-2 [H. sapiens], ESTs,

Highly similar to ELONGATION FACTOR 2

[R. norvegicus], ESTs, Weakly similar to

ELONGATION FACTOR 2 [R. norvegicus], G1

to phase transition 1, G1 to phase transition 2,

RIKEN cDNA 493594C11 gene, U5 snRNP-

specific protein, 116 kD, eukaryotic translation

elongation factor 1 alpha 1, eukaryotic

translation elongation factor 2, expressed

sequence AI45134, hypothetical protein

FLJ21661

106
15301
NM_017259
B-cell translocation gene
B-cell translocation gene 2, anti-proliferative, B-
General

2, anti-proliferative, BTG
cell translocation gene 3, B-cell translocation

family, member 2
gene 4, BTG family, member 2, BTG family,

member 3, BTG family, member 4, ESTs,

Highly similar to BTG2_HUMAN BTG2

PROTEIN PRECURSOR [H. sapiens]

106
15299
NM_017259
B-cell translocation gene
B-cell translocation gene 2, anti-proliferative, B-
General

2, anti-proliferative, BTG
cell translocation gene 3, B-cell translocation

family, member 2
gene 4, BTG family, member 2, BTG family,

member 3, BTG family, member 4, ESTs,

Highly similar to BTG2_HUMAN BTG2

PROTEIN PRECURSOR [H. sapiens]

106
15300
NM_017259
B-cell translocation gene
B-cell translocation gene 2, anti-proliferative, B-
General

2, anti-proliferative, BTG
cell translocation gene 3, B-cell translocation

family, member 2
gene 4, BTG family, member 2, BTG family,

member 3, BTG family, member 4, ESTs,

Highly similar to BTG2_HUMAN BTG2

PROTEIN PRECURSOR [H. sapiens]

107
3254
NM_017282
proteasome (prosome,
expressed sequence AA4947, proteasome
h

macropain) subunit, alpha
(prosome, macropain) subunit, alpha type 5,

type 5, proteasome
proteasome (prosome, macropain) subunit,

(prosome, macropain)
alpha type, 5

subunit, alpha type, 5

108
82
NM_017297
potassium inwardly-
potassium inwardly-rectifying channel,
i

rectifying channel,
subfamily J, member 5

subfamily J, member 5

109
1894
NM_017320

cathepsin S
General

110
356
NM_017334

General

110
355
NM_017334

General

111
20848
NM_017343

ESTs, Weakly similar to MOHULP myosin
c, g

regulatory light chain, placental [H. sapiens],

RIKEN cDNA 2973G15 gene, expressed

sequence C77744, myosin, light polypeptide,

regulatory, non-sarcomeric (2 kD)

112
460
NM_019131
tropomyosin 1 (alpha),
ESTs, Moderately similar to alpha-tropomyosin
a

tropomyosin 1, alpha
slow [M. musculus], tropomyosin 4

113
5622
NM_019143
fibronectin 1

General

114
17066
NM_019170

ESTs, Weakly similar to JC5284 carbonyl
e

reductase (NADPH) (EC 1.1.1.184), inducible -

rat [R. norvegicus], Homo sapiens, clone

MGC: 2328 IMAGE: 463754, mRNA, complete

cds, RIKEN cDNA 1111J5 gene, RIKEN cDNA

94359D4 gene, carbonyl reductase 1, carbonyl

reductase 3, expressed sequence C81353

115
1174
NM_019184

RIKEN cDNA 2131M18 gene, RIKEN cDNA
b

21318C6 gene, RIKEN cDNA 2219K14 gene,

cytochrome P45, 2c29, cytochrome P45,

subfamily IIC (mephenytoin 4-hydroxylase),

polypeptide 18

116
18569
NM_019212
actin, alpha 1, skeletal
BAF53, BRG1/brm-associated factor 53A, EST,
General

muscle
Weakly similar to ACTIN, ALPHA SKELETAL

MUSCLE [R. norvegicus], ESTs, Weakly similar

to ATHU actin alpha 1, skeletal muscle

[H. sapiens], Homo sapiens FKSG73 (FKSG73)

mRNA, complete cds, RIKEN cDNA 6141G9

gene, actin, alpha 1, skeletal muscle, actin-like

6, actin-related protein 3

117
20433
NM_019232
serum/glucocorticoid
3-phosphoinositide dependent protein kinase-1,
b, General

regulated kinase
EST, Weakly similar to SGK RAT

SERINE/THREONINE-PROTEIN KINASE SGK

[R. norvegicus], Mus musculus serine/threonine

protein kinase CISK (Cisk) mRNA, complete

cds, RIKEN cDNA 1196F7 gene,

serum/glucocorticoid regulated kinase,

serum/glucocorticoid regulated kinase 2,

serum/glucocorticoid regulated kinase-like,

thymoma viral proto-oncogene 3

118
17908
NM_019242
interferon-related
ESTs, Weakly similar to INTERFERON-
c

developmental regulator 1
RELATED PROTEIN PC4 [R. norvegicus],

interferon-related developmental regulator 1,

interferon-related developmental regulator 2

119
11218
NM_019247
paired-like homeodomain
paired-like homeodomain transcription factor 1,
General

transcription factor 3
paired-like homeodomain transcription factor 2,

paired-like homeodomain transcription factor 3

120
23419
NM_019257
splicing factor,
EST, Weakly similar to SPLICING FACTOR,
d

arginine/serine-rich 5,
ARGININE/SERINE-RICH 5 [R. norvegicus],

splicing factor,
RIKEN cDNA 1211E11 gene, splicing factor,

arginine/serine-rich 5
arginine/serine-rich 4, splicing factor,

(SRp4, HRS)
arginine/serine-rich 4 (SRp75), splicing factor,

arginine/serine-rich 5, splicing factor,

arginine/serine-rich 5 (SRp4, HRS), splicing

factor, arginine/serine-rich 6

121
21443
NM_019262
complement component
C1q-related factor, Homo sapiens, Similar to
General

1, q subcomponent, beta
complement component 1, q subcomponent, c

polypeptide
polypeptide, clone MGC: 17279

IMAGE: 4212772, mRNA, complete cds,

complement component 1, q subcomponent,

beta polypeptide, complement component 1, q

subcomponent, c polypeptide, expressed

sequence AI385742

122
20735
NM_019283
solute carrier family 3
EST, Moderately similar to SAHU4F cell
a, d,

(activators of dibasic and
surface antigen 4F2 heavy chain [H. sapiens],
General

neutral amino acid
ESTs, Moderately similar to 191425A AA

transport), member 2
transporter [H. sapiens], ESTs, Moderately

similar to SAHU4F cell surface antigen 4F2

heavy chain [H. sapiens], putative L-type neutral

amino acid transporter, solute carrier family 3

(activators of dibasic and neutral amino acid

transport), member 2, solute carrier family 3

(cystine, dibasic and neutral amino acid

transporters, activator of cystine, dibasic and

neutral amino acid transport), member 1, solute

carrier family 3, member 1

122
20734
NM_019283
solute carrier family 3
EST, Moderately similar to SAHU4F cell
d

(activators of dibasic and
surface antigen 4F2 heavy chain [H. sapiens],

neutral amino acid
ESTs, Moderately similar to 191425A AA

transport), member 2
transporter [H. sapiens], ESTs, Moderately

similar to SAHU4F cell surface antigen 4F2

heavy chain [H. sapiens], putative L-type neutral

amino acid transporter, solute carrier family 3

(activators of dibasic and neutral amino acid

transport), member 2, solute carrier family 3

(cystine, dibasic and neutral amino acid

transporters, activator of cystine, dibasic and

neutral amino acid transport), member 1, solute

carrier family 3, member 1

123
10016
NM_019289

EST, Highly similar to AR41_HUMAN ARP2/3
i

COMPLEX 41 KDA SUBUNIT [H. sapiens],

ESTs, Moderately similar to AR41_HUMAN

ARP2/3 COMPLEX 41 KDA SUBUNIT

[H. sapiens], actin related protein 2/3 complex,

subunit 1A (41 kD), actin related protein 2/3

complex, subunit 1A (41 kDa), actin related

protein 2/3 complex, subunit 1B (41 kDa),

expressed sequence AA4864, suppressor of

profilin/p41 of actin-related complex 2/3

124
15056
NM_019291

EST, Moderately similar to CARBONIC
General

ANHYDRASE II [R. norvegicus], EST, Weakly

similar to CARBONIC ANHYDRASE II

[M. musculus], carbonic anhydrase 2, carbonic

anhydrase 7, carbonic anhydrase I, carbonic

anhydrase II

125
20750
NM_019301

CUB and Sushi multiple domains 1, ESTs,
h

Highly similar to I7312 complement C3b/C4b

receptor, membrane-bound form precursor

[H. sapiens], ESTs, Weakly similar to JC254

complement regulatory protein, 5I2 antigen

precursor - rat [R. norvegicus], Mus musculus 8

days embryo cDNA, RIKEN full-length enriched

library, clone: 573478H2, full insert sequence,

complement component (3b/4b) receptor 1,

including Knops blood group system,

complement receptor related protein, decay

accelerating factor 1, decay accelerating factor

2, membrane cofactor protein

126
52
NM_019335

NIMA (never in mitosis gene a)-related
e

expressed kinase 4, RIKEN cDNA 261528K9

gene, eukaryotic translation initiation factor 2

alpha kinase 2, eukaryotic translation initiation

factor 2-alpha kinase 3, protein kinase,

interferon-inducible double stranded RNA

dependent, serine/threonine kinase 31

127
22675
NM_019358

glycoprotein 38, lung type-I cell membrane-
General

associated glycoprotein

128
20057
NM_019370

EST, Weakly similar to A578 cell surface
g

antigen RB13-6 - rat [R. norvegicus], ESTs,

Weakly similar to A55144 autotaxin precursor

[H. sapiens], ESTs, Weakly similar to A578 cell

surface antigen RB13-6 - rat [R. norvegicus],

Mus musculus
, Similar to alkaline

phosphodiesterase, clone MGC: 6548

IMAGE: 2655671, mRNA, complete cds,

ectonucleotide

pyrophosphatase/phosphodiesterase 1,

ectonucleotide

pyrophosphatase/phosphodiesterase 2,

ectonucleotide

pyrophosphatase/phosphodiesterase 3,

ectonucleotide

pyrophosphatase/phosphodiesterase 4

(putative function), ectonucleotide

pyrophosphatase/phosphodiesterase 5

(putative function), expressed sequence

AI876438

129
1324
NM_019371

EGL nine (C. elegans) homolog 1, EGL nine
General

(C. elegans) homolog 2, EGL nine (C. elegans)

homolog 3, EGL nine homolog 3 (C. elegans),

ESTs, Moderately similar to A5377 growth

factor-responsive protein, vascular smooth

muscle - rat [R. norvegicus], ESTs, Weakly

similar to A5377 growth factor-responsive

protein, vascular smooth muscle - rat

[R. norvegicus], SCAN domain-containing 2

130
22727
NM_019383

ATP synthase, H+ transporting, mitochondrial F
i

complex, subunit d, EST, Weakly similar to

ATP SYNTHASE D CHAIN, MITOCHONDRIAL

[R. norvegicus], EST, Weakly similar to

ATPQ_HUMAN ATP SYNTHASE D CHAIN,

MITOCHONDRIAL [H. sapiens], Homo sapiens

clone 23e8 My32 protein mRNA, complete cds,

RIKEN cDNA 619D1 gene

131
16
NM_019386

EST, Weakly similar to TGLC MOUSE
General

PROTEIN-GLUTAMINE GAMMA-

GLUTAMYLTRANSFERASE [M. musculus],

Homo sapiens
mRNA; cDNA DKFZp667H46

(from clone DKFZp667H46), Tissue

transglutaminase homologue {alternatively

spliced} [human, erythroleukemia cell line HEL

GM6141A, mRNA, 2362 nt], transglutaminase 2

(C polypeptide, protein-glutamine-gamma-

glutamyltransferase), transglutaminase 2, C

polypeptide, transglutaminase 5

131
17
NM_019386

EST, Weakly similar to TGLC MOUSE
General

PROTEIN-GLUTAMINE GAMMA-

GLUTAMYLTRANSFERASE [M. musculus],

Homo sapiens
mRNA; cDNA DKFZp667H46

(from clone DKFZp667H46), Tissue

transglutaminase homologue {alternatively

spliced} [human, erythroleukemia cell line HEL

GM6141A, mRNA, 2362 nt], transglutaminase 2

(C polypeptide, protein-glutamine-gamma-

glutamyltransferase), transglutaminase 2, C

polypeptide, transglutaminase 5

132
574
NM_019905
hydroxyacid oxidase
ESTs, Highly similar to (S)-2-HYDROXY-ACID
g, i,

(glycolate oxidase) 3,
OXIDASE, PEROXISOMAL [R. norvegicus],
General

hydroxyacid oxidase 3
ESTs, Highly similar to LUHU36 annexin II

(medium-chain)
[H. sapiens], RIKEN cDNA 1113P15 gene,

RIKEN cDNA B43311C9 gene, annexin A2,

annexin A2 pseudogene 2, caspase recruitment

domain family, member 6, expressed sequence

AW215814, hydroxyacid oxidase (glycolate

oxidase) 3, hydroxyacid oxidase 1, liver,

hydroxyacid oxidase 2 (long chain), nucleolar

protein 3 (apoptosis repressor with CARD

domain)

133
18713
NM_020075
eukaryotic translation
DNA segment, Chr 12, ERATO Doi 549,
General

initiation factor 5
expressed, KIAA1856 protein, eukaryotic

translation initiation factor 5

133
18715
NM_020075
eukaryotic translation
DNA segment, Chr 12, ERATO Doi 549,
General

initiation factor 5
expressed, KIAA1856 protein, eukaryotic

translation initiation factor 5

134
19696
NM_021699

ELKL motif kinase, ESTs, Weakly similar to
General

G125 serine/threonine protein kinase

[H. sapiens], ESTs, Weakly similar to

SN1L_RAT PROBABLE SERINE/THREONINE

PROTEIN KINASE SNF1LK (SALT-

INDUCIBLE PROTEIN KINASE) (PROTEIN

KINASE KID2) [R. norvegicus], Homo sapiens

mRNA; cDNA DKFZp434P81 (from clone

DKFZp434P81), MAP/microtubule affinity-

regulating kinase 1, MAP/microtubule affinity-

regulating kinase 3, RIKEN cDNA 2419P21

gene, RIKEN cDNA 573525O22 gene, SNF1-

like kinase, expressed sequence AW49115,

salt-inducible protein kinase

135
19710
NM_021744

CD14 antigen, ESTs, Weakly similar to CD14
i, General

RAT MONOCYTE DIFFERENTIATION

ANTIGEN CD14 PRECURSOR [R. norvegicus]

136
20035
NM_021754

DKFZP566J153 protein, ESTs, Moderately
General

similar to T17299 hypothetical protein

DKFZp564H2171.1 [H. sapiens], nucleolar

protein NOP5/NOP58

137
14397
NM_021909
FXYD domain-containing
EST, Weakly similar to A43932 mucin 2
g, General

ion transport regulator 5
precursor, intestinal [H. sapiens], ESTs, Weakly

similar to A43932 mucin 2 precursor, intestinal

[H. sapiens], FXYD domain-containing ion

transport regulator 5, Homo sapiens cDNA

FLJ12566 fis, clone NT2RM4852

138
17100
NM_022179

EST, Moderately similar to HXK3_HUMAN
h, General

HEXOKINASE TYPE III [H. sapiens], EST,

Weakly similar to HXK2 MOUSE

HEXOKINASE TYPE II [M. musculus], ESTs,

Moderately similar to HXK2 MOUSE

HEXOKINASE TYPE II [M. musculus], ESTs,

Weakly similar to HXK2 MOUSE

HEXOKINASE TYPE II [M. musculus],

hexokinase 2, hexokinase 3 (white cell)

138
17101
NM_022179

EST, Moderately similar to HXK3_HUMAN
General

HEXOKINASE TYPE III [H. sapiens], EST,

Weakly similar to HXK2 MOUSE

HEXOKINASE TYPE II [M. musculus], ESTs,

Moderately similar to HXK2 MOUSE

HEXOKINASE TYPE II [M. musculus], ESTs,

Weakly similar to HXK2 MOUSE

HEXOKINASE TYPE II [M. musculus],

hexokinase 2, hexokinase 3 (white cell)

139
20204
NM_022196

leukemia inhibitory factor, leukemia inhibitory
i, General

factor (cholinergic differentiation factor)

140
20385
NM_022229

EST, Moderately similar to CH6 MOUSE 6 KDA
h

HEAT SHOCK PROTEIN, MITOCHONDRIAL

PRECURSOR [M. musculus], EST, Moderately

similar to CH6_HUMAN 6 KDA HEAT SHOCK

PROTEIN, MITOCHONDRIAL PRECURSOR

[H. sapiens], ESTs, Highly similar to I5342

chaperonin [H. sapiens], ESTs, Weakly similar

to I5342 chaperonin [H. sapiens], Homo

sapiens
, clone IMAGE: 4155316, mRNA, partial

cds, heat shock 6 kD protein 1 (chaperonin),

heat shock protein, 6 kDa

141
6263
NM_022251

EST, Weakly similar to AMPN RAT
b

AMINOPEPTIDASE N [R. norvegicus], Leucine

arylaminopeptidase 1, alanyl (membrane)

aminopeptidase, alanyl (membrane)

aminopeptidase (aminopeptidase N,

aminopeptidase M, microsomal

aminopeptidase, CD13, p15), aminopeptidase,

glutamyl aminopeptidase, glutamyl

aminopeptidase (aminopeptidase A), type 1

tumor necrosis factor receptor shedding

aminopeptidase regulator

142
6585
NM_022266

WNT1 inducible signaling pathway protein 1,
i, General

WNT1 inducible signaling pathway protein 2,

WNT1 inducible signaling pathway protein 3,

connective tissue growth factor

143
17161
NM_022298

ESTs, Highly similar to A2335 tubulin alpha
g, General

chain [H. sapiens], tubulin alpha 1, tubulin alpha

2, tubulin alpha 3, tubulin alpha 6, tubulin, alpha

2, tubulin, alpha 3, tubulin, alpha, ubiquitous

144
13480
NM_022390

RIKEN cDNA 2618L4 gene, quinoid
f

dihydropteridine reductase

145
22415
NM_022392

EST, Highly similar to ISI1_HUMAN INSULIN-
General

INDUCED PROTEIN 1 [H. sapiens], ESTs,

Highly similar to INSULIN-INDUCED GROWTH

RESPONSE PROTEIN CL-6 [R. norvegicus],

Mus musculus
, clone MGC: 1894

IMAGE: 424711, mRNA, complete cds, insulin

induced gene 1, insulin induced protein 2

146
23705
NM_022396

EST, Weakly similar to I39159 GTP-binding
h

regulatory protein gamma-11 chain [H. sapiens],

ESTs, Moderately similar to GBGB_HUMAN

GUANINE NUCLEOTIDE-BINDING PROTEIN

G(l)/G(S)/G(O) GAMMA-11 SUBUNIT

[R. norvegicus], ESTs, Weakly similar to

GBGB_HUMAN GUANINE NUCLEOTIDE-

BINDING PROTEIN G(l)/G(S)/G(O) GAMMA-

11 SUBUNIT [R. norvegicus], RIKEN cDNA

6137B21 gene, expressed sequence AV96488,

guanine nucleotide binding protein (G protein),

gamma 1 subunit, guanine nucleotide binding

protein (G protein), gamma transducing activity

polypeptide 1, guanine nucleotide binding

protein (G protein), gamma transducing activity

polypeptide 2, guanine nucleotide binding

protein 11

147
23300
NM_022398

ESTs, Weakly similar to M2OM RAT
h

MITOCHONDRIAL 2-

OXOGLUTARATE/MALATE CARRIER

PROTEIN [R. norvegicus], ESTs, Weakly similar

to M2OM_HUMAN MITOCHONDRIAL 2-

OXOGLUTARATE/MALATE CARRIER

PROTEIN [H. sapiens], RIKEN cDNA

363241G24 gene, RIKEN cDNA 4933433D23

gene, solute carrier family 25 (mitochondrial

carrier, brain), member 14, solute carrier family

25 (mitochondrial carrier; dicarboxylate

transporter), member 1, solute carrier family 25

(mitochondrial carrier; oxoglutarate carrier),

member 11

148
24536
NM_022399

ESTs, Weakly similar to CALRETICULIN
c

PRECURSOR [R. norvegicus], Homo sapiens,

Similar to RIKEN cDNA 1731L1 gene, clone

MGC: 26577 IMAGE: 48221, mRNA, complete

cds, RIKEN cDNA 1731L1 gene, RIKEN cDNA

633586I2 gene, calreticulin

149
20915
NM_022407
aldehyde dehydrogenase
EST, Moderately similar to A Chain A, Human
General

1 family, member A1,
Mitochondrial Aldehyde Dehydrogenase

aldehyde dehydrogenase
Complexed With Nad+ And Mn2+ {SUB 24-517

family 1, subfamily A1
[H. sapiens], ESTs, Moderately similar to

ALDEHYDE DEHYDROGENASE,

MITOCHONDRIAL PRECURSOR

[R. norvegicus], RIKEN cDNA 277F14 gene,

aldehyde dehydrogenase 1 family, member B1,

aldehyde dehydrogenase 2 family

(mitochondrial), aldehyde dehydrogenase 2,

mitochondrial, aldehyde dehydrogenase 9

family, member A1, aldehyde dehydrogenase

9, subfamily A1

150
8212
NM_022500
ferritin light chain 1,
ESTs, Highly similar to FRHUL ferritin light
General

ferritin, light polypeptide
chain [H. sapiens], ESTs, Moderately similar to

FRHUL ferritin light chain [H. sapiens], PRO47

protein, RIKEN cDNA 4933416E14 gene,

ferritin light chain 2, ferritin, light polypeptide

151
1867
NM_022510

ESTs, Moderately similar to RL4_HUMAN 6S
General

RIBOSOMAL PROTEIN L4 [H. sapiens], H19,

imprinted maternally expressed untranslated

mRNA, Homo sapiens cDNA: FLJ23366 fis,

clone HEP15665

152
4242
NM_022521

ESTs, Highly similar to ORNITHINE
f

AMINOTRANSFERASE PRECURSOR

[R. norvegicus], RIKEN cDNA 1319H2 gene,

RIKEN cDNA 296B13 gene, hypothetical

protein MGC15875, ornithine aminotransferase,

ornithine aminotransferase (gyrate atrophy)

153
6100
NM_022531

f, General

154
8598
NM_022538

f

154
8597
NM_022538

b, General

155
11039
NM_022543

General

156
20925
NM_022594
enoyl Coenzyme A
AU RNA-binding protein/enoyl-coenzyme A
e

hydratase 1, peroxisomal,
hydratase, EST, Weakly similar to

enoyl coenzyme A
ECH1_HUMAN DELTA3, 5-DELTA2, 4-

hydratase 1, peroxisomal
DIENOYL-COA ISOMERASE PRECURSO

[H. sapiens], RIKEN cDNA 2619M2 gene, enoyl

Coenzyme A hydratase 1, peroxisomal, enoyl

coenzyme A hydratase 1, peroxisomal,

expressed sequence AA617331

157
20944
NM_022597

cathepsin B, lipocalin 7, tubulointerstitial
f, General

nephritis antigen

158
21211
NM_022607

EST, Weakly similar to S23 neurofilament
b, h

triplet H protein - rat [R. norvegicus], ESTs,

Weakly similar to S23 neurofilament triplet H

protein - rat [R. norvegicus], KIAA182 protein,

NADH dehydrogenase (ubiquinone)

flavoprotein 3 (1 kD)

159
2250
NM_022643

H2B histone family, member D, H2B histone
h

family, member G, H2B histone family, member

K, RIKEN cDNA 26122J1 gene, expressed

sequence AI413321, expressed sequence

R74621

160
12542
NM_022647

ESTs, Weakly similar to I4841 histone H2b -
f

mouse [M. musculus], H2B histone family,

member A, H2B histone family, member G,

H2B histone family, member K, expressed

sequence AI413321, expressed sequence

R74621

161
15727
NM_022953
slit (Drosophila) homolog
ESTs, Highly similar to T42626 secreted
General

1, slit homolog 1
leucine-rich repeat-containing protein SLIT2 -

(Drosophila)
mouse (fragment) [M. musculus], ESTs, Weakly

similar to T42626 secreted leucine-rich repeat-

containing protein SLIT2 - mouse (fragment)

[M. musculus], Homo sapiens mRNA; cDNA

DKFZp434N435 (from clone DKFZp434N435);

partial cds, glycoprotein IX (platelet),

glycoprotein lb (platelet), beta polypeptide,

glycoprotein lb, beta polypeptide, slit

(Drosophila) homolog 1, slit (Drosophila)

homolog 2, slit (Drosophila) homolog 3, slit

homolog 1 (Drosophila), slit homolog 2

(Drosophila), slit homolog 3 (Drosophila)

162
15729
NM_022955

EGF-like-domain, multiple 3, EST, Highly
General

similar to A443 notch protein homolog TAN-1

precursor [H. sapiens], EST, Weakly similar to

A443 notch protein homolog TAN-1 precursor

[H. sapiens], ESTs, Weakly similar to JH771

protein-tyrosine kinase [M. musculus], ESTs,

Weakly similar to T13954 MEGF6 protein - rat

[R. norvegicus], Notch (Drosophila) homolog 1

(translocation-associated), Notch (Drosophila)

homolog 2, Notch gene homolog 3,

(Drosophila), Rattus norvegicus CBL2 (CBL2)

mRNA, complete cds

163
21239
NM_024125
CCAAT/enhancer binding
CCAAT/enhancer binding protein (C/EBP), beta
c, General

protein (C/EBP), beta

164
353
NM_024127
growth arrest and DNA-
growth arrest and DNA-damage-inducible 45
i

damage-inducible 45
alpha, growth arrest and DNA-damage-

alpha, growth arrest and
inducible 45 beta, growth arrest and DNA-

DNA-damage-inducible,
damage-inducible, alpha

alpha

165
17226
NM_024131
D-dopachrome
D-dopachrome tautomerase, expressed
General

tautomerase
sequence C78655

166
24634
NM_024137
human immunodeficiency
ESTs, Weakly similar to Z177_HUMAN ZINC
General

virus type I enhancer
FINGER PROTEIN 177 [H. sapiens], KIAA1555

binding protein 2, human
protein, human immunodeficiency virus type I

immunodeficiency virus
enhancer-binding protein 2, human

type I enhancer-binding
immunodeficiency virus type I enhancer-binding

protein 2
protein 3, kappa B and Rss recognition

component

166
24632
NM_024137
human immunodeficiency
ESTs, Weakly similar to Z177_HUMAN ZINC
a

virus type I enhancer
FINGER PROTEIN 177 [H. sapiens], KIAA1555

binding protein 2, human
protein, human immunodeficiency virus type I

immunodeficiency virus
enhancer-binding protein 2, human

type I enhancer-binding
immunodeficiency virus type I enhancer-binding

protein 2
protein 3, kappa B and Rss recognition

component

167
22
NM_024388

nuclear receptor subfamily 4, group A, member 1
b

168
9929
NM_024392

Homo sapiens
cDNA FLJ13261 fis, clone
g

OVARC1885, weakly similar to

OXIDOREDUCTASE UCPA (EC 1.—.—.—),

Human DNA sequence from clone 168E13 on

chromosome 2p11.21-12.3. Contains two

putative novel genes, the gene for a novel

protein similar to bovine SCP2 (Sterol Carrier

Protein 2) and part of HSD17B4

(hydroxysteroid (17-beta) dehydrogenase 4), an

EEF1A1 (eukaryotic translation elongation

factor 1 alpha 1) pseudogene, ESTs, STSs and

GSSs, RIKEN cDNA 11129G7 gene, RIKEN

cDNA 171M22 gene, RIKEN cDNA 18126B4

gene, RIKEN cDNA 26127I16 gene, expressed

sequence AW2883, hydroxysteroid (17-beta)

dehydrogenase 4, hydroxysteroid 17-beta

dehydrogenase 4, hypothetical protein

MGC194, oxidoreductase UCPA, retinal short-

chain dehydrogenase/reductase 1

169
3582
NM_024396

ATP-binding cassette, sub-family A (ABC1),
a

member 2, ATP-binding cassette, sub-family A

(ABC1), member 3, ATP-binding cassette, sub-

family A (ABC1), member 4, ATP-binding

cassette, sub-family A (ABC1), member 7, ATP-

binding cassette, sub-family A (ABC1), member

8, ESTs, Weakly similar to ABC2 MOUSE ATP-

BINDING CASSETTE TRANSPORTER 2

[M. musculus], Homo sapiens mRNA for

KIAA1888 protein, partial cds, hypothetical

protein FLJ14297, hypothetical protein

PRO2543

170
22626
NM_024400

ESTs, Weakly similar to T47158 hypothetical
General

protein DKFZp762C111.1 [H. sapiens], Mus

musculus
papilin mRNA, complete cds, Mus

musculus
, Similar to a disintegrin and

metalloproteinase with thrombospondin motifs 1

(ADAMTS-1), clone IMAGE: 3491991, mRNA,

partial cds, RIKEN cDNA 672426B9 gene,

RIKEN cDNA A938K15 gene, a disintegrin-like

and metalloprotease (reprolysin type) with

thrombospondin type 1 motif, 1, a disintegrin-

like and metalloprotease (reprolysin type) with

thrombospondin type 1 motif, 4, a disintegrin-

like and metalloprotease (reprolysin type) with

thrombospondin type 1 motif, 8, a disintegrin-

like and metalloprotease (reprolysin type) with

thrombospondin type 1 motif, 9

171
13633
NM_024403

EST, Weakly similar to ATF4_HUMAN CYCLIC-
General

AMP-DEPENDENT TRANSCRIPTION

FACTOR ATF-4 [H. sapiens], activating

transcription factor 4 (tax-responsive enhancer

element B67), activating transcription factor 5

171
13634
NM_024403

EST, Weakly similar to ATF4_HUMAN CYCLIC-
General

AMP-DEPENDENT TRANSCRIPTION

FACTOR ATF-4 [H. sapiens], activating

transcription factor 4 (tax-responsive enhancer

element B67), activating transcription factor 5

172
17917
NM_024488

a, b

173
26164
NM_030836

ESTs, Weakly similar to PSA MOUSE
i

PUROMYCIN-SENSITIVE AMINOPEPTIDASE

[M. musculus], aminopeptidase, glutamyl

aminopeptidase, leucyl/cystinyl

aminopeptidase, thyrotropin-releasing hormone

degrading ectoenzyme, type 1 tumor necrosis

factor receptor shedding aminopeptidase

regulator

174
1221
NM_030845

GRO1 oncogene, GRO2 oncogene, Rattus
General

norvegicus
CXC chemokine RTCK1 (Rtck1)

mRNA, complete cds, interleukin 8, platelet

factor 4, pro-platelet basic protein, pro-platelet

basic protein (includes platelet basic protein,

beta-thromboglobulin, connective tissue-

activating peptide III, neutrophil-activating

peptide-2)

175
17342
NM_030873

EST, Weakly similar to A Chain A, Human
d

Platelet Profilin Complexed With The L-Pro1

Peptide {SUB 3-14 [H. sapiens], ESTs, Weakly

similar to profilin [R. norvegicus], RIKEN cDNA

1712P12 gene, profilin, profilin 1, profilin 2

176
23109
NM_031000

EST, Weakly similar to ALCOHOL
c, f, h

DEHYDROGENASE [R. norvegicus], RIKEN

cDNA 2315E1 gene, aldo-keto reductase family

1, member A1 (aldehyde reductase), aldo-keto

reductase family 1, member A4 (aldehyde

reductase), aldo-keto reductase family 1,

member E1

177
21165
NM_031005
actinin, alpha 1
ESTs, Weakly similar to FAHUAA alpha-actinin
General

1 [H. sapiens], Homo sapiens, Similar to

cysteine and histidine-rich protein, clone

IMAGE: 3945559, mRNA, partial cds, RIKEN

cDNA 31123F1 gene, actinin alpha 2, actinin

alpha 3, actinin, alpha 1, actinin, alpha 2,

actinin, alpha 3, actinin, alpha 4, alpha actinin

4, beta-spectrin 2, non-erythrocytic, beta-

spectrin 3

178
1845
NM_031010

ESTs, Moderately similar to ARACHIDONATE
a, b,

12-LIPOXYGENASE [R. norvegicus],
General

arachidonate 12-lipoxygenase, arachidonate 12-

lipoxygenase pseudogene 2, arachidonate 15-

lipoxygenase, expressed sequence AW259591

178
25517
NM_031010

ESTs, Moderately similar to ARACHIDONATE
a, b,

12-LIPOXYGENASE [R. norvegicus],
General

arachidonate 12-lipoxygenase, arachidonate 12-

lipoxygenase pseudogene 2, arachidonate 15-

lipoxygenase, expressed sequence AW259591

179
15886
NM_031035

guanine nucleotide binding protein (G protein),
c, f

alpha inhibiting activity polypeptide 2, guanine

nucleotide binding protein, alpha inhibiting 2,

guanine nucleotide binding protein, alpha

inhibiting 3

180
15957
NM_031050

ESTs, Weakly similar to LUM RAT LUMICAN
h

PRECURSOR [R. norvegicus], RIKEN cDNA

73349J17 gene, dermatan sulphate

proteoglycan 3, lumican, osteoglycin

(osteoinductive factor, mimecan),

osteomodulin, protein phosphatase 1,

regulatory (inhibitor) subunit 7

181
11849
NM_031065

EST, Moderately similar to R1A MOUSE 6S
h, General

RIBOSOMAL PROTEIN L1A [M. musculus],

EST, Weakly similar to 6S RIBOSOMAL

PROTEIN L1A [R. norvegicus], ESTs, Highly

similar to R1A_HUMAN 6S RIBOSOMAL

PROTEIN L1A [H. sapiens], ribosomal protein

L1A, ribosomal protein L1a

182
12639
NM_031099

ESTs, Weakly similar to S55912 ribosomal
e, General

protein L5, cytosolic [H. sapiens], ribosomal

protein L5

183
20812
NM_031100

EST, Moderately similar to 6S RIBOSOMAL
e

PROTEIN L1 [M. musculus], EST, Moderately

similar to 6S RIBOSOMAL PROTEIN L1

[R. norvegicus], ESTs, Highly similar to A42735

ribosomal protein L1, cytosolic [H. sapiens],

Homo sapiens
, Similar to ribosomal protein L1,

clone MGC: 22634 IMAGE: 3935452, mRNA,

complete cds, Human DNA sequence from

clone RP3-334F4 on chromosome 6 Contains

ESTs, STSs and GSSs. Contains a LAMR1

(laminin receptor 1, ribosomal protein SA)

pseudogene and an RPL1 (ribosomal protein

L1) pseudogene, Mouse 24.6 kda protein

mRNA, complete cds, ribosomal protein L1

184
23854
NM_031101

EST, Moderately similar to JC2368 ribosomal
General

protein L13 - rat [R. norvegicus], EST,

Moderately similar to S23753 ribosomal protein

L13, cytosolic [H. sapiens], EST, Weakly similar

to JC2368 ribosomal protein L13 - rat

[R. norvegicus], ESTs, Highly similar to S23753

ribosomal protein L13, cytosolic [H. sapiens],

ESTs, Moderately similar to RL13 MOUSE 6S

RIBOSOMAL PROTEIN L13 [M. musculus],

ribosomal protein L13

185
16938
NM_031103

ESTs, Weakly similar to 6S RIBOSOMAL
e

PROTEIN L19 [R. norvegicus], Homo sapiens

mRNA; cDNA DKFZp434D115 (from clone

DKFZp434D115), ribosomal protein L19

186
22205
NM_031105

ESTs, Highly similar to RL44_HUMAN 6S
h

RIBOSOMAL PROTEIN L44 [H. sapiens],

RIKEN cDNA 24138A3 gene, ribosomal protein

L36a, ribosomal protein L44

187
16847
NM_031109

DNA segment, Chr 4, ERATO Doi 429,
g, General

expressed, ESTs, Highly similar to S55918

ribosomal protein S1, cytosolic [H. sapiens],

Homo sapiens
cDNA: FLJ217 fis, clone

COL9849, highly similar to HSU14972 Human

ribosomal protein S1 mRNA, RIKEN cDNA

22142A9 gene, ribosomal protein S1

188
10878
NM_031110

EST, Weakly similar to 4S RIBOSOMAL
e, General

PROTEIN S11 [R. norvegicus], Homo sapiens

mRNA; cDNA DKFZp434A326 (from clone

DKFZp434A326), Human DNA sequence from

clone RP5-16K6 on chromosome 2p12.1-13.

