The present invention relates to a cart-window assembly comprising a cart for moving material to/from a clean room and at least one window adapted to allow the communication between a dirty space and the clean room. In particular, the invention relates to a flowed cart and the related interface for the connection with a fixed window.
In a known manner, in laboratories and industries which treat pharmaceutical products, but also chemical, biomedical, cosmetic, food, electronic and similar products, the need arises to ensure that at least some areas of the plant are free of pollutants.
The invention is intended in particular for use in plants comprising at least one controlled contamination area, or clean room, i.e., an area with a very low amount of dusts and sterile from a microbiological point of view (hereinafter referred to in short as “clean room”). For this reason, the following description will make specific reference to this field of use. However, as those skilled in the art may well understand, the invention can also be usefully employed in different environments, for example in environments subject to less stringent constraints.
In a known manner, one of the problems which constantly arises in systems comprising one or more clean rooms is that of correctly managing the transport of material from an unclassified external environment or an environment with a lower classification than that of the clean room (and therefore referred to in short as “dirty space”) to a clean room.
For this purpose, solutions have been developed which are described below.
The flowed transfer carts referred to as LAF (Laminar Air Flow) are used to transport clean material from a first clean room to a second clean room, passing through a dirty space. These carts comprise a closed compartment into which air is blown which is sucked in from the external environment, typically filtered through HEPA (High Efficiency Particulate Air) filters, and reintroduced into the external environment. A double effect is thus obtained. On the one hand, it is ensured that an overpressure is established inside the compartment with respect to the external environment, so as to prevent pollutants from entering the compartment. On the other hand, the filtered air is blown in the form of a laminar flow in order to carry out a continuous washing of the surfaces, removing any suspended pollutants from the compartment and thus preventing it from contaminating the material loaded inside the cart. Thereby, the material, which was already clean at the start, remains clean throughout the journey, up to the second clean room.
It is another arising need to introduce material from a dirty space into a clean room, without thereby contaminating the clean room itself. For this purpose, the use of the so-called pass box, or material pass-through, is known, consisting of a compartment with a first door which opens towards the dirty space and a second door which opens towards the clean room. The pass box can then comprise a biodecontamination system which is suitable for the treatment of the contents of the compartment. The correct use of the pass box requires that, keeping the second door hermetically closed, a first operator in the dirty space opens the first door, introduces the contaminated material into the compartment and closes the first door. When both doors are hermetically closed, the biodecontamination cycle is carried out, for example by means of hydrogen peroxide vapor. Once the biodecontamination has been completed and the hydrogen peroxide residues inside the compartment have been disposed of by catalysis, a second operator inside the clean room can open the second door and take the material, now biodecontaminated and clean, so as to put it in the clean room without any risk of contamination.
While appreciated, such solutions are not without drawbacks.
In accordance with relatively recent regulations, there are areas inside the clean rooms (classified as areas A) which are subject to more stringent cleaning requirements than other areas (areas B). Typically, the area where the pass box is located and the area where the material processing machine is located are classified as areas A. In contrast, the adjacent areas of the clean room can be classified as areas B. The flowed LAF carts of the known type allow transporting clean material from one area A to another area A by passing through an area B. However, to do this the flowed LAF carts require that specific areas be set up in the areas A for the material loading and unloading operations, areas in which a special fixed LAF system ensures a laminar flow of clean air. The laminar flow of clean air, similar to what occurs inside the cart itself, prevents the contamination of the material while it is exposed during the loading and unloading operations. The fixed LAF plant is quite complex, and it is therefore preferable that the affected areas are identified from the beginning of the plant's construction. However, this is not always possible, for example for plants which are converted for different uses or for plants built before the issue of stringent regulations on the classification of areas A and B. In these cases the plant must be adapted to create new areas A with an adequate LAF plant in positions where they had not been envisaged. In this case, the necessary works involve significant costs and prolonged unavailability of the clean room and therefore an at least partial shutdown of the entire plant.
On the other hand, pass boxes are an expensive and inflexible solution. In fact, at least one pass box must be provided for each chamber. Furthermore, like the fixed LAF plant, the pass box also requires a rather complex and laborious installation and it is preferable to arrange it from the beginning of the plant's construction. The construction of a new pass box also requires works which involve prolonged unavailability of the clean room and therefore an at least partial shutdown of the entire plant.
