Cartridge insertion for drug delivery device

Description

FIELD AND BACKGROUND OF THE INVENTION

The present invention, in some embodiments thereof, relates to a cartridge insertion assembly for a drug delivery device and, more particularly, but not exclusively, to an insertion assembly for a drug device including an internal telescoping assembly.

U.S. Pat. No. 6,800,071 discloses, “an improved pump, reservoir and reservoir piston for,” “controlled delivery of fluids. A motor is operably coupled to a drive member, such as a drive screw, which is adapted to advance a plunger slide in response to operation of the motor. The plunger slide is removably coupled to the piston. The piston comprises a first member and a second member. The first member has an external proximate side and an external distal side. The external proximate side is adapted to contact the fluid and is made of a material having a first stiffness. The second member has a first side and a second side and is at least partially disposed within the first member. The first side of the second member is adjacent to the external proximate side of the first member and is made of a material having a stiffness which is greater than the first stiffness.”

U.S. Patent Application Publication No. 2013/0253472 to Cabiri discloses, “A method and apparatus,” . . . “for delivery of a drug to a recipient. In some embodiments, the delivery apparatus may unseal a drug containing reservoir. In some embodiments, the delivery rate may be controlled and/or adjustable. Optionally the apparatus may be disposable. Optionally, the apparatus may have a low profile and/or be wearable and/or attachable to the recipient. Optionally, discharge of the drug and/or unsealing of the reservoir may be driven by a plunger moving parallel to the base of the apparatus. Optionally, the apparatus may release a hypodermic needle into the recipient. Optionally, release of the hypodermic needle may be in a direction non-parallel and/or orthogonal to the direction of movement of the plunger.

Optionally, prior to release, the hypodermic needle may be preserved in an aseptic state by a needle opening septum sealing a needle opening. Optionally, upon release, the hypodermic needle may pierce the needle opening septum.”

Additional background art includes International Patent Application Publication No. WO/2011/090956 by Cabiri, U.S. Patent Application Publication No. 2009/0093792 to Gross, U.S. Patent Application Publication 20130304021, U.S. Patent Application Publication 20130296799, U.S. Patent Application Publication 20130245596, U.S. Pat. No. 8,465,455, International Patent Application Publication No. WO/2011/090956 and U.S. Patent Application Publication No. 2009/0093792.

Examples of syringe stoppers actuated by telescopic assemblies can be found for example in International Patent Application Publication No. WO/2011/090956 to Cabiri and/or U.S. Patent Application Publication No. 2009/0093792 to Gross which are herein incorporated in their entirety by reference.

SUMMARY OF THE INVENTION

Unless otherwise defined, all technical and/or scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of embodiments of the invention, exemplary methods and/or materials are described below. In case of conflict, the patent specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and are not intended to be necessarily limiting.

According to an aspect of some embodiments of the invention, there is provided an interface for connecting a cylindrical reservoir to a drug delivery device having a skin contact surface comprising: a coupler attached to the drug delivery device independent of the cylindrical reservoir; the coupler sized and shaped to form a flow path between a distal opening of the cylindrical reservoir and a fluid path of the drug delivery device; an expanding assembly attached to the drug delivery device independent of the cylindrical reservoir and expanding along an axis parallel to the skin contact surface; a compartment shaped and sized to hold the cylindrical reservoir with a longitudinal axis of the cylindrical reservoir coaxial to the axis of expansion and a proximal opening of the cylindrical reservoir facing the expanding assembly and a distal opening of the reservoir facing the coupler.

According to some embodiments of the invention, the coupler includes a cannula sized and shaped for piercing a seal of the distal opening of the reservoir.

According to some embodiments of the invention, the interface further comprises: a channel shaped for directing a movement of the reservoir longitudinally along the channel towards the coupler such that the coupler pierces the seal of the distal opening of the reservoir.

According to some embodiments of the invention, the channel is inside the compartment the interface further comprising: a proximal opening of the channel sized and shaped for axial insertion of a proximal end of the reservoir into the channel toward the coupler; and a movable mount connecting the expanding assembly to the delivery device for moving between a first position proximal to the proximal opening of the channel and blocking insertion of the reservoir into the proximal opening of the channel and a second position wherein the expanding assembly is clear of the proximal opening of the channel.

According to some embodiments of the invention, the interface further comprises: a bay including the channel and movably mounted to the delivery device to move between a loading position and a delivery position; wherein in the loading position an opening of the channel is outside of the compartment and in the delivery position the channel and the opening of the channel are in the compartment.

According to some embodiments of the invention, the interface further comprises: a pivot movably attaching the bay to the delivery device.

According to some embodiments of the invention, the opening of the channel is on a proximal portion of the bay and the pivot is on a distal portion of the bay such that when the bay moves from the loading position to the delivery position the opening pivots around the pivot towards the compartment.

According to some embodiments of the invention, the bay moves independently from the coupler such that the coupler is aligned with the channel when the bay is in the delivery position and the coupler is not aligned with the channel when the bay is in the loading position.

According to some embodiments of the invention, the coupler is attached to the bay such that the coupler is aligned with the channel when the bay is in the delivery position and in the loading position.

According to some embodiments of the invention, the coupler is attached to the bay such that when the reservoir is inserted into the bay the coupler forms the flow path while the bay is in the loading position.

According to some embodiments of the invention, the expanding assembly includes a telescoping screw.

According to some embodiments of the invention, the interface further comprises: an opening in the device for inserting the reservoir laterally into the compartment.

According to some embodiments of the invention, the interface further comprises: a hollow needle in fluid communication with the flow path and extending outward from the skin contact surface.

According to an aspect of some embodiments of the invention, there is provided a method of loading a cylindrical reservoir containing a drug into a patch injector having a skin contact surface comprising: providing an expanding assembly mounted to the patch injector independently of the cylindrical reservoir with an axis of expansion parallel to the skin contact surface and also providing a coupler mounted to the patch injector independently from the cylindrical reservoir; positioning the cylindrical reservoir in a compartment of the patch injector between the coupler and an the expanding assembly coaxial to the axis of expansion and with a proximal opening of the cylindrical reservoir facing the expanding assembly and with a distal opening of the cylindrical reservoir facing the coupler; opening a fluid path between the reservoir and an injection device of the patch injector through the distal opening of the reservoir; and expanding the expanding assembly through a proximal opening of the reservoir to push a plunger seal along a longitudinal axis of the reservoir to drive the drug from the reservoir through the distal opening of the reservoir to the fluid path.

According to some embodiments of the invention, the method further comprises: breaking a seal of the distal opening of the cylindrical reservoir with the coupler.

According to some embodiments of the invention, the positioning includes inserting at least a distal portion of the reservoir into the compartment of the patch injector axially towards the coupler through an opening in the compartment and pushing the seal against the coupling after the inserting; and the method further comprising moving the expanding assembly between a first position proximal to the proximal opening and blocking insertion of the reservoir into the proximal opening and a second position wherein the pushing assembly clears the proximal opening.

According to some embodiments of the invention, the method further comprises: Inserting at least a distal portion of the cartridge axially into a channel of a cartridge bay, the inserting and the opening a fluid path occurring while the cartridge bay is in loading position and the proximal opening of the cylindrical reservoir remain outside the compartment; moving the cartridge bay and the cartridge together subsequent to the opening to a delivery position wherein the cartridge is inside the compartment between the expanding assembly and the coupler.

According to some embodiments of the invention, the method further comprises: Inserting at least a distal portion of the cartridge axially into a channel of a cartridge bay in a loading position wherein the proximal opening of the cylindrical reservoir remains outside the compartment; moving the cartridge bay and the cartridge together to position the cartridge inside the compartment between the expanding assembly and the coupler; and wherein the subsequent to the moving, the expanding of the expanding assembly pushes the distal seal of the cartridge against the coupler to cause the opening.