Contains an RPS11 (4S ribosomal protein S11)

pseudogene, ESTs, STSs and GSSs, RAD21

homolog (S. pombe), ribosomal protein S11

189
20839
NM_031113

EST, Moderately similar to S12583
General

polyubiquitin 4 - mouse [M. musculus], EST,

Moderately similar to ubiquitin/ribosomal

protein S27a [R. norvegicus], EST, Weakly

similar to R27A_HUMAN 4S RIBOSOMAL

PROTEIN S27A {SUB 77-156 [H. sapiens],

Homo sapiens
cDNA FLJ1163 fis, clone

HEMBA13926, RIKEN cDNA 616J14 gene,

expressed sequence AI132487, ribosomal

protein S27a, ubiquitin C

190
22749
NM_031116

small inducible cytokine A5, small inducible
b

cytokine A5 (RANTES), small inducible

cytokine subfamily A (Cys-Cys), member 17,

small inducible cytokine subfamily A (Cys-Cys),

member 26

191
1580
NM_031117

EST, Weakly similar to A3327 snRNP protein N
h

[H. sapiens], Homo sapiens RT-LI mRNA,

complete sequence, RIKEN cDNA 24145I1

gene, SNRPN upstream reading frame, WW

domain binding protein 11, ribosomal protein

S1, small nuclear ribonucleoprotein B, small

nuclear ribonucleoprotein N, small nuclear

ribonucleoprotein polypeptide N, small nuclear

ribonucleoprotein polypeptides B and B1

192
13929
NM_031131

Transforming growth factor, beta 3,
General

transforming growth factor, beta 2, transforming

growth factor, beta 3

193
15185
NM_031140

EST, Moderately similar to A2574 vimentin
c, General

[H. sapiens], EST, Weakly similar to A2574

vimentin [H. sapiens], ESTs, Moderately similar

to VIME RAT VIMENTIN [R. norvegicus], ESTs,

Weakly similar to A2574 vimentin [H. sapiens],

ESTs, Weakly similar to VIME RAT VIMENTIN

[R. norvegicus], vimentin

194
1638
NM_031143

EST, Weakly similar to JC6124 diacylglycerol
General

kinase (EC 2.7.1.17) IV - rat [R. norvegicus],

ESTs, Highly similar to KDGZ_HUMAN

DIACYLGLYCEROL KINASE, ZETA

(DIGLYCERIDE KINASE) (DGK-ZETA) (DAG

KINASE ZETA) [H. sapiens], ESTs, Weakly

similar to JC6124 diacylglycerol kinase (EC

2.7.1.17) IV - rat [R. norvegicus], ESTs, Weakly

similar to KDGA MOUSE DIACYLGLYCEROL

KINASE, ALPHA [M. musculus], diacylglycerol

kinase, alpha (8 kDa), diacylglycerol kinase,

iota, diacylglycerol kinase, zeta (14 kD)

195
21624
NM_031144

EST, Weakly similar to ACTB_HUMAN ACTIN,
g

CYTOPLASMIC 1 [R. norvegicus], ESTs, Highly

similar to ATHUB actin beta [H. sapiens], ESTs,

Weakly similar to ACTB_HUMAN ACTIN,

CYTOPLASMIC 1 [R. norvegicus], Homo

sapiens
FKSG3 (FKSG3) mRNA, complete

cds, RIKEN cDNA 1752K15 gene, RIKEN

cDNA 1761J2 gene, actin, beta, actin-like 7a,

actin-related protein 3-beta, melanoma X-actin

196
15277
NM_031237

EST, Moderately similar to UB5B_HUMAN
g, i,

UBIQUITIN-CONJUGATING ENZYME E2-17
General

KD 2 [R.norvegicus], ESTs, Moderately similar

to I59365 ubiquitin conjugating enzyme

[H. sapiens], ESTs, Moderately similar to

UB5B_HUMAN UBIQUITIN-CONJUGATING

ENZYME E2-17 KD 2 [M. musculus], RIKEN

cDNA 111F19 gene, RIKEN cDNA 1628I17

gene, RIKEN cDNA 2784L22 gene, Rattus

norvegicus
clone ubc2e ubiquitin conjugating

enzyme (E217 kB) mRNA, complete cds,

expressed sequence AL22654, ubiquitin-

conjugating enzyme E2D 1 (homologous to

yeast UBC4/5), ubiquitin-conjugating enzyme

E2D 2, ubiquitin-conjugating enzyme E2D 2

(homologous to yeast UBC4/5), ubiquitin-

conjugating enzyme E2D 3 (homologous to

yeast UBC4/5)

197
18597
NM_031325

UDP-glucose dehydrogenase
General

198
11258
NM_031327

ESTs, Moderately similar to CYR6 MOUSE
General

CYR61 PROTEIN PRECURSOR [M. musculus],

cysteine rich protein 61, cysteine-rich,

angiogenic inducer, 61

199
18654
NM_031358

expressed sequence AI842722, potassium
i, General

inwardly rectifying channel, subfamily J,

member 11, potassium inwardly-rectifying

channel, subfamily J, member 11

200
12581
NM_031514
Janus kinase 2, Janus
ESTs, Weakly similar to JAK2 RAT TYROSINE-
i, General

kinase 2 (a protein
PROTEIN KINASE JAK2 [R. norvegicus], Janus

tyrosine kinase)
kinase 2, Janus kinase 2 (a protein tyrosine

kinase), expressed sequence C81284

201
20449
NM_031530
small inducible cytokine
EST, Weakly similar to SY2 RAT SMALL
g, General

A2, small inducible
INDUCIBLE CYTOKINE A2 PRECURSOR

cytokine A2 (monocyte
[R. norvegicus], expressed sequence AI323594,

chemotactic protein 1,
expressed sequence AW987545, small

homologous to mouse Sig
inducible cytokine A2, small inducible cytokine

je)
A24, small inducible cytokine A7 (monocyte

chemotactic protein 3), small inducible cytokine

subfamily A (Cys-Cys), member 17

201
20448
NM_031530
small inducible cytokine
EST, Weakly similar to SY2 RAT SMALL
g

A2, small inducible
INDUCIBLE CYTOKINE A2 PRECURSOR

cytokine A2 (monocyte
[R. norvegicus], expressed sequence AI323594,

chemotactic protein 1,
expressed sequence AW987545, small

homologous to mouse Sig
inducible cytokine A2, small inducible cytokine

je)
A24, small inducible cytokine A7 (monocyte

chemotactic protein 3), small inducible cytokine

subfamily A (Cys-Cys), member 17

202
445
NM_031535
BCL2-like 1, Bcl2-like
BCL2-like 1, BCL2-like 2, Bcl-2-related ovarian
b

killer protein, Bcl-2-related ovarian killer protein-

like, Bcl-w protein, Bcl2-like, Bcl2-like 2

203
4011
NM_031543
cytochrome P45, 2e1,
cytochrome P45, 2e1, ethanol inducible,
a

ethanol inducible,
cytochrome P45, subfamily IIE (ethanol-

cytochrome P45,
inducible)

subfamily IIE (ethanol-

inducible)

204
18389
NM_031545
natriuretic peptide
expressed sequence AA48272, natriuretic
i, General

precursor B, natriuretic
peptide precursor B, natriuretic peptide

peptide precursor type B
precursor type B

205
692
NM_031557
prostaglandin I2
EST, Highly similar to PTGI_RAT
h

(prostacyclin) synthase
PROSTACYCLIN SYNTHASE

(PROSTAGLANDIN 12 SYNTHASE)

[R. norvegicus], cytochrome P45, 8b1, sterol 12

alpha-hydrolase, cytochrome P45, subfamily

VIIIB (sterol 12-alpha-hydroxylase), polypeptide

1, prostaglandin I2 (prostacyclin) synthase

206
18318
NM_031561
CD36 antigen, CD36
CD36 antigen, CD36 antigen (collagen type I
h

antigen (collagen type I
receptor, thrombospondin receptor)

receptor, thrombospondin

receptor)

207
24219
NM_031579
protein tyrosine
protein tyrosine phosphatase 4a1, protein
General

phosphatase 4a1, protein
tyrosine phosphatase 4a2, protein tyrosine

tyrosine phosphatase
phosphatase type IVA, member 1, protein

type IVA, member 1
tyrosine phosphatase type IVA, member 2,

protein tyrosine phosphatase type IVA, member 3

208
24235
NM_031614
thioredoxin reductase 1

Mus musculus
adult male small intestine cDNA,
General

RIKEN full-length enriched library, clone: 211F3,

full insert sequence, glutathione reductase 1,

thioredoxin reductase 1, thioredoxin reductase

2, thioredoxin reductase beta

209
567
NM_031628
nuclear receptor
ESTs, Moderately similar to NR42 MOUSE
General

subfamily 4, group A,
ORPHAN NUCLEAR RECEPTOR NURR1

member 3
[M. musculus], nuclear receptor subfamily 4,

group A, member 2, nuclear receptor subfamily

4, group A, member 3

210
211
NM_031664
solute carrier family 28
solute carrier family 28 (sodium-coupled
c

(sodium-coupled
nucleoside transporter), member 2, solute

nucleoside transporter),
carrier family 28 (sodium-coupled nucleoside

member 2
transporter), member 3

211
18403
NM_031677
four and a half LIM
EST, Weakly similar to SLI3 RAT SKELETAL
g

domains 2
MUSCLE LIM-PROTEIN 3 [R. norvegicus],

RIKEN cDNA 23126N9 gene, activator of

CREM in testis, four and a half LIM domains 2,

four and a half LIM domains 3, vascular Rab-

GAP/TBC-containing

212
20743
NM_031684
solute carrier family 29
ESTs, Weakly similar to ENT1_RAT
f, g,

(nucleoside transporters),
EQUILIBRATIVE NUCLEOSIDE
General

member 1
TRANSPORTER 1 (EQUILIBRATIVE

NITROBENZYLMERCAPTOPURINE

RIBOSIDE-SENSITIVE NUCLEOSIDE

TRANSPORTER) (EQUILIBRATIVE NBMPR-

SENSITIVE NUCLEOSIDE TRANSPORTER)

(NUCLEOSIDE TRANSPORTER, ES-TYPE)

[R. norvegicus], RIKEN cDNA 4933435C21

gene, hypothetical protein FLJ1116, solute

carrier family 29 (nucleoside transporters),

member 1, solute carrier family 29 (nucleoside

transporters), member 2

213
21575
NM_031698
ribophorin II
EST, Moderately similar to RIB2_HUMAN
b

DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE -

PROTEIN GLYCOSYLTRANSFERASE 63

KDA SUBUNIT PRECURSOR [H. sapiens],

ESTs, Moderately similar to DOLICHYL-

DIPHOSPHOOLIGOSACCHARIDE - PROTEIN

GLYCOSYLTRANSFERASE 63 KD SUBUNIT

PRECURSOR [R. norvegicus], ESTs,

Moderately similar to RIB2_HUMAN

DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE -

PROTEIN GLYCOSYLTRANSFERASE 63

KDA SUBUNIT PRECURSOR [H. sapiens],

ribophorin 2, related sequence 1, ribophorin II

214
16918
NM_031709

ESTs, Highly similar to R3HU12 ribosomal
e, General

protein S12, cytosolic [H. sapiens],

mitochondrial ribosomal protein L5, ribosomal

protein S12

215
19050
NM_031719

ESTs, Highly similar to ICLN_HUMAN
General

CHLORIDE CONDUCTANCE REGULATORY

PROTEIN ICLN [H. sapiens], RIKEN cDNA

26136D6 gene, RIKEN cDNA 2611O4 gene,

chloride channel, nucleotide-sensitive, 1A

215
19048
NM_031719

ESTs, Highly similar to ICLN_HUMAN
f

CHLORIDE CONDUCTANCE REGULATORY

PROTEIN ICLN [H. sapiens], RIKEN cDNA

26136D6 gene, RIKEN cDNA 2611O4 gene,

chloride channel, nucleotide-sensitive, 1A

216
3549
NM_031723

RIKEN cDNA 18129G24 gene, Rattus
h

norvegicus
mRNA for signal peptidase 21 kDa

subunit, complete cds, signal peptidase

complex (18 kD), similar to signal peptidase

complex (18 kD)

217
14184
NM_031776

guanine deaminase
General

217
14185
NM_031776

guanine deaminase
General

218
1169
NM_031789

ESTs, Highly similar to NFL2 RAT NUCLEAR
a

FACTOR ERYTHROID 2 RELATED FACTOR

2 [R. norvegicus], ESTs, Weakly similar to NFL2

RAT NUCLEAR FACTOR ERYTHROID 2

RELATED FACTOR 2 [R. norvegicus], nuclear

factor (erythroid-derived 2)-like 2, nuclear,

factor, erythroid derived 2, like 2

219
17195
NM_031814
G protein-coupled
EST, Weakly similar to T42627 ADP-
g

receptor kinase-interactor 1
ribosylation factor-directed GTPase activating

protein, isoform a - mouse [M. musculus], ESTs,

Highly similar to T42627 ADP-ribosylation

factor-directed GTPase activating protein,

isoform a - mouse [M. musculus], G protein-

coupled receptor kinase-interactor 1, G protein-

coupled receptor kinase-interactor 2, Homo

sapiens
p95 paxillin-kinase linker mRNA,

complete cds, RIKEN cDNA 173C1 gene,

development and differentiation enhancing

220
17535
NM_031816

ESTs, Weakly similar to GBLP_HUMAN
h

GUANINE NUCLEOTIDE-BINDING PROTEIN

BETA SUBUNIT-LIKE PROTEIN 12.3

[R. norvegicus], Homo sapiens cDNA:

FLJ21913 fis, clone HEP3888, Homo sapiens,

clone IMAGE: 35217, mRNA, partial cds, RAE1

(RNA export 1, S.pombe) homolog, WD repeat

domain 1, expressed sequence AI173248,

expressed sequence AI54353, guanine

nucleotide binding protein (G protein), beta

polypeptide 2-like 1, guanine nucleotide binding

protein, beta 2, related sequence 1,

retinoblastoma binding protein 7,

retinoblastoma-binding protein 7, transducin

(beta)-like 2

221
15840
NM_031817
osteomodulin
fibromodulin, fibronectin leucine rich
g, General

transmembrane protein 3, keratocan,

osteomodulin, proline arginine-rich end leucine-

rich repeat protein

222
2655
NM_031821
serum-inducible kinase
ESTs, Highly similar to A57286 probable
i

serine/threonine protein kinase [M. musculus],

ESTs, Highly similar to SNK_RAT

SERINE/THREONINE-PROTEIN KINASE SNK

(SERUM INDUCIBLE KINASE) [R. norvegicus],

ESTs, Weakly similar to SNK_RAT

SERINE/THREONINE-PROTEIN KINASE SNK

(SERUM INDUCIBLE KINASE) [R. norvegicus],

cytokine-inducible kinase, serine/threonine

kinase 18, serum-inducible kinase, tousled-like

kinase 2 (Arabidopsis)

223
3251
NM_031825

ESTs, Highly similar to 171348A fibrillin
b

[H. sapiens], ESTs, Weakly similar to TGFB

RAT LATENT TRANSFORMING GROWTH

FACTOR BETA BINDING PROTEIN 1

PRECURSOR [R. norvegicus], RIKEN cDNA

1315B4 gene, RIKEN cDNA 23146A13 gene,

fibrillin 1, fibrillin 1 (Marfan syndrome), latent

transforming growth factor beta binding protein

1, transforming growth factor-beta (TGF-beta)

masking protein large subunit

223
3252
NM_031825

ESTs, Highly similar to 171348A fibrillin
c

[H. sapiens], ESTs, Weakly similar to TGFB

RAT LATENT TRANSFORMING GROWTH

FACTOR BETA BINDING PROTEIN 1

PRECURSOR [R. norvegicus], RIKEN cDNA

1315B4 gene, RIKEN cDNA 23146A13 gene,

fibrillin 1, fibrillin 1 (Marfan syndrome), latent

transforming growth factor beta binding protein

1, transforming growth factor-beta (TGF-beta)

masking protein large subunit

224
22321
NM_031832
lectin, galactose binding,
EST, Weakly similar to X-Ray Crystal Structure
g, General

soluble 3, lectin,
Of The Human Galectin-3 Carbohydrate

galactoside-binding,
Recognition Domain [H. sapiens], galectin-

soluble, 3 (galectin 3)
related inter-fiber protein

225
4749
NM_031834

expressed sequence AI26689, expressed
c, d

sequence AI853643, sulfotransferase family

1A, phenol-preferring, member 1,

sulfotransferase family 4A, member 1,

sulfotransferase family, cytosolic, 1A, phenol-

preferring, member 1, sulfotransferase family,

cytosolic, 1A, phenol-preferring, member 2,

sulfotransferase family, cytosolic, 1A, phenol-

preferring, member 3

226
15603
NM_031851
prohibitin
B-cell receptor associated protein 37 (BAP-37)
i

mRNA, partial cds and 3′ untranslated

sequence, B-cell receptor-associated protein

37, EST, Moderately similar to PROHIBITIN

[R. norvegicus], EST, Weakly similar to PHB

MOUSE PROHIBITIN [M. musculus], ESTs,

Moderately similar to PHB MOUSE

PROHIBITIN [M. musculus], ESTs, Weakly

similar to PHB_HUMAN PROHIBITI

[H. sapiens], Homo sapiens, clone MGC: 2874

IMAGE: 4547239, mRNA, complete cds,

hypothetical protein MGC1371, prohibitin

227
22300
NM_031967

N-myc downstream regulated, N-myc
c

downstream regulated 1, N-myc downstream

regulated 2, N-myc downstream regulated-like,

N-myc downstream-regulated gene 2, NDRG

family, member 4, expressed sequence

R74996

228
17735
NM_031970

EST, Weakly similar to HHHU27 heat shock
g, i,

protein 27 [H. sapiens], ESTs, Moderately
General

similar to HHHU27 heat shock protein 27

[H. sapiens], crystallin, alpha C, heat shock

27 kD protein 1, heat shock 27 kD protein 3

228
17734
NM_031970

EST, Weakly similar to HHHU27 heat shock
g, i,

protein 27 [H. sapiens], ESTs, Moderately
General

similar to HHHU27 heat shock protein 27

[H. sapiens], crystallin, alpha C, heat shock

27 kD protein 1, heat shock 27 kD protein 3

228
17736
NM_031970

EST, Weakly similar to HHHU27 heat shock
f, g, i,

protein 27 [H. sapiens], ESTs, Moderately
General

similar to HHHU27 heat shock protein 27

[H. sapiens], crystallin, alpha C, heat shock

27 kD protein 1, heat shock 27 kD protein 3

229
18500
NM_031984
calbindin 1, (28 kD),
ESTs, Moderately similar to CALBINDIN
c

calbindin-28 K
[M. musculus], calbindin 1, (28 kD), calbindin-

28 K

230
18899
NM_031985

EST, Highly similar to TVRTK6 ribosomal
a

protein S6 kinase [R. norvegicus], ESTs, Highly

similar to K6B1_HUMAN RIBOSOMAL

PROTEIN S6 KINASE [H. sapiens], ESTs,

Moderately similar to K6B2_MOUSE

RIBOSOMAL PROTEIN S6 KINASE BETA 2

(S6K-BETA 2) (7 KDA RIBOSOMAL PROTEIN

S6 KINASE 2) (P7-S6KB) (P7 RIBOSOMAL S6

KINASE BETA) (P7 S6KBETA) (S6K2)

[M. musculus], RIKEN cDNA 261318I15 gene,

expressed sequence AW319595, hypothetical

protein FLJ14813, ribosomal protein S6 kinase,

7 kD, polypeptide 1, ribosomal protein S6

kinase, 7 kD, polypeptide 2

231
19768
NM_031986

ESTs, Highly similar to APB1 RAT AMYLOID
i

BETA A4 PRECURSOR PROTEIN-BINDING

FAMILY A MEMBER 1 [R. norvegicus], Mus

musculus
, Similar to hypothetical protein, clone

MGC: 1174 IMAGE: 3964815, mRNA, complete

cds, RIKEN cDNA 2318D1 gene, amyloid beta

(A4) precursor protein-binding, family A,

APBA1: amyloid beta (A4) precursor protein-

binding, family A, member 1 (X11), amyloid

beta (A4) precursor protein-binding, family A,

member 1 (X11), amyloid beta (A4) precursor

protein-binding, family A, member 3, syndecan

binding protein, syndecan binding protein

(syntenin), syntenin-2 protein

232
17829
NM_033234
hemoglobin beta chain

a, c

complex, hemoglobin,

beta

232
25468
NM_033234

a, b

232
25469
NM_033234

a, b

General

232
17832
NM_033234
hemoglobin beta chain

a, b

complex, hemoglobin,

General

beta

233
12364
NM_033351
Fc fragment of IgG,
EST, Weakly similar to A Chain A, Crystal
General

receptor, transporter,
Structure Of The Human Mhc-Related Fc

alpha, Fc receptor, IgG,
Receptor {SUB 24-29 [H. sapiens] , Fc fragment

alpha chain transporter
of IgG, receptor, transporter, alpha, Fc

receptor, IgG, alpha chain transporter

234
11714
NM_033352

General

235
15867
NM_053289
pancreatitis-associated
ESTs, Highly similar to PAP1_HUMAN
General

protein, poly(A)
PANCREATITIS-ASSOCIATED PROTEIN 1

polymerase alpha
PRECURSOR [H. sapiens], islet neogenesis

associated protein-related protein, pancreatitis-

associated protein

236
4093
NM_053290
phosphoglycerate mutase

General

1, phosphoglycerate

mutase 1 (brain)

237
16886
NM_053291

EST, Highly similar to PGK2 RAT
c

PHOSPHOGLYCERATE KINASE, TESTIS

SPECIFIC [R. norvegicus], Phosphoglycerate

kinase {alternatively spliced} [human,

phosphoglycerate kinase deficient patient with

episodes of muscl, mRNA Partial Mutant, 37

nt], phosphoglycerate kinase 1,

phosphoglycerate kinase 2

238
14928
NM_053330
ribosomal protein L21
EST, Moderately similar to 21132B ribosomal
e, h

protein L21 [H. sapiens], EST, Moderately

similar to RL21 MOUSE 6S RIBOSOMAL

PROTEIN L21 [M. musculus], EST, Weakly

similar to 21132B ribosomal protein L21

[H. sapiens], EST, Weakly similar to RL21

MOUSE 6S RIBOSOMAL PROTEIN L21

[M. musculus], EST, Weakly similar to

RL21_HUMAN 6S RIBOSOMAL PROTEIN L21

[H. sapiens], ESTs, Moderately similar to RL21

RAT 6S RIBOSOMAL PROTEIN L21

[R. norvegicus], RIKEN cDNA 2785M18 gene,

ribosomal protein L21

239
1609
NM_053338
Ras-related associated
ESTs, Weakly similar to RAD RAT GTP-
c, General

BINDING PROTEIN RAD [R. norvegicus], GTP

binding protein (gene overexpressed in skeletal

muscle), Ras-related associated with diabetes

240
9353
NM_053347
LIS1-interacting protein

Homo sapiens
cDNA FLJ1349 fis, clone
General

NUDE1, rat homolog,
NT2RP31428, highly similar to

nuclear distribution gene
NUCLEOPROTEIN TPR, Leman coiled-coil

E homolog (Aspergillus)
protein, RIKEN cDNA 4932416D9 gene, Rho-

associated coiled-coil forming kinase 2, nuclear

distribution gene E homolog (Aspergillus),

translocated promoter region (to activated MET

oncogene)

241
6155
NM_053356
collagen, type I, alpha 2,
ESTs, Weakly similar to CGHU2S collagen
e

procollagen, type I, alpha 2
alpha 2(l) chain precursor [H. sapiens], KIAA126

protein, RIKEN cDNA 1113G5 gene, RIKEN

cDNA 9349G11 gene, collagen, type I, alpha 1,

collagen, type I, alpha 2, collagen, type II, alpha

1 (primary osteoarthritis, spondyloepiphyseal

dysplasia, congenital), hypothetical protein

FLJ2654, nischarin, procollagen, type I, alpha

1, procollagen, type I, alpha 2, procollagen,

type II, alpha 1

241
6156
NM_053356
collagen, type I, alpha 2,
ESTs, Weakly similar to CGHU2S collagen
e

procollagen, type I, alpha 2
alpha 2(I) chain precursor [H. sapiens], KIAA126

protein, RIKEN cDNA 1113G5 gene, RIKEN

cDNA 9349G11 gene, collagen, type I, alpha 1,

collagen, type I, alpha 2, collagen, type II, alpha

1 (primary osteoarthritis, spondyloepiphyseal

dysplasia, congenital), hypothetical protein

FLJ2654, nischarin, procollagen, type I, alpha

1, procollagen, type I, alpha 2, procollagen,

type II, alpha 1

242
16017
NM_053401

X-linked protein, brain expressed, X-linked 1,
i

hypothetical protein FLJ197, nerve growth

factor receptor (TNFRSF16) associated protein 1

243
2242
NM_053433

ESTs, Highly similar to FMO3_HUMAN
d, General

DIMETHYLANILINE MONOOXYGENASE

[H. sapiens], Flavin-containing monooxygenase

1, Homo sapiens DNA sequence from PAC

127D3 on chromosome 1q23-25. Contains

FMO2 and FMO3 genes for Flavin-containing

Monooxygenase 2 and Flavin-containing

Monooxygenase 3 (Dimethylaniline

Monooxygenase (N-Oxide 3, EC1.14.13.8,

Dimethylaniline Oxidase 3, FMO II, FMO 3),

and a gene for another, unknown, Flavin-

containing Monooxygenase family protein.

Contains ESTs and GSSs, flavin containing

monooxygenase 1, flavin containing

monooxygenase 2, flavin containing

monooxygenase 3, hypothetical protein

PRO1257

244
8085
NM_053453

ESTs, Moderately similar to RGS8 RAT
General

REGULATOR OF G-PROTEIN SIGNALING 8

[R. norvegicus], regulator of G-protein signaling

18, regulator of G-protein signaling 2, regulator

of G-protein signaling 8, regulator of G-protein

signalling 13, regulator of G-protein signalling 2,

24 kD, regulator of G-protein signalling 8

245
11403
NM_053464

Human DNA sequence from clone RP5-157D4
General

on chromosome 2 Contains a spermidine

synthase (SPDSY) pseudogene, a CpG island,

ESTs, STSs and GSSs, spermidine synthase

246
23276
NM_053467

ESTs, Weakly similar to G1159 protein
General

trafficking protein tmp21-l [H. sapiens], ESTs,

Weakly similar to P24_MOUSE COP-COATED

VESICLE MEMBRANE PROTEIN P24

PRECURSOR (P24A) [M. musculus], RIKEN

cDNA 1812N21 gene, RIKEN cDNA 243B6

gene, RIKEN cDNA 39341E15 gene, coated

vesicle membrane protein, gp25L2 protein,

transmembrane trafficking protein

247
15556
NM_053483

ESTs, Weakly similar to A Chain A, Importin
General

Alpha, Mouse [M. musculus], expressed

sequence AW146299, karyopherin (importin)

alpha 2, karyopherin alpha 2 (RAG cohort 1,

importin alpha 1)

248
16394
NM_053485

EST, Moderately similar to CALCYCLIN
General

[R. norvegicus], S1 calcium-binding protein A6

(calcyclin), calcium binding protein A6

(calcyclin)

249
1886
NM_053523

EST, Moderately similar to Y25_HUMAN
c

HYPOTHETICAL PROTEIN KIAA25

[H. sapiens], RIKEN cDNA 5314M7 gene,

homocysteine-inducible, endoplasmic reticulum

stress-inducible, ubiquitin-like domain member

1, hypothetical protein FLJ22313

250
14380
NM_053536
Kruppel-like factor 15
Kruppel-like factor 15, Kruppel-like factor 5,
General

Kruppel-like factor 9, TGFB inducible early

growth response, basic transcription element

binding protein 1

251
15708
NM_053565

General

252
3050
NM_053582

ESTs, Highly similar to JC7189 tubulointerstitial
d, General

nephritis antigen [H. sapiens], P3ECSL,

cathepsin B, lipocalin 7, tubulointerstitial

nephritis antigen

252
3049
NM_053582

ESTs, Highly similar to JC7189 tubulointerstitial
d, General

nephritis antigen [H. sapiens], P3ECSL,

cathepsin B, lipocalin 7, tubulointerstitial

nephritis antigen

253
21709
NM_053596

KIAA64 gene product, endothelin converting
General

enzyme 1, endothelin converting enzyme-like 1,

expressed sequence AW3225, expressed

sequence BB127715, mel transforming

oncogene-like 1, membrane metallo

endopeptidase

254
2103
NM_053597

4S ribosomal protein S27 isoform, EST, Weakly
e, h

similar to RS27_HUMAN 4S RIBOSOMAL

PROTEIN S27 [H. sapiens], ESTs, Moderately

similar to RS27_HUMAN 4S RIBOSOMAL

PROTEIN S27 [H. sapiens], RIKEN cDNA

18134D23 gene, RIKEN cDNA 321M24 gene,

ribosomal protein S27 (metallopanstimulin 1)

255
7580
NM_053603

EST X83352, ESTs, Highly similar to T17226
General

hypothetical protein DKFZp566G223.1

[H. sapiens], ESTs, Weakly similar to S7484

RS43 protein - rat (fragment) [R. norvegicus],

Homo sapiens
, Similar to chloride intracellular

channel 4, clone MGC: 8812 IMAGE: 3861372,

mRNA, complete cds, RIKEN cDNA

573531E12 gene, chloride intracellular channel

1, chloride intracellular channel 2, chloride

intracellular channel 4, chloride intracellular

channel 4 (mitochondrial), intracellular chloride

ion channel protein p64H1

256
20243
NM_053615
casein kinase 1, alpha 1

h

257
13005
NM_053623
fatty acid-Coenzyme A

General

ligase, long chain 4, fatty-

acid-Coenzyme A ligase,

long-chain 4

258
18644
NM_053648
beta-carotene 15, 15′-
EST, Moderately similar to 86162D protein COII
c

dioxygenase, beta-
[M. musculus], EST, Weakly similar to 8124D

carotene 15, 15′-
cytochrome oxidase II [H. sapiens]

dioxygenase

259
6684
NM_053703

Mus musculus
12 days embryo head cDNA,
General

RIKEN full-length enriched library, clone: 32B1,

full insert sequence, mitogen activated protein

kinase kinase 5, mitogen activated protein

kinase kinase 6, mitogen-activated protein

kinase kinase 3, mitogen-activated protein

kinase kinase 4, mitogen-activated protein

kinase kinase 6

260
25379
NM_053713

d, General

260
22411
NM_053713

ESTs, Moderately similar to CPBP RAT CORE
d

PROMOTER ELEMENT-BINDING PROTEIN

[R. norvegicus], Kruppel-like factor 4 (gut),

RIKEN cDNA 7427M5 gene, core promoter

element binding protein

261
1218
NM_053748

expressed sequence C86324, hypothetical
e, General

protein FLJ2359

262
9059
NM_053783

interferon gamma receptor, interferon gamma
g, General

receptor 1

263
15103
NM_053814

EST, Moderately similar to MYSO_HUMAN
h

MYOSIN HEAVY CHAIN, NONMUSCLE TYPE

B [H. sapiens], EST, Weakly similar to T3868

RhoA-binding protein p116Rip - mouse

[M. musculus], ESTs, Weakly similar to JC5421

smooth muscle myosin heavy chain 2 - mouse

[M. musculus], Homo sapiens cDNA: FLJ23324

fis, clone HEP12482, highly similar to

HUMMYOHCB Human nonmuscle myosin

heavy chain-B (MYH1) mRNA, LIS1-interacting

protein NUDE1, rat homolog, PiUS protein,

RIKEN cDNA 177J1 gene, Rho interacting

protein 3, cingulin, expressed sequence

AI428493, expressed sequence AI647528,

hypothetical protein FLJ13881

264
15002
NM_053819

EST, Moderately similar to TIM1 RAT
f, g,

METALLOPROTEINASE INHIBITOR 1
General

PRECURSOR [R. norvegicus], EST, Weakly

similar to TIM1 RAT METALLOPROTEINASE

INHIBITOR 1 PRECURSOR [R. norvegicus],

tissue inhibitor of metalloproteinase, tissue

inhibitor of metalloproteinase 1 (erythroid

potentiating activity, collagenase inhibitor)

264
15003
NM_053819

EST, Moderately similar to TIM1 RAT
f, g,

METALLOPROTEINASE INHIBITOR 1
General

PRECURSOR [R. norvegicus], EST, Weakly

similar to TIM1 RAT METALLOPROTEINASE

INHIBITOR 1 PRECURSOR [R. norvegicus],

tissue inhibitor of metalloproteinase, tissue

inhibitor of metalloproteinase 1 (erythroid

potentiating activity, collagenase inhibitor)

265
17155
NM_053835

e

266
20868
NM_053843

General

266
20869
NM_053843

General

267
1571
NM_053857

EST, Moderately similar to 221415A initiation
d, General

factor 4E-binding protein: ISOTYPE, ESTs,

Weakly similar to A55258 insulin-stimulated

phosphoprotein PHAS-l - rat [R. norvegicus],

RIKEN cDNA 1114O12 gene, eukaryotic

translation initiation factor 4E binding protein 1,

eukaryotic translation initiation factor 4E

binding protein 2, eukaryotic translation

initiation factor 4E binding protein 3

268
18358
NM_053864

EST, Highly similar to TERA HUMAN
h

[H. sapiens], EST, Weakly similar to T46437

hypothetical protein DKFZp434K126.1

[H. sapiens], ESTs, Weakly similar to T46437

hypothetical protein DKFZp434K126.1

[H. sapiens], ESTs, Weakly similar to TERA

HUMAN [H. sapiens], ESTs, Weakly similar to

TERA RAT TRANSITIONAL ENDOPLASMIC

RETICULUM ATPASE [R. norvegicus], RIKEN

cDNA 4833413G1 gene, RIKEN cDNA

543414H2 gene, spermatogenesis associated

factor, valosin containing protein, valosin-

containing protein

269
17728
NM_053867

EST, Moderately similar to S659 IgE-dependent
a, b

histamine-releasing factor [H. sapiens], Homo

sapiens
mRNA full length insert cDNA clone

EUROIMAGE 926491, hypothetical protein

FLJ23, translationally regulated transcript (21 kDa),

tumor protein, translationally-controlled 1

270
19781
NM_053883

ESTs, Moderately similar to DUS6 RAT DUAL
General

SPECIFICITY PROTEIN PHOSPHATASE 6

[R. norvegicus], ESTs, Weakly similar to DUS6

RAT DUAL SPECIFICITY PROTEIN

PHOSPHATASE 6 [R. norvegicus], dual

specificity phosphatase 1, dual specificity

phosphatase 13, dual specificity phosphatase

14, dual specificity phosphatase 6, dual

specificity phosphatase 9, expressed sequence

BB14621, mitogen-activated protein kinase

phosphatase x, protein tyrosine phosphatase,

non-receptor type 16

271
385
NM_053885

i, General

272
1288
NM_053949

EST, Weakly similar to I38465 probable
General

potassium channel subunit [H. sapiens],

potassium voltage-gated channel, subfamily H

(eag-related), member 5

273
19774
NM_053961

a

274
16546
NM_053965

ESTs, Weakly similar to MCAT RAT
General

MITOCHONDRIAL

CARNITINE/ACYLCARNITINE CARRIER

PROTEIN [R. norvegicus], ESTs, Weakly similar

to MCAT_HUMAN MITOCHONDRIAL

CARNITINE/ACYLCARNITINE CARRIER

PROTEIN [H. sapiens], expressed sequence

W51672, solute carrier family 25

(carnitine/acylcarnitine translocase), member 2,

solute carrier family 25 (mitochondrial

carnitine/acylcarnitine translocase), member 2

275
19544
NM_053982

EST, Highly similar to 4S RIBOSOMAL
General

PROTEIN S15A [R. norvegicus], ESTs,

Moderately similar to S2251 ribosomal protein

S15a.e [H. sapiens], ribosomal protein S15a

276
15642
NM_053985

ESTs, Highly similar to HISTONE H3.3
General

[R. norvegicus], H3 histone, family 3A, H3

histone, family 3B, H3 histone, family 3B

(H3.3B)

277
17739
NM_053995

e

278
17329
NM_054008

RGC32 protein, RIKEN cDNA 1192H23 gene
General

279
19658
NM_057103
A kinase (PRKA) anchor

General

protein (gravin) 12

280
968
NM_057133

h

281
2413
NM_057141

ESTs, Weakly similar to ROK_HUMAN
e, h

HETEROGENEOUS NUCLEAR

RIBONUCLEOPROTEIN K [R. norvegicus],

heterogeneous nuclear ribonucleoprotein K,

poly(rC)-binding protein 4

281
2416
NM_057141

ESTs, Weakly similar to ROK_HUMAN
d

HETEROGENEOUS NUCLEAR

RIBONUCLEOPROTEIN K [R. norvegicus],

heterogeneous nuclear ribonucleoprotein K,

poly(rC)-binding protein 4

282
1892
NM_057144

cysteine and glycine-rich protein 3 (cardiac LIM
g, i,

protein), cysteine rich protein, cysteine-rich
General

protein 2, cysteine-rich protein 3, thymus LIM

protein

283
17477
NM_057194

EST, Weakly similar to B36298 proline-rich
g, General

protein PRB3S [H. sapiens], EST, Weakly

similar to CGHU3B collagen alpha 3(IV) chain

precursor, long splice form [H. sapiens], EST,

Weakly similar to D475 proline-rich protein

PRB1/2S [H. sapiens], EST, Weakly similar to

JE284 Mm-1 cell derived transplantability-

associated protein 1b [H. sapiens], galectin-

related inter-fiber protein, murine leukemia viral

(bmi-1) oncogene homolog, phospholipid

scramblase 1, phospholipid scramblase 2,

phospholipid scramblase 3

284
14126
NM_057208

g

285
8641
NM_057211

BTE-binding protein 4, ESTs, Weakly similar to
c

ZN42_HUMAN ZINC FINGER PROTEIN 42

(MYELOID ZINC FINGER 1) (MZF-1)