Document WO2015/015995A1 describes an example of a cart for transferring materials, while document U.S. Pat. No. 5,401,212A describes an example of a transport system for transferring products between stations with different HEPA classes.
Therefore, it is the object of the present invention to overcome the drawbacks highlighted above in relation to the background art.
In particular, it is a task of the present invention to provide a flowed cart which does not require a fixed LAF plant near the pass box.
Furthermore, it is a task of the present invention to provide a flowed cart which, in addition to the peculiar operation thereof, allows maintaining the functions of the carts of known type.
Such an object and such tasks are achieved by a cart-window assembly according to claim 1 and the methods of claims 11-13.
In order to better understand the invention and appreciate the further features and advantages thereof, some non-limiting exemplary embodiments thereof will be described below with reference to the accompanying drawings, in which:
In the context of the present discussion, some terminological conventions have been adopted in order to make reading easier and more fluent. Such terminological conventions are clarified below with reference to the accompanying drawings.
The invention relates to a movable cart in an industrial environment. The expression “fixed” refers hereinafter to elements of the environment, as opposed to the elements of the cart which are movable therewith.
The expression “clean room” means a constantly controlled environment which meets certain predefined requirements and which therefore has a very low amount of dust and is sterile from a microbiological point of view.
The expression “dirty space” means an environment outside a clean room and for which there is no requirement or there are less stringent requirements than those of the clean room.
The expression “HP mixture” hereinafter refers to a mixture of gas, for example air, and hydrogen peroxide (H2O2—Hydrogen Peroxide), adapted to obtain a biodecontamination effect on the surfaces with which it comes into contact.
The expression “HP apparatus” hereinafter refers to a device adapted to generate a flow of HP mixture. The HP apparatus can utilize different technologies: for example, it can utilize technologies based on the use of hydrogen peroxide in the vapor state such as VHP (Vaporized Hydrogen Peroxide), HPV (Hydrogen Peroxide Vapor), VPHP (Vapor Phase Hydrogen Peroxide) technologies, or it can utilize technologies based on ionized hydrogen peroxide such as IHP (Ionized Hydrogen Peroxide) or HPE technologies, or it can utilize so-called dry fog technologies such as spraying or atomizing hydrogen peroxide.
Within the scope of the invention, paths are defined within which a fluid moves in a unique direction. In relation to such a direction, the expressions “upstream”, “before” or the like are uniquely defined with respect to the expressions “downstream”, “after” or the like.
The invention relates to a cart-window assembly 66 comprising a cart 20 for moving material to/from a clean room 22 and at least one window 62 adapted to allow the communication between a dirty space 56 and the clean room 22.
In particular, the cart 20 for moving material from/to a clean room 22 comprises:
In accordance with some embodiments (for example those in
Preferably, the cart 20 can further comprise an exposed door 26, also adapted to alternatively allow accessing the compartment 24 and hermetically closing the compartment 24. From the following description, those skilled in the art can well understand how both doors 26, 28 are exposed in the same identical manner in many conditions of use. However, the possibility of obtaining a protection for one of the two doors 26, 28 is one of the technical features of the cart 20 which allows making the most of the advantages of the invention.
In accordance with some embodiments, the ventilation system 30 is adapted to create a laminar air flow.
The ventilation system 30 can be similar per se to those mounted on board the flowed LAF (Laminar Air Flow) carts of a known type. Preferably, the ventilation system 30 comprises a first opening 36 for the suction of air from the outside, one or more filters (described in greater detail below), a fan 38, a second opening 40 for expelling the air towards the outside, and a series of channels 42 adapted to connect the first opening 36 to the fan 38 and then to the compartment 24 of the cart 20, and adapted to connect the compartment 24 to the second opening 40. Preferably, the ventilation system 30 comprises one or more of the following filters:
Furthermore, in accordance with some embodiments (for example that in
Preferably, one or more of the filters listed above are so-called absolute filters, for example they can be said HEPA (High Efficiency Particulate Air) or ULPA (Ultra Low Penetration Air) filters based on the classification defined by the UNI EN 1822 standards. In particular, HEPA filters have a filtration efficiency between 85% and 99.995% depending on the class to which they belong, while ULPA filters have a filtration efficiency between 99.9995% and 99.999995% depending on the class to which they belong.