According to some embodiments of the invention, the method further comprises: placing the skin contact surface against a skin of a user; inserting a hollow needle in fluid communication with the fluid path into the user at an angle between 30 to 150 degrees with respect to the axis of expansion.

According to an aspect of some embodiments of the invention, there is provided an interface assembly for drug delivery device a drug cartridge having a seal on a distal portion thereof and a stopper inserted in a proximal opening thereof, the assembly comprising: a cartridge retention compartment; a stopper pushing assembly fixedly mounted to the delivery device proximal to the compartment; a cartridge bay movable mounted to the delivery device; the bay including: a channel fitting at least the distal portion of the cartridge for retaining the cartridge, the channel including a proximal opening sized for insertion of the distal portion of the cartridge longitudinally into the channel and a distal cannula protruding axially into a distal end of the channel for piercing the seal when the distal portion is inserted into the channel, and wherein the bay moves between a loading position wherein the cartridge is inserted into the channel and a delivery position wherein the cartridge is retained inside of the compartment.

Wherein the bay moves between a loading position wherein the cartridge is inserted into said channel and a delivery position wherein said cartridge is retained inside of said compartment.

According to an aspect of some embodiments of the invention, there is provided an interface assembly for drug delivery device a drug cartridge having a seal on a distal end thereof and a stopper inserted in a proximal opening thereof, the assembly comprising: a cartridge retention chamber; a stopper pushing assembly fixedly mounted to the delivery device proximal to the chamber a cartridge bay movable mounted to the delivery device; the bay including: a channel fitting at least a distal portion of the cartridge for retaining the cartridge, the channel including a proximal opening sized for insertion of the distal portion of the cartridge longitudinally into the channel and a distal cannula protruding axially into a distal end of the channel for piercing the seal when the proximal portion is inserted into the channel, and wherein the bay moves between a loading position wherein the cartridge is inserted into the channel and a delivery position wherein the cartridge is retaining inside of the chamber.

According to an aspect of some embodiments of the invention, there is provided an interface assembly for drug delivery device a drug cartridge having a seal on a distal end thereof and a stopper inserted in a proximal opening thereof, the assembly comprising: a cartridge retention chamber; a chamber fitting the cartridge including a proximal opening for insertion of the cartridge a coupler at a distal end of the chamber, the coupler configured to connect the cartridge to a fluid pathway of the delivery device a stopper pushing movable mounted to the delivery device for moving between a first position proximal to the proximal opening and blocking insertion of the cartridge into the proximal opening and a second position wherein the proximal opening is clear for insertion of the cartridge.

According to an aspect of some embodiments of the invention, there is provided a method for interfacing a drug cartridge and a drug delivery device comprising: providing the drug cartridge having a seal on a distal end thereof and a stopper inserted in a proximal opening thereof and also providing a stopper pushing assembly configured for mounting to the delivery device; inserting at least a distal portion of the cartridge into a chamber of the drug device through a proximal opening of the chamber; opening a fluid path between the drug delivery device and the cartridge by pushing the a seal located on a distal end of the cartridge against a coupling mounted to a distal end of the chamber; positioning a cartridge pushing assembly behind the proximal opening.

According to an aspect of some embodiments of the invention, there is provided a method for interfacing a drug cartridge and a drug delivery device comprising: providing the drug cartridge having a seal on a distal end thereof and a stopper inserted in a proximal opening thereof and also providing a stopper pushing assembly configured for mounting to the delivery device; inserting at least a distal portion of the cartridge longitudinally into a channel of movable cartridge bay of the; opening a fluid path between the drug delivery device and the cartridge by pushing the a seal located on a distal end of the cartridge against a coupling mounted to a distal end of the channel; moving the cartridge bay to position the cartridge distal to the cartridge pushing assembly.

According to an aspect of some embodiments of the invention, there is provided a method for interfacing between a drug cartridge and a drug delivery device comprising: coupling a distal opening of the drug cartridge to a flow path of the device; inserting a drug cartridge into the device distal to a stopper pushing assembly mounted to the device; discharging the drug by pushing a stopper distally in the cartridge with the stopper pushing device.

According to an aspect of some embodiments of the invention, there is provided an assembly for interfacing a drug cartridge and a drug delivery comprising: a chamber in the device for holding the cartridge; a coupler for connecting a distal opening of the cartridge to a fluid pathway in the device; an opening in the side of device for inserting the cartridge into the chamber; a stopper pushing assembly mounted to the device proximal to the chamber.

According to an aspect of some embodiments of the invention, there is provided an assembly for interfacing a drug cartridge and a drug delivery comprising: a chamber in the device for holding the cartridge; a coupler for connecting a distal opening of the cartridge to a fluid pathway in the device; a proximal opening in the proximal end of the chamber for inserting the cartridge into the chamber; a stopper pushing assembly movable mounted to the device for moving between a position clearing the proximal opening proximal to the chamber and a position proximal to and blocking the proximal opening of the chamber.

A stopper pushing assembly movable mounted to the device for moving between a position clearing said proximal opening proximal to the chamber and a position proximal to and blocking the proximal opening of the chamber.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

Some embodiments of the invention are herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to the drawings in detail, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of embodiments of the invention. In this regard, the description taken with the drawings makes apparent to those skilled in the art how embodiments of the invention may be practiced.

In the drawings:

FIG. 1A is a block diagram of a cartridge insertion assembly with a moving cartridge bay in a loading position in accordance with an embodiment of the present invention;

FIG. 1B is a block diagram of a cartridge insertion assembly with a moving cartridge bay in a delivery position in accordance with an embodiment of the present invention;

FIG. 1C is a block diagrams of a cartridge insertion assembly in accordance with an embodiment of the present invention;

FIG. 1D is a block diagram of a drug delivery device and cartridge insertion assembly in accordance with an embodiment of the present invention;

FIGS. 2A-B illustrate an exemplary drug delivery device in accordance with an embodiment of the present invention;

FIG. 3A is a flow chart illustrating a method of cartridge insertion in accordance with an embodiment of the present invention;

FIG. 3B is a flow chart illustrating a method of cartridge insertion in accordance with an embodiment of the present invention;

FIG. 4A is a perspective view of inserting a cartridge in accordance with an embodiment of the present invention;

FIG. 4B is a perspective view of closing a tilting bay in accordance with an embodiment of the present invention;

FIG. 4C is a perspective view of a closed tilting bay in accordance with an embodiment of the present invention;

FIG. 4D is a cross sectional view of a drug delivery device and cartridge in accordance with an embodiment of the present invention;

FIG. 5A is a perspective view of inserting a cartridge into a hinged bay in accordance with an embodiment of the present invention;

FIG. 5B is a perspective view of closing a hinged bay in accordance with an embodiment of the present invention;

FIG. 5C is a perspective view of a closed hinged bay in accordance with an embodiment of the present invention;

FIG. 6A is a perspective view of inserting a cartridge into a drug delivery device in accordance with an embodiment of the present invention;

FIG. 6B is a perspective view of closing a hinged cover in accordance with an embodiment of the present invention;

FIG. 6C is a perspective view of a closed hinged cover in accordance with an embodiment of the present invention;

FIG. 7A is a perspective view of inserting a cartridge into a drug delivery device in accordance with an embodiment of the present invention;

FIG. 7B is a perspective view of closing a sliding cover in accordance with an embodiment of the present invention;

FIG. 7C is a perspective view of a closed sliding cover in accordance with an embodiment of the present invention;

FIG. 8A is a close up cross sectional view of a stabilized stopper driver in a retracted configuration in accordance with an embodiment of the present invention;

FIG. 8B is a cross sectional view of a reservoir and a stabilized stopper driver in an extended configuration in accordance with an embodiment of the present invention;

FIG. 9 is a flow chart illustrating a method of driving a stopper in accordance with an embodiment of the present invention.