[H. sapiens], Kruppel-like factor 13, Kruppel-like

factor 15 (kidney), Kruppel-like factor 9, TGFB

inducible early growth response, basic

transcription element binding protein 1,

expressed sequence AI843742

286
10498
NM_078617

EST, Moderately similar to RS23_HUMAN 4S
e, f

RIBOSOMAL PROTEIN S2 [R. norvegicus],

EST, Weakly similar to RS23_HUMAN 4S

RIBOSOMAL PROTEIN S2 [R. norvegicus],

ESTs, Weakly similar to RS23_HUMAN 4S

RIBOSOMAL PROTEIN S2 [R. norvegicus],

Mus musculus
, Similar to mitochondrial

ribosomal protein S12, clone MGC: 13892

IMAGE: 429358, mRNA, complete cds, RIKEN

cDNA 24144J15 gene, expressed sequence

AI327385, mitochondrial ribosomal protein S12,

ribosomal protein S23

287
20392
NM_080477

General

288
23033
NM_080888

BCL2/adenovirus E1B 19 kDa-interacting
b, General

protein 3-like, BCL2/adenovirus E1B 19 kD-

interacting protein 3-like

289
15843
NM_080910

ESTs, Moderately similar to PUR6_HUMAN
h

MULTIFUNCTIONAL PROTEIN ADE2

[H. sapiens], RIKEN cDNA 261511I9 gene,

multifunctional polypeptide similar to SAICAR

synthetase and AIR carboxylase

290
21391
NM_130416

ESTs, Highly similar to LUHU7 annexin VII,
General

long form [H. sapiens], ESTs, Moderately similar

to ANX4 MOUSE ANNEXIN IV [M. musculus],

ZAP 36/annexin IV, annexin A4, annexin A7

291
25094
X77117

c

292
11663
AA800803

General

293
25717
X61296

i

294
5292
AI171607

d, General

295
23998
AI230578

General

296
5186
AA925674

d, General

297
1754
AA817837

potassium channel, subfamily K, member 1
General

(TWIK-1), potassium channel, subfamily K,

member 3 (TASK-1), potassium channel,

subfamily K, member 6 (TWIK-2), potassium

channel, subfamily K, member 7

298
6438
AA819269

General

299
6059
AI178245

ESTs, Highly similar to T13963 formin related
b, General

protein, lymphocyte specific - mouse

[M. musculus], ESTs, Moderately similar to

T13963 formin related protein, lymphocyte

specific - mouse [M. musculus], Homo sapiens

mRNA; cDNA DKFZp762B245 (from clone

DKFZp762B245); partial cds, KIAA192 protein,

formin-like

300
18663
U95052

eukaryotic translation initiation factor 4 gamma, 3
h

301
7414
AI137586

EST, Weakly similar to IMB3_HUMAN
g, General

IMPORTIN BETA-3 SUBUNIT [H. sapiens],

Homo sapiens
cDNA FLJ12978 fis, clone

NT2RP26321, RAN binding protein 6,

karyopherin (importin) beta 3

302
10019
AI178756

d, h

303
6226
AA818521

General

304
15571
M27207
collagen, type I, alpha 1,
EST, Highly similar to CA1B_HUMAN
e, h

procollagen, type I alpha 1
COLLAGEN ALPHA 1(XI) CHAIN

PRECURSOR [H. sapiens], EST, Weakly

similar to CA11_HUMAN COLLAGEN ALPHA

1(I) CHAIN PRECURSOR [H. sapiens], EST,

Weakly similar to CA25_HUMAN COLLAGEN

ALPHA 2(V) CHAIN PRECURSO [H. sapiens],

EST, Weakly similar to CGHU1S collagen

alpha 1(I) chain precursor [H. sapiens], ESTs,

Weakly similar to CA11_HUMAN COLLAGEN

ALPHA 1(I) CHAIN PRECURSOR [H. sapiens],

Homo sapiens
cDNA FLJ2845 fis, clone

ADKA191, Homo sapiens mRNA for putative

emu2 protein, collagen, type I, alpha 1

305
15089
AI009752

g

306
17214
AI639008

a

307
6073
AA818818

a

308
17781
AI175474

a

309
22386
AA800844

ESTs, Weakly similar to PROTEIN-LYSINE 6-
e

OXIDASE PRECURSOR [R. norvegicus], Lysyl

oxidase, lysyl oxidase, lysyl oxidase-like, lysyl

oxidase-like 1, lysyl oxidase-like 2

310
24765
AA900050

EST, Moderately similar to 6S RIBOSOMAL
h

PROTEIN L37A [R. norvegicus], EST,

Moderately similar to JN875 ribosomal protein

L37a [H. sapiens], EST, Weakly similar to 6S

RIBOSOMAL PROTEIN L37A [R. norvegicus],

EST, Weakly similar to JN875 ribosomal

protein L37a [H. sapiens], ESTs, Weakly similar

to 6S RIBOSOMAL PROTEIN L37A

[R. norvegicus], ESTs, Weakly similar to JN875

ribosomal protein L37a [H. sapiens], RIKEN

cDNA 28125M15 gene, ribosomal protein L37a

311
20984
D90109
fatty acid Coenzyme A
ESTs, Weakly similar to LCFB MOUSE LONG-
h

ligase, long chain 2, fatty-
CHAIN-FATTY-ACID-COA LIGASE 2

acid-Coenzyme A ligase,
[M. musculus], Mus musculus, Similar to fatty-

long-chain 2
acid-Coenzyme A ligase, long-chain 6, clone

MGC: 28744 IMAGE: 4481949, mRNA, complete

cds, Rattus norvegicus gonadotropin-regulated

long chain acyl-CoA synthetase (GR-LACS)

mRNA, complete cds, fatty acid Coenzyme A

ligase, long chain 2, fatty acid Coenzyme A

ligase, long chain 5, fatty-acid-Coenzyme A

ligase, long-chain 1, fatty-acid-Coenzyme A

ligase, long-chain 2, lipidosin

312
22873
AA923945

RIKEN cDNA 24142F5 gene, procollagen-
i, General

lysine, 2-oxoglutarate 5-dioxygenase (lysine

hydroxylase) 2, procollagen-lysine, 2-

oxoglutarate 5-dioxygenase (lysine

hydroxylase, Ehlers-Danlos syndrome type VI),

procollagen-lysine, 2-oxoglutarate 5-

dioxygenase 1

313
2341
AI012144

a, General

314
4861
AA901290

General

315
22796
AI072213

General

316
15935
AA866345

General

317
16038
AI177372

GABA(A) receptor-associated protein, GABA(A)
h

receptor-associated protein like 1, GABA(A)

receptor-associated protein-like 2, GABA(A)

receptors associated protein like 3, RIKEN

cDNA 111H21 gene, RIKEN cDNA 492251H4

gene, microtubule-associated protein 1 light

chain 3, microtubule-associated proteins 1A/1B

light chain 3

318
15212
AI229753

ADP-ribosylation factor 1, ADP-ribosylation
d, General

factor 2, ARF protein, Homo sapiens PRO2667

mRNA, complete cds, RIKEN cDNA 2318D22

gene, expressed sequence T25534

319
23157
AI172489

ESTs, Highly similar to STRI RAT STRIATIN
a

[R. norvegicus], ESTs, Weakly similar to STRI

RAT STRIATIN [R. norvegicus], Mus musculus,

Similar to RIKEN cDNA 1541N16 gene, clone

MGC: 1266 IMAGE: 378188, mRNA, complete

cds, RIKEN cDNA 2514D7 gene, expressed

sequence AA48785, nuclear autoantigen,

platelet-activating factor acetylhydrolase,

isoform 1b, beta1 subunit, striatin, striatin,

calmodulin-binding protein, zinedin

320
4710
AI168973

EST, Moderately similar to PHLP_HUMAN
General

PHOSDUCIN-LIKE PROTEIN [H. sapiens],

RIKEN cDNA 11161A19 gene, RIKEN cDNA

1211E13 gene, hypothetical protein MGC362,

phosducin-like, phosducin-like 2, phosducin-like

protein, rod photoreceptor 1

321
22697
AA945996

b, General

322
15892
AI179988

a, General

323
11404
AI237002

Human DNA sequence from clone RP5-157D4
g, General

on chromosome 2 Contains a spermidine

synthase (SPDSY) pseudogene, a CpG island,

ESTs, STSs and GSSs, spermidine synthase

324
23596
AI105435

expressed sequence D17825, glutaryl-
c, General

Coenzyme A dehydrogenase

325
15841
AI103465

POP4 (processing of precursor, S. cerevisiae)
d, g,

homolog
General

326
7220
AI013098

d

327
20647
AI639402

b

328
10829
AI044467

c, f

329
22043
AA943738

f

330
2936
AI229843

General

331
26133
AI009950

e

332
5867
AA858953

asparaginyl-tRNA synthetase, hypothetical
Geneal

protein FLJ23441

333
3278
AI008988

ESTs, Highly similar to 117276A gene bcr
General

[H. sapiens], ESTs, Highly similar to N-

CHIMAERIN [R. norvegicus], RIKEN cDNA

17112L9 gene, RIKEN cDNA 51334C9 gene,

RIKEN cDNA 57343H17 gene, SH3-domain

binding protein 1, breakpoint cluster region,

chimerin (chimaerin) 1, expressed sequence

AI84366, expressed sequence AU42359,

hypothetical protein DKFZp434K191

334
21101
AI175789

Actin, alpha, cardiac, ESTs, Highly similar to
g

ACTC_HUMAN ACTIN, ALPHA CARDIA

[R. norvegicus], ESTs, Weakly similar to

ACTA_HUMAN ACTIN, AORTIC SMOOTH

MUSCLE [R. norvegicus], Homo sapiens cDNA:

FLJ21441 fis, clone COL4422, actin, alpha 2,

smooth muscle, aorta, actin, alpha, cardiac,

actin, alpha, cardiac muscle

335
12613
H31620

Homo sapiens
cDNA FLJ13436 fis, clone
General

PLACE12598, weakly similar to

OLIGORIBONUCLEASE (EC 3.1.—.—), small

fragment nuclease

336
6927
AI010542

h

337
8789
AI070073

h

338
22995
AI232047

General

339
5129
AA925335

d

340
12462
AI175421

General

341
1760
U25281

EST, Weakly similar to G3PT MOUSE
General

GLYCERALDEHYDE 3-PHOSPHATE

DEHYDROGENASE, TESTIS-SPECIFIC

[M. musculus], ESTs, Moderately similar to

WASP-family protein [H. sapiens], ESTs,

Weakly similar to Y269_HUMAN

HYPOTHETICAL PROLINE-RICH PROTEIN

KIAA269 [H. sapiens], ESTs, Weakly similar to

p14mDia [M. musculus], ESTs, Weakly similar

to similar to CR16, SH3 domain binding protein

[H. sapiens], expressed sequence AI842788

342
24521
AA945636

EST, Weakly similar to R6HUP1 acidic
e

ribosomal protein P1, cytosolic [H. sapiens],

ESTs, Highly similar to R6HUP1 acidic

ribosomal protein P1, cytosolic [H. sapiens],

RIKEN cDNA 2749I22 gene, ribosomal protein,

large, P1

343
25354
L13025

e

344
24272
AA955948

Homo sapiens
DNA from chromosome 19p13.2
General

cosmids R3124, R3272 and R28549 containing

the EKLF, GCDH, CRTC, and RAD23A genes,

genomic sequence, deoxyribonuclease DLAD,

deoxyribonuclease II alpha, deoxyribonuclease

II beta, deoxyribonuclease II, lysosomal,

expressed sequence AI526873

345
18160
AA799448

h

346
11738
AI104213

General

347
15644
AI010256

ESTs, Highly similar to HISTONE H3.3
General

[R. norvegicus], H3 histone, family 3A, H3

histone, family 3B, H3 histone, family 3B

(H3.3B)

348
10971
AI073212

e

349
23578
AA955042

folate receptor 2 (fetal)
General

350
6217
AI230381

General

351
21514
AA851660

General

352
16909
AA942704

EST, Weakly similar to SUR2_HUMAN
e

SURFEIT LOCUS PROTEIN 2 [H. sapiens],

surfeit 2, surfeit gene 2

353
21284
AI170842

ESTs, Highly similar to A57291 cytokine
General

inducible nuclear protein C193 [H. sapiens],

ESTs, Weakly similar to A57291 cytokine

inducible nuclear protein C193 [H. sapiens],

ankyrin repeat domain 2 (stretch responsive

muscle), cardiac ankyrin repeat protein

354
23645
AI144653

General

355
8230
AI059117

General

356
9720
AI071727

g

357
24012
AA957335

a, i

358
14737
AI008416

g, General

359
7308
AA818407

b, General

360
6102
AI228335

General

361
19728
AI170394

c

362
6568
AA817891

General

363
20891
AI169337

hypothetical protein
General

364
11375
AI237594

makorin, ring finger protein, 1, makorin, ring
b, General

finger protein, 2, makorin, ring finger protein, 3,

makorin, ring finger protein, 4

365
1483
U34843

i

366
20684
H32977

General

367
3959
AA901338

g, General

368
19518
AA800817

a

369
22445
AA944530

PL6 protein
f

370
16312
AA875032

c, General

371
19255
M15562

expressed sequence AI323765,
b, General

histocompatibility 2, class II antigen E alpha,

major histocompatibility complex, class II, DP

alpha 2 (pseudogene), major histocompatibility

complex, class II, DR alpha

372
4048
AA851814

EST, Moderately similar to PM17 MOUSE
General

MELANOCYTE PROTEIN PMEL 17

PRECURSOR [M. musculus], Homo sapiens,

Similar to glycoprotein (transmembrane) nmb,

clone MGC: 1696 IMAGE: 3345861, mRNA,

complete cds, glycoprotein (transmembrane)

nmb, silver

373
7471
AI012379

General

374
21351
AA945932

annexin A1, annexin A3
d, General

375
23963
AA957139

General

376
9658
AA943748

d, General

377
14384
AI177096

EST, Moderately similar to APT RAT ADENINE
c

PHOSPHORIBOSYLTRANSFERASE

[R. norvegicus], Mouse adenine

phosphoribosyltransferase (APRT), complete

cds, adenine phosphoribosyl transferase,

adenine phosphoribosyltransferase, expressed

sequence C85684

378
5531
AI145859

d

379
3324
AA997981

e

380
13083
H31665

d

381
18400
AA799991

a, f,

General

382
15281
D13623

General

383
22578
AA924105

Macrophage inflammatory protein 1 alpha
g

(Small inducible cytokine A3), small inducible

cytokine A3, small inducible cytokine A3

(homologous to mouse Mip-1a), small inducible

cytokine A3-like 1, small inducible cytokine A6,

small inducible cytokine subfamily A (Cys-Cys),

member 23

384
12752
AI012146

General

385
6606
AI012308

f, g,

General

386
11936
AI228030

EST, Weakly similar to SP18_HUMAN SIN3
h

ASSOCIATED POLYPEPTIDE P18

[H. sapiens], Sin3-associated polypeptide 18,

sin3-associated polypeptide, l8 kD

387
2539
AI111960

General

388
6353
AI008442

EST, Weakly similar to JC5111 cyclin-
f

dependent kinase-related protein 1b - rat

[R. norvegicus], EST, Weakly similar to S1889

proline-rich protein [H. sapiens], ESTs, Highly

similar to JC5111 cyclin-dependent kinase-

related protein 1b - rat [R. norvegicus], Homo

sapiens
ALS2CR7 mRNA, complete cds,

PCTAIRE protein kinase 1, PCTAIRE-motif

protein kinase 1, PFTAIRE protein kinase 1

389
15786
AI013924

General

390
16596
AI102486

DNA segment, Chr 7, ERATO Doi 486,
General

expressed, EST, Weakly similar to S37583

RING finger protein rfp - mouse [M. musculus],

expressed sequence AI894158, expressed

sequence AW46487, hypothetical gene

MGC1127

391
18581
AI176160

General

392
4948
AA924428

h

393
12098
AI237075

d

394
20073
AI639152

b, General

395
18456
D00688
monoamine oxidase A
EST, Highly similar to AOFA_HUMAN AMINE
General

OXIDASE [H. sapiens], ESTs, Weakly similar to

JH817 amine oxidase [H. sapiens], Homo

sapiens
interleukin-4 induced gene-1 protein

(FIG. 1) mRNA, complete cds, KIAA61 protein,

monoamine oxidase A

396
11208
AI237586

EST, Weakly similar to JC1241 beta-interferon-
General

induced protein - rat [R. norvegicus], ESTs,

Moderately similar to JC1241 beta-interferon-

induced protein - rat [R. norvegicus], RIKEN

cDNA 11136C17 gene, RIKEN cDNA

4933438K12 gene, interferon induced

transmembrane protein 2 (1-8D)

397
8314
AI059386

General

398
1893
X51529
phospholipase A2, group

General

IIA (platelets, synovial

fluid)

399
10821
AI043999

e

400
20983
AI044900
fatty acid Coenzyme A
ESTs, Weakly similar to LCFB MOUSE LONG-
General

ligase, long chain 2, fatty-
CHAIN-FATTY-ACID--COA LIGASE 2

acid-Coenzyme A ligase,
[M. musculus], Mus musculus, Similar to fatty-

long-chain 2
acid-Coenzyme A ligase, long-chain 6, clone

MGC: 28744 IMAGE: 4481949, mRNA, complete

cds, Rattus norvegicus gonadotropin-regulated

long chain acyl-CoA synthetase (GR-LACS)

mRNA, complete cds, fatty acid Coenzyme A

ligase, long chain 2, fatty acid Coenzyme A

ligase, long chain 5, fatty-acid-Coenzyme A

ligase, long-chain 1, fatty-acid-Coenzyme A

ligase, long-chain 2, lipidosin

401
18472
AI168975

General

402
21592
AI102065

heme-binding protein
General

403
8665
AI071965

ESTs, Highly similar to T17342 hypothetical
General

protein DKFZp586K1924.1 [H. sapiens], ESTs,

Moderately similar to T17342 hypothetical

protein DKFZp586K1924.1 [H. sapiens]

404
11066
AI071602

h

405
19452
AA964500

e, f

406
6509
AI232361

General

407
22266
AA945601

a

408
2742
AI070173

g, i,

General

409
244
U38376

ESTs, Highly similar to FGD1_HUMAN
General

PUTATIVE RHO/RAC GUANINE

NUCLEOTIDE EXCHANGE FACTOR

[H. sapiens], ESTs, Weakly similar to B39898

phospholipase A2 [M. musculus], ESTs, Weakly

similar to FGD1 MOUSE PUTATIVE RHO/RAC

GUANINE NUCLEOTIDE EXCHANGE

FACTOR [M. musculus], ESTs, Weakly similar

to FGD1_HUMAN PUTATIVE RHO/RAC

GUANINE NUCLEOTIDE EXCHANGE

FACTOR [H. sapiens], FGD1 family, member 3,

RIKEN cDNA 583461L1 gene, faciogenital

dysplasia (Aarskog-Scott syndrome),

faciogenital dysplasia homolog, faciogenital

dysplasia homolog 2 (human)

410
4238
AI234816

KIAA13 gene product
b

411
9970
AI045198

General

412
6550
AA817947

h

413
5193
AA925693

General

414
22175
AA818999

General

415
16538
AA799449

ESTs, Moderately similar to NPL4_HUMAN
h

NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE

4 [H. sapiens], ESTs, Weakly similar to

NPL4_HUMAN NUCLEOSOME ASSEMBLY

PROTEIN 1-LIKE 4 [H. sapiens], SET

translocation, nucleosome assembly protein 1-

like 1, nucleosome assembly protein 1-like 4

416
1830
AI009002

cell division cycle 25 homolog B (S. cerevisiae),
a, b

cell division cycle 25 homolog C (S. cerevisiae),

cell division cycle 25B, cell division cycle 25C,

expressed sequence AI64853

417
17485
AI012352

General

418
3982
AI175100

General

419
3965
AI112118

General

420
5969
AI102520

ESTs, Weakly similar to GEF2_HUMAN
c, General

GANGLIOSIDE EXPRESSION FACTOR 2

[R. norvegicus], GABA(A) receptor-associated

protein-like 2, RIKEN cDNA 6112F2 gene,

gamma-aminobutyric acid (GABA(A)) receptor-

associated protein-like 1, ganglioside

expression factor 2

421
15088
AI232613

General

422
25691
X53504

e

423
2984
AA997015

General

424
11708
AI171807

General

425
23187
AI144591

General

426
16818
AI072906

a

427
19298
AI236338

ESTs, Highly similar to NHPX RAT NHP2/RS6
General

FAMILY PROTEIN YEL26W HOMOLOG

[R. norvegicus], RIKEN cDNA 24113M7 gene,

non-histone chromosome protein 2 (S.

cerevisiae)-like 1, nucleolar protein family A,

member 2 (H/ACA small nucleolar RNPs),

sperm specific antigen 1

428
14345
AA944773

DKFZP586L724 protein, Homo sapiens cDNA:
e

FLJ21737 fis, clone COLF3396

429
10109
X58465
ribosomal protein S5
EST, Moderately similar to 4S RIBOSOMAL
e

PROTEIN S5 [R. norvegicus], ESTs, Weakly

similar to S55916 ribosomal protein S5,

cytosolic [H. sapiens], ribosomal protein S5

430
5596
AI044747

e, General

431
14989
AI177366

ESTs, Highly similar to B2779 fibronectin
f, i,

receptor beta chain precursor [H. sapiens],
General

integrin beta 1 (fibronectin receptor beta),

integrin beta 2, integrin, beta 1 (fibronectin

receptor, beta polypeptide, antigen CD29

includes MDF2, MSK12), integrin, beta 2

(antigen CD18 (p95), lymphocyte function-

associated antigen 1; macrophage antigen 1

(mac-1) beta subunit)

432
17320
AI178069

General

433
13646
X62166

EST, Weakly similar to 6S RIBOSOMAL
General

PROTEIN L3 [R. norvegicus], EST, Weakly

similar to I8451 ribosomal protein L3

[H. sapiens], ESTs, Moderately similar to 6S

RIBOSOMAL PROTEIN L3 [R. norvegicus],

ESTs, Moderately similar to I8451 ribosomal

protein L3 [H. sapiens], ESTs, Weakly similar to

RL3 MOUSE 6S RIBOSOMAL PROTEIN L3

[M. musculus], RIKEN cDNA 11157H16 gene,

ribosomal protein L3, ribosomal protein L3-like

434
18611
X58200
ribosomal protein L29
EST, Moderately similar to 6S RIBOSOMAL
e, General

PROTEIN L29 [R. norvegicus], EST, Weakly

similar to S65784 ribosomal protein L29,

cytosolic [H. sapiens], ESTs, Highly similar to

S65784 ribosomal protein L29, cytosolic

[H. sapiens], ESTs, Weakly similar to 6S

RIBOSOMAL PROTEIN L29 [M. musculus],

Human DNA sequence from clone RP4-595K12

on chromosome 1p31.2-31.3 Contains a

pseudogene similar to 6S RPL29 (ribosomal

protein L29 (cell surface heparin binding protein

HIP)), a chromosome 1 specific mRNA

(KIAA499), a novel mRNA (KIAA433), ESTs,

STSs, GSSs and a CpG Island, ribosomal

protein L29

435
21671
AA900295

placental growth factor, placental growth factor,
General

vascular endothelial growth factor-related

protein

436
9452
AA955206

General

437
20901
AA942706

d

438
21985
AA943273

a

439
7168
AI012739

General

440
12195
AA899121

General

441
15929
AA849740

hypothetical protein
General

442
16322
AA866240

c

443
18047
AI171359

c

444
15966
AA923994

developmentally regulated GTP-binding protein 2
b

445
13251
AI179264

General

446
18095
AI177482

ESTs, Weakly similar to PTNB MOUSE
i, General

PROTEIN-TYROSINE PHOSPHATASE SYP

[M. musculus], Homo sapiens clone L48

polyadenylated HERV LTR sequence and

flanking cellular sequence, mRNA, expressed

sequence AA589446, hemopoietic cell

phosphatase, protein tyrosine phosphatase,

non-receptor type 11, protein tyrosine

phosphatase, non-receptor type 13, protein

tyrosine phosphatase, non-receptor type 6

447
16053
AI228596

General

448
10684
AA849687

ESTs, Highly similar to I39451 amyloid-beta
e, f

protein [H. sapiens], collagen, type VI, alpha 3

449
22691
AI177967

EST, Weakly similar to TGFB_HUMAN
General

LATENT TRANSFORMING GROWTH

FACTOR BETA BINDING PROTEIN 1

PRECURSOR [H. sapiens], RIKEN cDNA

23146A13 gene, hypothetical protein MGC131,

latent transforming growth factor beta binding

protein 1, latent transforming growth factor beta

binding protein 2, latent transforming growth

factor beta binding protein 3, transforming

growth factor-beta (TGF-beta) masking protein

large subunit

450
15438
AI179399
collagen, type V, alpha 2,
EST, Highly similar to CA13_HUMAN
e

procollagen, type V,
COLLAGEN ALPHA 1(III) CHAIN

alpha 2
PRECURSOR [H. sapiens], EST, Weakly

similar to CA25_HUMAN COLLAGEN ALPHA

2(V) CHAIN PRECURSO [H. sapiens], EST,

Weakly similar to I4967 procollagen type V

alpha 2 - mouse [M. musculus], RIKEN cDNA

2812D19 gene, collagen, type III, alpha 1

(Ehlers-Danlos syndrome type IV, autosomal

dominant), collagen, type V, alpha 2,

hypothetical protein DKFZp434F318,

hypothetical protein MGC12921, procollagen,

type III, alpha 1, procollagen, type V, alpha 2,

procollagen, type XIII, alpha 1

451
20975
AA799599

f, General

452
15048
M24542

EST, Moderately similar to UCRI RAT
c, i

UBIQUINOL-CYTOCHROME C REDUCTASE

IRON-SULFUR SUBUNIT, MITOCHONDRIAL

PRECURSOR [R. norvegicus], EST, Weakly

similar to UCRI_HUMAN UBIQUINOL-

CYTOCHROME C REDUCTASE IRON-

SULFUR SUBUNIT, MITOCHONDRIAL

PRECURSOR [H. sapiens], ESTs, Moderately

similar to UCRI_HUMAN UBIQUINOL-

CYTOCHROME C REDUCTASE IRON-

SULFUR SUBUNIT, MITOCHONDRIAL

PRECURSOR [H. sapiens], Human DNA

sequence from clone RP1-228J4 on

chromosome 6 Contains a pseudogene similar

to UQCRFS1 (ubiquinol-cytochrome c

reductase, Rieske iron-sulfur polypeptide 1),

ESTs, an STS and GSSs, RIKEN cDNA

44342G14 gene, expressed sequence

AI87555, ubiquinol-cytochrome c reductase,

Rieske iron-sulfur polypeptide 1

453
19379
AI102711

EST, Moderately similar to S34195 ribosomal
General

protein L3, cytosolic [H. sapiens], ESTs, Highly

similar to S34195 ribosomal protein L3,

cytosolic [H. sapiens], ESTs, Weakly similar to

RL3 MOUSE 6S RIBOSOMAL PROTEIN L3

[M. musculus]

454
12583
AI234251

General

455
19480
AA944442

ESTs, Moderately similar to JC2324 LIM
c

protein [H. sapiens], Homo sapiens cDNA

FLJ13238 fis, clone OVARC144, LIM and

senescent cell antigen-like domains 1,

expressed sequence AV278559, expressed

sequence AW18311, four and a half LIM

domains 2, paxillin, pinch-2, transforming

growth factor beta 1 induced transcript 1,

vascular Rab-GAP/TBC-containing

456
7700
AI105383

General

457
21996
AA946036

f

458
26148
AI013396

General

459
9551
AI013558

d

460
23632
AI237273

d, f,

General

461
15292
AF012714
multiple inositol

c

polyphosphate histidine

phosphatase 1, multiple

inositol polyphosphate

histidine phosphatase, 1

462
6632
AI235277

General

463
18406
AI236168

General

464
11865
AA866383

General

465
20461
AI639350

i, General

466
11728
AI007884

d

467
6562
AI177734

d, General

468
3046
AA997706

h

469
25730
X63369

General

470
23166
AA859954

General

471
3271
AI010303

e

472
4626
AI104744

General

473
6430
AI232319

RIKEN cDNA 18115E19 gene, erythrocyte
General

membrane protein band 7.2 (stomatin),

expressed sequence AI79225

474
6262
AI177125

General

475
8786
AA996993

IK cytokine, down-regulator of HLA II, Mus
d

musculus
, Similar to IK cytokine, down-

regulator of HLA II, clone MGC: 2558

IMAGE: 492184, mRNA, complete cds

476
12946
AI228291

General

477
23015
AI227724

f, General

478
15949
AA963780

i

479
5458
AI009756
programmed cell death 6
EST, Moderately similar to T14756 hypothetical
g, i,

interacting protein,
protein DKFZp564F923.1 [H. sapiens], EST,
General

programmed cell death 6-
Weakly similar to A28996 proline-rich protein

interacting protein
M14 precursor - mouse [M. musculus], EST,

Weakly similar to PRP4_HUMAN SALIVARY

PROLINE-RICH PROTEIN PO PRECURSOR

[H. sapiens], expressed sequence AI462446,

poly(A)-binding protein, nuclear 1, proline rich

protein, proline rich protein 2, proline-rich

protein BstNI subfamily 4, protein tyrosine

phosphatase, non-receptor type 23

480
11726
AA849518

d

481
22197
AI178527

General

482
21311
AI178688

General

483
16092
AI009012

ESTs, Moderately similar to T13152 WDR1
g, i,

protein [H. sapiens], WD repeat domain 1
General

484
15283
AA858548

i, General

485
23601
AA955126

ESTs, Moderately similar to MYB-RELATED
f

PROTEIN B [M. musculus], myeloblastosis

oncogene-like 2, v-myb avian myeloblastosis

viral oncogene homolog-like 2

486
2418
AI013790

DKFZP586D623 protein, hypothetical protein
e

MGC123

487
3214
AI235483

General

488
20056
AI639504

General

489
6431
AA859085

General

490
17145
M38566

serine (or cysteine) proteinase inhibitor, clade F
i

(alpha-2 antiplasmin, pigment epithelium

derived factor), member 2, serine protease

inhibitor 2-2

491
15492
AA892376

h

492
23687
AI137958

e

493
17224
AI179883

ESTs, Highly similar to MG15_HUMAN
c

TRANSCRIPTION FACTOR-LIKE PROTEIN

MRG15 (MORF-RELATED GENE 15

PROTEIN) (MSL3-1 PROTEIN) (PROTEIN

HSPC8/HSPC61) [H. sapiens], MORF-related

gene 15
c

494
3682
AA998964

c

495
21818
AF036537

ESTs, Highly similar to A55318
c

serine/threonine protein kinase [M. musculus],

ESTs, Weakly similar to RIP MOUSE

SERINE/THREONINE PROTEIN KINASE RIP

[M. musculus], Human DNA sequence from

clone RP5-1182A14 on chromosome 1

Contains part of a gene similar to rat Espin, a

pseudogene similar to KIAA454, a gene similar

to MST1 (macrophage stimulating 1

(hepatocyte growth factor-like)), a pseudogene

similar to KIAA445, two isoforms of a novel

gene (isoform 2 is the gene for KIAA1245

protein), ESTs, STSs, GSSs and CpG islands,

ankyrin repeat domain 3, cerebral cavernous

malformations 1, mitogen activated protein

kinase kinase kinase 12, mitogen-activated

protein kinase kinase kinase 12, receptor

(TNFRSF)-interacting serine-threonine kinase

1, receptor interacting protein 3, receptor-

interacting serine-threonine kinase 2

496
3434
AI232014

General

497
15084
AA799397

a

498
23013
AI230743
ARP3 (actin-related
ARP3 (actin-related protein 3, yeast) homolog,
General

protein 3, yeast) homolog,
EST, Weakly similar to ARP3_HUMAN ACTIN-

actin-related protein 3
LIKE PROTEIN 3 [H. sapiens], Homo sapiens

homolog (yeast)
FKSG73 (FKSG73) mRNA, complete cds,

RIKEN cDNA 6141G9 gene, actin, alpha 1,

skeletal muscle, actin-related protein 3-beta

429
25702
X58465
ribosomal protein S5
EST, Moderately similar to 4S RIBOSOMAL
e

PROTEIN S5 [R. norvegicus], ESTs, Weakly

similar to S55916 ribosomal protein S5,

cytosolic [H. sapiens], ribosomal protein S5

499
3817
AA926328

EST, Weakly similar to 143B_HUMAN 14-3-3
General

PROTEIN BETA/ALPHA [H. sapiens], ESTs,

Highly similar to A Chain A, 14-3-3

ZetaPHOSPHOPEPTIDE COMPLEX

[H. sapiens], makorin, ring finger protein, 3,

stratifin, tyrosine 3-monooxgenase/tryptophan 5

monooxgenase activation protein, beta

polypeptide, tyrosine 3-

monooxygenase/tryptophan 5-monooxygenase

activation protein, zeta polypeptide

500
3669
AA957535

g, i,

General

501
11331
AI145556

d

502
15558
AA875537

FUS-interacting protein (serine-arginine rich) 1,
General

FUS-interacting protein (serine-arginine rich) 2,

Homo sapiens
SRp46 splicing factor

transcribed retropseudogene, Mus musculus

splicing factor Sc35 (Pr264) mRNA, partial cds,

alternatively spliced, Splicing factor,

arginine/serine-rich, 46 kD, splicing factor,

arginine/serine-rich 2 (SC-35)

503
23409
AA956294

General

504
4652
AA899642

General

505
14117
AI171350

General

506
18744
AI170407

General

507
11561
AI233182

General

508
22711
AA946072

General

509
3941
AI011598

ESTs, Moderately similar to 2113291A
d, i,

laminin: SUBUNIT, Usher syndrome 2A
General

(autosomal recessive, mild) homolog (human),

hypothetical protein, MGC: 8159, laminin, alpha 5

510
23464
AA925876

General

511
168
AA924985
calsequestrin 2,
EST, Weakly similar to CAQC RAT
h

calsequestrin 2 (cardiac
CALSEQUESTRIN, CARDIAC MUSCLE

muscle)
ISOFORM PRECURSOR [R. norvegicus],

ESTs, Moderately similar to CAQC RAT

CALSEQUESTRIN, CARDIAC MUSCLE

ISOFORM PRECURSOR [R. norvegicus],

calsequestrin 1, calsequestrin 1 (fast-twitch,

skeletal muscle), calsequestrin 2, calsequestrin

2 (cardiac muscle)

512
14944
AA925364

e

513
24228
AA800318

serine (or cysteine) proteinase inhibitor, clade F
b

(alpha-2 antiplasmin, pigment epithelium

derived factor), member 2, serine (or cysteine)

proteinase inhibitor, clade G (C1 inhibitor),

member 1

514
23822
AA943114

General

515
12988
AI37070

b, General

516
4499
AA892511

RIKEN cDNA2111P9 gene, calcium binding
e

protein P22, hepatocellular carcinoma antigen

gene 52, hypothetical protein FLJ267, tescalcin

517
12274
AA964306

General

518
6094
AA818911

d

519
19257
AI030775

expressed sequence AI323765,
b

histocompatibility 2, class II antigen E alpha,

major histocompatibility complex, class II, DP

alpha 2 (pseudogene), major histocompatibility

complex, class II, DR alpha

520
17847
AI178214

General

521
18887
AA892860

General

522
20740
S69874

EST, Weakly similar to FABE HUMAN FATTY
c, d,

ACID-BINDING PROTEIN, EPIDERMAL
General

[H. sapiens], fatty acid binding protein 5,

epidermal

523
4770
AI235915

f

524
21705
AA900684

EST, Weakly similar to Y64_HUMAN
f

HYPOTHETICAL PROTEIN KIAA64

[H. sapiens], ESTs, Moderately similar to

Y64_HUMAN HYPOTHETICAL PROTEIN

KIAA64 [H. sapiens], ESTs, Weakly similar to

Y64_HUMAN HYPOTHETICAL PROTEIN

KIAA64 [H. sapiens], sorting nexin 17

525
18797
AI236618

Homo sapiens
cDNA FLJ13574 fis, clone
General

PLACE18625, hypothetical protein, hypothetical

protein FLJ2668, similar to S. cerevisiaeSSM4

526
22212
AI236294

EST, Weakly similar to IF6_HUMAN
General

EUKARYOTIC TRANSLATION INITIATION

FACTOR 6 [H. sapiens], Mus musculus 1 days

neonate cerebellum cDNA, RIKEN full-length

enriched library, clone: 65342L5, full insert

sequence, integrin beta 4 binding protein

527
2153
U75404
A kinase (PRKA) anchor

General

protein (gravin) 12

528
21654
U53184

i, General

529
3191
AI013075

ESTs, Weakly similar to T3454 ALR protein
General

[H. sapiens], chromatin-specific transcription

elongation factor, 14 kDa subunit, hypothetical

protein FLJ2144 similar to Rbig1,

myeloid/lymphoid or mixed-lineage leukemia 2

530
16613
AA874784

e, f,

General

531
5482
AI180252

General

532
14337
AI180414

EST, Highly similar to T1416 probable GTPase-
General

activating protein SPA-1 - rat [R. norvegicus],

ESTs, Highly similar to T1416 probable

GTPase-activating protein SPA-1 - rat

[R. norvegicus], KIAA44 protein, RIKEN cDNA

261511M17 gene, expressed sequence

AW213287, signal-induced proliferation

associated gene 1

533
23471
AA955162

General

534
4098
AI008642

Acid nuclear phosphoprotein 32 (leucine rich),
i, General

ESTs, Weakly similar to LEUCINE-RICH

ACIDIC NUCLEAR PROTEIN [R. norvegicus],

acidic nuclear phosphoprotein 32, acidic protein

rich in leucines, cerebellar ataxia 3, pp32

related 1, pp32 related 2, putative human HLA

class II associated protein I

535
23372
AI031002

h

536
18217
AA858930

General

537
3905
AI103403
neural polypyrimidine
ESTs, Moderately similar to S15552
General

tract binding protein,
polypyrimidine tract-binding protein 1 - rat

polypyrimidine tract
[R. norvegicus], ESTs, Weakly similar to

binding protein
S15552 polypyrimidine tract-binding protein 1 -

rat [R. norvegicus], RIKEN cDNA 28136L13

gene, expressed sequence AW17884,

heterogeneous nuclear ribonucleoprotein L,

neural polypyrimidine tract binding protein,

polypyrimidine tract binding protein,

polypyrimidine tract binding protein 2

538
24375
AI104979

General

539
14256
AI176845

HSPC163 protein, RIKEN cDNA D533D3 gene,
General

cornichon homolog (Drosophila)

540
18349
AA799744

General

541
2310
AI029969

General

542
3437
AA892897

General

543
806
AI169231

Gene 33/Mig-6, RIKEN cDNA 132F13 gene
General

544
11531
AA799773

EST, Moderately similar to ABP2_HUMAN
g, h, i,

ENDOTHELIAL ACTIN-BINDING PROTEIN
General

[H. sapiens], ESTs, Moderately similar to

ABP2_HUMAN ENDOTHELIAL ACTIN-

BINDING PROTEIN [H. sapiens], filamin A,

alpha (actin-binding protein-28), filamin B, beta

(actin-binding protein-278)

545
15181
AI235234

i

546
22689
AA945962

General

547
9084
AA893717

f

548
5307
AA893529

DNA segment, Chr 12, ERATO Doi 748,
b

expressed, General transcription factor IIIA

549
25663
X05472

e

550
18278
AI105080

3-oxoacid CoA transferase, hypothetical protein
General

FKSG25

551
6044
AI011285

a, General

552
17361
AA859114

i, General

553
22464
AI009713

d

554
8137
AA800749

e

555
16426
X70369
collagen, type III, alpha 1
EST, Highly similar to CA13_HUMAN
c, e

(Ehlers-Danlos syndrome
COLLAGEN ALPHA 1(III) CHAIN

type IV, autosomal
PRECURSOR [H. sapiens], EST, Moderately

dominant), procollagen,
similar to CA13_HUMAN COLLAGEN ALPHA

type III, alpha 1
1(III) CHAIN PRECURSOR [H. sapiens], EST,

Weakly similar to CGHU7L collagen alpha 1(III)

chain precursor [H. sapiens], ESTs, Highly

similar to CA21_HUMAN COLLAGEN ALPHA

2(l) CHAIN PRECURSOR [H. sapiens], collagen

type V, alpha 2, collagen, type III, alpha 1

(Ehlers-Danlos syndrome type IV, autosomal

dominant), macrophage receptor with

collagenous structure, procollagen, type III,

alpha 1

556
24237
AA817726

General

557
17950
AI236590

General

558
18172
AI058364

CDC37 (cell division cycle 37, S. cerevisiae,
d, g,

homolog), ESTs, Moderately similar to G2313
General

CDC37 homolog [H. sapiens], Hsp9-associating

relative of Cdc37

559
22614
AI031004

d

560
23005
AA942770

General

561
17285
J02827
branched chain keto acid

General

dehydrogenase E1, alpha

polypeptide (maple syrup

urine disease), branched

chain ketoacid

dehydrogenase E1, alpha

polypeptide

562
15885
AA965207

EST, Highly similar to T14795 hypothetical
d

protein DKFZp434E171.1 [H. sapiens]

563
5461
AI044338

General

564
22677
AA942718
BCL2-like 1, Bcl2-like
BCL2-like 1, BCL2-like 2, Bcl-2-related ovarian
General

killer protein, Bcl-2-related ovarian killer protein-

like, Bcl-w protein, Bcl2-like, Bcl2-like 2

565
18507
AI175551

ESTs, Highly similar to S25432 translation
General

elongation factor eEF-1 beta chain [H. sapiens],

eukaryotic translation elongation factor 1 beta 2

566
8012
AI058330

Complement component 4 binding protein,
General

alpha, ESTs, Moderately similar to NBHUC4

C4b-binding protein alpha chain precursor

[H. sapiens], ESTs, Weakly similar to

C4BP_HUMAN C4B-BINDING PROTEIN

ALPHA CHAIN PRECURSOR [H. sapiens], Mus

musculus
decay accelerating factor

glycosylphoshatidylinositol-anchored form

(DAF) mRNA, partial cds, complement

component 4-binding protein, alpha, decay

accelerating factor 1, decay accelerating factor

for complement (CD55, Cromer blood group

system), expressed sequence AI323748

567
13310
AI177119

ESTs, Weakly similar to COMPLEMENT C1Q
b, General

SUBCOMPONENT, C CHAIN PRECURSOR

[M. musculus], Homo sapiens, Similar to

complement component 1, q subcomponent, c

polypeptide, clone MGC: 17279

IMAGE: 4212772, mRNA, complete cds,

complement component 1, q subcomponent,

beta polypeptide, complement component 1, q

subcomponent, c polypeptide, expressed

sequence AI385742

568
6548
AI072658

d, General

569
7941
AI043958

g, i,

General

570
13619
AI179464

General

571
3207
AA997466

General

572
20582
AA859688

AU RNA-binding protein/enoyl-Coenzyme A
f, General

hydratase, EST, Weakly similar to I37195 AU-

specific RNA-binding protein/enoyl-CoA

hydratase homolog [H. sapiens], hypothetical

protein FLJ1948, uncharacterized

hypothalamus protein HCDASE

573
21796
AI012221

EST X83352, ESTs, Highly similar to T17226
g, General

hypothetical protein DKFZp566G223.1

[H. sapiens], Homo sapiens, Similar to chloride

intracellular channel 4, clone MGC: 8812

IMAGE: 3861372, mRNA, complete cds, RIKEN

cDNA 573531E12 gene, chloride intracellular

channel 1, chloride intracellular channel 4,

chloride intracellular channel 4 (mitochondrial),

hypothetical protein DKFZp434N127,

intracellular chloride ion channel protein p64H1

574
19071
AA850524

ESTs, Weakly similar to B5625 transcription
f

factor LBP1b [H. sapiens], Mus musculus, clone

MGC: 785 IMAGE: 349986, mRNA, complete

cds, upstream binding protein 1, upstream

binding protein 1 (LBP-1a)