Advantageously, the ventilation system 30 further comprises a shutter 50, preferably motorized, adapted to close the channel 42 upstream of the compartment 24.
Preferably, the fan 38 is a centrifugal fan.
Advantageously, the cart 20 comprises a control panel 52 which allows one or more of the following functions to be performed:
Preferably, the cart 20 comprises an electrical power supply system 54, adapted to power the devices on board the cart 20. The power supply system 54 preferably comprises a connection to the mains and/or a battery or an uninterruptible power supply which allows the on-board devices to be powered even while the cart 20 is disconnected from the mains, typically when it is in motion. A device on board the cart 20 which must be powered is certainly the fan 38 of the ventilation system 30 but, in accordance with the various embodiments, other devices may also require an energy supply.
In a manner known per se, the ventilation system 30 is adapted to achieve two purposes. Firstly, the ventilation system 30 ensures that an overpressure with respect to the external environment is established inside the compartment 24. Furthermore, the ventilation system 30 can be adapted to blow air in the form of a laminar flow inside the compartment 24.
These features allow the cart 20 to have the operating mode diagrammatically shown in
In accordance with some embodiments, the HP apparatus 32 is a generator of the VPHP (Vapor Phase Hydrogen Peroxide) type, known per se. In particular, a VPHP generator is adapted, starting from hydrogen peroxide in the liquid phase, to generate hydrogen peroxide in the vapor phase and thus to obtain the HP mixture. Advantageously, the cart 20 comprises a tank 58 of liquid phase hydrogen peroxide from which the HP apparatus 32 draws to obtain the vapor phase hydrogen peroxide. Preferably, the HP apparatus 32 is also adapted to suck an air flow from the outside, for mixing a predetermined flow rate of hydrogen peroxide vapor with a predetermined flow rate of air, so as to obtain the HP mixture. Preferably, the cart 20 of the invention comprises a first conduit 34 which connects the outlet of the HP apparatus 32 inside the compartment 24, so that the HP mixture can be introduced into the compartment 24 itself.
A particularly efficient VPHP generator 32 which is particularly suitable for use in the cart 20 of the invention is described in European patent application EP 3 669 896, filed by the same Applicant.
Preferably, the cart 20 further comprises one or more main catalysts 58, adapted to ensure the splitting of the hydrogen peroxide molecules (H2O2) into water (H2O) and oxygen (O2). The main catalysts 58, known per se, preferably comprise metal grids with a coating of heavy metals such as mixtures of palladium, iridium, chromium, and the like. Advantageously, the main catalysts 58 are placed along the ventilation system 30, downstream of the compartment 24 and preferably upstream of the second opening 40 for expelling the air towards the outside.
The technical features of these embodiments allow the cart 20 to have the operating mode diagrammatically shown in
The assembly 66 further comprises a fixed window 62 adapted to allow the communication between the dirty space 56 and the clean room 22, in which the window 62 comprises a panel 64 which can alternatively be open or sealingly closed, and second interface means 60.2 extending along the periphery of the panel 64 and which are complementary to the first interface means 60.1 arranged on board the cart 20 in accordance with the invention.
Advantageously, the panel 64 opens from the side of the window 62 opposite to the side on which the second interface means 60.2 are arranged. In accordance with some embodiments, the window 62 is mounted so that the panel 64 opens towards the clean room 22 and the second interface means 60.2 face the dirty space 56. In accordance with other embodiments, vice versa, the window 62 is mounted so that the panel 64 opens towards the dirty space 56 and the second interface means 60.2 face the clean room 22.
Advantageously, the cart 20 thus comprises first interface means 60.1 surrounding the protected door 28 and the window 62 comprises second interface means 60.2 extending along the periphery of the panel 64, in which the first interface means 60.1 and the second interface means 60.2 are mutually complementary and are referred to as interface means 60 as a whole.