DESCRIPTION OF SPECIFIC EMBODIMENTS OF THE INVENTION

Overview

An aspect of some embodiments of the present invention relates to an assembly and method for interfacing between a drug reservoir and a drug delivery device. In some embodiments the interface includes a compartment that retains the cartridge and/or an expanding assembly mounted to the device on one side of the compartment and/or a coupler to a fluid path on an opposing side. Optionally an axis of expansion of the pushing assembly is into the compartment and generally parallel to a skin contact surface of the device. Optionally the reservoir is retained in the compartment coaxial to the axis of expansion of the pushing assembly. For example a distal opening of the reservoir faces and/or is located proximal to and/or is connected to the coupler. Optionally the coupler couples the distal opening to a fluid path of the delivery device. Optionally, when the cartridge is in place the pushing assembly expands into a proximal opening of the reservoir and/or pushes a stopper, for example a plunger seal, distally in the reservoir.

Pushing the plunger seal optionally discharges the drug from the reservoir. For example the drug is discharged out the distal opening to the fluid path.

In some embodiments a cartridge may contain a drug in a cylindrical reservoir.

Optionally the reservoir includes a distal opening and/or a proximal opening.

For example the drug may be stored between a distal seal and a proximal seal.

Optionally the proximal seal may include a plunger seal inserted into the reservoir between the location of the drug and the proximal opening. For example the plunger seal may be free to slide along the reservoir. Optionally the distal seal may include a septum.

In some embodiments, a pushing assembly may include an expanding assembly. For example, an expanding assembly may include a telescoping screw and/or an expanding piston (for example driven by gas and/or fluid pressure).

Alternatively or additionally a pushing assembly may include a translating element and/or a linear actuator.

In some embodiments a coupler may unseal an opening in a reservoir and/or supply a connection between the reservoir and a fluid path in the delivery device. For example, an opening in the reservoir may be sealed by the septum. The coupler optionally includes a hollow needle sharpened on a first end. For example the needle and/or reservoir may be united by a longitudinal movement to pierce the septum with the first end of the needle. Optionally the second end of the needle is connected to a flow path of the delivery device.

For example the needle may supply a connection for fluid to flow from the reservoir to a fluid path. Alternatively or additionally, the coupler may include a septum pierced by a needle of the cartridge. Alternatively or additionally other type connectors may be included, for example a slip lock and/or luer lock. In some embodiments the coupler may be connected to the cartridge by a user action, for example inserting the cartridge into the device. For example inserting the cartridge into the device may cause a needle to puncture a septum. Alternatively or additionally, the coupler may be connected to the cartridge during by an action of another component of the device and/or as part of the order of functioning of the device. For example, force of an actuator, for example the pushing assembly, may force the cartridge into connection with the coupler. Alternatively or additionally, the coupler may be moved to connect to the cartridge.

In some embodiments a compartment of the delivery device may retain a cartridge in functional connection to a coupler and/or a pushing assembly. For example, the chamber may align the axis in a desired direction and/or may position the cartridge in a desired location. For example, the chamber may facilitate insertion of the cartridge in a particular orientation and/or into a particular position. For example the compartment may include an element that directs the cartridge and/or fits the cartridge (for example a tapered pin and/or a tapered opening). Alternatively or additionally a compartment may include an element that forces a cartridge into a desired position and/or orientation (for example an elastic element may push a cartridge to a desired position). Alternatively or additionally a compartment may include a retaining element (for example a clip and/or a latch) which holds the cartridge in place.

In some embodiments a cartridge and/or reservoir may be positioned in a compartment by sliding longitudinally into the compartment. Alternatively or additionally a first side of the cartridge and/or reservoir may be placed into the compartment and then the cartridge and/or reservoir may be rotated to position the second end in the compartment. Alternatively or additionally, the cartridge and/or reservoir may be positioned in the compartment by inserting laterally into the compartment. Optionally the cartridge and/or reservoir may be placed into a bay and positioned into the compartment with the bay.

For example a bay may tilt into the compartment and/or rotate and/or slide laterally or longitudinally into the comportment.

In some embodiments a drug delivery device may include a drug administration interface. Optionally a drug administration interface may include a skin contact surface. Alternatively or additionally, the drug administration interface may include an injection device. For example, an injection device may inject a drug under one or more layers of the skin of a user. For example an injection device may include a needle and/or a needle free injector, for example a jet injector.

In some embodiments, a longitudinal axis of a fluid reservoir (for example the longitudinal axis of a cylindrical portion of a cavity) will substantially be parallel to a skin contact surface. For example the angle between the longitudinal axis of the reservoir and the skin contact surface may range between 0 to 5 degrees and/or between 5 to 15 degrees and/or between 15 to 30 degrees and/or between 30 to 60 degrees. Optionally an injection device may have an axis (for example the longitudinal axis of a needle and/or the direction of a fluid jet). Optionally the axis of an injection device may be substantially perpendicular to the longitudinal axis of the reservoir. Additionally or alternatively, the angle between the axis of an injection device and the longitudinal axis of the reservoir may range between 90 to 85 degrees and/or between 85 to 70 degrees and/or between 70 to 30 degrees. In some embodiments a skin contact surface may not be flat. For example the axis of the reservoir may be parallel to the skin contact surface at a point on the surface in the vicinity of a needle hole and/or an injection location and/or at a point nearest to the center of the reservoir and/or in the vicinity of the axis of the reservoir.

In some embodiments a cartridge may fit a channel and/or a cartridge and/or a cartridge bay may exactly fit into a compartment of a delivery device (for example there may be tolerance of less than 0.1 mm and/or between 0.1 to 0.5 mm and/or between 0.5 to 1 mm and/or between 1 to 3 mm. Alternatively or additionally the compartment may be longer than the cartridge and the coupler. For example, the space between the pushing assembly and the cartridge may be between 3 to 5 mm greater than the length of the cartridge and/or 5 to 10 mm greater. For example the cartridge may be inserted into the compartment without connecting the coupler to the cartridge. After positioning the cartridge in the compartment, the pushing assembly may push the cartridge into the coupler and/or connect the reservoir to the coupler.

Optionally, a channel may be sized and shaped such that the distal opening of the reservoir faces the coupler.

For example, when the distal end of the cartridge is fully inserted into the channel, the distal opening of the reservoir may contact the coupler and/or the couple may form a flow path through the distal opening of the reservoir. For example, the channel may be sized and shaped to prevent the cartridge from twisting and/or rotating around in such a way that the distal opening of the reservoir would not contact and/or connect and/or be directly proximal to the coupler. For example the channel may fit the sides of the cartridge with high precision. Optionally, a channel may be sized and shaped so that the proximal opening of the reservoir faces the expanding assembly. For example, the channel may align the distal opening of the reservoir with the expansion axis of the expanding assembly such that distal expansion of the assembly moves the distal end of the assembly into the reservoir.

Optionally, the drug delivery device includes a compartment that retains the cartridge during drug delivery and/or a stopper pushing assembly mounted behind (proximal to) the compartment. In some embodiments, the cartridge may be inserted laterally into the compartment in front of (distal to) the pushing assembly.

In some embodiments, the delivery device may include a moving cartridge bay. The cartridge is optionally inserted into the bay while the bay is in a loading position. Subsequently the bay and cartridge optionally move into a delivery position, for example in the cartridge compartment. For example the cartridge may be loaded into the bay while the axis of the reservoir is not coaxial with the pushing assembly.

Subsequently, the bay and cartridge may be moved into the compartment and/or into alignment with the pushing assembly. For example, the bay may move laterally and/or rotate into the compartment. Optionally in the loading position a proximal opening of the bay is positioned outside the cartridge compartment of the drug delivery device.