575
24200
AI012356

General

576
24246
AA963703

g, General

577
6133
AA866234

elongation factor for selenoprotein translation
c

578
21632
AI009167

BCL2-associated athanogene 2, ESTs, Highly
General

similar to T8764 hypothetical protein

DKFZp586C21.1 [H. sapiens]

579
13772
AA851926

DEAD (aspartate-glutamate-alanine-aspartate)
General

box polypeptide 5, DEAD-box protein, DEAD/H

(Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA

helicase, 68 kD), ESTs, Highly similar to

146327A growth regulated nuclear 68 protein

[H. sapiens], Homo sapiens, Similar to RIKEN

cDNA 23161O4 gene, clone MGC: 21583

IMAGE: 4479998, mRNA, complete cds,

KIAA81 gene product, RIKEN cDNA 2617K22

gene, RIKEN cDNA 492156D17 gene, RIKEN

cDNA 91343L19 gene, RNA helicase, Rattus

norvegicus
RNA helicase with arginine-serine-

rich domain mRNA, complete cds, expressed

sequence AI32543

580
22247
AA943537

ajuba, expressed sequence AI48116,
i, General

expressed sequence R75157, zyxin

581
23732
AA957653

ESTs, Moderately similar to JC5614 RNB6
General

protein - rat [R. norvegicus], ESTs, Weakly

similar to NPC DERIVED PROLINE RICH

PROTEIN 1 [M. musculus], Ena-vasodilator

stimulated phosphoprotein, NPC derived

proline rich protein 1, RNB6, enabled homolog

(Drosophila), likely ortholog of mouse NPC

derived proline rich protein 1

582
22385
AA859805

ESTs, Weakly similar to PROTEIN-LYSINE 6-
e

OXIDASE PRECURSOR [R. norvegicus], Lysyl

oxidase, lysyl oxidase, lysyl oxidase-like, lysyl

oxidase-like 1, lysyl oxidase-like 2

583
2459
AA964755

i

584
23964
AI234748

g, General

585
4074
AI175990

g

586
17204
AI171844

ATP synthase, H+ transporting, mitochondrial
e, g

F1 complex, epsilon subunit, RIKEN cDNA

24143G19 gene, expressed sequence AV645

587
6560
AI230440

d

588
17883
M11851

a, b

589
22937
AA850290

ATPase, Class V, type 1B, ATPase, Class V,
i

type 1D, ATPase, class V, type 1A, EST,

Highly similar to AT5B_HUMAN POTENTIAL

PHOSPHOLIPID-TRANSPORTING ATPASE

VB [H. sapiens], ESTs, Weakly similar to AT5A

MOUSE POTENTIAL PHOSPHOLIPID-

TRANSPORTING ATPASE VA [M. musculus]

590
4944
AA924405

ESTs, Weakly similar to NEUROFILAMENT
g, General

TRIPLET H PROTEIN [M. musculus], RIKEN

cDNA 619L18 gene, RIKEN cDNA 133A17

gene, RIKEN cDNA 241142G14 gene,

nucleolar protein (KKE/D repeat)

591
3822
AA900863

DNA segment, Chr 17, human D6S81E 1,
g, General

ESTs, Highly similar to S33681 translation

initiation factor eIF-4A.I [H. sapiens], HLA-B

associated transcript 1, Human clone 23933

mRNA sequence, eukaryotic translation

initiation factor 4A, isoform 1, mitochondrial

DEAD-box polypeptide 28, nuclear RNA

helicase, DECD variant of DEAD box family

592
2729
AI170363

d

593
19282
AA955123

General

594
21740
AI176810

General

595
23773
AA956476

General

596
6843
AI009768

f

597
14840
AI237698

General

598
20038
AA899797

c, General

599
18541
X14671

ESTs, Highly similar to RL26_HUMAN 6S
e, h

RIBOSOMAL PROTEIN L26 [H. sapiens],

ESTs, Highly similar to S33713 ribosomal

protein L26, cytosolic [H. sapiens], ESTs,

Weakly similar to 6S RIBOSOMAL PROTEIN

L26 [R. norvegicus], ribosomal protein L26,

ribosomal protein L26 pseudogene 1

600
13966
AI231421

d, General

601
17234
AI102741
tissue inhibitor of
tissue inhibitor of metalloproteinase 3, tissue
h

metalloproteinase 3,
inhibitor of metalloproteinase 3 (Sorsby fundus

tissue inhibitor of
dystrophy, pseudoinflammatory)

metalloproteinase 3

(Sorsby fundus

dystrophy,

pseudoinflammatory)

602
22544
AA851245

apoptosis-associated speck-like protein
General

containing a CARD, death effector filament-

forming Ced-4-like apoptosis protein,

hypothetical protein PP144, tumor up-regulated

CARD-containing antagonist of caspase nine

603
13023
AI233740

Aldehyde reductase 1 (low Km aldose
General

reductase) (5.8 kb Pstl fragment, probably the

functional gene), EST, Highly similar to Aldose

Reductase (E.C.1.1.1.21) [H. sapiens], ESTs,

Moderately similar to ALDOSE REDUCTASE

[R. norvegicus], ESTs, Moderately similar to

ALDOSE REDUCTASE-RELATED PROTEIN 2

[M. musculus], Homo sapiens, Similar to RIKEN

cDNA 11118J12 gene, clone IMAGE: 3865164,

mRNA, partial cds, RIKEN cDNA 2315E1 gene,

aldo-keto reductase family 1, member A4

(aldehyde reductase), aldo-keto reductase

family 1, member B1 (aldose reductase), aldo-

keto reductase family 1, member B1 (aldose

reductase), aldo-keto reductase family 1,

member B3 (aldose reductase), fibroblast

growth factor regulated protein

604
24209
AI172423

i, General

605
23626
AA955540

General

606
4670
AI233714

h

607
18215
AA943367

h

608
3014
AI176362

c, General

609
16756
AA818089

glycyl-tRNA synthetase
General

610
22605
AA859447

i

611
5283
AF090113

ESTs, Highly similar to T32733 AMPA
h

glutamate receptor interacting protein GRIP -

rat [R. norvegicus], Glutamate receptor

interacting protein, KIAA1365 protein, Lin-7b

protein; likely ortholog of mouse LIN-7B;

mammalian LIN-7 protein 2, Mus musculus

grip1 mRNA for glutamate receptor interacting

protein 1a-L, complete cds, Vertebrate LIN7

homolog 1, Tax interaction protein 33, channel-

interacting PDZ domain protein, discs, large

(Drosophila) homolog 2 (chapsyn-11), multiple

PDZ domain protein, semaF cytoplasmic

domain associated protein 3, syntaxin binding

protein 4

612
6043
AI059588

g

613
21474
AA851361

d

614
23038
AA900881
branched chain

Homo sapiens
cDNA: FLJ2127 fis, clone
General

aminotransferase 1,
COL1749, branched chain aminotransferase 1,

cytosolic
cytosolic

615
13336
AI237070

a, b,

General

616
3988
AI008546
proteasome (prosome,
EST, Weakly similar to SNHUC8 multicatalytic
d

macropain) subunit, alpha
endopeptidase complex [H. sapiens], ESTs,

type 3, proteasome
Highly similar to PRC8 MOUSE

(prosome, macropain)
PROTEASOME COMPONENT C8

subunit, alpha type, 3
[M. musculus], ESTs, Highly similar to

PROTEASOME COMPONENT C8

[R. norvegicus], ESTs, Weakly similar to

SNHUC8 multicatalytic endopeptidase complex

[H sapiens], proteasome (prosome, macropain)

subunit, alpha type 3, proteasome (prosome,

macropain) subunit, alpha type, 3

617
20823
AI176302

EST, Weakly similar to UBIM_HUMAN
d

UBIQUITIN-LIKE PROTEIN FUBI {SUB 1-74

[H. sapiens], EST, Weakly similar to ubiquitin-

like protein/ribosomal protein S3

[R. norvegicus], Finkel-Biskis-Reilly murine

sarcoma virus (FBR-MuSV) ubiquitously

expressed (fox derived), Finkel-Biskis-Reilly

murine sarcoma virus (FBR-MuSV) ubiquitously

expressed (fox derived); ribosomal protein S3

618
23044
AF034218

RIKEN cDNA 4632428M18 gene,
General

hyaluronidase 1, hyaluronidase 2,

hyaluronoglucosaminidase 1,

hyaluronoglucosaminidase 2,

hyaluronoglucosaminidase 3, sperm adhesion

molecule

619
19013
AI639256

a

620
16124
AI176963

Cbp/p3-interacting transactivator, with Glu/Asp-
c

rich carboxy-terminal domain, 2, Cbp/p3-

interacting transactivator, with Glu/Asp-rich

carboxy-terminal domain, 4, ESTs, Weakly

similar to MRG1_HUMAN MSG-RELATED

PROTEIN 1 [H. sapiens], expressed sequence

AW742964

621
17848
AA900460

T-complex 1, chaperonin containing TCP1,
General

subunit 7 (eta), chaperonin subunit 7 (eta),

expressed sequence AI528772, expressed

sequence AL22769, t-complex 1, t-complex

protein 1

622
19074
AI009391

f

623
3615
AI237645

Homo sapiens
mRNA; cDNA DKFZp434M2227
d, General

(from clone DKFZp434M2227), Homo sapiens

prostate-specific membrane antigen PSM

mRNA, exon 6 alternative splice variant, partial

cds, RIKEN cDNA 26128K12 gene, folate

hydrolase, transferrin receptor, transferrin

receptor (p9, CD71), transferrin receptor 2

624
11387
AA891677

General

625
25765
X89706

General

626
21653
AI237535

General

627
5228
AI233311

General

628
7299
AI013911

H.sapiens
PABII pseudogene, Human DNA
c, d,

sequence from PAC 56B9 on chromosome
General

1q24-1q25. Contains profilin-like pseudogene,

6S ribosomal protein L4 pseudogene RNA

binding protein, ESTs, GSS, Mus musculus

adult male tongue cDNA, RIKEN full-length

enriched library, clone: 23174E15, full insert

sequence, RNA binding motif protein 3, RNA

binding motif protein, X chromosome, RNA

binding motif protein, X chromosome retrogene,

cold inducible RNA-binding protein, testes-

specific heterogenous nuclear

ribonucleoprotein G-T

629
2093
AI102097

General

630
9166
AI137406

protein C receptor, endothelial, protein C
i, General

receptor, endothelial (EPCR)

631
19723
AA818761

General

632
2741
AA963077

General

633
22667
AA945069

General

634
17687
AA799531

a, e

635
23217
AI235953

General

636
12135
AI176418

c

637
19894
AA859581

EST, Highly similar to SPERM-COATING
d

GLYCOPROTEIN PRECURSOR

[R. norvegicus], ESTs, Weakly similar to

JC4131 glioma pathogenesis-related protein

[H. sapiens], Human DNA sequence from clone

RP5-881L22 on chromosome 2 Contains ESTs,

GSSs, STSs and CpG islands. Contains a gene

for a novel protein similar to a trypsin inhibitor

and four other genes for novel proteins, RIKEN

cDNA 18149K24 gene, RIKEN cDNA

241114O14 gene, RIKEN cDNA 923112K8

gene, acidic epididymal glycoprotein 1, acidic

epididymal glycoprotein 2, epididymal

glycoprotein, glioma pathogenesis-related

protein

638
15345
AI171587

h

639
23165
AI231799

Friedreich ataxia region gene X123
General

640
3391
AA998197

General

641
16215
AA874999

protein translocation complex beta
General

642
19086
AA892598

General

643
4725
AA900290

Alpha-2-macroglobulin, ESTs, Moderately
d, General

similar to A2M2 MOUSE MURINOGLOBULIN 2

PRECURSOR [M. musculus], RIKEN cDNA

26137121 gene, alpha-2-macroglobulin, carbon

catabolite repression 4 homolog (S. cerevisiae),

expressed sequence AW456442, pregnancy-

zone protein

644
6727
AI233213

a, g

645
21816
AI231217

EST, Highly similar to S61A RAT PROTEIN
h, General

TRANSPORT PROTEIN SEC61 ALPHA

SUBUNIT [R. norvegicus], ESTs, Highly similar

to S61A RAT PROTEIN TRANSPORT

PROTEIN SEC61 ALPHA SUBUNIT

[R. norvegicus], SEC61, alpha subunit (S.

cerevisiae), SEC61, alpha subunit 2 (S.

cerevisiae), Sec61 alpha form 2, protein

transport protein SEC61 alpha subunit isoform 1

646
2069
AI103616

ESTs, Weakly similar to B Chain B, Crystal
g, i,

Structure Of Rac1 In Complex With The
General

Guanine Nucleotide Exchange Region Of

Tiam1 [H. sapiens], ESTs, Weakly similar to

RAS-RELATED C3 BOTULINUM TOXIN

SUBSTRATE 1 [M. musculus], KIAA717 protein,

KIAA74 gene product, Mus musculus mRNA for

Rac3, complete cds, RAS-related C3 botulinum

substrate 1, RIKEN cDNA 178H16 gene,

aplysia ras-related homolog A2, plysia ras-

related homolog A2, ras homolog gene family,

member A, ras homolog gene family, member

C, ras-related C3 botulinum toxin substrate 1

(rho family, small GTP binding protein Rac1)

647
22717
AI235948

ESTs, Weakly similar to NIDOGEN
e, g

[R. norvegicus], RIKEN cDNA 2945C1 gene,

nidogen (enactin), nidogen 1,

sparc/osteonectin, cwcv and kazal-like domains

proteoglycan 1

648
11205
AI172057

General

649
22498
AA944806

c

650
7192
AI178530

c

651
8058
AA818475

General

652
18800
AI178504

General

653
12376
AI103939

i

654
12695
AI170948

G protein-coupled receptor 4, G protein-coupled
i, General

receptor 65

655
5227
AA925924

f, i,

General

656
7936
AA875495

i, General

657
4491
AA818798

cathepsin Z
General

658
13647
AA892367

EST, Weakly similar to 6S RIBOSOMAL
General

PROTEIN L3 [R. norvegicus], EST, Weakly

similar to I8451 ribosomal protein L3

[H. sapiens], ESTs, Moderately similar to 6S

RIBOSOMAL PROTEIN L3 [R. norvegicus],

ESTs, Moderately similar to I8451 ribosomal

protein L3 [H. sapiens], ESTs, Weakly similar to

RL3 MOUSE 6S RIBOSOMAL PROTEIN L3

[M. musculus], RIKEN cDNA 11157H16 gene,

ribosomal protein L3, ribosomal protein L3-like

659
25716
X61295

e

660
10547
AA800186

General

661
7760
AI030806

b, General

662
16687
AI013553

a

663
24040
AA957422

CD3 antigen, zeta polypeptide, CD3Z antigen,
General

zeta polypeptide (TiT3 complex), Fc fragment

of IgE, high affinity I, receptor for; gamma

polypeptide, Fc receptor, IgE, high affinity I,

gamma polypeptide, expressed sequence

AI573376

664
16154
AI009661

ALL1-fused gene from chromosome 1q
i

665
14390
AI232385

g

666
14651
AI235919

General

667
17289
AA891785

ESTs, Highly similar to ISOCITRATE
b

DEHYDROGENASE [R. norvegicus], Isocitrate

dehydrogenase 1, soluble, isocitrate

dehydrogenase 1 (NADP+), soluble, isocitrate

dehydrogenase 2 (NADP+), mitochondrial

668
12609
AA997486

d, i,

General

669
21657
X61381

ESTs, Moderately similar to S17182 interferon-
b, i,

induced protein 1-8U [H. sapiens], ESTs,
General

Weakly similar to putative haemopoietic

membrane protein [M. musculus], Human DNA

sequence from clone RP4-781L3 on

chromosome 1p34.3-36.11 Contains a

pseudogene similar to IFITM3 (interferon

inducedntransmembrane protein 3 (1-8U)),

STSs and GSSs, RIKEN cDNA 1114C5 gene,

interferon induced transmembrane protein 3 (1-8U),

interferon induced transmembrane protein

3-like, interferon-inducible protein 16

670
5384
AA891041

Jun-B oncogene, jun B proto-oncogene
General

671
5613
AI044850

b

672
16136
AI103983

RIKEN cDNA B43311C9 gene, caspase
General

recruitment domain family, member 6, nucleolar

protein 3 (apoptosis repressor with CARD

domain)

673
23270
AI179601

General

674
14464
AI104848

General

675
6053
AA818655

d

676
19067
AA859663

General

677
22877
AI178819

adrenal gland protein AD-4
General

678
14257
AI230460

MARCKS-like protein, Mus musculus 8 days
e

embryo cDNA, RIKEN full-length enriched

library, clone: 573519L1, full insert sequence,

Myristoylated alanine-rich protein kinase C

substrate, macrophage myristoylated alanine-

rich C kinase substrate, myristoylated alanine

rich protein kinase C substrate, myristoylated

alanine-rich protein kinase C substrate

(MARCKS, 8K-L)

679
5132
AA925342

myomesin 1, myomesin 1 (skelemin) (185 kD),
General

myomesin 2

680
2706
AA965083

General

681
22615
AA945643

f, General

682
13460
AI175375

General

683
8707
AI059707

i, General

684
17948
AA944581

HIV-1 Rev binding protein-like, Rev/Rex
General

activation domain binding protein-related

685
13082
AI136848

a, b

686
16074
AA874874

alcohol dehydrogenase 5, alcohol
f

dehydrogenase 5 (class III), chi polypeptide

687
8861
AI070306

General

688
8594
AI012932

General

689
22311
AI176007

pM5 protein
General

690
24268
AI172281

e

691
9073
AA892273

a, b

692
22423
AA893164

b

693
5550
AI044628

General

694
3895
AA894029

b

695
19069
AA943737
endothelial differentiation
endothelial differentiation sphingolipid G-protein-
General

sphingolipid G-protein-
coupled receptor 1, endothelial differentiation,

coupled receptor 1,
G-protein-coupled receptor 6, endothelial

endothelial differentiation,
differentiation, sphingolipid G-protein-coupled

sphingolipid G-protein-
receptor, 1, endothelial differentiation,

coupled receptor, 1
sphingolipid G-protein-coupled receptor, 3,

endothelial differentiation, sphingolipid G-

protein-coupled receptor, 5, endothelial

differentiation, sphingolipid G-protein-coupled

receptor, 8, sphingosine 1-phosphate receptor

696
22666
AA900974

d, General

697
2852
AI177059

e, General

698
12108
AA848963

a

699
23240
AA893939

Deleted in split-hand/split-foot 1 region, split
i

hand/foot deleted gene 1

700
4161
AI112141

General

701
18272
AA799294

c, e,

General

702
23612
AI170751

General

703
4790
AA900875

Cbp/p3-interacting transactivator, with Glu/Asp-
General

rich carboxy-terminal domain, 1, Cbp/p3-

interacting transactivator, with Glu/Asp-rich

carboxy-terminal domain, 2, Cbp/p3-interacting

transactivator, with Glu/Asp-rich carboxy-

terminal domain, 4, expressed sequence

AW742964

704
16168
AA893280

RIKEN cDNA 1312C15 gene, RIKEN cDNA
General

23176L9 gene, adipose differentiation related

protein, adipose differentiation-related protein

705
11644
AI235282

EST, Moderately similar to S25111 alpha-2-
General

macroglobulin receptor precursor - mouse

[M. musculus], ESTs, Highly similar to S25111

alpha-2-macroglobulin receptor precursor -

mouse [M. musculus], low density lipoprotein

receptor-related protein 1, low density

lipoprotein-related protein 1 (alpha-2-

macroglobulin receptor), low density lipoprotein-

related protein 1B (deleted in tumors)

706
19057
AI235094

Homo sapiens
cDNA FLJ13271 fis, clone
General

OVARC11, Homo sapiens, Similar to cortactin

isoform B, clone MGC: 3591 IMAGE: 3637586,

mRNA, complete cds, Mus musculus, Similar to

cortactin isoform B, clone MGC: 18474

IMAGE: 3981559, mRNA, complete cds,

R.norvegicus
myr3 mRNA for myosin I heavy

chain, RIKEN cDNA 2312N23 gene, RIKEN

cDNA 91323P14 gene, cortactin, ems1

sequence (mammary tumor and squamous cell

carcinoma-associated (p8/85 src substrate),

myosin IE

707
9501
AI638949

a

708
24310
AA924578

e, General

709
1283
U61729

DNA segment, Chr 4, Brigham & Women's
General

Genetics 593 expressed, ESTs, Moderately

similar to JC4899 proline rich protein - rat

[R. norvegicus], RIKEN cDNA 6111E17 gene,

hypothetical protein FLJ2312, proline-rich

protein with nuclear targeting signal

710
7681
AI030449

General

711
1439
U57391

General

712
20872
X51707
ribosomal protein S19
EST, Moderately similar to 4S RIBOSOMAL
f

PROTEIN S19 [R. norvegicus], EST, Weakly

similar to RS19_HUMAN 4S RIBOSOMAL

PROTEIN S19 [H. sapiens], ribosomal protein

S19

713
21660
AI169751

ESTs, Moderately similar to S17182 interferon-
b, General

induced protein 1-8U [H. sapiens], ESTs,

Weakly similar to putative haemopoietic

membrane protein [M. musculus], Human DNA

sequence from clone RP4-781L3 on

chromosome 1p34.3-36.11 Contains a

pseudogene similar to IFITM3 (interferon

inducedntransmembrane protein 3 (1-8U)),

STSs and GSSs, RIKEN cDNA 1114C5 gene,

interferon induced transmembrane protein 3 (1-8U),

interferon induced transmembrane protein

3-like, interferon-inducible protein 16

714
19454
AA998888

Mus musculus
adult male stomach cDNA,
f

RIKEN full-length enriched library,

clone: 22118M5, full insert sequence, expressed

sequence AI8352, fibronectin type 3 and SPRY

domain-containing protein, midline 1, midline 1

(Opitz/BBB syndrome), midline 2, ring finger

protein 28

715
12979
AI169177

immediate early response 3
General

716
5675
AI045026

General

717
17903
AI231083

d, General

718
6743
AI231219

d, General

719
23538
AI102727

solute carrier family 2 (phosphate transporter),
General

member 1, solute carrier family 2 (phosphate

transporter), member 2, solute carrier family 2,

member 1, solute carrier family 2, member 2

720
20617
X53581

e

721
19416
AA850244

General

722
16191
AA874982

c

723
8745
AI069939

d

724
14494
AI234222

g

725
22681
AA944413

General

726
21579
AI103572

General

727
23978
AA925352

h, General

728
25742
X80130

a, b, c

729
14458
AI145095

General

730
6172
AA819646

General

731
1998
AA817864

b

732
25545
S77900

c

733
12999
AI176276

Homo sapiens
cDNA FLJ1257 fis, clone
d

NT2RM4895, UDP-N-acteylglucosamine

pyrophosphorylase 1

734
1159
AA891949

g, General

735
18907
AI178971

EST, Moderately similar to HART1 hemoglobin
a, b,

alpha-1 chain - rat [R. norvegicus], EST, Weakly
General

similar to A45964 hemoglobin alpha chain -

mouse [M. musculus], ESTs, Moderately similar

to HART1 hemoglobin alpha-1 chain - rat

[R. norvegicus], Hemoglobin, alpha 1,

hemoglobin alpha, adult chain 1, hemoglobin,

alpha 1, hemoglobin, alpha 2

736
25647
U83119

e

737
17892
AI228438

a

738
18447
AA849939

b, General

401
18473
AI168975

General

739
4222
AA860024

EST, Moderately similar to EF1G_HUMAN
General

ELONGATION FACTOR 1-GAMMA

[H. sapiens], ESTs, Highly similar to

EF1G_HUMAN ELONGATION FACTOR 1-

GAMMA [H. sapiens], Homo sapiens cDNA

FLJ11216 fis, clone PLACE182, eukaryotic

translation elongation factor 1 gamma

740
15197
AI105444

General

741
22958
AI171374

d, General

742
9111
AI073176

makorin, ring finger protein, 1, makorin, ring
General

finger protein, 2, makorin, ring finger protein, 3,

makorin, ring finger protein, 4

743
23110
AI169640

d

744
20998
AA799803

EST, Moderately similar to MAS2_HUMAN
General

MANNAN-BINDING LECTIN SERINE

PROTEASE 2 PRECURSOR [H. sapiens],

Rattus norvegicus
mRNA for serine protease,

complete cds, complement C1r-like proteinase

precursor, complement component 1, r

subcomponent, complement component 1, s

subcomponent, protein C

745
23184
AI176554

d

746
14149
AA998172

platelet-activating factor acetylhydrolase,
i

isoform 1b, alpha2 subunit, platelet-activating

factor acetylhydrolase, isoform lb, beta subunit

(3 kD)

747
23816
AA956596

e

748
8494
AI059968

i, General

749
21841
AA996499

EST, Weakly similar to C1QA_HUMAN
b, General

COMPLEMENT C1Q SUBCOMPONENT, A

CHAIN PRECURSO [H. sapiens], complement

component 1, q subcomponent, alpha

polypeptide, complement component 1, q

subcomponent, beta polypeptide, expressed

sequence AI255395, expressed sequence

AI385742

750
19765
AI230945

d

751
6002
AA818101

b

752
21945
AI104132

e

753
4496
AA892400

i

754
12921
AI112636

Homo sapiens
BAC clone RP11-335J18 from 2,
General

RIKEN cDNA 17124F2 gene, expressed

sequence AI325217, uridine phosphorylase

755
14516
AI013197

e

756
11504
AI171652

General

757
3698
AI172193

e

758
5886
AI045807

General

759
4154
AI009467

General

760
4330
AA818747

c, General

390
16597
AI102486

DNA segment, Chr 7, ERATO Doi 486,
General

expressed, EST, Weakly similar to S37583

RING finger protein rfp - mouse [M. musculus],

expressed sequence AI894158, expressed

sequence AW46487, hypothetical gene

MGC1127

761
15191
AI176456

ESTs, Moderately similar to AF78844 1 hqp376
General

protein [H. sapiens], expressed sequence

AA49533

762
10654
AI235991

f

763
14341
AI227596

General

764
22915
AI228299

a, c,

General

765
6638
AI137579

c, General

766
25250
D10706

h

767
24072
AI231093

e

768
15628
AI230338

EST AI31731, EST, Weakly similar to R3HU16
General

ribosomal protein S16, cytosolic [H. sapiens],

expressed sequence AA42385, ribosomal

protein S16

769
18831
AI104357

ESTs, Weakly similar to A29861 actin gamma
c, h,

[H. sapiens], ESTs, Weakly similar to I39393
General

alpha-actin [H. sapiens], ESTs, Weakly similar

to S38782 actin beta' chain [H. sapiens], Homo

sapiens
mRNA; cDNA DKFZp434B2115 (from

clone DKFZp434B2115), RIKEN cDNA

1752K15 gene, RIKEN cDNA 1761J2 gene,

actin-like 7a, expressed sequence AL2324,

expressed sequence AV259599, melanoma X-

actin, uncharacterized hypothalamus protein

HARP11

770
8343
AI059502

i

771
7749
AA848804

ESTs, Moderately similar to 167338A
General

transcription factor BTF3a [H. sapiens], ESTs,

Weakly similar to 167338A transcription factor

BTF3a [H. sapiens], Homo sapiens cDNA

FLJ14844 fis, clone PLACE1133, highly similar

to TRANSCRIPTION FACTOR BTF3, RIKEN

cDNA 1754E11 gene, RIKEN cDNA

4632412E9 gene, basic transcription factor 3,

expressed sequence AI316863

772
9984
AA955536

ELL gene (11-19 lysine-rich leukemia gene),
General

ESTs, Weakly similar to ELL MOUSE RNA

POLYMERASE II ELONGATION FACTOR ELL

[M. musculus], Mus musculus, clone

IMAGE: 358397, mRNA, partial cds, Mus

musculus
, clone MGC: 11987 IMAGE: 361737,

mRNA, complete cds, eleven-nineteen lysine-

rich leukemia gene, hypothetical protein

FLJ2279

773
17264
D25233
retinoblastoma 1,
ESTs, Highly similar to RB MOUSE
General

retinoblastoma 1
RETINOBLASTOMA-ASSOCIATED PROTEIN

(including osteosarcoma)
[M. musculus], retinoblastoma 1, retinoblastoma

1 (including osteosarcoma)

774
5356
AI177813

modulator recognition factor I
General

775
8626
AI059449

General

776
2522
AA964957

a

777
6291
AI144797

h

642
19085
AA892598

General

778
18366
AA799442

General

779
1686
AI179971
hemoglobin alpha, adult
EST, Moderately similar to HART1 hemoglobin
b, General

chain 2, hemoglobin,
alpha-1 chain - rat [R. norvegicus], ESTs,

alpha 1
Moderately similar to HART1 hemoglobin alpha-

1 chain - rat [R. norvegicus], RIKEN cDNA

25142H12 gene, hemoglobin alpha, adult chain

1, hemoglobin, alpha 1, hemoglobin, alpha 2

780
20004
AI031036

DNA segment, Chr 3, ERATO Doi 555,
c

expressed, ESTs, Weakly similar to A3521

ferroxidase [R. norvegicus], ESTs, Weakly

similar to CERU MOUSE CERULOPLASMIN

PRECURSOR [M. musculus], ESTs, Weakly

similar to KUHU ferroxidase [H. sapiens],

ceruloplasmin, ceruloplasmin (ferroxidase),

coagulation factor V, coagulation factor VIII,

procoagulant component (hemophilia A),

hephaestin

781
4969
AI113008

f, g,

General

782
6697
AI045340

General

783
13420
AA892042

d, h,

General

784
21527
AA851733

f

785
22017
AA944209

ESTs, Highly similar to PROTO-ONCOGENE
General

SERINE/THREONINE-PROTEIN KINASE PIM-

1 [M. musculus], ESTs, Highly similar to S55333

protein kinase pim-2 [M. musculus], ESTs,

Moderately similar to S55333 protein kinase

pim-2 [M. musculus], Pim-1 oncogene, pim-1

oncogene, pim-2 oncogene, proviral integration

site 1, serine threonine kinase pim3

786
9388
AA894173

b

787
23197
AI172159

General

788
3518
AA944584

b, f

422
18606
X53504

EST, Moderately similar to S35531 ribosomal
e, General

protein L12, cytosolic [H. sapiens], EST, Weakly

similar to 6S RIBOSOMAL PROTEIN L12

[R. norvegicus], hypothetical protein, ribosomal

protein L12

789
23123
AA924794

g, General

790
3081
AA999171
signal transducer and
Signal transducer and activator of transcription
h

activator of transcription
3, expressed sequence AA48197, signal

1, signal transducer and
transducer and activator of transcription 1,

activator of transcription
signal transducer and activator of transcription

1, 91 kD
1, 91 kD, signal transducer and activator of

transcription 2, signal transducer and activator

of transcription 3, signal transducer and

activator of transcription 3 (acute-phase

response factor), signal transducer and

activator of transcription 4

791
17358
AI179147

electron-transfer-flavoprotein, beta polypeptide
e, h

792
2435
AI639411

hypothetical protein
h

793
24651
M83678

RAB13, member RAS oncogene family, RIKEN
b

cDNA 617N3 gene, expressed sequence

AW17754

794
17675
AI137597

f

795
4407
H33528

General

796
4874
AA923850

General

797
16001
AA866452
actin, alpha, cardiac,
EST, Moderately similar to ATHUC actin,
a, b, c, g,

actin, alpha, cardiac
cardiac muscle [H. sapiens], ESTs, Highly
General

muscle
similar to ACTC_HUMAN ACTIN, ALPHA

CARDIA [R. norvegicus], actin, alpha, cardiac,

actin, alpha, cardiac muscle, smooth muscle

alpha-actin

798
18883
AA799992

General

799
10972
AI233956

General

800
1114
AI029917

f

801
15382
AI172302

General

802
15568
AI010257

General

803
10532
AI009602

g, General

804
11873
AI232326

General

805
13161
AI138093

e

806
11485
AI235348

f

807
25689
X52815

g, General

808
1831
AI071137

cell division cycle 25 homolog B (S. cerevisiae),
a, b,

cell division cycle 25 homolog C (S. cerevisiae),
General

cell division cycle 25B, cell division cycle 25C,

expressed sequence AI64853

809
25846
AI638988

General

810
20086
AI013260

g

811
20041
AI112161

i, General

812
18867
D88250

EST, Moderately similar to MAS2_HUMAN
a, b,

MANNAN-BINDING LECTIN SERINE
General

PROTEASE 2 PRECURSOR [H. sapiens], EST,

Weakly similar to JC6554 probable serine

proteinase [R. norvegicus], ESTs, Weakly

similar to JC6554 probable serine proteinase

[R. norvegicus], MASP-2 protein, complement

component 1, r subcomponent, complement

component 1, s subcomponent, mannan-

binding lectin serine protease 1, mannan-

binding lectin serine protease 2

813
7615
AI030163

d

814
23833
AI113026

ESTs, Weakly similar to AGP2_RAT
General

ANGIOPOIETIN-2 (ANG-2) [R. norvegicus],

angiopoietin 1, angiopoietin 2, angiopoietin-like

3, angiopoietin-like 4, angiopoietin-like factor

815
23731
AA894004

ESTs, Highly similar to CAPG MOUSE
f, g,

MACROPHAGE CAPPING PROTEIN
General

[M. musculus], ESTs, Moderately similar to

CAPG MOUSE MACROPHAGE CAPPING

PROTEIN [M. musculus], RIKEN cDNA

573416F2 gene, capping protein (actin

filament), gelsolin-like

816
21400
M36410
sepiapterin reductase,

General

sepiapterin reductase (7, 8

dihydrobiopterin: NADP+

oxidoreductase)

817
20763
AA925516

b

818
15218
AI102495

RIKEN cDNA 1319I21 gene, expressed
General

sequence AL2431, nucleoside phosphorylase,

purine-nucleoside phosphorylase

819
3088
AI013369

c

820
10317
AI172339

General

821
17468
AA892545

d

822
23566
AA955482

Mitochondrial Acyl-CoA Thioesterase, acyl-
General

Coenzyme A thioesterase 2, mitochondrial, acyl

Coenzyme A thioesterase 3, mitochondrial

823
15510
AA875428

g, General

824
17408
AA818971

h

825
16608
AA996840

h

826
15308
AI072896

h

827
7397
AI104244

ATP synthase, H+ transporting, mitochondrial
h

F1 complex, O subunit, ATP synthase, H+

transporting, mitochondrial F1 complex, O

subunit (oligomycin sensitivity conferring

protein), EST, Moderately similar to ATPO RAT

ATP SYNTHASE OLIGOMYCIN SENSITIVITY

CONFERRAL PROTEIN PRECURSOR,

MITOCHONDRIAL [R. norvegicus], EST,

Weakly similar to ATPO RAT ATP SYNTHASE

OLIGOMYCIN SENSITIVITY CONFERRAL

PROTEIN PRECURSOR, MITOCHONDRIAL

[R. norvegicus], ESTs, Highly similar to

ATPO_HUMAN ATP SYNTHASE

OLIGOMYCIN SENSITIVITY CONFERRAL

PROTEIN PRECURSOR, MITOCHONDRIAL

[H. sapiens], ESTs, Moderately similar to

ATPO_HUMAN ATP SYNTHASE

OLIGOMYCIN SENSITIVITY CONFERRAL

PROTEIN PRECURSOR, MITOCHONDRIAL

[H. sapiens], Human DNA sequence from clone

RP4-730D4 on chromosome 20q12 Contains a

pseudogene similar to part of ATP50 (ATP

synthase, H+ transporting, mitochondrial F1

complex, O subunit (oligomycin sensitivity

conferring protein)), an EST, an STS and

GSSs, Mus musculus adult male cerebellum

cDNA, RIKEN full-length enriched library,

clone: 1500031D10, full insert sequence

828
18542
AA893493

ESTs, Highly similar to RL26_HUMAN 6S
e

RIBOSOMAL PROTEIN L26 [H. sapiens],

ESTs, Highly similar to S33713 ribosomal

protein L26, cytosolic [H. sapiens], ESTs,

Weakly similar to 6S RIBOSOMAL PROTEIN

L26 [R. norvegicus], ribosomal protein L26,

ribosomal protein L26 pseudogene 1

829
19094
AI232021

ESTs, Highly similar to Human Translation
e

Initiation Factor Eif1, Nmr, 29 Structures

[H. sapiens], RIKEN cDNA 151M16 gene,

RIKEN cDNA 3111N14 gene, putative

translation initiation factor, suppressor of

initiator codon mutations, related sequence 1

(S. cerevisiae)

830
14449
AI234152

General

831
12096
AA819415

i

832
6135
AA819065

d

833
21785
AI177312

g, General

834
18454
AI231776

General

835
21581
AA944828

c, General

836
15383
AA955358

General

837
16071
AA997821

General

838
16533
AA998174

g, General

839
5950
AI169266

Homo sapiens
cDNA FLJ13819 fis, clone
General

THYRO1452, actin related protein 2/3 complex,

subunit 5 (16 kD), hypothetical protein similar to

actin related protein 2/3 complex, subunit 5

840
15004
AI235224

EST, Moderately similar to TIM1 RAT
f, g,

METALLOPROTEINASE INHIBITOR 1
General

PRECURSOR [R. norvegicus], EST, Weakly

similar to TIM1 RAT METALLOPROTEINASE

INHIBITOR 1 PRECURSOR [R. norvegicus],

tissue inhibitor of metalloproteinase, tissue

inhibitor of metalloproteinase 1 (erythroid

potentiating activity, collagenase inhibitor)

798
18881
AA799992

a, General

841
21185
AI170056

General

842
5049
D10655

ESTs, Weakly similar to ODP2 RAT
e

DIHYDROLIPOAMIDE

ACETYLTRANSFERASE COMPONENT OF

PYRUVATE DEHYDROGENASE COMPLEX

[R. norvegicus], Mus musculus, clone

IMAGE: 3586777, mRNA, partial cds, Pyruvate

dehydrogenase complex, lipoyl-containing

component X; E3-binding protein, RIKEN cDNA

1617E1 gene, RIKEN cDNA 493529O8 gene,

dihydrolipoamide S-acetyltransferase (E2

component of pyruvate dehydrogenase

complex), dihydrolipoamide branched chain

transacylase (E2 component of branched chain

keto acid dehydrogenase complex; maple syrup

urine disease), dihydrolipoamide branched

chain transacylase E2

843
17810
AA799778

ATP synthase, H+ transporting, mitochondrial
i

F complex, subunit b, isoform 1, ATP synthase,

H+ transporting, mitochondrial F complex,

subunit b, isoform 1, ESTs, Moderately similar

to ATPF RAT ATP SYNTHASE B CHAIN,

MITOCHONDRIAL PRECURSOR

[R. norvegicus], expressed sequence C76477

844
10071
AI639058

chromosome 18 open reading frame 1,
i, General

transmembrane, prostate androgen induced

RNA

845
2913
AI232272

General

846
5703
AI045136

i, General

847
3143
AI232408

General

848
10780
AI136555

DC6 protein, DKFZP564O823 protein, ESTs,
g, General

Weakly similar to S24169 mucin - rat

[R. norvegicus], hypothetical protein FLJ13725,

mucin 13, epithelial transmembrane

849
5357
AI179507

b, General

850
18909
AA849426

General

321
22696
AA945996

General

851
9815
AA848218

General

852
20761
AA900331

General

853
18686
D00729
dodecenoyl-Coenzyme A
ESTs, Highly similar to D3D2 RAT 3,2-TRANS-
e, h

delta isomerase (3,2 trans
ENOYL-COA ISOMERASE, MITOCHONDRIAL

enoyl-Coenyme A
PRECURSOR [R. norvegicus], Homo sapiens,

isomerase), dodecenoyl-
Similar to dodecenoyl-Coenzyme A delta

Coenzyme A delta
isomerase (3,2 trans-enoyl-Coenzyme A

isomerase (3,2 trans-
isomerase), clone MGC: 393 IMAGE: 363566,

enoyl-Coenzyme A
mRNA, complete cds, dodecenoyl-Coenzyme A

isomerase)
delta isomerase (3,2 trans.enoyl-Coenyme A

isomerase), dodecenoyl-Coenzyme A delta

isomerase (3,2 trans-enoyl-Coenzyme A

isomerase)