In the assembly 66, the interface means 60 allow, if necessary (i.e., reversibly), the cart 20 to be firmly coupled to the window 62 so as to define a sealingly closed gap 68 between the two. In particular, when the interface means 60 are fully activated, the gap 68 is sealingly closed towards the compartment 24 of the cart 20, towards the dirty space 56, and towards the clean room 22.
Preferably, the interface means 60 comprise sensors adapted to detect the correct position of the cart 20 with respect to the fixed window 62. The sensors can be positioned on the cart 20, on the window 62 or, preferably, on both. Preferably, the interface means 60 comprise electromagnets adapted to be activated to lock the cart 20 in the correct position with respect to the fixed window 62. The electromagnets can be positioned on the cart 20, on the window 62, or on both.
A particular embodiment of the interface means 60 is described below with reference to
Preferably, the interface means 60 further comprise a gasket 72. In accordance with the embodiment shown in the figures, the gasket 72 is of the pneumatically actuated type, known per se, and is adapted to bridge the distance d between the two sleeve flanges 70 so as to ensure the closure of the gap 68 (see the detail in
In the embodiment shown in
As those skilled in the art can well understand, the embodiment of the interface means 60 described above is only one among many possible ones. For example, in accordance with other embodiments (not shown), the interface means 60 can comprise plates designed to come into contact with each other and an electromagnetic coupling. The activation of the electromagnetic coupling, in addition to ensuring that the cart 20 remains firmly in position, also ensures that a gasket 72 is adequately compressed to obtain the seal.
Preferably, the window 62 can comprise a mouth 80 between the panel 64 and the second interface means 60.2, connected to a fixed HP system 82. It should be noted that, in accordance with the terminological convention adopted in the description, the HP system 82 is defined as “fixed”, meaning thereby that it is not mounted on board the cart 20. However, as those skilled in the art can well understand, the HP system 82 can in turn be a movable device to connect to the mouth 80 only when necessary, without thereby modifying the invention in any manner. In any case, when the cart 20 is firmly coupled to the window 62 and the interface means 60 are activated, the mouth 80 is inside the gap 68. Thereby, it is possible to introduce the HP mixture produced by the fixed HP system 82 inside the gap 68 itself.
Preferably, the cart 20 comprises a second conduit 74 connecting the interior of the compartment 24 to a mouth 76 outside the compartment 24, between the protected door 28 and the first interface means 60.1 (
In accordance with some embodiments, the second conduit 74 connects the mouth 76 to the first conduit 34. Thereby, the second conduit 74 allows, if required, connecting the outlet of the HP apparatus 32 to the mouth 76 and/or the mouth 76 to the compartment 24.
Thereby, by means of the fixed mouth 80 of the window 62 and/or through the mouth 76 of the cart 20, it is possible to introduce the HP mixture into the gap 68 itself.
Preferably, the window 62 comprises a second ventilation system 78 of the gap 68, in turn comprising an exhaust filter and a fixed catalyst, both similar to the corresponding components of the cart 20 described above. In order obtain the forced circulation of the air inside the gap 68 and the second ventilation system 78, it is possible to utilize the flow arriving from the HP apparatus 32. Alternatively or in addition, it is possible to arrange a second fixed fan or another ventilation device (such as a source of compressed air).
These features allow the cart 20 to have the operating mode diagrammatically shown in
Advantageously, the cart 20 can comprise a third conduit 84 connecting the outlet of the HP apparatus 32 to a point inside the ventilation system 30, downstream of the main catalysts 58 and preferably upstream of the second opening 40 for the expulsion of the air towards the outside. In some embodiments, such as that diagrammatically shown in
These features allow the cart 20 to have the operating mode diagrammatically shown in
The different modes of use described above with reference to
One possible mission is to transfer already cleaned material from a first clean room 22 to a second clean room 22 passing through a dirty space 56. In order to carry out this mission safely, it is possible to arrange a cart 20 in accordance with the invention in the dirty space 56; arrange the first clean room 22 with a first window 62 and the second clean room 22 with a second window 62, in accordance with what is described above. In particular, the window 62 must be arranged so that the second interface means 60.2 face the dirty space 56 and the panel 64 opens towards the clean room 22. It is then possible to carry out the following steps:
It should be noted that in this type of mission, the steps of biodecontaminating the gaps 68 can be completed using both the HP system 82 of the window 62, and using the optional HP apparatus 32 of the cart 20, by virtue of the presence of the second conduit 74.