In some embodiments, the cartridge compartment may have a proximal opening into which the cartridge is inserted. Optionally, the pushing assembly may be moved into position behind the proximal opening after insertion of the cartridge.

In some embodiments the cartridge may be sealed. Optionally a seal may be broken by a longitudinal movement. For example, a cartridge may include a seal (for example a septum) on a front (distal) end of the cartridge. The seal is optionally punctured by inserting a cannula axially through the front of the cartridge.

For example, the cannula may be mounted to a cartridge bay and/or a distal opening of the cartridge may be unsealed by longitudinally inserting a distal portion of the cartridge into the bay. The bay and the cartridge may be moved laterally into the cartridge compartment.

Alternatively or additionally, the seal may be punctured by a cannula located in the housing of the delivery device. For example, the seal may be punctured when the cartridge is inserted into the compartment. For example the cartridge may be inserted longitudinally into a proximal opening of the cartridge compartment.

Alternatively or additionally subsequent to insertion the seal may be broken.

For example, the plunger driving assembly may push the cartridge distally into the cannula, puncturing the cartridge seal.

In some embodiments, the cartridge is fully loaded to the bay and/or connected to the coupler while the bay is in the loading position. For example, when the cartridge is fully loaded while the bay is in the loading position, the proximal opening of the reservoir is outside the cartridge compartment and/or a portion the reservoir is outside of the compartment, for example between 5 to 15% and/or between 15 to 40% and/or between 40 to 80% and/or between 80 to 100% of the reservoir. For example the portion of the reservoir outside the compartment may be defined as the portion of the drug contained in the reservoir that is outside the compartment.

In some embodiments, the pushing assembly may include a telescoping assembly (TSA) and/or a linear and/or a rotational stabilizer. For example a rotational stabilizer may be mounted to a housing of the drug delivery device and/or a motor mount such that torque on the final element of the telescoping assembly that pushes the stopper is balanced against the motor and/or the housing of the delivery device.

Optionally the torque will not be applied to the drug reservoir and/or the stopper and/or any component that is in contact with the drug.

In some embodiments a cartridge pushing assembly may be positioned behind to a proximal opening of the drug cartridge without regard to the precise longitudinal position of a stopper in the cartridge. Optionally, after positioning the stopper pushing assembly and/or the cartridge, the TSA may be extended until the pushing assembly contacts the stopper. For example, the TSA may be extended after inserting the cartridge into the drug delivery device and/or after positioning the TSA behind the cartridge.

In some embodiments, the stroke length of the TSA may be greater than the minimum length of the TSA.

For example a TSA may have three or more telescoping shafts and/or one or more telescoping guides. For example a telescoping shaft may include an extension rod. Alternatively or additionally a TSA may have four telescoping shafts and/or one, two or more telescoping guides. Alternatively or additionally a TSA may have five telescoping shafts and/or two, three or more telescoping guides. For example a TSA may have a contracted configuration with length ranging between 0.8 and 1.6 cm and/or between 1.6 to 3.2 cm. For example a TSA may have an extended configuration with length ranging between 2.0 to 6.0 cm and/or between 6 to 12 cm.

Optionally, the extended length of the TSA may range between 2.0 to 3.0 times the contracted length and/or between 3.0 to 5.0 times the contracted length.

Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not necessarily limited in its application to the details of construction and the arrangement of the components and/or methods set forth in the following description and/or illustrated in the drawings and/or the Examples. The invention is capable of other embodiments or of being practiced or carried out in various ways.

Cartridge Insertion Assembly

Referring now to the drawings, FIG. 1A is a block diagrams of a cartridge inserted into a cartridge bay in a loading position in accordance with an embodiment of the present invention. In some embodiments, a cartridge bay 123 is movably connected to the delivery device (for example a housing 122a of the delivery device) by a multi-position mount 125 (for example including a pivot and/or a slider and/or a hinge). Optionally the bay includes a coupling 148 connecting a reservoir 120 of drug cartridge 153 to a fluid path 149 of the delivery device. Optionally, all or part of cartridge 153 is loaded to bay 123 while bay 123 is in the loading position. For example when the cartridge 153 is loaded into the bay, cartridge 153 may be connected to coupling 148. Optionally while bay 123 is in the loading position all or part of bay 123 is located outside of a housing of the delivery device. For example, in the loading position between 100% to 75% and/or between 75% to 50% and/or between 50% to 25% and/or between 25% to 5% of bay 123 and/or cartridge 153 may be outside of the delivery device and/or housing 122a and/or a cartridge compartment of the delivery device. Alternatively or additionally, bay 123 may include a proximal opening for loading cartridge 153 to bay 123. In the loading position, the proximal is optionally clear of the delivery device.

In some embodiments, cartridge 153 includes a drug reservoir 120. For example reservoir 120 may include a proximal opening 141 and/or a distal opening.

Optionally an opening may be closed by a seal 146, for example a septum. While loaded into bay 123 in the loaded position, opening 141 may be free of the and/or outside of the delivery device. Reservoir 120 may contain a drug. For example the drug may be sealed between stopper 140 and seal 146.

In some embodiments, coupling 148 may include a cannula. When cartridge 153 is loaded into bay 123, the cannula is optionally inserted through a septum of seal 146 providing fluid communication between drug 144 and fluid path 149. Optionally coupling 148 is mounted to and/or moves with bay 123. Optionally, coupling 148 is mounted to housing 122a. Optionally, fluid path 149 keeps fluid communication open between coupling 148 and the delivery device for the different positions of bay 123.

For example, fluid path 149 may include a flexible tube. In some embodiments the cannula and/or fluid path may be in fluid communication with an injection needle.

In some embodiments, the delivery device may include a patch in injector.

Optionally in the distribution position, the long axis of the cartridge and/or the long axis of the cartridge compartment is substantially parallel to and/or at an angle of less the 10 degrees and/or between 10 and 30 degrees to a base of the patch injector.

Optionally the base of the injector contacts the skin of a patient. Optionally the base of the injector may include an adhesive for adhering to the patient. In some embodiments an injection needle may be inserted into a patient. For example the injection needle may be inserted into the patient in a direction substantially perpendicular to the base and/or at an angle of between 85 to 90 degrees to the base and/or between 75 to 85 degrees to the base and/or between 60 to 75 degrees to the base.

In some embodiments the delivery device may include a stopper driving assembly 150. Driving assembly 150 is optionally fixedly mounted onto housing 122a proximal to a cartridge compartment. In the loading position, cartridge 153 and/or bay 123 may not be aligned with and/or couple to driving assembly 150.

We refer now to the FIG. 1B which is a block diagram of a cartridge inserted into a cartridge bay in a delivery position in accordance with an embodiment of the present invention. In the delivery position, driving assembly 150 is optionally positioned proximal to cartridge 153 and/or opening 141. In the delivery position, driving assembly 150 is optionally aligned with opening 141 and/or engaged to stopper 140. For example, after positioning bay 123 and/or cartridge 153 in the delivery position, driving assembly 150 may advance a stopper interface to contact and/or push stopper 140 and/or discharge drug 144 through coupling 148 to fluid path 149.

For example, in the delivery position, between 100% to 75% and/or between 75% to 50% and/or between 50% to 25% and/or between 25% to 5% of bay 123 and/or cartridge 153 may be inside of the delivery device and/or housing 122a and/or the cartridge compartment.

We refer now to the FIG. 1C which is a block diagram of a cartridge inserted into a delivery device in accordance with an embodiment of the present invention. In some embodiments, coupling 148 may be mounted to a housing 122b of the delivery device. Optionally, housing 122b may include a proximal opening to a cartridge compartment. For example cartridge 153 may be inserted longitudinally into the proximal opening until coupling 148 engages the distal opening of reservoir 120 and/or pierces seal 146. Alternatively or additionally, housing 122b may have a side opening. For example, cartridge 153 may be inserted laterally into the side opening.