854
2378
AA964501

d

855
17307
H32747

h

856
10837
AI072144

General

857
4130
AA800298

e, f,

General

858
18529
AI230716

g, General

859
7362
AI029026

General

860
2730
AI012962

CAAX box 1, DKFZP564B147 protein, EST,
General

Moderately similar to CXX1_HUMAN CAAX

BOX PROTEIN 1 [H. sapiens]

861
21766
AA850916

General

862
13240
AI169311

d, General

863
12664
AA999110

preferentially expressed antigen in melanoma
General

864
24520
L20869

ESTs, Highly similar to PAP1_HUMAN
General

PANCREATITIS-ASSOCIATED PROTEIN 1

PRECURSOR [H. sapiens], RIKEN cDNA

212L15 gene, expressed sequence AI449515,

pancreatitis-associated protein, regenerating

islet-derived 3 gamma

865
10549
AA801255

General

866
8737
AI071926

h

867
12674
AI235358

ESTs, Moderately similar to UCR2 RAT
a, c

UBIQUINOL-CYTOCHROME C REDUCTASE

COMPLEX CORE PROTEIN 2 PRECURSOR

[R. norvegicus], RIKEN cDNA 15406 gene,

ubiquinol-cytochrome c reductase core protein

II

868
8032
AI058398

f

869
2587
AI232103

General

870
13547
M63983
hypoxanthine guanine
EST, Moderately similar to The Crystal
i

phosphoribosyl
Structure Of Icam-2 {SUB 25-216 [H. sapiens],

transferase, hypoxanthine
ESTs, Weakly similar to HPRT RAT

phosphoribosyltransferas
HYPOXANTHINE-GUANINE

e 1 (Lesch-Nyhan
PHOSPHORIBOSYLTRANSFERASE

syndrome)
[R. norvegicus], HHGP protein, hypoxanthine

guanine phosphoribosyl transferase,

hypoxanthine phosphoribosyltransferase 1

(Lesch-Nyhan syndrome), intercellular

adhesion molecule 2

871
2135
AI010195

General

872
6881
AI010169

General

873
5494
AI044425

General

874
16834
AA963324

d

875
5699
AI045128

ESTs, Highly similar to T5615 hypothetical
General

protein DKFZp761G1515.1 [H. sapiens], protein

kinase, lysine deficient 3, serologically defined

colon cancer antigen 43

876
6282
AA819523

c

877
18598
AI070775

General

878
5297
AI170379

General

879
7867
AI043695

ESTs, Highly similar to PUR1_HUMAN
d

AMIDOPHOSPHORIBOSYLTRANSFERASE

PRECURSOR [H. sapiens], ESTs, Moderately

similar to PUR1_HUMAN

AMIDOPHOSPHORIBOSYLTRANSFERASE

PRECURSOR [H. sapiens], RIKEN cDNA

573454C12 gene, expressed sequence

AA675351, expressed sequence C79945,

glutamine fructose-6-phosphate transaminase

2, glutamine-fructose-6-phosphate

transaminase 2, phosphoribosyl pyrophosphate

amidotransferase

880
6097
AA818929

General

881
10115
AI058890

d

882
3738
AA998256

General

883
9770
AI060016

General

884
18830
AA964496

ESTs, Weakly similar to A29861 actin gamma
g, h

[H. sapiens], ESTs, Weakly similar to I39393
General

alpha-actin [H. sapiens], ESTs, Weakly similar

to S38782 actin beta' chain [H. sapiens], Homo

sapiens
mRNA; cDNA DKFZp434B2115 (from

clone DKFZp434B2115), RIKEN cDNA

1752K15 gene, RIKEN cDNA 1761J2 gene,

actin-like 7a, expressed sequence AL2324,

expressed sequence AV259599, melanoma X-

actin, uncharacterized hypothalamus protein

HARP11

885
7161
AI233407

General

886
19729
AA818910

General

887
15524
D13124

ATP synthase, H+ transporting, mitochondrial F
b

complex, subunit c (subunit 9) isoform 3, ATP

synthase, H+ transporting, mitochondrial F

complex, subunit c (subunit 9), isoform 2,

ESTs, Moderately similar to AT93 MOUSE ATP

SYNTHASE LIPID-BINDING PROTEIN P3

PRECURSOR [M. musculus], RIKEN cDNA

18141M8 gene

888
16679
AI105268

d

889
19184
AI178025

ESTs, Weakly similar to TGIF MOUSE 5′-TG-3′
General

INTERACTING FACTOR [M. musculus], Homo

sapiens
TGF beta-induced transcription factor 2

like mRNA, partial sequence, RIKEN cDNA

54345H2 gene, RIKEN cDNA 573599O9 gene,

TG interacting factor, TGFB-induced factor

(TALE family homeobox), TGFB-induced factor

2 (TALE family homeobox)

890
6015
AA818158

f

891
21659
AI010584

ESTs, Moderately similar to S17182 interferon-
General

induced protein 1-8U [H. sapiens], ESTs,

Weakly similar to putative haemopoietic

membrane protein [M. musculus], Human DNA

sequence from clone RP4-781L3 on

chromosome 1p34.3-36.11 Contains a

pseudogene similar to IFITM3 (interferon

inducedntransmembrane protein 3 (1-8U)),

STSs and GSSs, RIKEN cDNA 1114C5 gene,

interferon induced transmembrane protein 3 (1-

8U), interferon induced transmembrane protein

3-like, interferon-inducible protein 16

892
18612
AI228624
ribosomal protein L29
EST, Moderately similar to 6S RIBOSOMAL
General

PROTEIN L29 [R. norvegicus], EST, Weakly

similar to S65784 ribosomal protein L29,

cytosolic [H. sapiens], ESTs, Highly similar to

S65784 ribosomal protein L29, cytosolic

[H. sapiens], ESTs, Weakly similar to 6S

RIBOSOMAL PROTEIN L29 [M. musculus],

Human DNA sequence from clone RP4-595K12

on chromosome 1p31.2-31.3 Contains a

pseudogene similar to 6S RPL29 (ribosomal

protein L29 (cell surface heparin binding protein

HIP)), a chromosome 1 specific mRNA

(KIAA499), a novel mRNA (KIAA433), ESTs,

STSs, GSSs and a CpG Island, ribosomal

protein L29

893
19291
AA963933

General

732
21583
S77900

EST, Weakly similar to MOHULP myosin
c, General

regulatory light chain, placental [H. sapiens],

ESTs, Moderately similar to MOHULP myosin

regulatory light chain, placental [H. sapiens],

myosin regulatory light chain, myosin, light

polypeptide, regulatory, non-sarcomeric (2 kD)

894
7888
AI233583

Homo sapiens
, clone MGC: 14993
h

IMAGE: 361346, mRNA, complete cds, arginyl-

tRNA synthetase

895
21079
AA800245

Mus musculus
adult male stomach cDNA,
f

RIKEN full-length enriched library,

clone: 22118M5, full insert sequence, expressed

sequence AI8352, fibronectin type 3 and SPRY

domain-containing protein, midline 1, midline 1

(Opitz/BBB syndrome), midline 2, ring finger

protein 28

896
17949
AI011480

HIV-1 Rev binding protein-like, Rev/Rex
g, i

activation domain binding protein-related

897
4089
AI180251

d

898
3823
AI233147

DNA segment, Chr 17, human D6S81E 1,
General

ESTs, Highly similar to 533681 translation

initiation factor elF-4A.I [H. sapiens], HLA-B

associated transcript 1, Human clone 23933

mRNA sequence, eukaryotic translation

initiation factor 4A, isoform 1, mitochondrial

DEAD-box polypeptide 28, nuclear RNA

helicase, DECD variant of DEAD box family

899
17506
AI070068

growth arrest and DNA-damage-inducible 45
General

beta, growth arrest and DNA-damage-inducible,

alpha, growth arrest and DNA-damage-

inducible, beta

900
21667
AI013773

General

901
8919
AI103388

ADP-ribosylation factor 6, ADP-ribosylation
g, i,

factor domain protein 1, 64 kD, ESTs,
General

Moderately similar to S39543 GTP-binding

protein - mouse [M. musculus], RIKEN cDNA

23175M17 gene, RIKEN cDNA 2919I22 gene,

hypothetical protein FLJ22595

902
24064
AA957480

h

903
5902
AI045871

i

904
7913
AI043849

ELL-RELATED RNA POLYMERASE II,
General

ELONGATION FACTOR, ESTs, Highly similar

to ELL2_HUMAN RNA POLYMERASE II

ELONGATION FACTOR ELL2 [H. sapiens],

ESTs, Weakly similar to ELL MOUSE RNA

POLYMERASE II ELONGATION FACTOR ELL

[M. musculus], ESTs, Weakly similar to

ELL2_HUMAN RNA POLYMERASE II

ELONGATION FACTOR ELL2 [H. sapiens],

Mus musculus
, clone IMAGE: 358397, mRNA,

partial cds, Mus musculus, clone MGC: 11987

IMAGE: 361737, mRNA, complete cds, eleven-

nineteen lysine-rich leukemia gene,

hypothetical protein FLJ22637

905
2980
AI177761

CD68 antigen, Lysosomal associated
b

membrane protein 1 (12 kDa), lysosomal

membrane glycoprotein 1, similar to S6841

(cattle) glucose induced gene

906
8477
AI179167

General

907
11203
AA892554

General

908
22150
AA893607

General

909
10185
H33426

g

910
15626
X17665

EST AI31731, EST, Weakly similar to R3HU16
f, h,

ribosomal protein S16, cytosolic [H. sapiens],
General

expressed sequence AA42385, ribosomal

protein S16

911
2096
AI233801

h

912
1809
AA946503

f

913
23501
AA955251

General

914
23927
AA957007

RIKEN cDNA 615A7 gene, glutathione S-
e

transferase M2 (muscle), glutathione S-

transferase M5, glutathione 5-transferase, mu

5, glutathione S-transferase, mu type 3 (Yb3)

915
6205
AI104907

e

916
8822
AI070158

i

917
5754
AA850738

General

918
21822
AI228642

h

919
19075
AI236473

General

920
2361
AA875512

ESTs, Moderately similar to E Chain E, Human
a

Embryonic Gower Ii Carbonmonoxy

Hemoglobin {SUB 2-147 [H. sapiens],

hemoglobin Z, beta-like embryonic chain,

hemoglobin beta chain complex, hemoglobin,

epsilon 1

921
4420
AI171916

g, General

922
3819
AI176209

EST, Weakly similar to 143B_HUMAN 14-3-3
General

PROTEIN BETA/ALPHA [H. sapiens], ESTs,

Highly similar to A Chain A. 14-3-3

ZetaPHOSPHOPEPTIDE COMPLEX

[H. sapiens], makorin, ring finger protein, 3,

stratifin, tyrosine 3-monooxgenase/tryptophan 5

monooxgenase activation protein, beta

polypeptide, tyrosine 3-

monooxygenase/tryptophan 5-monooxygenase

activation protein, zeta polypeptide

923
22042
AA946476

i, General

924
3016
AA818069

a, f

925
22487
AI102578

EST, Highly similar to I49523 Mouse primary
General

response gene B94 mRNA, 3′end - mouse

[M. musculus], Homo sapiens, clone

MGC: 16332 IMAGE: 3842543, mRNA, complete

cds, RIKEN cDNA 129I6 gene, RIKEN cDNA

1613K19 gene, similar to S. cerevisiae Sec6p

and R. norvegicus rsec6, tumor necrosis factor,

alpha-induced protein 2

926
5507
AI176584

General

927
22077
AI177099

General

928
25386
L37970

b

929
13930
AA800613

zinc finger protein 36, zinc finger protein
General

homologous to Zfp-36 in mouse

930
11484
AI179612

General

931
3417
AI012337

ESTs, Weakly similar to NHPX RAT NHP2/RS6
g, General

FAMILY PROTEIN YEL26W HOMOLOG

[R. norvegicus], RIKEN cDNA 24113M7 gene,

non-histone chromosome protein 2 (S.

cerevisiae
)-like 1, nucleolar protein family A,

member 2 (H/ACA small nucleolar RNPs),

sperm specific antigen 1

932
14677
AI234620

c

933
2134
AA894212

a

586
17203
AI171844

ATP synthase, H+ transporting, mitochondrial
b, e

F1 complex, epsilon subunit, RIKEN cDNA

24143G19 gene, expressed sequence AV645

934
13291
AI137286

General

935
22899
AA956555

General

936
19913
AI639155

General

937
1097
AF016296

General

938
4594
Y07704

e, General

939
22146
AA893980

General

940
13382
AI101527

signal recognition particle 19 kD
a, g

941
2399
AI030247

General

942
17644
AA924036

General

943
895
AI009614

General

944
1802
AA817841

c

945
3003
AA997330

d, General

946
9757
AI170693

c

947
23583
AI234819

General

948
8886
AI233766

proteasome (prosome, macropain) activator
f, General

subunit 3 (PA28 gamma; Ki)

949
24185
AA893708

KIAA56 gene product, KIAA144 protein
h

950
22929
AI071578

DNA segment, human D4S114, P311 protein
General

951
18271
AA925267

e

952
3773
AA998356

B-cell CLL/lymphoma 3, molecule possessing
General

ankyrin repeats induced by lipopolysaccharide

(MAIL), homolog of mouse, nuclear factor of

kappa light polypeptide gene enhancer in B-

cells inhibitor, epsilon

953
18108
X62528

EST, Highly similar to 16527A RNase inhibitor
f

[H. sapiens], EST, Moderately similar to RINI

RAT RIBONUCLEASE INHIBITOR

[R. norvegicus], ESTs, Weakly similar to

AF7418 1 MATER protein [M. musculus],

expressed sequence AW546468, expressed

sequence C835, ribonuclease/angiogenin

inhibitor

954
6176
AA819657

a

955
14250
AA799729
phosphodiesterase 4B,
endothelin receptor type A, phosphodiesterase
General

cAMP specific,
1B, Ca2+-calmodulin dependent, 63 kDa,

phosphodiesterase 4B,
phosphodiesterase 4B, cAMP specific,

cAMP-specific (dunce
phosphodiesterase 4B, cAMP-specific (dunce

(Drosophila)-homolog
(Drosophila)-homolog phosphodiesterase E4),

phosphodiesterase E4)
phosphodiesterase 8A, phosphodiesterase 8B,

phosphodiesterase 9A

956
22948
AI105421

d

957
10991
AI104342

b

958
11563
AI102560

a

959
25669
X07314

a, b

960
9277
AI072424

i

961
13467
AI138034

UDP-glucose ceramide glucosyltransferase
General

962
11516
AI103962

h

963
20110
AF071204

KIT ligand, kit ligand, stem cell factor KL-2
b

precursor

964
19320
AA891666
melanoma antigen, family

Homo sapiens
, Similar to neurofilament, heavy
i

D, 1
polypeptide (2 kD), clone MGC: 271

IMAGE: 463424, mRNA, complete cds, MAGE-

E1 protein, MAGEF1 protein, Neurofilament,

heavy polypeptide, RIKEN cDNA 2117K23

gene, RIKEN cDNA 383417A13 gene, General

transcription factor IIH, polypeptide 1 (62 kD

subunit), melanoma antigen, family D, 1,

melanoma antigen, family D, 2, necdin,

neurofilament, heavy polypeptide,

neurofilament, heavy polypeptide (2 kD)

965
13029
AI179391

d, General

966
10348
AI069934

e

967
8495
AI059971

Homo sapiens
(clone NCD18) tumor necrosis
d, g, i,

factor receptor related protein mRNA, complete
General

exon and repeat region, lymphotoxin B

receptor, lymphotoxin beta receptor (TNFR

superfamily, member 3), tumor necrosis factor

receptor superfamily, member 8

968
14968
K02815

ESTs, Moderately similar to S4363 class II
General

histocompatibility antigen RT1-B alpha chain

precursor - rat [R. norvegicus], histocompatibility

2, O region alpha locus, major

histocompatibility complex, class II, DO alpha

969
19358
AI009675

a, b,

General

970
4031
AI176989

a

971
19005
AI175875

d

972
21661
AI176479

ESTs, Moderately similar to S17182 interferon-
b, f,

induced protein 1-8U [H. sapiens], ESTs,
General

Weakly similar to putative haemopoietic

membrane protein [M. musculus], Human DNA

sequence from clone RP4-781L3 on

chromosome 1p34.3-36.11 Contains a

pseudogene similar to IFITM3 (interferon

inducedntransmembrane protein 3 (1-8U)),

STSs and GSSs, RIKEN cDNA 1114C5 gene,

interferon induced transmembrane protein 3 (1-8U),

interferon induced transmembrane protein

3-like, interferon-inducible protein 16

973
13596
U90261

Arg/Abl-interacting protein ArgBP2, EST,
c, h

Weakly similar to JC5583 85K SH3 domain-

containing proline-rich protein - mouse

[M. musculus], ESTs, Moderately similar to

T1418 SH3-containing protein p415 - rat

[R. norvegicus], Homo sapiens, clone MGC: 212

IMAGE: 36777, mRNA, complete cds, Mus

musculus
betaPix-d mRNA, complete cds,

Pak3 binding protein, RIKEN cDNA 1738J6

gene, RIKEN cDNA 2123O3 gene, SH3-domain

kinase binding protein 1

974
11724
AI102812

a, b,

General

975
2042
AI101921

General

976
25632
U75405

e

977
10227
AI102248

h, General

978
7224
AI009820

h

979
2131
AI171091

h

980
20055
AI230762

ESTs, Weakly similar to CALPONIN, ACIDIC
General

ISOFORM [R. norvegicus], Human DNA

sequence from clone RP1-9E21 on

chromosome 1q24-25 Contains a pseudogene

similar to calponin, a novel mRNA (clone

25151), STSs, GSSs and a CpG Island, RIKEN

cDNA 1614M3 gene, acidic calponin, calponin

2, calponin 3, acidic

981
18897
AA875207
hemoglobin beta chain

d

complex, hemoglobin,

beta

982
18468
AA859966

Homo sapiens
cDNA FLJ14666 fis, clone
General

NT2RP23, weakly similar to TUMOR

NECROSIS FACTOR, ALPHA-INDUCED

PROTEIN 1, Homo sapiens polymerase delta-

interacting protein 1 mRNA, complete cds,

MSTP28 protein, tumor necrosis factor, alpha-

induced protein 1 (endothelial)

983
22820
AA848315

GMPR2 for guanosine monophosphate
General

reductase isolog, IMP (inosine monophosphate)

dehydrogenase 2, RIKEN cDNA 2314P21

gene, RIKEN cDNA 573544D12 gene,

expressed sequence AA95985, guanosine

monophosphate reductase, inosine 5′-

phosphate dehydrogenase 2

984
17901
AA944355

General

985
8305
AI111695

a

986
14842
AI237724

General

26167
AI044866

General

987
10097
AI639425

f, General

988
6861
AI176970

h

989
18859
AA799467

g

990
21510
AA851620

General

991
3561
AB020504

General

992
22898
AA901107

General

993
14668
AI012185

c

994
23035
AA945712

d

995
6330
AI170426

b

996
3808
AI008643

DnaJ (Hsp4) homolog, subfamily B, member 1,
General

DnaJ (Hsp4) homolog, subfamily B, member

12, DnaJ (Hsp4) homolog, subfamily B,

member 4, DnaJ (Hsp4) homolog, subfamily B,

member 5, ESTs, Weakly similar to

HS4L_HUMAN HEAT SHOCK 4 KDA

PROTEIN 1 HOMOLOG [H. sapiens], RIKEN

cDNA 1729A2 gene, RIKEN cDNA 2136G19

gene

997
10334
AI060295

RAB5B, member RAS oncogene family, RIKEN
a

cDNA 3732413A17 gene, expressed sequence

AI663973

998
22762
D89730

EGF-containing fibulin-like extracellular matrix
c, General

protein 1, EGF-containing fibulin-like

extracellular matrix protein 2, EST, Weakly

similar to FBL3_RAT EGF-CONTAINING

FIBULIN-LIKE EXTRACELLULAR MATRIX

PROTEIN 1 PRECURSOR (FIBULIN-3) (FIBL-

3) (T16 PROTEIN) [R. norvegicus], ESTs,

Weakly similar to FBL3_RAT EGF-

CONTAINING FIBULIN-LIKE

EXTRACELLULAR MATRIX PROTEIN 1

PRECURSOR (FIBULIN-3) (FIBL-3) (T16

PROTEIN) [R. norvegicus], epidermal growth

factor-containing fibulin-like extracellular matrix

protein 1, epidermal growth factor-containing

fibulin-like extracellular matrix protein 2

999
15837
AI010411

ESTs, Highly similar to 2819A set gene
g

[R. norvegicus], ESTs, Highly similar to I59377

template activating factor-I, splice form alpha

[H. sapiens], ESTs, Highly similar to

SET_HUMAN SET PROTEIN [H. sapiens],

Human DNA sequence from PAC 3P2 on

chromosome Xq21.1-Xq21.3. Contains set

pseudogene, ESTs and STS, KIAA175 protein,

NADH dehydrogenase (ubiquinone) 1,

subcomplex unknown, 2 (14.5 kD, B14.5b), SET

translocation, SET translocation (myeloid

leukemia-associated)

1000
4169
AI009669

RIKEN cDNA 229H22 gene, membrane-
General

spanning 4-domains, subfamily A, member 1,

membrane-spanning 4-domains, subfamily A,

member 11, membrane-spanning 4-domains,

subfamily A, member 12 4-domains, subfamily

A, member 7, membrane-spanning 4-domains,

subfamily A, member 2 (Fc fragment of IgE,

high affinity I, receptor for; beta polypeptide),

membrane-spanning 4-domains, subfamily A,

member 3 (hematopoietic cell-specific),

membrane-spanning 4-domains, subfamily A,

member 4A, membrane-spanning 4-domains,

subfamily A, member 5, membrane-spanning 4-

domains, subfamily A, member 6A, membrane-

spanning 4-domains, subfamily A, member 8,

testes development-related NYD-SP21

1001
22596
AA955298

General

1002
11483
AF020618

General

1003
17540
AA955914

EST, Highly similar to FBRL MOUSE
General

FIBRILLARIN [M. musculus], EST, Weakly

similar to A38712 fibrillarin [H. sapiens], ESTs,

Highly similar to A38712 fibrillarin [H. sapiens],

ESTs, Weakly similar to FBRL MOUSE

FIBRILLARIN [M. musculus], expressed

sequence AL22665, fibrillarin

1004
26030
M34331

e

1005
15569
Z78279
collagen, type I, alpha 1,
EST, Highly similar to CA1B_HUMAN
c, e

procollagen, type I, alpha 1
COLLAGEN ALPHA 1(XI) CHAIN

PRECURSOR [H. sapiens], EST, Weakly

similar to CA11_HUMAN COLLAGEN ALPHA

1(I) CHAIN PRECURSOR [H. sapiens], EST,

Weakly similar to CA25_HUMAN COLLAGEN

ALPHA 2(V) CHAIN PRECURSO [H. sapiens],

EST, Weakly similar to CGHU1S collagen

alpha 1(I) chain precursor [H. sapiens], ESTs,

Weakly similar to CA11_HUMAN COLLAGEN

ALPHA 1(I) CHAIN PRECURSOR [H. sapiens],

Homo sapiens
cDNA FLJ2845 fis, clone

ADKA191, Homo sapiens mRNA for putative

emu2 protein, collagen, type I, alpha 1

1006
22378
AA944212

General

1007
23155
AA926016

DNA segment, Chr 7, ERATO Doi 486,
i

expressed, EST, Weakly similar to S37583

RING finger protein rfp - mouse [M. musculus],

ESTs, Weakly similar to JE343 terf protein - rat

[R. norvegicus], RING finger protein terf,

expressed sequence AI894158, expressed

sequence AW46487, hypothetical protein

FLJ22638, hypothetical protein MGC16175, ret

finger protein, ret finger protein-like 3 antisense,

tripartite motif protein 11, tripartite motif protein

17

1008
4832
AA800190

ESTs, Moderately similar to 17149A glycogen
General

phosphorylase [H. sapiens], ESTs, Weakly

similar to 17149A glycogen phosphorylase

[H. sapiens], phosphorylase, glycogen; brain

1009
18774
AI010279

a, i

1010
21798
AA926365

CGI-69 protein, EST, Moderately similar to
b

T43493 hypothetical protein DKFZp434C119.1

[H. sapiens], mitochondrial carrier family protein,

mitochondrial solute carrier

1011
3392
AA998205

d

1012
9796
AI071990

General

1013
16314
AA859348

General

1014
2757
AA997851

c, General

1015
4636
AA899491

i

1016
21644
AI179609

General

480
11727
AA849518

d

1017
345
AI059916

Signal transducer and activator of transcription
f

1, signal transducer and activator of

transcription 1, signal transducer and activator

of transcription 1, 91 kD, signal transducer and

activator of transcription 3, signal transducer

and activator of transcription 3 (acute-phase

response factor)

1018
22773
AA859885

c

1019
2767
AA963201

General

1020
22036
AI070141

General

1021
8580
AI060314

c

1022
9362
AI102706

General

1023
10659
AI103059

General

1024
16549
AA892270

a

1025
2254
AI235325

h, General

1026
12366
AI232088

General

1027
20897
AI175812

coatomer protein complex, subunit alpha,
General

embryonic ectoderm development

1028
13270
AI228760

d

1029
12031
AA893860

ESTs, Highly similar to YSHUT threonine-
General

tRNA ligase [H. sapiens], ESTs, Moderately

similar to YSHUT threonine- tRNA ligase

[H. sapiens], hypothetical protein FLJ12528,

threonyl-tRNA synthetase

1030
16859
AI236753

General

1031
6982
AI170793

Down syndrome cell adhesion molecule,
General

RIKEN cDNA 212A2 gene, deleted in colorectal

carcinoma, myopalladin, palladin, putative

neuronal cell adhesion molecule, titin

immunoglobulin domain protein (myotilin)

1032
15518
AI072945

General

1033
8612
AI058527

a, b,

General

1034
14289
AA891838

b

580
22248
AA943537

ajuba, expressed sequence AI48116,
General

expressed sequence R75157, zyxin

1035
12303
AA944786

d

1036
17632
AI102472

c

1037
19722
AI013508

General

1038
15051
AI236332

ESTs, Weakly similar to ATDA_HUMAN
General

DIAMINE ACETYLTRANSFERASE

[H. sapiens], RIKEN cDNA 26116A3 gene,

RIKEN cDNA 49344K22 gene,

spermidine/spermine N1-acetyl transferase,

spermidine/spermine N1-acetyltransferase

1039
7273
AI234712

f

1040
15879
AI228313

General

1041
10020
AI045632

f, General

1042
22432
AI171263

EST, Highly similar to FBRL MOUSE
g, General

FIBRILLARIN [M. musculus], EST, Weakly

similar to A38712 fibrillarin [H. sapiens], ESTs,

Highly similar to A38712 fibrillarin [H. sapiens],

ESTs, Weakly similar to FBRL MOUSE

FIBRILLARIN [M. musculus], expressed

sequence AL22665, fibrillarin

1043
25705
X59375

General

1044
4696
AI237009

c

1045
18673
AA849028

EST, Weakly similar to SNHUC8 multicatalytic
d

endopeptidase complex [H. sapiens], ESTs,

Highly similar to PRC8 MOUSE

PROTEASOME COMPONENT C8

[M. musculus], ESTs, Weakly similar to

SNHUC8 multicatalytic endopeptidase complex

[H. sapiens], proteasome (prosome, macropain)

subunit, alpha type 3, proteasome (prosome,

macropain) subunit, alpha type, 3

1046
13166
AI178736

b

1047
24128
AA849766

DKFZP586E1519 protein
c

1048
24042
AI230002

General

1049
9339
AI101160

General

1050
15190
AI102562

EST, Moderately similar to Cd-7 Metallothionein
General

2 [H. sapiens], EST, Moderately similar to

SMHU1E metallothionein 1E [H. sapiens]
General

1051
3433
AI030339

General

1052
4459
AA891721

General

1053
19012
AI172056

General

1054
2802
D85435

c

1055
14763
AA944481

ESTs, Highly similar to AGP2_RAT
General

ANGIOPOIETIN-2 (ANG-2) [R. norvegicus],

angiopoietin 1, angiopoietin 2, angiopoietin-like

3, angiopoietin-like 4, angiopoietin-like factor

1056
9583
AI071185

d, General

1057
10394
AA943564

General

1058
16821
AA999042

General

1059
3718
AI229643

General

1060
8022
AI058357

General

1061
19840
AA899197

EST, Moderately similar to JH148 nucleolin -
g, General

rat [R. norvegicus], EST, Weakly similar to

NUCL_HUMAN NUCLEOLIN [H. sapiens],

ESTs, Highly similar to FUS_HUMAN RNA-

BINDING PROTEIN FUS [H. sapiens], ESTs,

Highly similar to PAB1_HUMAN

POLYADENYLATE-BINDING PROTEIN 1

[H. sapiens], ESTs, Moderately similar to

PAB1_HUMAN POLYADENYLATE-BINDING

PROTEIN 1 [H. sapiens], ESTs, Moderately

similar to POLYADENYLATE-BINDING

PROTEIN 1 [M. musculus], Mus musculus adult

male testis cDNA, RIKEN full-length enriched

library, clone: 493347N23, full insert sequence,

RIKEN cDNA 493272K14 gene, fusion, derived

from t(12;16) malignant liposarcoma, poly A

binding protein, cytoplasmic 1, poly(A)-binding

protein, cytoplasmic 3, poly(A)-binding protein,

cytoplasmic, pseudogene 2

1062
15215
AI060260

d

1063
8053
AI175033

General

1064
12086
AA801116

c

1065
21447
AI009608

d

1066
4232
AI012958

General

1067
12978
X96437

immediate early response 3
General

1068
1031
AA892863

d

1069
18682
AI059499

Homo sapiens
, Similar to chaperonin containing
h

TCP1, subunit 8 (theta), clone MGC: 1224

IMAGE: 393332, mRNA, complete cds, T-

complex 1, chaperonin containing TCP1,

subunit 8 (theta), chaperonin subunit 8 (theta),

expressed sequence AI528772, potassium

large conductance calcium-activated channel,

subfamily M, beta member 3-like, t-complex 1, t-

complex protein 1

1070
25806
E00898

g

1071
4432
AI101851

d

1072
2997
AI030545

i, General

1073
6936
AI010593

d

1074
11684
AI010917

g, General

1075
804
AI169756

Gene 33/Mig-6, RIKEN cDNA 132F13 gene
General

1076
15192
AI101099

ESTs, Moderately similar to AF78844 1 hqp376
General

protein [H. sapiens], expressed sequence

AA49533

1077
19145
AA964613

f

1078
3887
AA893307

a

1079
13539
AI177280

General

1080
5258
AA926089

DKFZP564B769 protein, ESTs, Weakly similar
d

to T12483 hypothetical protein

DKFZp564B769.1 [H. sapiens], KIAA164 protein

1081
17380
AA799612

ESTs, Highly similar to S17516 hypothetical
h

protein [H. sapiens], ESTs, Highly similar to

UBIQUITIN-CONJUGATING ENZYME E2-17

KD [R. norvegicus], ESTs, Moderately similar to

UBC2_HUMAN UBIQUITIN-CONJUGATING

ENZYME E2-17 KD [H. sapiens], ESTs, Weakly

similar to UBIQUITIN-CONJUGATING

ENZYME E2-17 KD [R. norvegicus], RIKEN

cDNA 26131N2 gene, ubiquitin-conjugating

enzyme E2A (RAD6 homolog), ubiquitin-

conjugating enzyme E2B (RAD6 homolog),

ubiquitin-conjugating enzyme E2B (RAD6

homology), ubiquitin-conjugating enzyme E2C,

ubiquitin-conjugating enzyme E2I, ubiquitin-

conjugating enzyme E2I (homologous to yeast

UBC9)

544
11530
AA799773

EST, Moderately similar to ABP2_HUMAN
i

ENDOTHELIAL ACTIN-BINDING PROTEIN

[H. sapiens], ESTs, Moderately similar to

ABP2_HUMAN ENDOTHELIAL ACTIN-

BINDING PROTEIN [H. sapiens], filamin A,

alpha (actin-binding protein-28), filamin B, beta

(actin-binding protein-278)

1082
8541
AI112310

DKFZP564O92 protein, disrupter of silencing 1
d

1083
15876
AA892582

EST, Highly similar to 6S RIBOSOMAL
e, h

PROTEIN L8 [R. norvegicus], EST, Moderately

similar to 6S RIBOSOMAL PROTEIN L8

[R. norvegicus], EST, Weakly similar to JN923

ribosomal protein L8, cytosolic [H. sapiens],

ESTs, Highly similar to 6S RIBOSOMAL

PROTEIN L8 [R. norvegicus], ESTs, Highly

similar to RL8_HUMAN 6S RIBOSOMAL

PROTEIN L [M. musculus], ESTs, Moderately

similar to RL8_HUMAN 6S RIBOSOMAL

PROTEIN L [M. musculus], expressed

sequence AL2498, ribosomal protein L8

1084
7806
AA818421

General

1085
19011
AI102618

General

1086
8938
AI070590

General

1087
13266
AI172326

General

1088
22765
AI176265

General

1089
22196
U21719

General

1090
6789
AA998207

i, General

1091
1287
AI172299

f, General

1092
13985
AA819429

e

1093
5887
AI179099

biotinidase, vanin 1, vanin 2, vanin 3
b

1094
15189
M11794

General

1095
657
AI010262

colony stimulating factor 2 receptor, beta 1, low-
General

affinity (granulocyte-macrophage), interleukin 4

receptor, interleukin 4 receptor, alpha

1096
14554
U48828

f, i,

General

1097
23096
AA924352

ESTs, Moderately similar to acid phosphatase
a, b

[H. sapiens], LPAP for lysophosphatidic acid

phosphatase, acid phosphatase 6,

lysophosphatidic, expressed sequence

AU22842

1098
7120
AI012393

ESTs, Weakly similar to JE343 terf protein - rat
a, b

[R. norvegicus], RIKEN cDNA 4921519C19

gene, RING finger protein terf, butyrophilin,

subfamily 1, member A1, expressed sequence

AA41499, expressed sequence AI894158,

hypothetical protein FLJ22638, hypothetical

protein MGC16175, ret finger protein, ret finger

protein-like 3 antisense, tripartite motif protein

11, tripartite motif protein 17

1099
13033
AI113076

c

1100
12745
AI011799

a, General

1101
8759
AI237646

General

950
22930
AI071578

DNA segment, human D4S114, P311 protein
e

1102
4490
AA851184

cathepsin Z
General

1103
600
AA800222

c, e

779
1687
AI179971
hemoglobin alpha, adult
EST, Moderately similar to HART1 hemoglobin
a, b,

chain 2, hemoglobin,
alpha-1 chain - rat [R. norvegicus], ESTs,
General

alpha 1
Moderately similar to HART1 hemoglobin alpha-

1 chain - rat [R. norvegicus], RIKEN cDNA

25142H12 gene, hemoglobin alpha, adult chain

1, hemoglobin, alpha 1, hemoglobin, alpha 2

1104
23139
AI180040

d, f

1105
11876
AI009321

General

1106
13568
AA800169

General

1107
25671
X07686

e

1108
2410
AA964589

General

1109
23230
AI236146

d

766
15134
D10706

EST, Moderately similar to I3859 hypothetical
c

protein [H. sapiens], EST, Weakly similar to

I3859 hypothetical protein [H. sapiens], ESTs,

Weakly similar to ORNITHINE

DECARBOXYLASE ANTIZYME [R. norvegicus],

ornithine decarboxylase antizyme, ornithine

decarboxylase antizyme 1, ornithine

decarboxylase antizyme 2

1110
6166
AI136516

General

1111
12066
AA800566

c

684
17947
AA944581

HIV-1 Rev binding protein-like, Rev/Rex
i

activation domain binding protein-related

371
19256
M15562

expressed sequence AI323765,
f, General

histocompatibility 2, class II antigen E alpha,

major histocompatibility complex, class II, DP

alpha 2 (pseudogene), major histocompatibility

complex, class II, DR alpha

1112
23210
H31420

h

1113
5844
AA944367

N-acetylglucosamine-phosphate mutase
General

1114
2992
AI171776

General

1115
8515
AA849917

a, b

1116
21974
AA945769

ESTs, Weakly similar to T43483 translation
a

initiation factor IF-2 homolog [H. sapiens],

hypothetical protein MGC536, novel putative

protein similar to YIL91C yeast hypothetical 84

kD protein from SGA1-KTR7, translation

initiation factor IF2

1117
11896
AA997845

dual-specificity tyrosine-(Y)-phosphorylation
a

regulated kinase 1B, dual-specificity tyrosine-

(Y)-phosphorylation regulated kinase 3, kinase

interacting with leukemia-associated gene

(stathmin)

1118
10820
AI009411

EST, Moderately similar to R3RT3 ribosomal
e, General

protein S3 - rat [R. norvegicus], EST, Weakly

similar to R3RT3 ribosomal protein S3 - rat

[R. norvegicus], hypothetical protein FLJ2359,

ribosomal protein S3

1119
6532
AI234105

General

1120
6274
AA819206

General

1121
23099
AI112365

RIKEN cDNA 2112C16 gene, hypothetical
General

protein FLJ1292, mago-nashi (Drosophila)

homolog, proliferation-associated, mago-nashi

homolog, proliferation-associated (Drosophila)

1122
12898
AI105049

General

1123
22011
AI176212

General

1124
14693
AI234830

General

1125
12107
AI172460

d

1126
3799
AF002281

ESTs, Weakly similar to LIM PROTEIN CLP36
f, General

[R. norvegicus], PDZ and LIM domain 1 (elfin),

PDZ and LIM domain 3, PDZ-LIM protein

mystique, RIKEN cDNA 1113B1 gene, Rattus

norvegicus
LIM-domain protein LMP-1 mRNA,

complete cds, Z-band alternatively spliced PDZ-

motif, alpha-actinin-2-associated LIM protein,

reversion induced LIM gene

1127
14955
AA945750

d

1128
14862
AI236048

f

1129
9317
AI029174

h

1130
24028
AI180239

General

1131
16081
AI179610
heme oxygenase
heme oxygenase (decycling) 1
General

(decycling) 1

1132
25918
AI639204

e

1133
15042
AI179422

General

1134
11242
AI179260

General

1135
18018
D12771
solute carrier family 25
EST, Moderately similar to S3894 ADP, ATP
i