It should further be noted that in this type of mission, between the step of uncoupling the cart 20 from the first window 62 of the first clean room 22 and the step of coupling the cart 20 to the second window 62 of the second clean room 22, an indefinite period of time can elapse. In fact, the cart 20 can be positioned in a waiting area where, ensuring the power supply of the on-board devices, the cart 20 can remain in total safety for an indefinite time.
Another possible mission is to transfer dirty material from a dirty space 56 to a clean room 22. In order to carry out this mission safely, it is possible to arrange a cart 20 in accordance with the invention and comprising the second conduit 74 in the dirty space 56; and arrange the clean chamber 22 with a window 62 in accordance with what is described above. In particular, the window 62 must be arranged so that the second interface means 60.2 face the dirty space 56 and the panel 64 opens towards the clean room 22. It is then possible to carry out the following steps:
It should be noted that in this mission, the cart 20 of the invention behaves exactly like a movable pass box, i.e., a pass box which can be applied from time to time to the window 62 of the clean room 22 which requires it.
It should also be noted that the step of biodecontaminating the gap 68, the interior of the compartment 24 of the cart 20 and the material can be completed either by using the HP system 82 of the window 62, or by using the optional HP apparatus 32 of the cart 20, by virtue of the presence of the second conduit 74 connecting the interior of the compartment 24 to the mouth 76. In this case it may be preferable to provide auxiliary fans (not shown) to facilitate the circulation of the HP mixture between the compartment 24 and the gap 68 and finally to convey it towards the catalysts.
A further possible mission is to transfer dirty material from a dirty space 56 to a clean room 22 and then move it safely inside the clean room 22, typically between two areas A passing through an area B.
In order to carry out this mission safely, it is possible to arrange a cart 20 in accordance with the invention and comprising the second conduit 74 in the clean room 22; and arrange the clean chamber 22 with a window 62 in accordance with what is described above. In particular, the window 62 must be arranged so that the second interface means 60.2 face the clean room 22 and the panel 64 opens towards the dirty space 56. It is then possible to carry out the following steps:
It should be noted that in this mission, the cart 20 of the invention behaves like a pass box and then allows the clean and biodecontaminated material to be transported in complete safety also through the areas B of the clean room 22.
Therefore, it should be noted how the cart 20 of the invention greatly simplifies the management of accesses to the clean rooms. In fact, by adopting at least one cart 20 in accordance with the invention, it is no longer necessary to provide each clean room 22 with a pass box thereof nor with a fixed LAF plant. On the contrary, it is sufficient to provide a simple window 62 in accordance with what is described above for each clean room 22. The window 62 is much simpler than the pass box and the fixed LAF plant. In the most essential version thereof, the window 62 comprises only the interface means 60 and the watertight panel 64. Therefore, the provision of such a window 62 does not require complex work and reduces the unavailable time of the clean room 22 and partial shutdown of the system to a minimum.
The foregoing description elaborates on the technical features which distinguish the invention from the solutions of the known art. For all the other features, which may be common to the known art and the invention, reference should be made to the introduction where the prior art is described and commented.
As those skilled in the art can well understand, the invention allows overcoming the drawbacks highlighted above with reference to the background art.
In particular, the present invention provides a flowed cart 20 which does not require a fixed LAF plant.
Furthermore, the present invention provides a flowed cart 20 which, in addition to the peculiar operations thereof, allows maintaining the functions of the carts of known type.
It is apparent that the specific features are described in relation to different embodiments of the invention with an illustrative and non-limiting intent. Obviously, those skilled in the art can make further changes and variations to the present invention, in order to meet contingent and specific needs. For example, the technical features described in relation to an embodiment of the invention can be extrapolated therefrom and applied to other embodiments of the invention. Such changes and variations are however contained within the scope of protection of the invention, as defined by the following claims.
Number | Date | Country | Kind |
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102020000031400 | Dec 2020 | IT | national |
Filing Document | Filing Date | Country | Kind |
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PCT/IB2021/061218 | 12/2/2021 | WO |