Optionally, driving assembly 150 may initially push cartridge 153 distally until coupling 148 engages the distal opening of reservoir 120 and/or pierces seal 146.

We refer now to the FIG. 1D which is a block diagram of a cartridge inserted into a cartridge bay in a delivery position showing details of the plunger pushing assembly in accordance with an embodiment of the present invention.

Driving assembly 150 is optionally supported by housing 122b. For example, housing 122b may balance linear forces between driver assembly 150 and stopper 140 and/or cartridge 153. Driver assembly 150 optionally includes an anti-rotational guide, for example guide 104. Anti-rotational guide 104 optionally supports the driver assembly and/or balances torque between the driver assembly and a motor for example motor 108.

In some embodiments, stopper driver assembly 150 may include a telescoping assembly (for example TSA 152).

Optionally, TSA 152 includes a proximal shaft, for example a threaded drive shaft 110 and/or a threaded mid shaft 112 and/or a distal shaft, for example a threaded pushing shaft 114. Shafts 110, 112 and/or 114 may be coupled such that rotating drive shaft 110 with respect to pushing shaft 114 causes TSA 152 to lengthen and/or shorten. Optionally axial movement of drive shaft 110 is limited by linear stabilizer 106 such that rotating drive shaft 110 with respect to pushing shaft 114 causes pushing shaft 114 to move linearly with respect to linear stabilizer 106. Optionally, a coupling links guide 104 and/or pushing shaft 114 to housing 122b. For example, rotation of pushing shaft 114 may be limited by housing 122b such that rotating drive shaft 110 with respect to housing 122b causes TSA 152 to lengthen and/or shorten.

Alternatively or additionally, drive shaft 110 and/or pushing shaft 114 may be replaced by a nut and/or threaded disk and/or ring.

In some embodiments motor 108 may include a DC electric motor, a chemical engine, a brushless motor, an AC motor, an actuator etc.

In some embodiments, linear stabilizer 106 and/or housing 122b may be attached to drug cartridge 153 and/or pushing shaft 114 may abut against stopper 140 such that extending TSA 152 moves stopper 140 axially with respect to reservoir 120.

Axial back forces of stopper 140 with respect to reservoir 120 (for example due to friction between stopper and the walls of the reservoir and/or due to flow resistance) are optionally balanced against linear stabilizer 106 and/or housing 122b.

In some embodiments, motor 108 may apply a torque to drive shaft 110.

Optionally, anti-rotational guide 104 may be attached to drug cartridge 153 such that activating motor 108 moves pushing shaft 114 axially with respect to drive shaft 110. Friction between driving shaft 110, mid shaft 112, and/or pushing shaft 114 are optionally balanced by an anti-torque between motor 108 guide 104 and/or housing 122b such that TSA 152 acts as a linear actuator putting a net linear force (and/or a negligible torque) on the parts of the device that are in contact with the drug (for example stopper 140 and/or cartridge 153).

In some embodiments, mid-shaft 112 and/or anti-rotational guide 104 may move axially. For example mid-shaft 112 and/or anti-rotational guide 104 may move into and/or out of reservoir 120. For example guide 104 may be slidably and/or anti-rotationally connected to housing 122b for example by a track.

In some embodiments, the order of movement of parts of TSA 152 may be not fixed.

For example, in some embodiments, mid shaft 112 is free to rotate along with driving shaft 110 and/or rotate along with pushing shaft 114. For example, the position of some part (for example mid shaft 112) may be indeterminate in some configurations (for example when TSA 152 is partially extended). For example the part may move without changing the length of TSA 152.

In some embodiments, guide 104 may slide and/or anti-rotationally connect to housing 122b. For example the connection may include a longitudinal track. Pushing shaft 114 may slide and/or be anti-rotationally connected to guide 104 for example by a longitudinal track.

In some embodiments, driver shaft 110 may be an inner shaft and the pushing shaft 114 may be an outer shaft. Alternatively or additionally driver shaft 110 may be an outer shaft and the pushing shaft 114 may be an inner shaft. Any or all of the components of the current invention may be made of plastic and/or metal and/or another material.

Drug Delivery Device

FIGS. 2A and 2B illustrate a drug delivery device in accordance with some embodiments of the present invention. Optionally a drug delivery device includes a plunger pushing assembly and/or a fluid path coupler on opposing ends of a cartridge compartment. Optionally the cartridge compartment fits a drug cartridge with the axis of the cartridge reservoir parallel to a skin contact surface of the device.

FIG. 2A is a perspective view of a drug delivery device 222 and a cartridge 220 In accordance with an exemplary embodiment of the current invention. In some embodiments drug delivery device 222 may include a cartridge compartment 224.

Optionally, compartment 224 is sized to fit cartridge 220. For example cartridge 220 fits into compartment 224 snugly between a piston pushing assembly 252 and a coupler (for example including a coupler may include a hollow needle 248 as illustrated for example in FIG. 2B).

In some embodiments, cartridge 220 fits into compartment 224 inside a cartridge bay 223. Optionally, bay 223 opens out from compartment 224. For example, in the open position (for example as illustrated in FIG. 2A) cartridge 220 may be inserted into bay 223. For example, to position cartridge 220 into compartment 224 a user may insert cartridge 220 into bay 223 in the open position and then close bay 223; thereby 220 into compartment the inserting cartridge.

Optionally bay 223 opens and/or closes by pivoting into and/or out of compartment 224.

In some embodiments a drug delivery device 222 may include an administration interface. For example, device 222 includes a skin contact surface 230.

For example, when delivering a drug, skin contact surface 230 is placed against the skin of a user. Optionally, all or part of skin contact surface 230 is coated with an adhesive.

For example the adhesive may hold the device to a user during drug delivery.

Optionally skin contact surface 230 includes a needle shield 232 and/or a drug delivery hole 234.

For example, a needle may be extended out of hole 234 into the skin of a user and/or a drug may be discharged through the needle and/or through hole 234 into the user. Optionally after use, shield 232 may extend to cover the needle and/or to prevent a stick hazard. Alternatively or additionally, a needle may retract into device 222 after drug discharge, for example to prevent a stick hazard. Alternatively or additionally a drug delivery device may include a jet injector and/or other injection device.

FIG. 2B is a cutaway view of injector 222 in accordance with an embodiment of the current invention. In FIG. 2B, cartridge 220 is illustrated positioned inside compartment 224. Optionally, cartridge 220 includes a cylindrical reservoir 219. For example, when positioned inside compartment 224, the longitudinal axis of cylindrical reservoir 219 is parallel to skin contact surface 230. In exemplary injection device 222, an injection needle 236 is illustrated in an extended position. Optionally, needle 236, in the extended position, is perpendicular to the longitudinal axis of reservoir 219. Optionally a fluid path, for example including a flexible tube 249, connects needle 236 to a coupler. For example, the coupler may include a hollow needle 248. Optionally, needle 248 of the coupler is mounted to device 222 at one end of compartment 224. Optionally, piston pushing assembly 252 is mounted to device 222 at an opposing end of compartment 224. When cartridge 220 is loaded into device 222, it is optionally placed between piston pushing assembly 252 and the coupler. Optionally, piston pushing assembly 252 expands along an axis of expansion that is coaxial to cartridge 220 when cartridge 220 is positioned inside compartment 224.

In some embodiments a coupler includes a hollow needle 248. For example needle 248 opens a fluid communication between fluid path 249 and reservoir 219.

For example, when cartridge 220 is inserted into bay 223, a septum 246 is pierced by needle 248.