(mitochondrial carrier;
carrier protein T3 [H. sapiens], EST, Weakly

adenine nucleotide
similar to A29132 ADP, ATP carrier protein T2

translocator), member 5
[H. sapiens], ESTs, Moderately similar to

ADT2_HUMAN ADP, ATP CARRIER PROTEIN,

FIBROBLAST ISOFORM [H. sapiens], Mus

musculus
, Similar to CG4995 gene product,

clone MGC: 7958 IMAGE: 358457, mRNA,

complete cds, RIKEN cDNA 136L1 gene,

RIKEN cDNA 493443G12 gene, folate

transporter/carrier, solute carrier family 25

(mitochondrial carrier; adenine nucleotide

translocator), member 5, solute carrier family

25 (mitochondrial carrier; adenine nucleotide

translocator), member 6

1136
6655
AA850688

f

1137
10182
AI176185
FBJ osteosarcoma

General

oncogene, v-fos FBJ

murine osteosarcoma

viral oncogene homolog

1138
20990
AI176509

protein kinase C, nu
i

1139
12118
AA892775
lysozyme, lysozyme
EST, Weakly similar to A Chain A, Mutant
g

(renal amyloidosis)
Human Lysozyme With Foreign N-Terminal

Residues {SUB 18-148 [H. sapiens], EST,

Weakly similar to LYC1 RAT LYSOZYME C,

TYPE 1 PRECURSOR [R. norvegicus], ESTs,

Weakly similar to A Chain A, Mutant Human

Lysozyme With Foreign N-Terminal Residues

{SUB 18-148 [H. sapiens], RIKEN cDNA

1738F2 gene, RIKEN cDNA 9533J23 gene,

lysozyme, lysozyme (renal amyloidosis),

lysozyme homolog

1140
4355
AI103410

General

[0187]

5

TABLE 4

Compound
Time (hrs)
Model Code

Ifosfamide
48, 144
a

Cyclophosphamide
48, 192
b

Minoxidil
24, 360
c

Hydralazine
6
d

BI-QT
168, 336
e

Clenbuterol
6, 24
f

Isoproterenol
3, 6, 24
g

Norepinephrine
3, 6, 24
h

Epinephrine
3, 6, 24
I

General

General

[0188]

6

TABLE 5

GENERAL Attorney Docket No. 44921-5090US

Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

8938
72.49846847
35.616941
32.58413333
33.33534129
70.53453453

19696
61.17825826
20.87718965
41.4072
17.99470437
70.3003003

16448
316.0752853
106.4032634
196.5678667
148.6244308
72.45645646

1638
170.6204204
45.98409061
125.5168
50.68216788
67.8018018

17832
6223.652042
2633.02861
3682.600133
3280.902039
68.69069069

5596
129.2716817
48.34165983
86.29226667
48.08313596
65.53153153

15056
26.02435435
16.4477125
12.2056
15.84966299
65.66366366

1689
11552.76066
4830.350287
7248.0156
6306.417948
66.13813814

14464
151.2832132
63.47873283
100.9436
65.22443435
66.06606607

19913
50.12765766
19.66490555
34.7712
22.36177941
65.66966967

7362
185.6274775
46.43226766
150.2716
47.46886886
67.3993994

19067
51.95087087
25.98485092
31.64626667
22.82603751
65.44144144

7936
80.7251952
20.87755258
64.16906667
25.68788494
68.57057057

21400
122.3365165
36.82117511
93.13653333
43.86216043
66.1021021

14299
53.59687688
14.79619568
43.20906667
14.058604
67.74774775

18907
483.0658559
247.056126
297.2048
251.5669094
65.83183183

25517
188.9551051
94.03518084
115.5454667
105.9832198
67.26726727

1288
67.87501502
23.54663557
51.23253333
24.83954694
65.03303303

23822
337.497988
140.9213721
236.9002667
143.0727342
67.46546547

12613
89.39780781
31.97196903
94.58813333
53.76216973
65.85585586

22995
346.6827628
122.2171839
263.3754667
129.50731
66.15015015

18366
97.31693694
24.44041591
81.6344
24.11334744
66.94894895

4874
129.3038438
50.3843815
96.86506667
57.67563452
65.73573574

10547
26.3566967
11.08758866
19.384
11.36075476
65.81381381

11663
109.3640841
39.98991383
83.52146667
48.6847472
65.15315315

23099
113.1338438
62.46411954
156.8176
48.00433316
68.78078078

17285
246.9660661
68.23201281
208.7148
75.2358579
67.2012012

20975
157.1995195
37.21790724
135.5798667
44.41549326
66.33633634

3615
296.4857958
139.717057
216.0168
157.8900781
65.73573574

25469
3875.094264
1933.847909
3281.065067
2846.942639
66.13813814

18400
37.38276276
13.28625502
32.34986667
16.79435664
65.73573574

3561
62.44954955
35.76106582
45.69293333
34.03616518
65.30930931

6509
1.827387387
29.44622307
28.80293333
31.81768541
70.87087087

9111
110.7656757
44.35117669
68.14826667
53.68408666
68.28828829

12462
135.381021
42.97715274
97.76493333
48.98317153
68.5045045

1845
72.01876877
75.85335582
2.699866667
86.41553255
67.43543544

8594
243.5170571
68.45132346
302.068
77.87824043
68.25225225

4652
236.917958
75.80952172
175.702
90.61425001
65.36936937

2730
1383.565465
317.1048745
1138.2416
336.7685506
65.63363363

8919
219.293994
50.3691595
258.7578667
67.28264037
67.12312312

21185
595.4060961
186.9327029
474.0896
194.2886934
67.73573574

1831
212.2755556
76.52515314
152.4144
105.3498365
69.27327327

2997
80.00204204
28.71912254
59.6192
35.59476247
67.40540541

18909
1671.732853
392.4116077
1384.6024
451.8576469
66.53453453

26167
134.7165165
47.59463132
126.3729333
81.03451486
65.57357357

11865
65.93768769
16.95174622
61.7544
27.42951484
67.33933934

1283
107.8844745
35.04454514
97.00293333
52.32959867
65.40540541

14842
111.2535736
38.17357051
101.8753333
56.75867104
68.69069069

17264
30.31930931
10.9046027
24.5472
11.79646747
66.9009009

16092
369.1881381
133.2415014
383.0384
197.2260892
65.20720721

16001
6956.653874
4429.730358
7700.967467
5339.923013
65.97597598

385
53.32657658
20.34513196
24.41373333
19.32565245
81.59159159

6166
352.6468168
103.7327299
247.1990667
126.8492915
65.62162162

5132
1110.373213
230.1370785
886.4596
241.8634169
69.63363363

15727
49.35342342
15.34697312
35.6312
15.48039719
68.6006006

11403
−4.132762763
101.6886382
84.9084
109.9803583
66.55255255

4861
171.4952252
48.73056765
124.3810667
61.74762146
71.03903904

19282
−42.65402402
87.74398555
28.23106667
110.6660663
67.53753754

15383
79.91810811
30.652448
55.4604
38.95519784
65.003003

16071
140.2272372
49.35971496
109.4429333
72.91664278
65.33933934

17848
194.3432132
58.06606118
212.2409333
95.04139603
65.14114114

15628
106.193964
53.66420537
72.38413333
59.12261967
66.30630631

24886
1398.435015
383.9561012
1510.2572
582.9668179
66.00600601

3417
444.3617417
120.8043364
467.0837333
177.560328
65.20720721

18456
237.4204805
102.3981852
224.7922667
142.9449073
65.12312312

22711
219.0362462
49.22663825
165.8392
51.01685608
67.65165165

23773
252.4870571
83.55121918
334.7781333
82.8740413
69.58558559

22697
464.0506607
145.4066285
294.1353333
193.0841828
69.83783784

20776
69.56924925
16.97614522
55.06893333
19.69728055
66.12012012

22696
319.6695495
111.2920825
215.6545333
149.7528706
67.55555556

11684
180.4317718
53.62509097
134.8041333
81.03253826
67.63963964

4154
192.7478979
68.26975549
218.1085333
125.7269822
66.55855856

19291
26.68984985
16.60798861
34.80786667
29.24204855
67.95795796

3214
33.65321321
14.5901984
44.16
15.92048791
65.53753754

19781
55.21522523
26.60262402
59.48026667
47.15136707
65.35735736

13568
117.4451952
31.74744654
98.47613333
43.88527614
65.95795796

24107
111.7821622
27.76698092
105.1286667
43.0198754
69.44144144

2399
54.42369369
18.87054417
60.1316
30.20835042
65.48948949

12988
19.73492492
13.43661964
26.04933333
19.45953385
66.54054054

8612
44.25837838
26.76734752
43.31693333
38.46574605
67.50750751

20073
46.95612613
18.37152689
24.33906667
21.00683603
69.77177177

23409
784.9057357
234.5443921
514.8028
285.4738576
70.12012012

23566
202.5740541
51.57262868
247.5364
59.10443706
69.40540541

23833
3.16003003
19.1547679
20.5952
22.24789892
68.13813814

1349
63.36246246
18.54507329
46.76426667
23.6663677
66.82282282

1571
171.1223724
44.14656407
192.9042667
83.37646024
70.34234234

4459
51.14861862
18.05307097
35.30733333
21.06236097
67.38738739

14554
108.7731832
30.90475217
92.1288
53.21609427
70.19219219

19255
249.8988288
94.46639357
172.4934667
136.1692967
68.02402402

4355
116.2907207
41.25938907
132.4930667
69.32780921
65.42342342

14380
369.6702402
106.6646804
314.9093333
190.0506953
67.95795796

18447
689.994955
154.965744
665.2398667
273.6720581
65.59159159

9658
91.44114114
56.37854523
108.8808
80.81962342
66.74474474

10394
127.6029429
33.74101819
144.1212
59.26738732
69.95795796

2984
820.9295796
296.6266834
642.7485333
398.8418716
66.55855856

23187
382.4496697
84.05252115
338.7626667
132.5344805
65.12312312

14651
22.97741742
11.88799972
35.14666667
13.31225358
68.24024024

15556
773.6088288
170.1184709
580.3448
207.3705142
68.13813814

15929
226.1643844
73.67163957
298.5917333
109.9870393
65.95795796

22378
258.03
61.21775049
199.0550667
82.91016084
67.20720721

14184
219.4502703
100.3089978
265.0389333
189.0891682
66.24024024

6568
113.7420721
37.12194787
112.3276
67.20321817
67.22522523

26148
46.32885886
31.16904645
24.33973333
47.28917355
65.20720721

3143
327.6772973
85.34914028
265.438
130.1184031
65.27327327

3405
255.8100601
72.91699692
279.1788
114.8346427
65.89189189

2135
113.2241441
48.6776077
128.3670667
102.1457422
68.42642643

4594
101.8178679
36.76081853
64.6076
43.38325041
69.15315315

17320
193.7527027
56.48179636
216.2656
109.0445704
67.24324324

12946
214.3218919
48.7516373
169.7182667
64.40548158
67.63963964

5005
64.97573574
17.07035037
50.6384
24.06437257
66.24024024

2587
128.6519219
49.02276069
138.8965333
86.68669157
65.22522523

22036
232.5344745
70.13135612
288.1818667
90.96748966
69.42342342

18468
103.6571471
26.34536999
84.50693333
31.75542899
71.20720721

22247
547.1983483
167.2471262
600.6785333
306.5840909
65.50750751

20204
48.7542042
13.12382882
38.2412
18.85018108
67.80780781

18611
1866.745556
561.2759596
1985.5172
989.2441283
66.94294294

6262
833.3602703
209.3539434
667.2974667
262.0166407
66.35435435

24310
300.4368769
92.5559206
292.298
172.1727988
66.39039039

9970
41.8290991
16.71326192
53.35293333
22.98860668
68.10810811

3391
65.42762763
23.17844683
73.84173333
38.98158947
65.95795796

1867
563.8847447
144.4354691
617.586
252.7746934
67.44144144

22762
43.69891892
18.7980068
38.3012
30.06706931
66.10810811

21659
398.0121021
119.1107764
515.552
146.6284508
68.05405405

18406
103.7865465
38.59483955
126.8301333
74.69609428
66.55855856

956
248.7113213
78.1677381
165.5565333
101.821794
70.07207207

5950
310.0055856
91.83088416
333.1805333
170.7325037
66.42642643

2069
325.0245946
80.5912804
387.7393333
143.8666882
74.49249249

23166
106.8232132
27.84324275
111.3249333
53.83331056
67.80780781

6059
133.9323724
37.17657273
119.3445333
63.46730525
68.12612613

9339
169.3109309
44.91784911
188.1286667
84.28460894
67.05705706

1894
153.4639339
62.86198889
182.2790667
111.1631361
66.69069069

6430
155.9801201
68.97035674
183.3576
110.0622628
67.97597598

6044
228.932042
67.60066509
267.0017333
99.42927714
66.64264264

2042
157.1421021
70.75267
179.5984
120.4462597
65.44144144

20897
236.3516517
51.74161557
253.342
85.02425018
65.07507508

20461
93.10510511
26.50362991
60.50453333
31.08815397
72.00600601

24867
48.31201201
15.52563294
32.08106667
25.64892767
66.32432432

17361
97.88654655
33.24848768
63.50213333
42.27341108
66.95495495

13023
39.76930931
17.59981107
55.8428
25.74507088
65.87387387

2936
77.56312312
26.66715017
55.54626667
46.81207412
68.40840841

12195
40.29054054
28.19399017
67.17093333
34.30477164
66.5045045

7308
173.0977477
52.3843028
186.2728
105.4884207
65.97597598

7941
143.4922222
59.61799581
178.7176
114.5027757
72.84084084

3965
1082.078468
215.0078492
885.6898667
264.1772007
65.9039039

16613
104.2170571
30.30979396
75.58706667
43.71236237
68.09009009

20055
203.1345946
98.95872235
239.5048
162.7233699
66.42642643

9984
53.41801802
18.57642971
60.2156
33.93376956
65.74174174

19416
51.55012012
23.65535112
61.37493333
42.65959448
68.66066066

23501
570.5681381
188.6893698
600.8397333
313.8877745
65.39339339

22873
218.6465165
69.42724004
242.9489333
126.1457279
66.25825826

20392
108.1697898
36.74729252
91.06426667
58.95886771
66.12612613

22175
122.7006607
60.73210182
146.3976
102.685777
65.82582583

21644
42.73414414
20.02239798
27.44893333
27.65488167
66.02402402

12609
233.4871171
60.64644968
251.8496
101.0000546
65.97597598

11561
64.27129129
26.06807716
74.09653333
42.81586396
67.07507508

12364
167.1453453
34.88732627
180.3305333
101.9126453
67.11111111

6684
46.39993994
17.61944269
23.29093333
18.45816242
73.88588589

15088
234.1487087
50.98531943
298.5472
66.90284801
67.78978979

22042
80.95408408
64.01668998
134.0318667
71.90333572
70.96096096

10780
170.215015
52.15528635
216.1777333
103.2157802
70.06006006

13310
263.6483183
84.94409905
335.0121333
163.1743769
71.37537538

5867
125.3911411
28.71252609
153.1288
49.53867263
67.89189189

895
52.09792793
31.27119755
61.64933333
63.07948599
66.64264264

25765
69.91843844
15.25861986
53.73533333
20.65170364
70.30630631

8626
50.23366366
26.43575146
73.9184
40.96692697
65.37537538

20684
151.0114114
31.00777899
119.2346667
43.21294705
65.63963964

16546
274.2533333
69.74767882
201.9084
88.68051698
69.47147147

17903
136.4756156
43.38108814
154.49
81.74623287
65.60960961

20229
77.35189189
23.10267263
54.49306667
32.50505615
65.35735736

1687
5403.358649
1841.285364
3390.540933
2737.843207
69.29129129

9362
196.7336637
42.60975263
155.3865333
61.28247745
67.65765766

1097
291.0685886
93.99259964
205.6634667
145.7332274
69.30930931

22820
418.5933934
90.02872862
482.8748
142.1782873
65.22522523

22212
34.41504505
15.89632599
43.12893333
27.91798454
65.90990991

22146
78.36675676
27.69105018
53.51706667
38.33774334
67.63963964

22077
143.718018
57.69355684
155.6457333
99.80830983
65.05705706

8707
196.0183784
48.34247102
207.6557333
89.02444141
66.09009009

7681
78.76585586
32.16112279
91.39706667
50.62460284
66.12612613

8888
61.45741742
24.54918629
31.1132
35.73105445
70.54054054

18109
156.0742042
55.81778773
218.1410667
77.47029568
66.69069069

3982
268.0332132
75.24003617
183.6764
89.5029389
69.40540541

14737
216.4417718
57.2904164
276.9370667
85.0585165
65.07507508

20041
162.7117117
66.1931698
204.4074667
136.2028514
67.30930931

23963
50.19213213
27.25661616
72.6608
34.91346924
66.94294294

23015
76.28105105
21.35348484
84.84493333
42.91649851
66.06006006

12695
3.236666667
31.83601273
33.17786667
47.92099541
66.55855856

6697
72.20354354
25.83488711
97.43946667
34.27944486
66.09009009

8886
149.2603003
27.11847144
162.3432
53.10939425
69.07507508

21391
182.8798198
62.3648526
232.0578667
106.4582716
67.82582583

22544
96.31168168
45.91951934
99.76533333
82.65850379
65.24324324

5886
105.5642342
43.68595668
123.5329333
80.96381669
68.10810811

4093
761.2472372
171.2305171
753.6394667
320.9534796
65.87387387

19722
105.7899099
43.47888541
102.1081333
76.9549177
66.12612613

13772
831.1903303
186.4790627
832.472
347.4316136
65.07507508

6638
170.9305405
46.16586712
153.616
81.14338217
65.74174174

8230
64.91228228
22.10574191
64.138
40.92817014
65.14114114

16130
4786.742523
2836.481592
5484.7164
3926.112296
65.69369369

4790
173.9938438
84.09043096
428.1037333
790.0992435
65.0990991

15840
44.64630631
14.56553354
49.0236
55.86485158
65.42942943

21671
40.08372372
19.31257365
57.3588
54.19357641
65.1951952

10227
887.740991
218.0449747
580.4258667
314.355664
71.57357357

24028
400.1148048
104.0176495
256.5913333
152.1790505
66.77477477

19050
131.9762763
27.51290769
100.1389333
53.45738077
65.45945946

22487
18.75924925
11.45640602
31.10826667
18.85726968
66.79279279

3773
25.65585586
25.17539957
46.98506667
37.82222125
66.37837838

1159
114.0870871
32.96098549
75.41066667
40.31298622
70.95495495

5507
1321.152042
406.4159467
862.4322667
485.470829
68.13813814

15299
94.47942943
57.73406292
114.3178667
92.88693964
67.14714715

18569
1244.146697
488.8296588
1342.794267
1047.069388
68.44444444

23197
242.457027
65.24136019
168.2028
83.99489168
68.88888889

18272
88.60597598
50.87240463
110.8405333
93.53148608
66.29429429

20891
112.2740841
43.6111356
163.6264
66.8717327
68.54054054

20743
156.6083483
23.13382173
127.0229333
38.72581832
73.89189189

18887
193.9248348
38.32142815
153.4470667
56.84990586
71.50750751

4098
118.7078979
56.06679909
151.8290667
105.6281798
72.81081081

17644
473.8572072
88.11026526
382.0854667
151.7742492
65.89189189

2852
468.4916216
156.8990485
296.9326667
204.4010076
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5351
805.1087087
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374.2614004
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5754
311.9932132
90.10901524
379.9041333
150.3765953
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15218
446.0465766
118.9354806
469.6905333
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17226
193.6157658
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11387
65.62636637
19.53063089
48.0472
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12898
1155.093604
326.9983162
920.6853333
556.14818
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13266
88.83081081
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22415
169.1916517
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1714
190.2463664
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7760
332.0363363
68.75841865
237.5545333
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12664
100.1887087
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17541
75.40276276
35.37305084
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11714
688.3123724
141.9171508
511.8988
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70.57657658

12752
18.40444444
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29.5148
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1218
70.99513514
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4420
459.2146847
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1287
642.0570571
156.8171393
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4832
820.3085586
203.9557534
592.4816
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1324
540.7645045
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431.7101333
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21660
1799.216336
582.415201
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16756
124.3146246
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13539
74.31735736
27.19784127
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3959
386.8933934
90.70995601
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13647
546.5458559
171.8763562
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297.5909747
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21510
412.0168468
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11724
117.5545045
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13336
363.4029129
111.7914019
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18278
3944.232192
998.8950354
2938.5136
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65.85585586

7580
252.0656456
66.83673414
269.3414667
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12274
118.6513213
43.99173734
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4161
50.6696997
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11375
99.21636637
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20038
196.8626126
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11205
384.3533333
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318.15
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23217
808.4991592
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640.1121333
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5844
33.20618619
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9770
46.44246246
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3207
253.0190991
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23033
536.1412613
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15935
81.22621622
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18581
215.9942042
55.20408872
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14337
322.3194294
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257.1765333
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22691
1075.303183
228.9954085
784.5778667
424.8754518
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10878
1385.995916
414.8758472
1866.4344
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5356
−5.118978979
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66.85885886

8861
29.17072072
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65.45945946

10097
124.147988
26.54127344
93.0952
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3822
673.761982
186.9080741
872.1389333
350.816601
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15568
246.6630631
83.93584731
297.0686667
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16597
658.9440541
130.1613616
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21785
90.4812012
32.50010122
110.3524
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66.51051051

14458
41.40780781
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68.64264264

14397
66.74069069
45.47819109
118.4668
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65.20720721

11504
544.7894294
138.227504
406.5510667
256.3281666
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20582
473.1648348
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386.0477333
141.7973162
67.24324324

25846
78.24933934
23.01624996
51.4856
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15786
92.55792793
39.70677047
133.7984
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69.82582583

20915
361.9305706
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280.1098667
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4710
138.5577477
40.89817673
145.0194667
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65.45945946

18726
117.1451351
35.4755811
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63.49358782
66.42642643

9353
179.7312012
43.05211274
133.356
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66.02402402

18454
77.9424024
21.87075514
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67.82582583

7749
1094.882583
214.8318019
1330.865067
358.0804114
73.09309309

19379
369.4203303
68.83430484
388.168
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66.12612613

6632
118.8854655
42.29574415
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65.30930931

23596
319.7261261
76.98365859
257.4506667
138.4931514
65.00900901

17101
402.5251952
84.47841158
358.5670667
168.1087789
66.04204204

17901
306.0611712
61.0008545
354.7029333
111.765356
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5458
152.2901201
57.22131483
202.6198667
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11218
123.8714715
39.88322913
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66.39136006
66.62462462

5703
186.4057357
57.53155348
215.8356
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66.12612613

5969
447.1866967
131.1009133
443.3448
238.403989
65.90990991

14256
281.3109309
55.06653776
309.9438667
100.9660491
65.30930931

21583
378.1696697
104.8760736
296.7974667
186.0371966
69.59159159

13966
95.99645646
29.92445819
103.2432
57.73805872
65.59159159

15281
121.7892492
31.12274069
127.6637333
61.30898267
66.92492492

15879
203.2204805
53.26954563
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66.85885886

20839
1313.201411
381.4093254
1380.0756
720.1580309
66.21021021

958
116.6435736
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65.20720721

16847
968.6696396
266.3889987
1007.937333
502.0256491
65.00900901

6562
83.82294294
22.0288454
69.6552
35.19942849
66.51051051

23854
639.7981982
186.0579446
1106.001067
835.6522508
66.78078078

6431
85.04474474
33.9730999
112.5750667
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66.22822823

1439
263.1485586
44.01928161
206.8229333
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65.62762763

8495
119.0903604
32.55673471
165.8949333
64.95183826
70.66066066

1754
185.4703604
46.72545297
120.4281333
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73.85585586

19298
311.8326126
101.6730563
432.0438667
159.034197
68.22822823

20983
430.2093994
86.98985623
324.0536
160.9977404
66.57657658

15708
−2.214954955
17.56851948
21.55906667
29.04976049
68.12612613

11738
309.9483183
60.96372833
254.6993333
128.5746206
65.39339339

25730
216.6359159
52.68303932
220.2433333
124.4837884
68.87687688

16721
416.0622222
85.01057014
336.1954667
146.7998256
66.14414414

4222
862.0381682
176.5955454
841.7009333
394.791692
65.11111111

23978
161.4975075
32.00206436
124.3706667
60.97444
69.22522523

22248
377.2372372
120.7632366
484.9410667
239.3602421
65.90990991

17948
104.0551652
43.81607287
158.1704
73.64095512
68.70870871

1760
188.8481081
39.96338126
143.2396
56.35055556
66.77477477

22011
73.38075075
21.79957488
95.94973333
34.24838903
65.39339339

18800
50.7418018
28.55545096
75.78813333
54.26756691
65.60960961

16596
304.4108408
85.19455004
207.3538667
135.8143346
67.22522523

22596
61.19957958
21.32527899
69.88026667
43.86778542
66.52852853

21661
1069.555405
352.3216968
1334.385067
717.4373056
74.14414414

23270
157.5835135
49.86066962
189.7304
110.3524169
67.90990991

18612
101.4829429
29.32672384
110.9098667
60.75506965
65.39339339

14968
266.143003
78.1768716
182.1364
125.6208288
67.45945946

17329
309.0369369
106.691949
348.3042667
228.0234129
66.79279279

15558
262.0998198
56.66623661
250.9046667
117.1831148
66.79279279

23464
160.2329129
44.51031583
195.8149333
81.59754346
67.67567568

16918
1413.133213
460.8671011
1629.528533
964.4253086
67.59159159

17394
317.0911712
90.98244545
362.8506667
173.2022245
70.57657658

18313
2157.747387
789.8817749
2653.856667
1515.939988
74.81081081

11039
503.3321021
157.1580278
481.8897333
308.5116227
65.74174174

22150
156.7123123
42.50597598
161.4842667
85.18488354
68.77477477

12639
1460.773393
444.0930486
1532.136267
827.6481876
65.84384384

22552
452.1078979
128.6560655
397.0625333
223.6136537
65.72372372

18713
213.5248048
45.86269132
316.8322667
181.996688
66.0960961

6217
49.97828829
17.40052541
70.66093333
60.18859693
68.22822823

11484
43.83453453
33.19740784
98.62786667
90.02330089
65.57957958

22898
81.10201201
32.79572472
122.5690667
102.3056384
68.82882883

6789
472.1047748
73.2765577
396.8628
231.7026096
67.26126126

19086
76.89486486
21.62493249
94.3248
62.04318693
68.52852853

4232
177.7873273
83.58675137
201.4142667
182.0039652
65.44744745

24520
56.30951952
29.47547907
75.4008
68.456624
66.46246246

13029
196.834024
70.15560213
267.1646667
203.5623949
73.04504505

24237
217.5224324
82.75251167
302.9657333
199.4963587
65.47747748

17847
1113.351321
201.1117315
812.0026667
380.90747
68.51051051

25567
77.7403003
27.1627134
93.72613333
72.91970052
67.56156156

15510
272.4407808
55.22298509
200.1338667
99.88071575
67.17717718

11876
62.22171171
19.88087401
72.2732
47.79009971
66.21021021

13467
51.40810811
25.57745758
81.73026667
41.97561251
67.45945946

4130
249.0733634
69.7014771
158.9117333
109.0187202
67.95795796

7414
283.2390991
52.04591174
327.2016
105.3800878
67.09309309

2555
54.72588589
21.23393369
64.0644
46.62585561
70.74474474

10020
100.8382583
47.24575942
135.8046667
70.65937512
66.0960961

14185
436.7817417
182.2642932
549.93
410.4846216
68.62462462

22877
64.27474474
20.36443332
86.88
33.84910454
66.10810811

6532
474.2814414
113.5953258
580.0912
242.3604877
69.45945946

20313
35.65138138
14.1217306
20.53386667
19.15284637
67.97597598

1435
846.9484985
157.1005438
908.9862667
348.3857446
67.02702703

18744
101.0285285
27.59011635
108.8517333
62.28678176
68.55855856

8212
461.3372673
118.7607732
517.1966667
237.3930463
67.69369369

2913
723.989039
143.8207512
640.2332
269.3334688
65.00900901

21311
173.7901201
38.25513248
175.5097333
80.92387205
68.19219219

3278
83.38897898
34.32457211
172.1812
217.7508072
67.44744745

23276
864.8205706
125.0984636
866.9262667
382.9781801
66.44444444

19710
50.87462462
21.10533047
74.98946667
44.87698519
67.34534535

10532
57.90630631
19.90646746
87.9208
39.20180911
69.11111111

18797
95.17507508
48.29428804
156.7506667
96.37476132
65.90990991

20735
109.1551952
37.54872752
142.3949333
84.04939678
68.21021021

15277
757.2586486
119.9808792
772.7332
288.8291533
65.75975976

1686
115.4446847
148.2121685
126.2946667
331.9836149
67.32732733

20056
160.4448949
27.21506574
126.5577333
51.13005332
67.14114114

8597
157.2614114
34.24367592
183.6321333
76.66422264
69.00900901

24375
100.4056456
31.10670046
119.3706667
65.09911537
70.89489489

19069
402.5671772
120.7772574
499.0681333
256.026845
67.90990991

9815
78.68213213
21.46012066
74.7772
45.70091798
66.06006006

15365
1052.608979
246.8184515
1075.352133
560.3357167
67.60960961

6097
10.70741742
19.10787732
30.47386667
31.40837855
65.89189189

3819
184.0441742
53.0645961
189.8553333
116.8066017
67.54354354

4330
499.2403604
146.4246876
445.0722667
325.0491692
70.34234234

22796
40.27414414
17.36701142
58.12186667
29.99494889
67.37537538

19256
418.5910511
122.8042598
305.5228
209.8678472
72.66066066

23523
185.5400901
50.98658976
199.4593333
101.4936327
68.72672673

25689
1086.230781
330.8253231
1171.6916
684.1791479
69.37537538

8665
372.092973
137.4462761
624.3146667
937.9525293
67.38138138

23538
61.26486486
25.00630833
138.8268
167.9882378
65.08108108

15867
39.75294294
27.36145508
78.18026667
129.9322765
68.4984985

2153
211.6812312
59.63630688
333.5897333
329.2563808
65.5975976

21351
15.94681682
17.28550647
52.00893333
75.78061318
65.36336336

5357
23.81036036
13.3662107
45.72693333
55.65476952
66.54654655

4626
30.00354354
26.99813854
76.3696
88.61559315
67.51351351

3905
99.72459459
59.91890871
203.3474667
170.4065695
66.97897898

3808
492.6752553
142.0629658
603.0476
412.3249868
65.72972973

20193
11.44021021
14.63339473
31.99226667
27.42250706
66.56456456

19031
226.5542042
80.71764495
316.426
261.0315285
69.64564565

11203
48.56756757
15.08008286
70.0172
38.56319302
67.11111111

4490
72.03528529
74.96309352
158.0234667
146.7958664
65.72972973

16859
82.11129129
31.38637404
115.0214667
85.19712603
66.89489489

15518
363.7106907
72.93920813
316.3657333
200.8114001
69.34534535

5550
20.18411411
12.63553326
38.39026667
27.0406112
66.66066066

14989
637.2671471
135.4981746
654.208
329.2529091
68.82882883

22899
37.78258258
29.93899336
56.64346667
65.64725464
69.72972973

1514
219.8367568
52.39364439
221.7862667
127.4380644
65.84384384

3437
100.6198198
26.50625625
129.4196
63.31158428
72.14414414

22017
170.6417417
151.2467146
328.8046667
203.913878
67.71171171

8494
468.2971772
92.6200257
451.1066667
237.8252614
68.29429429

6743
1114.827808
214.5651039
921.2714667
440.2561661
65.11111111

5227
134.3546547
45.77664557
174.9353333
104.6009944
76.96096096

2767
32.35042042
36.14976138
45.7332
81.02978982
67.62762763

24783
147.3642342
35.36879761
112.6877333
56.06313294
65.7957958

14693
17.43990991
13.55657195
29.88053333
29.68700712
70.87687688

22915
128.6723123
32.54275983
143.9506667
69.03744709
66.51051051

2254
191.3588288
40.96615757
191.9765333
95.34089695
65.39339339

22689
17.02327327
10.95011976
26.6544
21.30223001
65.39339339

3014
224.8988288
56.86046275
155.4037333
104.1163236
73.45945946

2242
175.0172673
84.92653403
219.9044
174.5829997
69.26126126

11152
189.5948649
59.08901035
224.5426667
128.3708172
70.51051051

14117
1323.556096
231.1844794
1069.146933
350.1422127
66.40840841

8829
256.9392192
64.59833933
273.9869333
136.6482686
65.67567568

24042
110.1422523
35.33224916
122.708
74.49565322
69.60960961

19840
1389.296787
364.2648838
1418.3772
705.7096386
68.66066066

17107
3085.335195
786.4229829
3162.925067
1656.771851
65.90990991

3431
521.6373874
133.7542256
587.462
279.2035761
69.37537538

6100
1733.87003
500.8862283
1813.900533
971.1778472
68.04204204

4169
15.23216216
13.79962699
65.66466667
101.0717607
65.53153153

20761
40.35207207
22.88404336
74.42493333
75.27113246
65.42942943

8053
158.3908408
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8314
37.74684685
20.62061151
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13251
24.79555556
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56.8832
48.20654526
67.71171171

19057
37.59798799
26.6987731
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18598
2.265165165
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22681
290.1493994
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5699
474.8620721
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4944
97.85765766
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18654
225.9345946
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1748
13.15117117
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19723
110.8291592
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11644
240.3689189
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17100
1169.730811
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15642
244.0573273
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8085
90.8796997
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2341
214.7996096
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19544
877.0103003
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24246
259.5653754
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7471
174.3034535
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24634
16.77540541
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355
6.891771772
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23165
143.0078679
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14341
13.8921021
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18715
141.1687688
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12366
41.18138138
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13646
539.8878378
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21592
124.7615015
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23964
78.86081081
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18472
62.04138138
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18507
526.0994595
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680.3916
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3433
847.1170571
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1110.959467
924.250964
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20944
395.7508108
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14449
61.24468468
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13929
104.2424925
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18172
49.80393393
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3669
26.48882883
18.05107279
29.7056
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21975
171.0662462
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3191
158.8891892
42.30405855
215.4716
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15197
339.3753453
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250.0181333
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18217
124.8142042
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138.7856
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6172
21.8966967
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9059
261.9566066
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360.6361333
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5193
1921.493814
375.9558746
1838.5492
938.8969967
66.87687688

19012
415.4101201
102.7400568
488.3222667
259.8339431
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10972
179.3564865
58.78370918
255.3004
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6274
356.3527327
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20998
284.8785586
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21816
256.1336937
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2093
329.9577477
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5622
201.8865465
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18529
298.7122222
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815
1294.80985
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1445.012
797.6685248
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12031
81.85009009
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10549
20.88075075
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19949
84.83585586
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19729
98.26867868
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22958
222.3516216
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332.0626667
184.4991397
67.21321321

22196
53.36306306
18.57336843
48.3064
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67.42942943

16080
11.52768769
28.05513739
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22675
34.77126126
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3817
170.7467267
54.41675831
253.9452
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20868
56.04309309
26.6401069
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50.53188746
65.77777778

21632
199.0260961
70.73366374
277.3632
210.302496
72.52852853

5228
13.29966967
35.9860809
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73.81005446
66.29429429

18695
33.05660661
35.62163487
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23998
33.52453453
15.11942669
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16394
799.7536336
252.3122848
919.6201333
622.9247718
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2539
16.97189189
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4407
78.10762763
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18473
214.0645946
63.96883025
268.3337333
138.6580163
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17563
1512.565075
336.0712844
1552.276933
788.9080025
67.99399399

3430
113.1247748
24.63319195
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15626
1559.982192
392.9104244
1587.424667
857.0575602
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12921
193.4437838
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123.8728695
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18883
65.9106006
19.09173712
346.6489333
638.9246984
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19075
112.8835736
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134.2096951
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18881
19.10243243
7.86572788
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24272
9.686756757
22.75875573
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100.2345994
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1893
331.2993994
138.696175
619.7997333
519.3306369
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6438
27.83207207
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7168
−1.737027027
19.39544478
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15192
60.8587988
29.37339287
111.5484
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5186
58.5721021
24.67471847
105.746
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15841
45.80051051
15.16607716
71.3828
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10659
119.6529129
40.63333371
180.052
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65.11111111

8012
23.92666667
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23123
291.002042
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3823
367.4383483
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473.9110667
191.4850628
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5461
107.45003
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152.7890667
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13005
20.45213213
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9796
3.506786787
12.46437314
24.92586667
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18867
175.3500601
45.30841723
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3941
162.8698198
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6585
671.153994
331.4712674
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751.7989804
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18389
686.5324925
327.0174426
1031.984133
716.273277
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3799
347.6641742
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421.5834667
235.3294566
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17
102.115015
51.55145585
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23732
283.160991
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363.3473333
280.470972
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8022
11.01855856
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3434
782.4078679
306.6851584
974.8838667
741.4375723
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18831
2653.003964
594.2303789
2892.579333
1600.98895
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15729
29.23543544
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8058
313.8185285
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320.8578667
155.8802739
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18606
755.4990991
177.0235611
787.5954667
439.0702126
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23612
135.0208408
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5482
298.6487688
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23645
85.75402402
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7913
38.34870871
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106.9607276
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12978
74.58318318
19.9642456
118.052
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3718
27.41858859
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61.1336
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10837
72.48654655
25.13861801
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66.46246246

21682
−19.73867868
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26.7004
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68.82882883

19658
8.038738739
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28.9032
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65.94594595

2310
34.66915916
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12583
25.53441441
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25.2762214
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16168
183.7095495
39.71588486
223.3278667
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67.42942943

17950
39.89375375
17.03772996
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71.06306306

21667
25.55798799
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71.84384384

11483
105.6160961
33.39285637
140.626
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21766
102.3873874
30.78764276
154.6985333
60.50836756
68.51051051

17485
37.34957958
18.51871628
41.9596
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66.74474474

6548
223.351982
64.71562964
309.3073333
182.737113
71.34534535

16136
111.0614114
38.38598665
168.1841333
92.55572117
67.62762763

23013
312.8023423
67.22989834
314.1472
191.3850765
68.74474474

11708
656.2660961
100.9917709
672.7158667
295.123462
66.29429429

23583
55.02069069
15.34138636
67.3188
41.45032967
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21581
574.5948649
100.9941053
585.4786667
247.833259
65.71171171

21709
251.0371772
46.08494762
304.7734667
105.6013574
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23731
156.557988
34.90185251
178.8264
93.8952906
74.59459459

21443
211.1505105
55.24450794
252.3273333
130.5721587
69.47747748

10820
2016.868679
394.8495465
2134.5488
916.5400649
66.42642643

6226
180.9392192
56.11190149
208.4389333
126.2274074
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6881
187.4048048
36.38697325
541.9369333
770.4809513
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15540
50.16471471
19.80763612
125.0138667
146.3339
67.81381381

16053
104.7786486
40.36047993
203.0978667
222.8617765
65.38138138

11258
9.338348348
12.8288048
46.81333333
66.06550364
65.21321321

6102
34.6881982
14.54131359
67.62853333
59.94280266
65.06306306

2992
32.3545045
14.84118742
72.47946667
60.57864843
69.57957958

16312
62.09135135
18.03624356
105.7618667
84.27319098
73.72972973

21579
89.67822823
30.10965619
156.6705333
114.2049362
66.46246246

21514
51.22918919
17.14684899
86.27786667
58.87843485
66.6966967

13619
126.2540541
35.20172348
165.5262667
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66.97897898