In some embodiments, needle 248 may pierce septum 246 after cartridge 220 is positioned inside compartment 224. For example, piston pushing assembly 252 may push cartridge 220 longitudinally into needle 248. For example, compartment 224 may be slightly longer than cartridge 220. Optionally the needle may penetrate the septum for example between 1 to 3 mm and/or between 3 to 6 mm and/or between 6 to 12 mm. Optionally, the cartridge may move between 1 to 3 mm and/or between 3 to 6 mm more than the needle penetration. For example the compartment may be 3 to 6 mm and/or 6 to 12 mm longer than the cartridge.

In some embodiments, cartridge 220 may include a syringe. For example, a syringe may include a cylindrical reservoir 219. Reservoir 219 optionally includes a cylindrical cavity having a distal opening 256 and/or a proximal opening 241.

Optionally, the distal portion of reservoir 219 is filled with a drug.

In some embodiments, a plunger seal 240 is inserted into reservoir 219. For example, the plunger seal 240 may seal reservoir 219 between the location of the drug and proximal opening 241. Optionally the syringe may include a proximal flange 221. For example, flange 221 may facilitate positioning and/or retaining the syringe in bay 223 and/or compartment 224. Alternatively or additionally, syringe may be filled in an automated filling machine. For example, flange 221 may be used by the filling machine for handling and/or positioning the syringe. For example, the syringe of cartridge 220 may be a standard size and/or shape that fits into a standard filling machine. In some embodiments, opening 256 is coaxial to reservoir 219.

Alternatively or additionally, opening 256 may be positioned eccentrically with respect to reservoir 219.

Optionally, piston pushing assembly 252 includes a telescoping screw assembly.

For example, piston pushing assembly 252 includes a driver 210 that is optionally rotated by a transmission and/or a motor. For example a transmission may include a gear 226. Optionally the transmission and/or driver and/or motor remain permanently engaged. For example the transmission and/or motor and/or driver may remain engaged before insertion of the cartridge, during insertion of the cartridge and/or after insertion of the cartridge into the compartment of the device.

Driver 210 is optionally supported from a distal end by a linear stabilizer, for example, a bearing 206 pushing against a housing of device 222. Optionally, driver 210 is threadably connected by two mid screws 212a and 212b and/or to a plunger driver 214.

For example, plunger driver 214 may be allowed to move longitudinally with respect to driver 210 and/or prevented from rotating with respect to the housing of device 222, for example by a anti-rotational guide 204. For example, rotating driver 210 causes relative rotation of threaded parts, for example driver 210, mid screws 212a, 212b and plunger driver 214 and/or longitudinally extension of piston pushing assembly 252. For example, plunger driver 214 may be driven along the axis of reservoir 219 and/or into reservoir 219. As plunger driver 214 moves into reservoir 219 it optionally pushes plunger seal 240 distally and/or drives the drug out of the opening in septum 246 and/or through needle 248 and/or into fluid path 249 and/or through needle 236 and/or into a user. In some embodiments, piston pushing assembly 252 drives plunger driver 214 to into opening 241. For example, plunger driver 214 may move into opening 241 until it engages and/or contacts plunger seal 240. Optionally, further expansion of piston pushing assembly 252 after plunger driver 214 engages plunger seal 240 drives plunger seal 240 distally into reservoir 219.

Optionally driving plunger seal 240 distally into the reservoir 219 causes discharge of the drug for example through distal opening 256 of reservoir 219.

Filling a Cartridge

In accordance with some embodiments of the present invention, a reservoir may be fillable with standard pharmaceutical equipment (for example in an existing clean room with filling equipment made for a standard syringe and/or cartridge).

Optionally, the stopper driver engages the stopper located at an arbitrary position within the reservoir. In some embodiments the stopper driver may be assembled with snap together parts. The parts are optionally made of molded materials such as plastic, for example polyoxymethylene (POM) resin.

In some embodiments a drug reservoir is supplied. Optionally the reservoir may be prefilled. For example, the reservoir may be filled using standard filling equipment. For example, the reservoir may have a cylindrical and/or tubular bore or cavity and/or a bore of arbitrary cross section. For example the body may be in the form of a right circular cylinder. Optionally, the internal cavity may be of arbitrary shape. For example, the internal cavity may have a smooth wall over at least half its length and/or over at least 90% of its length. For example the cavity of the reservoir may be substantially a right circular cylinder over at least half its length and/or over at least 90% of its length. For example the internal cavity may be coaxial with the outer walls of the cartridge over at least half its length and/or over at least 90% of its length.

For example the cross section of the cavity may be uniform over at least half its length and/or over at least 90% of its length. Optionally the reservoir may include a distal opening.

In some embodiments, a distal portion of the reservoir may include cannula for example a hypodermic needle and/or a mount for such. Alternatively or additionally the distal portion of the reservoir and/or the distal opening may include a seal, for example a septum and/or sterile cover for example a needle cover. The proximal end of the reservoir may include a proximal opening. Optionally the proximal opening may be larger than the distal opening. For example the cross sectional area of the proximal opening may range between 5 to 50 times the cross sectional area of the distal opening and/or 50 to 500 times the cross sectional area of the distal opening. Optionally, an opening may be beveled and/or may smoothly connect to the internal cavity of the reservoir. Optionally, a stopper may be inserted into the proximal opening. Optionally, a plunger seal, for example a stopper may seal and/or preserve sterility of the contents of the reservoir. Optionally the position of the stopper may vary dependent on the volume of the contents of the reservoir. Optionally the proximal end of the cartridge may include a flange. For example the flange may extend from the between 20% to 100% of the perimeter of the cartridge. For example the flange may extend between 1 mm and 2 cm from the internal walls of the proximal opening. Optionally the reservoir may be made as a single integral unit for example of molded glass or plastic and/or cut and/or processed tubing.

Insertion of a Drug Cartridge

FIG. 3A is a flow chart illustrating a method of cartridge insertion in accordance with an embodiment of the present invention. For example, the cartridge may be inserted with a moving bay. For example, the bay may be opened 385 to a loading position. With the bay in a loading position, the cartridge and/or a portion thereof is optionally loaded 323a to the bay. For example, the bay may include a proximal opening and/or a distal portion of the cartridge may be inserted longitudinally into the bay for example through the proximal opening thereof. For example between 1 to 5% of the cartridge may be inserted into the bay and/or between 5 to 15% of the cartridge may be inserted into the bay and/or between 15 to 40% of the cartridge may be inserted into the bay and/or between 40 to 75% of the cartridge may be inserted into the bay and/or between 75 to 100% of the cartridge may be inserted into the bay. In some embodiments, inserting the cartridge into the bay may connect 326a a coupler to the cartridge. For example, the bay may include a cannula that protrudes proximally into the distal end of a cartridge channel in the bay.

When the cartridge is inserted into the channel, the cannula optionally pierces a septum on a distal end of the cartridge.

In some embodiments, with the cartridge loaded 323a into the bay, the bay may be closed 325 to position the bay and/or the cartridge into a distribution position.

For example, the bay may slide or pivot into an opening in the side of the delivery device. When the cartridge is in the delivery position, the stopper pushing assembly may optionally be located proximal to the cartridge and/or aligned with a proximal opening in the drug reservoir and/or with the stopper.

In some embodiments, with the cartridge and/or bay in the closed 325 (e.g. in the distribution position), the stopper driving assembly may be advanced 313.

Extending the stopper driver may result in engagement of the stopper by a stopper interface and/or driving the stopper forward into the drug reservoir and/or discharging 314 the drug.

FIG. 3B is a flow chart illustrating a method of cartridge insertion in accordance with an embodiment of the present invention. In some embodiments a cartridge may be inserted to 323b laterally into the distribution device without a moving bay. Alternatively or additionally, the cartridge may be inserted 323b longitudinally into the device.

In some embodiments, the cartridge may be inserted 323b laterally into the delivery device. For example, the cartridge may be inserted 323b into an opening in the side of a housing of the device that leads to a cartridge compartment. Optionally after insertion 323b, a stopper driver is advanced 313 from behind the cartridge toward the stopper. The stopper driver optionally engages the stopper. The cartridge is optionally driven forward (for example by the stopper driver). For example, while the distal end of the cartridge is sealed, pressure on the plunger may not drive a discharge the drug. The pressure on the stopper and/or the fluid pressure optionally drive the cartridge forward. Driving the cartridge forward optionally connects 326b the drug reservoir to a coupler and/or forms a fluid pathway between the cartridge and the delivery device (for example by puncturing a septum). Opening a fluid path exiting the reservoir to the drug delivery device may facilitate advancement of the stopper inside the drug reservoir and/or discharge of the drug.

Further advance 313 of stopper driving assembly optionally advances the stopper into the drug reservoir and/or discharges 314 the drug. For example the drug may be discharged 314 through the coupler and/or into a fluid pathway of the delivery device and/or into a user. Alternatively or additionally, the syringe may be driven forward to connect to the coupler after insertion into the bay (for example while the bay is being closed to the delivery position and/or after the bay is closed to the delivery position) by a mechanism other than the expanding assembly, for example by a being pushed forward by an inclined surface.

In some embodiments the cartridge may be inserted 323b longitudinally into the device. For example the device may have a proximal opening leading to a cartridge compartment. The inserting 323b the cartridge longitudinally into the cartridge compartment optionally connects 326b the drug reservoir to a coupler and/or forms a fluid pathway between the cartridge and the delivery device (for example by puncturing a septum). Optionally, after the septum has been punctured, a stopper driver is advanced 313 from behind the cartridge toward the stopper. The stopper driver optionally engages the stopper. Further advance 313 of stopper driving assembly optionally advances the stopper into the drug reservoir and/or discharges 314 the drug. For example the drug may be discharged 314 through the coupler and/or into a fluid pathway of the delivery device and/or into a user.

Insertion Assembly with a Tilting Cartridge Bay

FIG. 4A is a perspective view of inserting a cartridge into a tilting bay in accordance with an embodiment of the present invention. In some embodiments, a cartridge bay 423 tilts out of a drug delivery device 422 to a loading position for example as shown in FIG. 4A. Optionally bay 423 has a proximal opening 441b to a cylindrical channel (which can be seen for example through a window 447). The channel is optionally sized to fit a cartridge 420. For example cartridge 420 is illustrated optionally being inserted 473 through opening 441b into the channel. For example, bay 423 tilts along a movable, multiposition mount (for example a pivot 425). An optional support 445 supports bay 423 in the loading position. Optionally bay 423 and/or cartridge 420 rotate around pivot 425 into a closed position in a cartridge compartment 424, for example as illustrated in FIG. 4B. Optionally, in the closed position, cartridge 420 and/or bay 423 are coaxial with a plunger pushing assembly and/or compartment 424, for example as illustrated in FIG. 2B.

In some embodiments, cartridge 420 may include a standard syringe. For example, cartridge 420 may include a proximal opening 441a. A plunger seal 440 is optionally inserted through opening 441a to seal off a proximal portion of cartridge 420 from a drug included in a distal portion thereof. The distal end of reservoir optionally includes an opening 456 and/or a seal (for example a septum 446 for example as illustrated in FIG. 4D) and/or a needle mount. Optionally cartridge 420 includes a proximal flange 421.

In some embodiments delivery device 422 may include a patch injector. For example a skin contact surface 430 of the injector may be oriented parallel and/or nearly parallel to the long axis of cartridge 420. For example in FIGS. 4A-D, the skin surface base of the injector is facing into the page. The skin contact surface is optionally fully or partially covered by an adhesive 429 layer. Delivery device optionally includes an electronics compartment 435. Delivery device optionally includes an injection needle insertion assembly 433. For example after placing the skin contact surface onto the body of a patient, a user may push a protruding button of assembly 433 into the injector to release a needle outward from the skin contact surface into the patient.

FIG. 4B is a perspective view of a tilting bay in a loading position with a cartridge inserted in accordance with an embodiment of the present invention. In FIG. 4B cartridge 420 has optionally been inserted 473 into bay 423 and is visible through window 447. In the exemplary embodiment of FIGS. 4A-D, subsequent to insertion 473 of the cartridge into bay 423, bay 423 is optionally closed 475 by tilting into a cartridge compartment of delivery device 422.

FIG. 4C is a perspective view of a closed tilting bay in accordance with an embodiment of the present invention. Once the bay 423 is closed, a plunger driving assembly optionally located in the proximal end of device 422 proximal to opening 441a may drive plunger seal 440 distally and/or discharge the drug.

FIG. 4D is a cross sectional view of a drug delivery device with a tilting bay and cartridge in a loading position in accordance with an embodiment of the present invention. In FIG. 4D, an exemplary embodiment of a stopper driving assembly is illustrated. A stopper driver may include a TSA including for example an anti-rotational guide 404 and/or a stopper driver shaft 410 and/or a mid-shaft 412 and/or a stopper pushing shaft 414. Optionally guide 404 is connected to device 422 by a track that allows guide to slide linearly in a distal direction but prevents guide 404 from rotating with respect to device 422. Optionally, stopper driver shaft 410 is supported by a linear stabilizer, for example a bearing 406. For example, bearing 406 rests on the housing of device 422. Bearing 406 optionally allows stopper driver shaft 410 to rotate, but prevents stopper driver shaft 410 from moving proximally with respect to device 422.

In some embodiments, a transmission, including, for example, a gear 426 optionally connects stopper driver shaft 410 to a motor 408. Motor 408 optionally rotates stopper driver shaft 410 with respect to device 422. Rotating stopper driver shaft 410 with respect to device 422 while guide 404 optionally prevents stopper pushing shaft 414 from rotating with respect to device 422 optionally creates relative rotation between stopper driver shaft 410 and stopper pushing shaft 414. An optional set of screw threads mating stopper driver shaft 410, mid-shaft 412 and stopper pushing shaft 414 optionally translate relative rotation into linear telescoping of the assembly. Optionally the stopper pushing assembly is fixed in a proximal portion of device 422 and/or proximal to the cartridge compartment and/or proximal to the distribution position of cartridge 420. Electronics compartment 435 may include, for example, a power source (for example a battery 493) and/or a controller (for example a printed circuit board 499).

In some embodiments, in the loading position, the bay may pivot an angle of between 1 to 10 degrees and/or 10 to 30 degrees and/or 30 to 60 degrees and/or an angle between 60 to 90 degrees out of compartment 424.

In some embodiments, when cartridge 420 is inserted into bay 423 and bay 423 is closed and/or cartridge 420 is in the distribution position, distal advancement of stopper pushing shaft 414 pushes plunger seal 440 distally and/or discharges a drug 444 into a fluid path of the injector. The fluid path of the injector may optionally include a cannula 448 leading from cartridge 420 to a tube 449 to the injection needle of insertion assembly 433 and/or out into the patient. Optionally tube 449 is flexible and/or allows cannula 448 to move relative device 422 and/or insertion assembly 433 (for example cannula 448 may move along with bay 423 when bay 423 is opened and/or closed). Optionally cannula 448 is bent for example ranging between 90 to 85 degrees and/or between 85 to 60 degrees and/or between 60 to 45 degrees.

Insertion Assembly with a Hinged Cartridge Bay

FIG. 5A is a perspective view of inserting a cartridge into a hinged bay in accordance with an embodiment of the present invention. In exemplary device 522, a cartridge bay 523 swings out to a loading position (for example as illustrated in FIG. 5A).

In the loading position, cartridge 420 may be inserted 573 through a proximal opening 541 into bay 523. For example the opening 541 may lead to a channel.