7161
37.29990991
14.33737399
64.94226667
34.29983416
66.61261261

2410
17.10996997
9.41125795
24.29386667
32.68288621
70.18018018

7806
32.89921922
12.13507758
51.75133333
33.42676074
66.31231231

20035
160.8397898
51.06549667
231.2181333
153.5927743
71.94594595

16
1215.400871
271.7923445
1738.301333
669.9464909
71.1951952

18095
851.0671171
114.9507612
826.31
360.5139865
69.27927928

21165
26.14231231
19.68375564
62.034
45.32615008
69.11111111

23632
117.9095495
35.38523686
145.4554667
107.2681995
68.46246246

20869
65.51135135
31.29957449
121.7910667
62.82875419
70.37837838

24040
367.1426426
108.9136658
462.4882667
299.6696857
70.31231231

2706
445.8896396
93.42872356
418.4548
256.4528316
68.82882883

13460
339.8782282
58.70581576
244.3704
90.92216048
71.30930931

17540
338.986006
101.9061709
406.9857333
274.3575698
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2757
855.6433033
177.028321
1118.036
404.6706488
70.14414414

2742
77.8221021
60.84443291
−2.269733333
113.8540968
69.24324324

16982
1.248288288
13.68589859
124.3068
417.5962153
67.76576577

24716
−9.734984985
7.656839278
29.73813333
81.36529343
65.68168168

9452
222.9467267
74.4629772
544.6782667
684.875271
68.28228228

356
32.46015015
31.50629355
134.3224
195.0399764
69.5975976

17506
37.83588589
22.00037604
118.3630667
122.8476271
70.41441441

22626
68.76153153
29.2925403
144.0328
125.3132555
66.1981982

23005
78.15855856
30.11948205
158.4333333
155.1551272
69.2972973

15300
219.4616517
88.68064613
311.8266667
287.0270087
69.68168168

17734
820.2270571
276.7461649
1276.288267
898.5903168
70.91291291

24235
184.918018
49.36407201
273.1097333
144.2502354
66.46246246

2741
28.07504505
16.06701889
47.6888
39.7256073
65.66366366

16314
47.75924925
46.46160475
119.6102667
83.53206694
72.03003003

5494
47.25780781
24.4794228
55.16266667
76.43192798
65.34534535

7299
224.0332733
96.06234119
400.7057333
225.7313284
68.59459459

23044
224.0903604
40.57434413
241.4468
121.4169255
65.86186186

16821
737.4866967
122.45802
776.4358667
364.0221538
66.66066066

15185
836.8953754
182.6575292
876.6856
449.6124882
66.96096096

15283
304.6465165
59.01860559
335.8565333
134.6477232
71.30930931

17104
533.3456156
140.8351573
579.2497333
305.4651559
66.29429429

5675
126.4663664
44.91054543
313.3089333
357.5454003
67.68168168

11873
136.426997
52.38531024
295.0414667
330.1990618
66.1981982

22765
19.95795796
9.841589035
49.7652
48.36528961
66.54654655

17161
196.9924625
63.30941186
344.6728
305.35076
69.5975976

2629
21.25555556
9.303175262
35.06306667
45.76494903
68.03003003

11531
347.5362763
125.6397047
546.3824
512.2328472
68.41441441

10182
14.42633634
45.39196964
99.80266667
141.6511343
65.44744745

5297
208.922012
59.24907417
321.2946667
201.7556369
68.18018018

22667
49.03594595
33.93458508
123.0734667
105.981439
66.24624625

21239
106.1072072
43.32188757
180.5274667
121.9250473
68.61261261

18349
171.9368769
41.29067474
215.8301333
142.6442584
68.82882883

3003
49.46108108
48.66360051
113.7446667
117.8949655
65.64564565

18830
3900.264985
802.5740391
4205.326133
2430.213531
67.26126126

14250
150.0712012
40.36395039
164.3112
114.6934595
66.52852853

16215
215.1935736
46.06168644
201.6325333
109.0627132
65.1951952

23578
302.91997
69.08516771
321.9876
155.9602644
67.77777778

3738
207.3542943
57.37567983
226.4605333
130.4036913
65.02702703

16081
81.31096096
37.49730539
417.8996
776.3912064
68.58258258

567
8.786756757
19.6043637
119.8282667
194.0106893
66.43243243

6982
9.056966967
12.04326158
84.65053333
136.9829322
68.1981982

8759
29.31588589
30.75732946
117.6049333
149.3627949
67.01501502

15382
40.64624625
27.64454786
130.1093333
138.4893887
68.18018018

15212
48.23750751
21.91906398
102.0592
92.55491027
66.26426426

12581
40.43765766
14.53283175
76.5044
64.68039423
69.21321321

15301
86.80627628
47.38871887
143.158
166.8604371
73.31531532

11242
29.36057057
16.46344227
59.1448
57.52839734
69.42942943

17735
872.2572072
315.0601774
1495.168667
967.1088715
68.01201201

20433
63.74864865
21.11187056
93.78546667
72.70130138
74.84684685

9424
294.5164565
73.42587321
375.1704
261.9582482
69.27927928

1609
752.904024
207.8298617
910.3266667
706.5647674
65.12912913

21841
363.3037237
98.73789477
431.2704
274.1229162
66.51051051

19011
558.6072072
112.2070055
604.9225333
312.0176449
69.1951952

13420
394.5314114
82.81294506
420.2732
237.3869261
66.89489489

19085
54.89846847
12.86081694
60.8328
34.85106767
69.11111111

11849
839.1966967
180.5114352
877.4672
435.6222224
66.31231231

25705
330.1517117
76.02852844
373.9126667
179.3556642
71.71171171

23471
68.07546547
27.22670055
350.3384
553.0776103
69.3993994

20449
77.32024024
56.32117764
261.8505333
376.7640297
67.23123123

23626
52.57429429
23.49905084
131.8013333
133.2193841
68.11411411

11114
31.76129129
15.33633558
81.476
83.14401664
70.26426426

5384
39.72459459
30.39866325
108.9032
122.9407092
67.23123123

357
23.45963964
10.14080555
42.20293333
47.2347585
67.57957958

21683
47.01618619
17.95548224
87.94773333
74.53349783
68.91291291

4491
41.94915916
25.39221348
46.314
95.16841592
67.66366366

22197
120.2223123
36.70029871
189.3146667
92.40831407
70.21021021

11153
416.2181682
95.50995272
466.0797333
254.846382
68.96096096

11208
330.6584685
103.4859949
400.4674667
249.141563
70.24624625

25379
185.6321021
40.4422624
201.9674667
102.7164965
66.14414414

19358
2787.216847
870.0544471
1645.817733
1445.279135
70.64264264

1221
4.623993994
6.543957295
162.8805333
351.0642505
69.0990991

244
58.45195195
21.55924157
230.3276
403.0327754
68.13213213

657
213.6305105
44.46268652
438.9708
365.3515242
69.44744745

18597
94.84132132
24.63570978
165.3626667
174.1846481
74.04804805

13930
97.47840841
25.86326313
169.7642667
155.6754159
73.68168168

3050
70.99321321
30.97427774
178.296
152.017052
71.96396396

14840
16.23504505
9.495416923
29.5148
45.54277471
73.2972973

15892
46.68723724
28.17584274
113.8484
106.7604541
70.33033033

19184
16.72972973
15.38497159
42.66706667
53.94375038
67.94594595

13291
158.8336937
36.43992152
190.7336
125.3794767
68.46246246

21653
108.6768168
33.8784464
180.1490667
85.84586661
71.86186186

21740
254.009009
65.86437227
345.4734667
223.7874086
72.82882883

21796
253.457958
76.45052978
344.1602667
201.6813064
77.71171171

4048
6.934114114
28.88749489
109.7854667
203.1293868
69.6996997

4725
67.20492492
45.50835024
196.1262667
241.2131264
66.26426426

12979
283.0270571
69.70681028
474.0812
466.1164226
70.33033033

10317
168.6707207
98.09793834
398.7746667
372.3880631
67.81381381

4969
−27.81138138
29.49309846
39.90693333
109.5442595
66.78078078

22666
64.99294294
29.95874228
132.2769333
77.22446481
72.46246246

24219
270.5740541
56.99366137
310.9173333
195.1191918
70.03003003

9166
58.24063063
36.37848468
115.5628
87.83244861
67.41141141

16533
297.6689489
80.00007371
353.3222667
204.2514635
74.44444444

13240
36.84933934
24.2983443
217.4728
295.2240047
71.01501502

15191
73.55387387
147.0000176
835.7512
1240.522261
68.64864865

22615
38.06543544
38.14715918
179.3072
213.8526855
71.98198198

20589
141.2745946
40.41159864
220.17
222.0598445
66.86486486

21284
11.28018018
11.32357446
42.2628
45.75836649
68.03003003

7700
38.38453453
15.97951121
74.8852
63.58685582
68.11411411

24209
−0.938468468
32.11077523
98.36706667
131.0425901
70.84684685

12745
171.2609309
45.01220927
256.3192
127.4189463
70.31231231

10071
255.8928829
73.65188401
333.818
244.1968914
74.0960961

20740
416.8621321
104.9626061
504.2676
311.2743053
72.37837838

15004
272.1264565
96.15890067
711.5694667
654.1443082
69.98198198

21663
329.2990991
103.8992814
468.7245333
414.0000322
68.04804805

13634
865.2964264
132.9344871
1009.422133
569.5991098
70.97897898

22311
129.7924324
36.03268841
167.8010667
130.8693873
69.57957958

15644
1108.512883
193.4400937
1168.529067
588.9984693
71.71171171

21657
810.1552553
149.7486347
950.3389333
452.1725091
77.34534535

15051
100.5486787
36.5306203
423.4646667
539.2944453
71.83183183

804
48.453003
17.3476378
136.0454667
252.5131317
70.4984985

17477
48.03099099
18.31845744
130.196
122.9390777
73.53153153

9583
63.32945946
23.97049962
156.3501333
138.8519633
70.56456456

806
104.0790991
38.57735781
262.0394667
206.8242271
75.38138138

17736
495.3388889
193.1228301
840.7049333
673.1283815
74.3963964

8477
633.9702102
137.901978
773.1670667
441.5078833
71.27927928

13633
305.4563664
90.26020694
409.7552
276.7145158
70.67867868

11404
95.40525526
25.45018912
124.0573333
81.37672486
75.06306306

23038
12.70459459
31.90466814
123.0434667
144.4113666
75.2972973

22432
117.0051652
32.59966127
143.2058667
83.64197807
68.89489489

21654
195.4411111
36.28835456
269.9418667
198.8356806
71.8978979

15042
39.07891892
31.16281275
133.2384
112.6081482
73.96396396

9423
161.4653153
43.39107869
234.2049333
186.0967937
69.64564565

23869
37.38426426
23.1410014
146.1506667
169.2856008
69.44744745

15189
263.7455856
123.0099327
829.2574667
845.5430688
72.18018018

22677
130.0316817
78.66102337
291.6418667
164.9890655
74.37837838

15190
192.534955
113.543054
768.8886667
843.1346494
68.48048048

14763
15.69915916
55.29195278
160.1976
217.6567383
68.03003003

24200
589.2201201
119.7479072
757.8837333
476.5973886
72.46246246

574
557.0646847
127.5518084
682.7218667
404.188059
76.0960961

1892
982.935015
274.4452657
1255.822533
798.7510893
75.72972973

15003
57.02492492
43.85939442
361.8852
467.3514167
70.43243243

17401
519.3374474
129.24869
1091.634533
771.6544413
72.93093093

3049
237.4652252
63.18596703
414.9229333
350.7621453
76.48048048

5292
80.4015015
36.86776863
190.9689333
128.0774443
73.23123123

22321
153.3996697
50.22365877
299.7406667
179.4179144
75.74774775

6606
1714.972342
475.267636
2441.403733
1648.142289
75.8978979

15002
155.3522823
52.61286866
957.8806667
1185.872821
77.91591592

[0189]

7

TABLE 5A

IFOSFAMIDE Attorney Docket No. 44921-5090US

Timepoint(s): 48, 144 hrs Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

16448
295.3424587
122.9466968
75.04222222
17.90922442
96.9924812

26150
3548.292872
2396.6288611
261.2477778
231.8709164
96.74185464

24012
893.9981198
297.5327424
1533.29
247.1554579
96.49122807

19358
2632.632831
1141.272779
398.9844444
344.5671647
96.11528822

1687
5198.764855
2223.536206
734.3333333
690.6095483
95.98997494

18907
460.9429339
259.0969563
59.24111111
41.11022058
95.73934837

23096
86.6802686
114.0827577
325.1088889
55.08510812
95.36340852

1689
11121.36928
5507.347687
1809.905556
1809.714704
94.98746867

4031
62.98836777
33.23422192
131.4044444
16.31989439
94.61152882

12745
188.7965909
81.83675846
279.2366667
29.31450665
94.61152882

7120
52.7047314
30.78982343
4.4
8.386788718
94.48621554

9073
23.56423554
15.1644237
60.74222222
12.81258442
94.36090226

18881
24.01061983
21.70350112
36.94333333
4.767224035
94.36090226

17832
5911.541281
2981.707879
745.6577778
722.4025935
94.11027569

17883
4401.742872
2443.409704
2660.705556
301.8011314
94.11027569

25517
175.8206612
106.8012091
69.60333333
9.200444283
93.98496241

25742
8347.828905
5377.253327
4622.804444
568.0292832
93.98496241

20859
5611.207438
3111.792163
3360.028889
326.5182489
93.85964912

17687
82.56880165
27.62361939
135.0622222
16.95063625
93.85964912

14981
5912.081136
3450.077362
3177.887778
363.279144
93.60902256

13382
130.2001033
65.68493084
271.6855556
61.41857478
93.60902256

1845
60.05626033
81.65511417
66.3544444444
23.27943788
93.35839599

8515
473.0626033
167.3302597
211.4588889
47.70883551
93.23308271

19518
37.11066116
37.86481857
63.35444444
14.86912751
93.23308271

19013
19.1711157
11.63088946
37.75666667
5.040974608
93.10776942

6727
142.0419628
37.81757964
224.84
31.88848969
93.10776942

8612
48.80396694
32.68228712
1.941111111
8.541677886
93.10776942

13336
342.3178926
143.4507323
164.2811111
43.96638757
92.85714286

1831
201.9417769
86.41174095
73.95777778
27.44454581
92.85714286

21152
6146.16719
3971.973661
3550.796667
411.3731839
92.85714286

17917
156.96514462809
154.714297
108.8144444
67.88608493
92.85714286

16001
7525.862996
4857.843227
3916.177778
472.7264354
92.0651629

460
3364.606777
1604.578237
2261.226667
182.9600171
92.60651629

16687
198.8393802
57.67831435
275.5644444
18.73961053
92.48120301

23157
285.4082645
617.3022225
224.7822222
10.76623167
92.35588972

25669
6222.719731
3227.407969
3764.182222
347.3161204
92.23057644

1169
50.48876033
27.83295948
74.21777778
8.167539069
92.10526316

3016
3592.913471
1785.617911
2301.943333
216.9545399
92.10526316

16274
55.744462809917
47.41495515
141.867777777
25.78003965
91.85463659

24632
52.85609504
18.69125368
82.03666667
14.81684008
91.85463659

11896
55.327334710743
42.34783266
18.16222222
28.27681284
91.85463659

13082
10.859938016528
26.2467805
23.61222222
9.427467552
91.72932331

2522
184.46438016528
111.8533887
46.68888888888
51.38384776
91.72932331

3887
46.36555785
57.74475168
73.69222222
17.93160393
91.72932331

12108
73.58801653
52.40913753
163.39
29.09819754
91.47869674

17541
76.55303719
44.33328287
201.26
71.45394531
91.31161236

20484
5409.051632
3145.685654
3026.711111
370.2778782
91.22807018

2134
65.17946281
18.86782948
95.17666667
11.55191326
91.22807018

15084
176.612562
89.38204501
122.1722222
13.03599227
91.22807018

2361
0.3254958677685
19.51740492
26.99444444444
7.107026648
91.10275689

16549
79.11066116
40.95106431
98.56888889
8.069004654
90.97744361

25469
3999.101715
2264.177054
702.9644444
600.79311881
90.97744361

20735
112.5160124
52.71330364
175.523333
22.133977271
90.85213033

25468
5394.421612
3205.5442951
824.2277778
807.14183881
90.85213033

25439
4434.09407
2841.5371851
2727.964444
324.22106681
90.85213033

449
3119.018574
1522.513541
2215.582222
195.3333825
90.85213033

12674
1727.625393
573.63472451
1266.653333
82.76753817
90.85213033

11563
174.858657
303.62734
214.8022222
29.01315339
90.72681704

18774
66.48446281
31.75449128
114.2411111
16.06167912
90.60150376

6044
231.0816736
76.35066102
348.8511111
57.568058951
90.60150376

1748
14.56117769
12.82988335
49.91333333
22.47527031
90.55973266

14983
6793.828554
4617.087648
3724.592222
430.8225521
90.47619048

22266
284.4200826
89.54957173
384.9488889
72.4625021
90.47619048

3582
107.9265289
49.73139083
139.1611111
15.562306581
89.97493734

9501
122.450186
39.23734565
174.8344444
17.04399242
89.84962406

8305
188.2241322
80.74238021
299.8333333
35.697739421
89.84962406

1321
257.13541322314
246.8321581
336.54
27.19207605
89.72431078

6073
77.30741736
45.53543396
2.547777778
15.49715762
89.47368421

17214
105.1832231
37.14938326
153.9688889
17.60818378
89.47368421

16130
5153.919545
3243.176778
2936.187778
393.2186706
89.34837093

17781
483.679938
99.18061461
610.55
47.74043151
89.22305764

1685
20026.96275
13736.02987
3216.13
2935.386281
89.22305764

11724
106.343719
62.42593547
41.25111111
21.447198211
89.22305764

25051
4810.628574
2521.049129
2890.385556
362.7703017
89.09774436

14982
4946.49657
2696.923427
2752.296667
286.3110091
89.09774436

21974
240.1690289
61.55796238
316.4166667
27.59858828
89.09774436

4011
19.46816116
27.20707326
43.91444444
8.420742413
89.05597327

17728
3421.904587
1622.29565
2250.813333
252.529158
88.97243108

1684
6011.583285
3680.358832
1062.024444
953.8925876
88.97243108

16132
5183.351736
3083.300296
3153.822222
430.5672499
88.97243108

956
234.1724587
94.16687929
134.0722222
31.39964521
88.84711779

16818
161.801095
135.1141994
0.75888888888
18.92479752
88.84711779

21985
53.52345041
19.80522822
93.46555556
21.81963514
88.8053467

22915
127.3294008
42.33833705
209.1655556
47.93496091
88.8053467

18400
34.77673554
14.19749027
54.33
8.082788813
88.59649123

15666
4342.886095
2307.299639
2738.857778
401.0623884
88.59649123

2341
211.188719
84.11933769
328.2733333
52.26430426
88.59649123

25319
7042.756198
4653.236324
3585.176667
527.9172732
88.59649123

1830
90.31886364
49.04982802
26.87222222
15.87381317
88.47117794

19774
88.07989669
142.4449065
182.3022222
57.69461322
88.34586466

18899
55.8539876
45.8862251
69.30555556
7.4076432
88.34586466

17892
480.7777273
340.3353069
90.3
47.72109282
88.34586466

17829
3872.9525
2217.680538
1132.295556
803.6216543
88.34586466

15892
59.0617562
57.20439404
114.7355556
29.46817483
88.17878028

10334
16.015123966942
42.1503708
39.90777778
24.16863814
88.0952381

19421
5009.232851
2685.195976
2845.693333
357.5013906
87.96992481

1688
11130.52589
7196.98987
2484.48
2360.420294
87.96992481

18867
176.6817149
66.61303833
284.2722222
52.36278229
87.92815372

6176
154.8005992
169.3703287
44.49444444
18.01095855
87.84461153

[0190]

8

TABLE 5B

CYCLOPHOSPHAMIDE Attorney Docket No. 44921-5090US

Timepoint(s): 48, 192 hrs Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

26150
3550.217066
2394.035515
157.7688889
162.0784058
98.37092732

25386
24.9310124
36.32254298
−68.57555556
15.60065312
97.86967419

16448
295.9027893
121.8653206
44.90888889
18.08804954
97.7443609

19358
2636.427252
1134.146396
194.9288889
156.5233457
97.11779449

24228
168.861095
40.48597179
333.42
69.01608979
96.86716792

21661
1086.248058
455.9224318
2415.018889
423.7342941
96.86716792

1687
5202.480537
2216.464369
534.5122222
565.4217475
96.49122807

18907
461.2086777
258.6905152
44.95
35.28762283
96.11528822

1686
148.1554959
218.0270589
−201.9277778
67.46000644
96.11528822

1998
40.01597107
38.7933197
71.79555556
9.409961625
95.98997494

1689
11129.27421
5494.666153
1384.795556
1607.871884
95.61403509

20073
43.11921488
19.54197757
−0.895555556
7.625319848
95.23809524

13336
342.4632025
143.3142244
156.4666667
33.10822368
94.98746867

7120
52.70555785
30.79313655
4.355555556
7.29294884
94.98746867

1831
201.9578306
86.42452713
73.09444444
19.2436081
94.61152882

8612
48.78669421
32.71563104
2.87
6.185450671
94.61152882

11724
106.6169008
62.1452118
26.56
13.12789968
94.36090226

1845
60.04539256
81.69007625
−65.77
19.051931
94.36090226

17832
5916.115806
2973.775003
499.65
667.4359424
94.23558897

25468
5399.580888
3198.650731
546.7733333
612.8920215
94.11027569

13082
−10.82754132
26.30571767
21.87
5.790556968
93.98496241

1830
90.50177686
48.82027778
17.03555556
9.656973013
93.98496241

3251
−61.64512397
81.86963205
81.07444444
30.20336451
93.73433584

17917
−156.6332438
155.4144821
90.96555556
42.50735351
93.73433584

4238
318.5010744
99.31434354
473.2188889
45.50499738
93.35839599

16924
284.114814
236.6961766
57.18888889
48.89563898
93.35839599

25742
8356.250227
5370.596207
4169.924444
782.1241441
93.35839599

19255
231.8945248
108.3436072
79.43888889
49.01015238
93.35839599

25517
176.3818595
106.1264971
39.42333333
22.40504017
93.23308271

25469
4003.064938
2258.520949
489.8311111
522.1870591
93.10776942

21841
360.488595
139.5071375
870.68
189.0930325
92.94068505

22697
420.5272727
166.7676437
144.0044444
72.63931375
92.73182957

18695
40.07559917
49.03434584
114.08
27.53621888
92.60651629

18867
173.8182025
55.92279476
438.2655556
131.8203047
92.5647452

6330
160.3402479
54.52644832
240.7866667
22.77017128
92.48120301

1174
−48.14640496
47.57161759
27.14555556
18.43397414
92.43943191

20763
258.8693595
130.0566692
151.8366667
22.57655144
92.35588972

20110
−2.24018595
28.2945376
42.64444444
16.35918863
92.31411863

3518
404.4912397
138.5004293
215.8088889
56.08156971
92.10526316

23033
502.3732438
155.7958596
359.8811111
43.27514975
91.97994987

2980
171.7519215
89.4989369
518.63
180.6041871
91.93817878

17203
2171.309979
878.7260956
1319.43
172.0204484
91.85463659

20859
5610.85407
3111.772817
3379.032222
457.9566721
91.72932331

15966
249.7821694
74.82839403
152.0977778
32.29464343
91.60401003

8515
473.117624
167.1169592
208.5
69.50892694
91.60401003

17883
4402.743079
2442.456899
2606.916667
397.6454441
91.35338346

21211
1538.095062
538.7278117
901.0088889
200.9820645
91.22807018

13310
271.6145661
101.156491
558.1344444
173.5313029
91.0609858

17728
3422.378161
1622.03739
2225.345556
215.6580097
90.97744361

21657
832.9477893
275.7890614
1094.251111
90.77742181
90.85213033

15174
161.2747521
57.93907132
279.3077778
31.29556829
90.81035923

12988
20.65045455
15.46554859
38.92444444
4.434817108
90.72681704

11375
94.3567562
40.54539428
48.32444444
13.41039999
90.72681704

15524
1465.04093
489.2772934
1043.641111
119.2313393
90.60150376

24651
65.80146694
22.37305955
98.52555556
7.582849252
90.60150376

3895
20.64446281
14.16436528
71.39333333
29.04984725
90.55973266

5887
130.3261777
57.18441991
283.29
98.99798344
90.55973266

449
3127.170289
1516.361114
1777.201111
235.8423585
90.47619048

21575
144.471095
44.31940873
212.9177778
21.65509454
90.35087719

21798
1159.905062
287.1257193
702.1577778
174.5795168
90.3091061

25669
6228.35157
3222.530309
3461.314444
489.4610866
90.22556391

6263
206.163843
69.44186843
116.5922222
29.10138518
90.22556391

21660
1806.16876
731.2076053
3494.71
712.7416667
90.18379282

445
44.98719008
18.89067489
67.78777778
8.422898518
90.10025063

13166
3.887975207
35.11781292
42.94333333
16.84001633
90.10025063

25676
210.0928926
171.2011894
50.54333333
45.36792094
89.97493734

1688
11144.47357
7181.274687
1734.404444
1994.331749
89.97493734

17305
3940.808802
1953.453496
2324.277778
192.1924222
89.97493734

14289
34.21475207
17.22421328
60.96444444
13.73651076
89.97493734

1684
6017.427397
3672.839597
747.74111111
796.7840408
89.84962406

6059
132.4696901
43.4127263
60.36111111
13.91325128
89.80785297

23096
86.53258264
113.7166287
333.0511111
61.13002647
89.80785297

16001
7528.734483
4855.212997
3761 .755556
695.9839265
89.72431078

22
116.6855992
93.01095806
193.5
61.61612228
89.47368421

22749
38.73283058
42.66388367
−65.43333333
63.23661657
89.43191312

5357
26.56760331
27.40335928
55.77555556
8.202799996
89.43191312

8597
156.9250207
47.15359875
264.1766667
46.35992558
89.43191312

7308
167.7827273
64.37333882
330.7888889
73.19458458
89.43191312

6002
126.4257851
130.9476267
174.8411111
33.83913579
89.34837093

18447
672.8122521
185.9974265
1110.67
260.403038
89.30659983

9073
23.56169421
15.18098129
60.87888889
11.06225389
89.30659983

5613
164.2440289
58.38802972
92.37111111
18.86019581
89.22305764

20647
17.54665289
13.04689843
49.17444444
14.26841977
88.93065998

22423
93.0628719
51.79439474
203.6655556
63.38365781
88.93065998

17289
2775.794938
1111.145258
1625.054444
320.3537481
88.84711779

10991
460.4735331
153.3327258
812.2366667
192.550642
88.68003342

20433
66.49049587
38.21838922
122.35
37.76470939
88.68003342

5307
42.15944215
100.4921326
51.52222222
5.932277762
88.59649123

21152
6144.862479
3972.39901
3620.961111
607.7025155
88.47117794

344
1165.158781
479.1208035
2218.087778
646.4923876
88.42940685

7760
308.1499587
98.82016401
251.4311111
19.11712874
88.34586466

19257
−19.99838843
37.95188675
33.55777778
22.04014563
88.30409357

16925
861.1141116
256.1801506
441.9555556
152.8097041
88.30409357

[0191]

9

TABLE 5C

MINOXIDIL Attorney Docket No. 44921-5090US

Timepoint(s): 24, 360 hrs Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

22773
437.8067556
113.9173578
770.9766667
186.8354675
96.76616915

14668
52.87129363
22.73990709
112.885
12.59923768
96.64179104

16426
1350.468049
590.2190351
2794.431667
568.1514554
95.89552239

15185
833.5899795
276.3338857
1365.58
220.1438492
94.7761194

21239
120.463306
69.30761948
22.36166667
26.2895199
94.52736318

20740
421.6917864
176.0108843
658.555
67.87724295
93.53233831

1514
218.1905339
120.2409921
350.3033333
76.61980049
93.53233831

22300
807.8076386
277.8860352
1278.253333
336.4332626
93.28358209

5969
440.1926078
161.104246
289.7616667
31.34946342
92.66169154

8580
51.76552361
27.86640474
56.36666667
3.172429143
92.1641791

24128
236.1605133
238.7952892
298.9316667
9.054462804
91.91542289

25094
129.5336345
54.38900928
180.97
12.31225893
91.41791045

15134
1062.092444
298.8329959
1215
76.86737279
91.29353234

22762
41.85238193
21.96300286
16.695
4.829284626
91.16915423

22915
128.4721971
43.93624616
157.3266667
6.991568255
90.7960199

15098
238.0394867
751.9793033
40.31166667
6.580618259
90.67164179

20848
1347.288172
440.8872106
1885.28
179.2055575
90.29850746

15292
68.32913758
25.701704461
38.195
6.108986004
90.29850746

6638
168.8499384
59.642012651
100.725
19.79344715
90.29850746

19480
1688.225893
545.93845291
2041.73
65.26765661
90.17412935

18725
42.04147844
24.15465745
25.46666667
2.55266658
89.30348259

24106
41.35211499
56.74408849
16.57166667
2.102678451
89.17910448

16322
112.6205544
33.29871385
157.76
12.297368821
88.93034826

18047
182.3833881
65.23717287
156.8233333
3.930957475
88.93034826

3088
42.74778234
32.65876885
36.32166667
2.583597621
88.93034826

24536
856.056037
267.7588433
1092.88
78.40703846
88.80597015

13596
1759.77768
617.566612
2637.788333
450.2181273
88.68159204

10829
53.38402464
32.19043564
91.23166667
25.31275285
88.1840796

4749
217.9386653
220.4647071
118.0333333
10.68132326
88.1840796

23596
301.3894251
101.2974417
216.15
32.28049442
88.05970149

23109
722.1644969
230.6924095
993.4616667
57.08507665
87.81094527

21818
39.564846
21.39138776
67.12666667
17.1317304
87.81094527

16312
70.97347023
42.54349354
36.005
8.413006003
87.68656716

18500
257.9291786
65.24252149
417.76
156.6989757
87.68656716

16124
224.9221561
101.6943359
131.69
19.99114204
87.68656716

7063
2777.985873
1129.206637
3441.838333
176.2347945
87.56218905

15569
401.426694
190.4056947
515.0683333
33.01171151
87.43781095

6282
185.8444559
66.66380694
222.7066667
17.68440631
87.43781095

3014
207.0456263
79.85192971
167.0216667
17.48674746
87.31343284

2005
37.20353183
19.95236328
15.27
9.920762068
87.31343284

1609
794.7036756
398.5283242
975.035
83.35706059
87.18905473

17224
1521.834374
458.5879475
1286.183333
91.95915412
87.06467662

7299
268.1671047
158.3330032
287.415
29.82061351
86.8159204

21583
357.890924
134.8922926
649.1816667
148.858798
86.8159204

12674
1706.457515
558.4805731
2754.293333
745.0542962
86.69154229

21581
571.0711704
161.1591653
712.2466667
73.11932649
86.69154229

14983
6631.179507
4479.972588
15391.655
5866.928943
86.69154229

19728
38.61924025
25.9328192
50.46333333
6.484111864
86.56716418

15048
1611.983429
522.4000395
2280.323333
234.5551045
86.44278607

16130
5031.751396
3133.431058
11743.30333
4153.659745
86.44278607

15886
399.6893224
123.6458295
489.11
29.43699373
86.31840796

20038
184.9781314
66.60638817
135.2616667
21.11623017
86.31840796

22498
73.93030801
77.50115096
98.645
15.11319258
86.31840796

17541
78.86632444
48.15834116
75.85166667
8.561437769
86.31840796

25050
4339.285318
2419.508026
9783.871667
2938.951862
86.19402985

16191
20.2310883
14.26758646
4.41
4.338188562
86.19402985

25319
6869.121766
4515.612917
15949.715
5786.841993
86.19402985

17908
47.90513347
39.02335634
14.825
7.884016109
86.19402985

18826
935.1048255
304.215653
683.405
108.4606395
86.06965174

2757
903.1013347
270.6404596
1366.795
213.6819286
86.06965174

4696
238.4688296
90.50570088
214.46
18.47564018
85.94527363

17632
89.20907598
33.46363831
125.705
17.0903935
85.94527363

12086
51.39412731
23.122172
54.58333333
4.50703746
85.94527363

3252
258.1934702
91.63035437
348.4483333
45.97108675
85.69651741

14384
513.7437577
159.8243939
625.8883333
35.06961501
85.69651741

19421
4905.447166
2612.813526
10187.86167
2889.206221
85.69651741

21152
6009.901417
3871.75871
13313.35
3985.438002
85.69651741

15741
278.6177002
91.60974085
198.5683333
40.29901359
85.69651741

14677
40.8373306
19.03190667
33.94833333
2.932817189
85.44776119

25439
4340.748193
2767.496686
9451.473333
3142.022674
85.44776119

25051
4710.8946
2442.685332
10025.33833
2691.144779
85.44776119

18272
93.70318275
63.79624646
56.58
5.891994569
85.32338308

17829
3780.245647
2195.997395
7286.673333
2466.488402
85.19900498

12135
41.10051335
18.68621179
30.72833333
5.003268598
85.19900498

7192
37.9426694
19.2370438
19.48166667
7.447752457
85.07462687

18021
141.865154
49.71003269
104.6766667
14.10675252
85.07462687

13033
81.59747433
28.86269731
101.9116667
14.09055062
84.95024876

8641
286.4467351
108.7810528
206.685
28.50822109
84.95024876

211
324.7765092
106.4010454
351.405
22.32212064
84.95024876

16132
5081.47
3013.732273
10408.45833
3076.016463
84.95024876

25742
8155.523142
5230.123357
18369.11
5977.202401
84.82587065

3682
162.7474127
76.60995297
186.9
12.30250056
84.82587065

20484
5303.545113
3085.010121
10399.15333
3206.107941
84.82587065

16886
1122.859877
543.2204479
1799.311667
394.2385372
84.82587065

18644
3361.113121
1749.187247
6525.706667
2192.432727
84.82587065

25545
386.3327515
254.1459957
516.5216667
112.7519602
84.82587065

9757
562.985462
133.7021905
565.03
25.3630495
84.82587065

18831
2631.251478
977.9807206
3436.33
405.701451
84.82587065

14981
5794.853676
3386.181972
11325.75333
3532.04975
84.70149254

16001
7355.064107
4741.387194
15974.51167
5460.203589
84.57711443

2802
398.1116632
105.2482808
550.6433333
97.96724303
84.57711443

16224
1413.696817
705.4146787
2619.071667
453.1790805
84.57711443

12066
379.866961
109.3099973
512.685
57.09029681
84.45273632

600
302.0152567
62.04587159
263.125
18.47615084
84.45273632

6133
625.038501
196.2520832
823.2183333
78.76218215
84.45273632

20004
39.32911704
20.17920335
71.94833333
20.30710951
84.45273632

[0192]

10

TABLE 5D

HYDRALAZINE Attorney Docket No. 44921-5090US

Timepoint(s): 6 hrs Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

21351
25.28877049
50.01340774
80.7
6.247287411
99.50372208

11728
334.3587705
101.5532665
753.134
68.66121125
99.37965261

13270
149.1222746
73.25022364
476.398
65.59619936
99.25558313

15885
123.8732172
45.22333596
280.744
25.11900934
99.13151365

2416
304.2884631
93.70017094
501.23
5.625997689
99.00744417

6548
229.8347541
94.58230898
694.764
100.4268218
98.75930521

23110
186.4067623
60.6339517
344.77
15.43075176
98.75930521

25567
76.14856557
37.53074352
230.18
33.0816505
98.75930521

11727
291 .7623975
103.4853208
604.39
48.07210054
98.75930521

5258
369.7012705
94.61155347
664.15
45.82124889
98.63523573

3050
90.40352459
81.2674084
228.84
38.57028455
98.63523573

11726
252.4103279
113.6082746
533.508
40.55234297
98.38709677

3601
79.51719262
113.1260376
143.32
14.31897343
98.38709677

22464
108.1432172
46.05567267
278.934
40.19916765
98.38709677

19765
307.5082582
99.80835218
198.27
13.5588071
98.38709677

5129
78.23938525
35.29730289
169.976
12.30108654
98.2630273

7867
65.29440574
53.54378614
248.112
37.43640367
98.2630273

6936
75.82836066
36.41221995
198.006
27.93613484
98.13895782

20735
112.1542623
51.03917009
261.236
24.8571364
98.01488834

2378
53.8614959
22.53663678
129.844
19.37597043
98.01488834

19894
191.3700205
73.43627719
446.052
124.8858075
98.01488834

7299
263.2301025
149.2293008
773.116
120.8479132
98.01488834

7615
24.77413934
27.20961181
91.918
11.35597508
97.89081886

6562
79.63844262
27.10251 284
47.556
3.120437469
97.76674938

6053
7.246311475
11.37850051
36.264
5.106792535
97.76674938

8745
100.6684631
32.79596914
215.862
38.97077007
97.76674938

3003
59.87430328
63.74773452
417.552
106.1544362
97.76674938

23419
209.1499385
112.264608
347.558
37.75746774
97.76674938

6094
94.49360656
45.97738444
223.658
29.8297464
97.76674938

15841
52.45456967
26.02317729
85.158
5.254756893
97.6426799

6743
1056.460881
304.7263469
691.138
71.24019245
97.6426799

6560
261.8389139
76.83317084
432.406
30.29522537
97.6426799

5531
91.45577869
33.33677889
172.85
10.81836864
97.51861042

22614
39.96616803
26.33375601
156.954
73.5844544
97.51861042

12999
358.3752664
406.08666
639.448
135.479653
97.51861042

15212
58.32362705
48.5372259
116.17
20.97174409
97.51861042

20734
99.62717213
46.30310971
247.582
38.20457198
97.51861042

13083
12.19112705
11.35329523
49.166
8.230603259
97.51861042

23139
889.4179303
280.7060842
624.278
26.8757199
97.51861042

23035
125.0278893
44.18525457
245.704
21.65331915
97.39454094

12303
24.63354508
39.92502514
112.714
15.48603338
97.39454094

20901
126.0247131
49.181078
192.442
12.25019877
97.39454094

12609
229.6128689
70.58678004
395.284
29.79925553
97.39454094

17468
63.40719262
14.11477671
41.45
2.517806585
97.39454094

3430
110.9984016
34.42005532
189.106
13.11816794
97.27047146

3615
273.272418
142.0209262
575.834
43.26622967
97.27047146

2729
526.5145902
211.8606837
276.05
17.51608546
97.27047146

3941
178.5560656
73.37835308
380.742
47.43371923
97.27047146

4749
216.1424795
220.4400788
273.36
7.217873648
97.27047146

13240
82.07870902
170.9465173
177.364
78.48562945
97.27047146

22958
242.8463934
113.1769807
375.692
31.51711075
97.27047146

3988
103.0042828
44.78536688
201.586
16.73593828
97.14640199

23230
263.4350205
77.37219894
162.82
9.76721813
97.14640199

18897
143.05782791
58.80227535
66.48
4.752252098
97.14640199

13966
94.300655741
36.7385077
194.022
33.47051419
97.02233251

8495
127.5997131
44.48435803
192.222
8.326732252
97.02233251

23632
120.1993648
57.71823343
219.914
21.75806126
96.89826303

22411
89.94428279
39.81299229
183.18
16.21797614
96.89826303

22666
78.62934426
49.73954055
125.038
7.350821043
96.77419355

18673
133.5581967
39.76929661
237.244
27.73314137
96.77419355

5292
103.9889959
77.71665696
376.76
113.5779994
96.77419355

3049
270.0245287
176.9428259
498.444
86.81850022
96.77419355

12098
−4.470143443
38.06130214
90.994
33.14980513
96.65012407

4725
89.900799181
121.3694137
239.676
67.29365074
96.65012407

25379
182.44686481
58.70865091
314.97
26.02254695
96.52605459

23184
51.544364751
20.45905428
99.778
11.46841183
96.52605459

4432
44.89356557
28.7463111
116.542
21.41826253
96.52605459

11331
84.0029918
27.00256457
140.22
14.35317212
96.52605459

2242
179.3839549
109.2501927
449.872
63.97026981
96.40198511

22948
226.7368238
88.46303286
406.712
35.71772767
96.27791563

21474
26.06686475
37.62057819
58.854
16.86412405
96.27791563

13420
392.077377
136.1010405
643.844
55.5189907
96.27791563

9658
89.48319672
60.98883523
244.732
62.7517846
96.15384615

8786
227.0502869
57.31974738
354.85
38.90896812
96.15384615

10019
135.9156148
51.50047551
215.752
15.05196067
96.15384615

21447
84.93477459
72.3054854
134.306
15.02143402
96.15384615

1031
70.47788934
23.78814851
110.658
6.08208188
96.15384615

4089
86.77180328
50.36619051
152.214
18.13651786
96.15384615

7220
76.98762295
52.95135462
51 .862
0.787953044
96.02977667

14955
−144.6063525
185.8863263
181.094
80.56877081
96.02977667

15215
46.76629098
71.69519515
96.74
4.716312119
96.02977667

101151
72.56655738
39.87979807
176.686
32.01721303
96.02977667

51861
68.7789959
43.12884438
140.366
31.8155682
95.9057072

6135
96.06844262
60.215514
18.306
5.138353822
95.9057072

3392
18.26368852
19.32174615
37.24
5.439172731
95.9057072

19005
23.93286885
27.2110811
58.162
3.216227604
95.78163772

16834
82.12
36.37427009
148.728
10.54378111
95.78163772

12107
214.0981148
48.85349382
306.29
27.59810954
95.78163772

20823
4789.302008
1460.120187
3761.908
72.57799164
95.78163772

1571
172.7995902
52.57153601
290.112
33.25647711
95.78163772

16679
85.16483607
55.49961919
114.73
3.186847973
95.78163772

20740
420.9239754
173.9236038
780.866
98.83567059
95.65756824

13029
203.5453893
109.8932269
435.558
85.38083315
95.65756824

17903
134.3879918
52.4369357
244.54
29.13306197
95.65756824

8541
52.66313525
43.41680816
155.044
32.98623092
95.65756824

9583
81.29731557
72.74693735
147.982
35.59071396
95.65756824

18172
56.73938525
31.97006523
114.12
11.09620881
95.5756824

17342
96.22192623
40.72937854
186.694
24.4790059
95.53349876

[0193]

11

TABLE 5E

BI-QT Attorney Docket No. 44921-5090US

Timepoint(s): 168, 336 hrs Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

15571
1146.880144
395.2301612
344.0114286
78.5393484
99.50124688

4130
224.4683539
90.2743589
61.24857143
21.27678346
99.25187032

13985
192.7222428
107.6912308
940.0885714
548.037149
99.12718204

6155
2926.942387
1119.661491
839.7942857
183.1872543
99.12718204

6153
545.0967695
216.1557262
150.66
30.14385012
99.00249377

22385
157.9224074
76.66175396
26.55
7.325947038
98.87780549

24072
21.71541152
30.2751282
58.57571429
11.67921067
98.87780549

25632
1153.660144
384.1645161
332.5
83.94025951
98.62842893

16909
282.7741975
106.2392905
497.3228571
47.77587387
98.62842893

17739
96.96164609
61.17559301
15.43
9.458525255
98.62842893

22386
377.1867078
156.9790178
80.55714286
28.64955364
98.37905237

3780
265.3458642
204.4183726
1800.691429
455.8843974
98.37905237

18541
1459.720021
519.9366207
2922.245714
346.1402564
98.25436409

25647
188.3438683
104.7747009
650.29
186.492508
98.25436409

2852
428.362037
187.9366738
135.16
25.3881685
98.25436409

23927
105.5380864
89.82305587
472.3742857
134.9741641
98.12967581

20925
1087.997305
385.8777079
2342.994286
432.2368176
98.12967581

14516
127.7729835
70.60924102
518.35
279.8149362
98.00498753

16426
1381.330185
604.334374
445.4371429
127.9430389
98.00498753

17358
1801.238971
591.0796197
3310.938571
322.5233568
97.75561097

6156
612.5829218
252.0319969
178.0885714
39.95518424
97.75561097

15438
225.8336214
74.28338074
78.97571429
17.44229425
97.75561097

2103
2781.732942
832.9661434
4941.147143
817.8200858
97.63092269

25663
398.4210082
286.1815128
2127.534286
860.1651723
97.63092269

20617
225.4005761
146.6464791
637.2714286
207.0700452
97.63092269

24521
5871.713724
1743.189805
11366.89286
2042.009624
97.50623441

15569
407.4651646
186.980155
79.59142857
23.82907847
97.50623441

26030
1019.45144
416.7005322
2307.601429
329.0417094
97.50623441

25716
629.3167284
321.6678121
2028.478571
531.6434546
97.50623441

25671
96.61096708
54.5217446
324.9414286
104.2805727
97.50623441

25918
40.67644033
24.17785017
151.8957143
52.53468056
97.38154613

4468
238.3986831
90.76454198
87.61
25.76276836
97.25685786

10820
2016.776502
528.6935889
3615.775714
669.0374831
97.25685786

25691
910.3856584
238.3647268
1740.794286
305.2156721
97.25685786

14928
875.0561111
272.4300315
1524.474286
184.1657844
97.25685786

5596
118.6190741
52.69410791
48.98142857
5.334752192
97.13216958

17203
2126.510741
848.1329048
4186.382857
491.1376271
97.13216958

19094
1802.569053
511.7092442
3011.387143
403.2550496
97.13216958

26133
187.2550412
152.2951324
651.9285714
291.6253559
97.13216958

16953
1149.682613
395.8125977
2207.674286
341.0510964
97.0074813

17687
84.04351852
28.20993149
47.67285714
4.369506892
97.0074813

24264
226.0653704
60.74150388
104.7857143
21.85609058
96.88279302

24268
160.5231687
93.51216047
48.98571429
15.7582157
96.75810474

18542
1410.127613
591.2972027
3140.035714
530.3397695
96.75810474

25702
669.0991152
161.3180834
1261.007143
209.6897601
96.75810474

14696
1412.849074
542.7044511
2881.84
376.1605253
96.63341646

6205
418.8476543
103.1580387
277.4428571
24.53683742
96.63341646

22930
325.4591564
178.4676831
65.04428571
24.94755423
96.63341646

18606
747.3085185
251.2163681
1476.484286
266.8125197
96.50872818

24310
294.4701029
113.7572958
86.83714286
30.73016689
96.50872818

3324
22.2987037
20.44562524
74.09714286
16.49790766
96.3840399

10498
1222.585761
451.0798756
2408.967143
311.0807358
96.3840399

5049
619.2253909
166.158467
363.0071429
70.05085812
96.25935162

8137
271.8144444
88.72552217
168.51
14.26964844
96.25935162

10109
1183.328992
282.8203183
2069.12
324.8440536
96.25935162

12639
1454.544053
544.733031
2790.017143
354.1095492
96.25935162

16938
1732.038395
603.1174343
3439.441429
525.2777621
96.25935162

18686
797.3768313
271.7240004
1443.837143
186.2989828
96.25935162

17066
98.15664609
33.72052363
215.0885714
53.79859336
96.25935162

23687
3345.324444
1382.257243
7377.175714
1444.234973
96.25935162

20812
1511.57249
561.539999
2893.697143
338.0689935
96.13466334

815
1320.18214
490.833371
2569.515714
392.7361894
96.00997506

15876
1311.420782
462.6508596
2416.09
321.7240623
96.00997506

16918
1453.174733
600.1195123
3050.62
559.0751988
96.00997506

10971
41.39814815
20.52713419
89.83857143
19.14333951
95.88528678

4594
96.26329218
56.87162938
34.98285714
8.56469831
95.88528678

18611
1884.292037
683.8558856
3369.444286
364.8119431
95.63591022

10684
634.5722634
194.941 2802
243.7285714
63.49565351
95.63591022

14944
58.02588477
31.88395661
147.6442857
46.06569253
95.51122195

17204
3058.224198
1371.907148
6358.744286
945.0767043
95.51122195

13161
121.0037654
66.35605552
5.641428571
12.79682569
95.51122195

600
302.8107202
61.35003616
213.4528571
13.31856188
95.26184539

2413
550.3817078
157.9279858
393.6171429
25.89780539
95.26184539

20484
5276.654918
3057.15583
11538.15714
2130.598132
95.26184539

2418
132.1191358
59.23141538
253.6085714
33.20308943
95.26184539

961
106.1441975
72.02636277
198.4485714
29.59039114
95.26184539

22717
660.8265226
261.2636841
213.93
65.08793052
95.26184539

19452
209.6715638
157.5847402
375.5571429
58.84777983
95.13715711

3271
449.0984979
108.7471593
281.7471429
23.07254625
95.13715711

21945
218.1630041
109.3266587
448.4914286
101.8108389
95.13715711

4499
719.5167901
247.3565527
1216.784286
136.5163842
95.13715711

1218
63.7545679
32.64389831
29.65
5.581594754
95.13715711

10821
28.84495885
92.35105778
195.0385714
76.96438774
95.13715711

16613
96.69055556
35.6771092
39.28285714
12.23417306
95.01246883

17305
3852.408107
1893.75281
7999.945714
1186.256538
94.88778055

25354
−8.257839506
17.0880336
20.40571429
4.437070569
94.88778055

3698
33.28786008
27.43589635
80.73
13.43121737
94.76309227

14345
77.20395062
46.0865573
126.7142857
13.59995693
94.63840399

52
73.23440329
32.77127365
41.34571429
6.458371459
94.63840399

18272
91.36792181
61.71129822
224.0171429
54.62458016
94.51371571

17155
550.6687243
206.3019369
1013.405714
154.9823162
94.51371571

10878
1540.94323
698.826885
2431.565714
292.1649588
94.38902743

23816
25.7423251
31.57965814
91.71714286
17.98398242
94.38902743

14257
278.4844239
118.5763469
95.20571429
43.19293031
94.26433915

18271
366.7478189
234.4263298
758.8957143
120.4147542
94.13965087

10348
42.71962963
22.74256127
90.58
27.06055309
94.13965087

[0194]

12

TABLE 5F

CLENBUTEROL Attorney Docket No. 44921-5090US

Timepoint(s): 6, 24 hrs Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

15002
370.7732305
762.3101051
857.3685714
201.3203655
98.12967581

15003
111.9262757
226.4263127
803.4357143
204.423891
97.75561097

15004
352.0210082
330.3718172
1485.817143
313.2749957
97.63092269

1114
289.5106996
128.09997
616.3842857
115.4233377
96.63341646

10654
167.5170576
183.1920641
342.4728571
116.8456235
96.13466334

23015
76.27308642
26.56987258
149.2642857
33.70650227
96.13466334

3799
363.2015226
137.4649001
592.75
88.40371862
94.76309227

22445
187.4601852
96.30841724
346.9
73.06204008
93.89027431

8598
92.98133745
30.67544775
122.1057143
4.580188705
93.76558603

6353
1105.17216
361.2250369
1556.151
84.84804712
93.51620948

3518
397.6903909
137.6434541
634.0728571
71.35343666
93.3915212

19048
63.7594856
27.04252873
26.51285714
6.722062467
93.3915212

23731
158.5925309
56.30608791
242.5957143
29.07243417
93.26683292

19074
424.6941152
99.82039291
593.8114286
57.41912208
93.26683292

19452
209.7605761
157.5451603
369.3771429
82.57209975
93.26683292

20743
149.177284
28.99798959
96.58142857
21.32392352
92.89216808

21996
261.8768519
104.143056
112.9628571
43.96131205
92.64339152

14982
4860.389568
2678.032152
8103.668571
940.6427668
92.39401496

8032
75.87524691
53.81786981
141.9471429
32.61585081
92.39401496

14989
629.8680453
200.2881357
891.6857143
101.9140749
92.26932668

1287
594.0475926
196.3334958
353.5457143
71.27292236
92.1446384

1809
32.34382716
58.37065997
293.4257143
129.594233
92.10901318

22043
102.109177
96.83781169
148.4242857
16.99378598
91.89526185

21661
1101.633868
485.7460291
1726.452857
226.0415466
91.64588529

25319
6920.877058
4634.32659
11059.19143
2293.2798
91.64588529

345
112.8551852
266.5500429
224.4
42.67381008
91.64588529

25050
4374.355391
2497.20802
6571.208571
1012.44378
91.64588529

23601
384.3886008
116.1146338
554.39
50.0575622
91.52119701

14981
5813.459815
3435.434206
9243.827143
1354.118299
91.39650873

15434
195.1638477
97.45664823
100.8371429
16.67855281
91.39650873

21527
75.16168724
45.20590689
106.3257143
15.41491362
91.39650873

11114
40.55353909
38.70912826
237.0042857
146.076882
91.36088351

4770
180.5046091
60.88092848
267.2942857
27.91134468
91.14713217

6015
120.4807407
40.49804833
65.17285714
17.13646669
91.14713217

13480
185.4077984
139.8113369
107.6842857
9.097274055
91.14713217

20582
450.8917901
111.5774689
336.2228571
39.54263678
91.14713217

19454
332.32
191.2144958
589.4842857
109.3836124
91.02244389

6100
1768.235638
676.3611509
2666.937143
328.8918907
90.89775561

23139
888.9618724
281.9240049
731.6957143
30.00259925
90.89775561

4969
−15.96524691
53.65377688
190.3014286
104.7143313
90.86213039

14983
6685.244938
4598.068119
10386.47286
2329.410815
90.64837905

25439
4368.391687
2826.996699
6802.121429
1259.273538
90.64837905

20859
5537.508374
3107.487037
7833.655714
691.3458646
90.52369077

18313
2294.341728
1076.241882
3669.408571
557.9740799
90.39900249

21152
6045.10216
3947.773763
9826.062857
1984.203876
90.39900249

15666
4273.786008
2282.850009
7078.084286
1502.015073
90.39900249

21079
621.3493621
190.0544448
903.9914286
181.3617693
90.39900249

10829
53.25578189
32.17850139
94.72857143
14.33844765
90.39900249

14862
173.56107
103.8304052
313.7571429
41.23265684
90.27431421

8886
150.7763374
36.02695349
197.3885714
13.45373359
90.27431421

25650
65.36985597
81.73459012
27.37285714
3.678630698
90.14962594

10097
115.1417284
36.54092976
80.26428571
11.00299029
90.14962594

18400
35.27985597
14.3952905
24.98571429
1.97574338
90.02493766

4242
223.0401029
79.47610213
141.5642857
28.33963588
89.90024938

23632
119.0809053
55.29789649
269.0771429
76.56900172
89.86462415

10684
633.1000412
197.1977869
345.9428571
115.571451
89.7755611

10020
107.3964403
54.06388278
234.8757143
59.68441082
89.73993587

20484
5335.127654
3144.056813
7478.478571
887.0682476
89.65087282

9084
47.74730453
20.27875282
23.58428571
5.660526646
89.65087282

19071
65.65384774
40.19826257
166.9
26.36572586
89.49055932

19145
352.1509259
86.22845731
430.0128571
13.94929235
89.40149626

16074
179.5921605
44.12121825
149.5614286
9.893212199
89.40149626

6655
47.39563786
45.76462342
75.70285714
63.85409768
89.36587104

11485
147.5652469
63.95343317
94.19
10.3080163
89.27680798

16130
5073.927263
3229.765392
7856.3
1434.059483
89.27680798

19256
388.9738889
155.386905
263.9557143
32.81897919
89.1521197

16613
96.35598765
36.11198381
62.51142857
9.952628511
89.1521197

20872
1267.149588
381.2549453
1749.421429
210.9154919
89.02743142

6843
227.6846296
126.3785005
323.74
37.41478407
89.02743142

3016
3546.519774
1779.472329
5154.142857
502.8494973
89.02743142

4130
223.36393
91.7292491
137.9271429
35.95580422
88.90274314

20944
391.7425514
111.4665412
519.79
57.30979817
88.90274314

12542
193.5654938
67.02161167
277.7957143
32.18979075
88.90274314

6606
1847.296523
927.5598068
3657.978571
955.8918461
88.86711792

5227
142.4888889
66.57666343
322.36
96.11474549
88.86711792

10498
1231.989856
469.1475752
1756.054286
236.0194512
88.77805486

21705
132.8482305
71.83874577
48.9
41.86501563
88.77805486

17736
557.2155556
368.3172294
1245.955714
344.7801629
88.74242964

23109
724.9338272
232.8308439
762.4342857
50.51037644
88.65336658

14554
103.3044444
36.04972964
69.87142857
8.746093278
88.5286783

17675
276.5611317
83.82010501
230.74
18.6991408
88.5286783

15626
1554.498724
554.6532886
2088.282857
269.7848761
88.5286783

18108
161.9191358
27.31024814
189.0414286
11.60434894
88.40399002

20975
151.1588477
43.90183399
101.5428571
15.55203064
88.40399002

22615
71.49800412
120.413319
168.23
77.57154418
88.3683648

15886
399.2487654
123.4960866
506.9228571
28.74756495
88.27930175

7273
43.3237037
16.16773292
35.15285714
2.460641612
88.27930175

[0195]

13

TABLE 5G

ISOPROTERENOL Attorney Docket No. 44921-5090US

Timepoint(s): 3, 6, 24 hrs Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

6606
1800.953354
841.8089691
4533.411538
976.4774713
97.34177215

15002
362.1182917
761.5650645
952.3530769
353.3322857
94.38169426

2069
330.4443333
99.06165286
528.5230769
63.4645261
94.30379747

15004
340.5709583
304.91227
1385.297692
580.7340909
94.25511198

15003
101.0504792
194.3109826
885.8453846
459.6024724
94.25511198

22321
175.5143542
95.44895753
480.2076923
181.5534099
92.86270691

1892
1014.269417
431.5795254
2036.402308
441.2482924
92.3563778

23964
87.10035417
36.01308076
146.31
28.23942693
92.27848101

24246
258.3080625
103.8022036
420.2730769
76.96344569
91.89873418

3959
385.6767292
112.3892003
643.9315385
134.1636163
91.85004869

18313
2264.4315
1049.245188
4139.14
636.8504939
90.83739046

3669
24.24370833
25.41941681
61.18692308
13.12603735
90.07789679

4969
−15.42985417
58.24869563
75.33307692
46.63097672
90.0292113

23709
1016.678979
330.0606558
1487.833846
307.0387944
89.57156767

19840
1354.720813
457.9859582
2096.473846
395.7357092
89.31840312

20743
149.6088542
28.98896918
104.9215385
12.37454029
89.06523856

17736
547.4900833
358.0131362
1287.17
348.8565629
88.88997079

1159
105.747
38.69650897
63.84769231
15.54218729
88.60759494

14737
224.8601458
64.13600274
339.1892308
59.31126628
88.55890944

574
564.377375
209.6574783
1093.738462
264.717403
88.51022395

17734
894.7706667
475.7469159
1926.886923
478.4763098
88.51022395

22432
117.4335417
48.45540046
220.7423077
46.81354792
88.51022395

4420
432.5164792
132.8366231
282.9146154
47.80957394
88.17916261

25050
4367.979354
2513.148279
5792.699231
1037.709475
88.10126582

7414
286.8900208
63.9356574
435.0638462
95.41052689
87.87731256

15510
258.4175833
78.34841326
171.8730769
39.83706825
87.79941577

23123
313.5087083
106.6805904
539.3753846
168.5141659
87.624148

18172
56.3719375
32.08588383
92.37615385
20.41992635
87.34177215

15277
746.0483958
180.8008198
991.1115385
163.9308576
87.29308666

2742
62.1860625
78.24081855
−112.1046154
118.687108
87.24440117

15840
45.2428125
31.12066696
21.56230769
4.773264351
87.16650438

3417
436.0942917
135.1741359
646.2084615
94.274477
87.0399221

17161
210.4053333
114.7786226
702.9215385
445.4059396
86.81596884

10185
36.474875
19.37632107
17.75615385
5.00987448
86.58227848

11531
367.8715625
247.9511191
984.9476923
415.6048795
86.43622201

12118
525.9024375
286.5326737
1465.937692
830.3963866
86.43622201

6727
144.8295625
38.96930285
96.43692308
14.21936847
86.40701011

16001
7345.807333
4838.698104
11675.05923
2291.390292
86.28042843

25689
1079.736667
440.6276535
1835.08
326.588564
86.28042843

1435
850.562875
227.4687537
1162.532308
75.79278167
85.97857838

20086
339.539
144.1424378
609.0123077
127.8668778
85.85199611

17477
68.31060417
75.88876388
109.0323077
48.77181976
85.72541383

6477
5.359333333
15.35545886
22.17461 538
16.11649653
85.67672833

17735
989.8021875
537.5096938
2383
662.4920784
85.55014606

1714
174.2624792
56.10541512
124.7115385
23.63710496
85.52093476

16092
360.0260417
151.5217582
591.7107692
142.5327169
85.52093476

21624
2033.794917
921.0432897
3697.166154
1089.50728
85.47224927

8495
127.1643333
44.65774149
168.53
25.3563848
85.44303797

18859
95.7876875
32.60736678
61.36307692
16.69836339
85.39435248

16533
300.4727917
119.4261477
496.9438462
129.0346388
85.34566699

17949
237.7122292
81.85675264
366.7838462
47.06676739
85.34566699

15089
120.1443333
52.12069944
203.1538462
65.88051654
85.34566699

11684
172.3714167
64.35917746
93.21230769
32.84176943
85.2677702

5458
156.57825
68.43444463
290.8907692
49.90688137
85.09250243

15365
1018.750083
343.2321479
1480.175385
235.1792331
85.01460565

1606
40.3269375
19.28859363
32.19923077
4.513729909
84.93670886

14397
75.95272917
52.19745226
171.3492308
54.78632029
84.83933788

14126
−12.87691667
41.57314317
52.57692308
43.59800079
84.83933788

11404
98.37770833
44.48352439
188.2038462
46.46541878
84.79065239

4944
101.6122083
43.04690565
202.1107692
61.72363492
84.79065239

18403
2207.970875
927.6718268
2522.709231
214.4526646
84.43037975

17401
659.922375
472.3825853
1060.563846
329.8673005
84.03115871

20057
25.6423125
28.07360317
39.74769231
9.578609984
84.00194742

25439
4352.672708
2836.742218
6259.254615
1468.846717
83.87536514

4074
66.60789583
51.21037266
1.167692308
21.81347602
83.87536514

18529
295.4269792
102.4645218
459.8169231
84.03101524
83.82667965

9720
58.4780625
27.10112016
114.7053846
55.47800504
83.77799416

21152
6031.195688
3970.47468
8594.473846
1968.859692
83.74878286

22717
656.7182708
267.8686827
571.8792308
63.22450085
83.74878286

20448
80.24770833
108.8299206
515.7284615
404.6230235
83.72930867

6043
46.586875
26.67707328
82.86538462
18.27293336
83.70009737

15032
40.13775
16.13252205
30.22692308
7.604412518
83.67088608

15741
279.19375
92.18165366
220.4023077
29.92799112
83.67088608

20848
1339.717271
436.8491685
1875.133077
329.9010208
83.62220058

22578
233.7812083
97.26518768
366.1269231
104.8709029
83.57351509

18830
3838.6645
1335.735088
6680.843077
2106.098773
83.5248296

17305
3870.303771
1954.445915
5424.934615
718.797816
83.49561831

17204
3073.473479
1424.8566621
4272.376923
474.0101731
83.49561831

3822
697.3917292
234.9086936
1196.067692
338.7275933
83.39824732

8919
223.3019167
55.93447508
314.5523077
34.97798025
83.32035054

9929
222.790625
86.93019568
157.6746154
23.94974273
83.29113924

21785
91.6991875
41.01657742
167.7553846
45.87078675
83.27166504

15837
513.2281875
149.8040944
723.5046154
109.1594744
83.24245375

20449
103.2453958
167.2783907
701.81
549.4084078
83.22297955

13382
134.4617708
68.16933521
70.797692311
33.81142069
83.16455696

11137
1708.081146
672.1168288
2312.163846
292.5725507
83.16455696

7941
146.1314375
73.11194489
310.5623077
103.0019034
83.14508277

14390
88.9756875
35.05866141
73.76153846
8.114264031
83.11587147

14494
220.109125
57.14414432
174.4023077
25.75250478
83.11587147

9059
279.2145
101.1511552
428.9946154
88.0439283
83.06718598

15841
52.17541667
26.06232737
75.34
15.9500559
83.06718598

17195
572.3617292
139.5046295
734.0430769
72.94451903
82.98928919

21101
48.02770833
47.96669222
76.54307692
24.39873371
82.98928919

23731
157.1883958
54.41178011
255.67
64.86708654
82.89191821

25806
49.2876875
11.70393941
35.52153846
7.93145725
82.86270691

16847
970.4330833
347.2918939
1382.567692
209.2795291
82.86270691

10532
63.6660625
28.75410722
97.56846154
22.81496725
82.81402142

10780
177.7290208
67.53442396
268.5346154
45.48876887
82.81402142

17563
1505.677375
501.166256
2170.345385
344.9394213
82.81402142

[0196]

14

TABLE 5H

NOREPINEPHRINE Attorney Docket No. 44921-5090US

Timepoint(s): 3, 6, 24 hrs Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

20826
258.7765145
73.83046558
8.665454545
5.441719147
100

18831
2701.02971
902.4997428
12.83
17.86234867
100

168
2667.635685
650.4891795
367.9990909
88.51448655
100

15876
1357.014232
440.9642379
16.57
3.755039281
100

16953
11191.077344
379.7935463
9.108181818
4.834130363
100

11849
1865.7830705
248.1407998
20.31
8.51322853
100

15492
1292.0097095
82.35511783
13.51
11.36765323
100

7888
324.7854979
75.98150734
40.00181818
20.22509472
100

15626
1597.37305
509.1606259
15.50454545
7.333530342
100

18682
514.2239004
145.6935245
31.97
7.347626828
100

15843
380.979917
98.04058409
41.20727273
15.37995129
100

18686
824.6674481
257.1839854
12.93545455
4.370193048
100

15345
172.306805
58.27631348
−35.76818182
9.988857611
100

17358
1863.2689
558.8049123
43.91818182
15.50249452
100

3203
313.5804772
81.62083102
41.95272727
10.88050283
100

18318
1165.68083
348.3546489
2.997272727
9.69866495
100

2096
2451.416369
695.361932
32.81909091
39.101207
100

10227
823.3695228
258.3265781
−72.06363636
25.16414206
100

23978
153.6884232
40.89784476
15.28727273
8.150722779
100

1580
636.5954772
179.4959326
16.11
14.35383085
100

20984
546.2710996
155.5949645
−31.04
14.24214029
100

968
121 .9038382
30.64176184
−0.500909091
6.679936309
100

20385
770.4556224
203.3023468
45.79090909
22.17806099
100

13596
1810.789336
569.1435287
3.454545455
6.840249065
100

20243
129.0574689
37.6968512
−2.9
5.883240604
100

21816
260.0651037
74.61300111
−1.751818182
7.742645308
100

16038
2615.561763
767.9946959
24.85
14.65344874
100

23300
880.673278
226.537123
50.66
38.86598822
100

8789
506.2074896
143.295597
14.34090909
15.86950563
100

9317
654.9811826
184.0629493
17.41454545
19.26111075
100

13420
403.804917
125.1092091
−7.362727273
2.670884089
100

18160
1953.342905
669.0636466
2.142727273
3.021476761
100

730
146.8325934
41.118501
−3.327272727
15.87339478
100

11531
1392.2085477
269.4537066
30.74090909
35.84799449
100

21211
1560.984502
496.0263201
13.86909091
11.47315428
100

10019
1140.5473237
45.77309846
−30.74818182
8.831346237
100

8737
829.5111826
270.0174124
0.809090909
6.715150712
100

1514
225.5738174
115.6570504
−33.27
21.5859042
100

5283
68.47738589
21.21791889
−3.467272727
2.931996217
100

4670
983.1897303
268.442193
63.66727273
37.3271644
100

24765
8698.1611
2736.932551
−107.0854545
118.6060407
100

6550
432.3638382
131.5445574
−10.41636364
13.92439677
100

3202
386.2796888
107.8897806
29.91363636
17.24658649
100

3081
386.0928838
116.5134935
−18.26181818
11.95994216
100

15957
337.8810581
103.8628968
2.243636364
6.556252394
100

15239
838.2483817
252.8998782
7.542727273
10.01967973
100

8829
262.205083
83.13534615
−4.712727273
6.07799653
100

6291
102.256722
42.41222875
−51.31636364
18.26697472
100

17100
1195.278278
362.7244946
27.93181818
13.41732374
100

4948
319.2764938
84.0755349
33.645454551
7.327518494
100

692
141.6327801
45.02646423
−1.7272727271
3.0384736
100

16608
886.6689834
258.0808715
7.421
40.76969733
100

17380
546.1136515
142.0524293
−50.93363636
78.15540177
100

17234
288.0742946
76.62794552
14.30363636
9.793244889
100

24185
79.67609959
21.07355559
4.180909091
3.012754403
100

6861
179.5580498
49.98628922
5.142727273
8.269084703
100

11066
291.9389627
89.63060929
−11.11818182
6.621064594
100

18830
4002.810249
1320.092723
5.034545455
21.76197986
100

18215
−13.02128631
27.8157068
116.2727273
18.53949411
100

7224
468.9245851
121.384228
45.83272727
22.3816653
100

17408
3033.101079
948.9602239
−25.32181818
36.9366403
100

24783
139.1163693
39.73307083
5.153636364
2.656310497
100

15571
1161.553154
369.1839332
−6.980909091
12.89713957
100

6927
550.1127178
154.4853899
24.69636364
25.61807498
100

24596
116.1997303
35.60561059
−15.29363636
8.096082105
100

3549
102.1588797
27.48608017
4.924545455
4.636889828
100

15365
1054.916888
313.7007295
−20.69272727
34.80709384
100

15308
264.0688382
78.16576449
17.53454545
16.16938735
100

24064
438.5977801
121.1468558
6.629090909
32.59995597
100

23705
257.5565145
72.23324097
12.20909091
7.991269554
100

23372
292.9917842
103.874663
−86.64727273
33.45484392
100

2250
755.4497718
209.0912074
24.20636364
14.2096814
100

19408
1230.174647
382.1879294
4.725454545
14.95432136
100

18663
598.094668
164.4549192
3.831818182
8.740671391
100

23109
742.8126971
202.9740661
−34.62181818
6.237901599
100

3254
200.6041079
137.1574
1086.558182
93.09191155
100

24528
37.71585062
168.6386969
1093.480909
136.4743304
100

25250
1227.876784
368.4067726
−15.41181818
7.229391148
100

3046
−91.81815353
101.5951868
683.6272727
290.0463678
100

17535
235.9384855
61.09067701
0.272727273
5.405567668
100

2131
152.2524896
47.30103826
−23.71909091
8.362459512
100

18541
1514.294979
503.4161297
−0.957272727
2.214023897
100

15103
330.838361
71.95446887
5.620909091
6.117156945
100

18358
389.3404772
84.80796568
56.13818182
21.38603087
100

23210
207.9242946
50.957339
12.97454545
8.530906591
100

2435
123.8113693
34.12545346
1.357272727
2.768819571
100

2254
190.9323651
53.97349834
1.659090909
3.713471299
100

21822
542.4963485
104.8273279
109.2954545
23.83776767
100

11936
533.6882988
146.0354132
−29.16727273
32.27326265
100

22205
695.3240664
170.2714155
87.88818182
18.07752739
100

2103
2876.211846
769.3677303
16.01181818
16.50655313
100

17307
254.348527
66.81528147
−33.49090909
6.670976622
100

11516
117.570083
49.71968898
−26.68454545
15.52986244
100

2413
560.0561618
138.3695518
26.70545455
12.44173972
100

16538
285.3856224
74.85853067
−12.47818182
6.74247257
100

15511
487.8557676
135.2102351
12.42090909
2.812619614
100

14928
904.0945021
252.3238249
15.91272727
12.98053242
100

20750
221.4425311
45.74314584
11.22636364
5.453324257
100

7427
408.6870332
93.45830495
13.85727273
9.079045204
100

[0197]

15

TABLE 5I

EPINEPHRINE Attorney Docket No. 44921-5090US

Timepoint(s): 3, 6, 24 hrs Document No. 1828250.1

Identifier
NonToxMean
NonToxSD
ToxMean
ToxSD
LDA score

17734
888.2450722
418.3316328
2967.57375
919.3804659
97.875

11531
366.5253814
225.3556456
1452.2325
595.7111333
97.875

17736
542.5831959
312.8985462
2046.95
809.1560881
97.25

6585
711.781732
439.0153319
2196.87375
557.9498605
96.875

4098
118.7445979
63.79468172
309.755
107.3850764
96.5

385
47.90284536
22.42491611
−1.535
7.489754907
95.375

21657
830.2778144
270.4242843
1288.78125
225.8066116
93.875

5458
157.4439588
68.27623153
322.3525
66.81148527
93.5

5227
143.2841443
69.29449686
251.66375
41.31225136
93.375

20041
164.6427629
82.38204257
313.96
49.87761737
93.25

2069
332.6504948
100.9144709
518.57375
79.72361649
92.625

15277
748.0543299
182.1555459
1022.66625
111.9218696
92.375

16017
117.0040206
26.56818581
79.4475
8.153501877
92.125

18654
207.2880825
76.29506097
104.18
38.72291422
91.625

22937
18.95884536
18.38238104
50.77875
11.76095166
91.625

15283
306.3364124
85.1441326
436.77125
57.95379032
91.375

17735
995.2225773
522.782963
2925.1375
973.5225995
91.25

6789
449.154701
138.2297816
359.835
27.13126241
91.125

2655
163.7682887
72.87378638
356.14
113.777997
91.125

22247
553.3174433
208.9330121
883.6025
221.399766
90.875

25717
50.10529897
34.58913722
19.7575
3.491445669
90.375

12376
1960.584433
624.6888448
1264.64
263.3373639
90.125

1892
1019.932247
428.2951523
2331.92625
591.4267078
90.125

14989
627.0824536
195.6606757
1027.835
168.3073491
90

17810
1493.767773
569.0764586
1603.45875
88.72371038
90

24209
21.31257732
81.64677329
122.2275
56.00067136
89.875

22042
96.09375258
70.77738592
131.2975
22.11521826
89.75

19710
53.04616495
26.30615046
122.3625
31.83640852
89.625

574
569.978701
216.8213901
1085.00875
293.1615851
89.5

8919
224.3806804
56.72687008
306.18375
34.96332648
89.375

9166
68.21876289
52.54762518
200.9225
94.02400662
89.375

17949
238.0037113
79.79173057
429.7825
104.2303763
89.375

17361
91.87804124
39.57467877
53.98125
9.356979729
89.375

20461
86.35030928
31.05618459
48.105
12.54410732
89.375

18389
775.2413196
506.6075311
1720.30875
416.281741
89.375

18313
2294.41367
1079.245371
3493.16375
482.7251869
89.25

12695
5.350185567
36.75666009
82.9525
38.93520139
89.25

12609
229.6410515
71 .4952706
331 .44875
38.34897147
88.875

1714
173.6201443
56.23925673
132.68375
15.0060054
88.625

4636
119.3749691
72.97797428
180.37625
24.15894152
88.5

15048
1617.959423
528.6993884
1750.94375
133.3480796
88.375

10071
265.9264742
134.3201197
479.4825
124.2355416
88.375

14149
131.0243711
89.55041357
221.705
45.87699828
88.375

15032
40.0965567
16.05370374
26.53
7.701617641
88.25

1483
27.79618557
22.28955541
−3.34875
14.07984825
88.25

18018
764.9609072
193.4526605
979.63875
69.04549213
88.125

26164
80.68028866
33.33373002
111.5275
9.02472279
88.125

2742
60.12063918
82.15513864
−95.82
62.86507934
88

14554
103.4118557
36.00705678
67.53875
10.90265818
87.875

8707
193.2597113
63.01577128
271.675
29.02663358
87.75

23240
442.1703918
137.4123052
518.92125
18.93327942
87.75

15949
281.7723505
72.62837121
352.95875
23.64593438
87.75

8494
451.5067423
171.6423091
607.5525
45.40360425
87.75

15181
160.2542268
47.84356903
150.69625
9.379378501
87.625

15603
45.94983505
37.69467445
42.9275
3.258236815
87.625

8495
127.0749278
43.9921576
199.80375
30.07248003
87.5

17947
140.6838763
54.78480727
245.63625
64.99176738
87.375

3405
251.0247835
79.63950605
421.23375
70.31434744
87.375

16154
122.7517732
309.7565389
168.96625
45.83850345
87.375

3669
24.59857732
25.52578984
62.7625
17.01112472
87.25

7941
149.1416082
78.32922502
230.84
33.51091038
87.25

12581
52.69251546
57.30569446
81.97875
29.11044606
87.125

20990
118.4963918
51.60603594
199.04125
46.08950219
87.125

22873
215.6249278
84.79180636
374.4175
84.61650291
87.125

13547
173.9781443
55.77956063
229.9025
19.9192095
87

5902
51.03164948
33.30889814
85.59875
17.2955068
86.875

18095
826.025134
210.4110436
1122.11875
133.4793588
86.875

16092
363.112268
154.8973929
549.41125
70.32665649
86.875

9277
49.07348454
18.38794729
83.37375
23.5619772
86.875

8822
131.5994227
84.01472082
198.895
48.51834322
86.75

4496
60.76754639
22.7136402
43.95875
7.690518165
86.75

24012
909.5962887
309.4378079
667.5625
86.87059337
86.5

20204
45.97138144
14.86260572
18.33625
13.96489674
86.5

7936
75.96758763
23.26395527
53.92625
8.149094494
86.5

19768
684.5306186
188.7390939
915.77
92.35212674
86.375

23155
219.8035258
63.23831524
303.14125
39.03249724
86.375

5703
189.27259791
73.01735577
255.63375
30.86881271
86.375

18774
67.780082471
32.25676833
41 .66375
6.299668784
86.25

3941
178.642268
74.52946804
299.69625
65.18136389
86.25

19320
108.0233196
34.25470953
97.82
5.847399911
86.125

22727
7269.390247
2432.77062
6112.755
594.1530463
86

2997
74.51882474
33.02943782
56.02875
8.847379656
86

12096
131.6709278
53.17077259
235.45125
57.54323255
86

8343
55.92898969
19.9088009
59.54125
3.826958649
86

10016
257.6524536
332.4004743
355.33625
79.38333001
86

1521
75.17245361
42.17580483
156.41125
41.7286354
85.875

2459
115.9692371
265.1998591
1327.6475
966.8365364
85.875

82
41.9002268
19.59839295
21.44375
6.478637285
85.75

17145
186.5703299
91.1146045
110.36875
29.37672813
85.75

22605
45.56035052
41.38235837
223.62375
129.4260965
85.625

19392
596.7033402
175.621725
834.42
135.9808925
85.625

21654
203.556433
94.47999788
448.57875
177.9926862
85.625

353
99.58771134
42.81116446
357.2475
264.3302602
85.625

[0198]

Number	Date	Country
60303819	Jul 2001	US
60305623	Jul 2001	US
60369351	Apr 2002	US
60377611	May 2002	US

Cardiotoxin molecular toxicology modeling

Information

Publication Number

Date Filed

Date Published

Inventors

CPC

US Classifications

International Classifications

Abstract

Description

Claims

RELATED APPLICATIONS

Provisional Applications (4)