Optionally the channel is cylindrical and/or snugly fits the cartridge. A closed distal wall 545 optionally supports the distal end of bay 523. Optionally, bay 523 rotates to a closed position (for example as illustrated in FIG. 5C) wherein bay 523 and/or cartridge 520 inserted therein is coaxial with a cartridge compartment 524 and/or a cartridge pushing assembly.

FIG. 5B is a perspective view of a hinged bay in a loading position and loaded with a cartridge in accordance with an embodiment of the present invention. For example, once loaded, bay 523 is closed 575 into a distribution position by swinging around a movable, multiposition mount (for example a hinge 525 for example as illustrated in FIG. 5C).

FIG. 5C is a perspective view of a hinged bay in a distribution position in accordance with an embodiment of the present invention. The proximal end of device 422 optionally includes a stopper driving assembly as illustrated for example in FIG. 4D. Bay 523 optionally includes a cannula.

FIG. 6A is a perspective view of inserting a cartridge into a drug delivery device in accordance with an embodiment of the present invention. For example, the device may have a hinged cover 623. For example the embodiment of FIGS. 6A-C does not include a cartridge bay. Optionally, in the loading position the proximal cover 623 of a device 622 swings open revealing an opening 641 to a cartridge compartment 624 (seen for example through window 447). Cartridge 420 may optionally be inserted 673 longitudinally into cartridge compartment 624. A cannula optionally protruding in the distal end of the cartridge compartment optionally pierces a septum on the distal end of cartridge 420 upon insertion 673 and/or connects cartridge 420 to a fluid path of device 622 upon insertion. Alternatively or additionally, the septum may be pierced after insertion. For example, the cartridge may be pushed into the coupler by the expanding assembly. FIG. 6B is a perspective view of a hinged cover device in a loading position after insertion of a cartridge in accordance with an embodiment of the present invention. After insertion 673 of cartridge 420, the proximal cover 623 of device 622 optionally swings 675 closed.

FIG. 6C is a perspective view of a closed a hinged cover 623 in accordance with an embodiment of the present invention. Optionally a plunger pushing assembly is located in the proximal cover 623 and/or is positioned proximal to cartridge 420 when the cover is closed.

FIG. 7A is a perspective view of inserting a cartridge into a drug delivery device in accordance with an embodiment of the present invention. For example device of FIGS. 7A-7C include a sliding cover 723. For example the embodiment of FIGS. 7A-7C do not include a cartridge bay. Optionally, in the loading position the proximal cover 723 of a device 722 slides open revealing an opening 741 to a cartridge compartment (seen for example through window 447). Cartridge 420 may optionally be inserted 773 longitudinally into cartridge compartment 724. A cannula optionally protrudes into the distal end of cartridge compartment 724. The cannula optionally pierces a septum on the distal end of cartridge 420 upon insertion 773 and/or connects cartridge 420 to a fluid path of device 722 upon insertion and/or after insertion.

FIG. 7B is a perspective view of a sliding cover device in a loading position after insertion of a cartridge in accordance with an embodiment of the present invention. After insertion 773 of cartridge 420, the proximal cover 723 of device 722 optionally slides 775 closed.

FIG. 7C is a perspective view of a closed sliding cover 723 in accordance with an embodiment of the present invention. Optionally a plunger pushing assembly is located in the proximal cover 723 and/or is positioned proximal to cartridge 420 when cover 723 is closed.

A Stopper Driver with Anti-Rotational Guide Stabilized by the Device Housing

FIG. 8A is a close up cross sectional view of a stopper driver in a contracted configuration in accordance with an embodiment of the present invention. In some embodiments, a TSA 452 is stabilized by a housing of a drug delivery device 822. For example, projection 405 of anti-rotational guide 404 connects to a guide track 805 that is attached to and/or intrinsic to the housing of device 822. Stopper driver shaft 410 is optionally linearly stabilized against the housing of device 822. For example, linear stabilization may be via a bearing 806. For simplicity the transmission and motor assembly are not shown in the FIGS. 8A-8B. Optionally device 822 has a skin contact surface 830.

FIG. 8B is a cross-sectional view of a cartridge and a stopper driver in an extended configuration in accordance with an embodiment of the present invention.

Optionally stopper driver shaft 410 is rotated expanding TSA 452. For example TSA 452 expands into cartridge 420 and/or pushes plunger seal 440 into cartridge 420 and/or discharges a drug from cartridge 420. Optionally as TSA 452 expands, an anti-rotational guide moves into cartridge 420. For example projection 405 may slide down track 805 as anti-rotation guide 404 slides into cartridge 420 and/or projection 415a may slide down track 415b as stopper pushing shaft 414 slides with respect to anti rotation guide 404. A ridge 821 holds cartridge 420 from moving linearly distally with respect to device 822. Optionally contact surface 830 is parallel to an axis of a reservoir of cartridge 420 when cartridge 420 is inserted into a cartridge compartment of device 822 (for example in a delivery position). Optionally contact surface 830 is parallel to an axis of TSA 452. Optionally, and axis of expansion of TSA 452 is coaxial to cartridge 420 when cartridge 420 is inserted into a cartridge compartment of device 822.

Driving a Stopper

FIG. 9 is a flow chart illustrating a method of driving a plunger seal in accordance with an embodiment of the present invention. In some embodiments, a TSA may be extended or retracted by more than 100% its minimum length by rotating 910 a single shaft and/or by inhibiting rotation of a single shaft. For example, a TSA may be opened by rotating 910 a drive shaft. Optionally a proximal drive shaft may be located proximally to a distal pushing shaft. For example, the drive shaft may be rotated 910 with respect to a drug delivery device by a motor mounted on the device.

For example rotation 910 of the drive shaft may be with respect to the housing of the drug delivery device and/or with respect to a mount of the motor. Optionally, while the drive shaft is rotating, a pushing shaft may be inhibited 902 from rotating.

For example, an anti-rotational guide may prevent the pushing shaft from rotating with respect to the drug delivery device housing and/or with respect to the motor and/or with respect to a motor mount. Rotating 910 the drive shaft with respect to the pushing shaft optionally extends the TSA and/or the pushing shaft and/or a stopper.

In some embodiments and/or in some configurations, the mid shaft may axially move independently of the length of the TSA. For example, as the TSA is extended the mid shaft may either extend linearly 912 with the pushing shaft and/or rotate 913 with the drive shaft.

Optionally, for some lengths of the TSA, the position of the mid shaft may be indeterminate. For example, rotating 910 the drive shaft may, for example, extend 912 a mid-shaft into a reservoir (for example when the drive shaft rotates faster than the mid-shaft and/or by means of threading coupling the drive shaft to the mid shaft).

Optionally, extending 912 the mid-shaft into the reservoir simultaneously extends 914 the pushing shaft into the reservoir. Alternatively or additionally, rotating 910 the drive shaft may rotate 913 the mid-shaft. Optionally, rotating 913 the mid-shaft extends 914 a pushing shaft into the reservoir (for example by means of threading coupling the drive shaft to the mid shaft). Rotation and/or extension of the mid shaft may occur concurrently and/or sequentially.

In some embodiments, the anti-rotational guide may axially float. For example, when the TSA is extended the anti-rotational guide may either extend 904 (for example moving axially with respect to and/or into the reservoir) along with the pushing shaft and/or the anti-rotational guide may remain stationary with respect to the reservoir and/or the pushing shaft may extend 914 axially with respect to the anti-rotational guide. Optionally, for some lengths of the TSA, the position of the anti-rotational guide may be indeterminate.

Exemplary Dimensions of a Drug Delivery Device

In some embodiments the payload of a reservoir (for example a syringe) may include, for example between 0.5 and 3 ml and/or between 3 and 6 ml and/or between 6 and 10 ml and/or between 10 and 15 ml of a drug and/or more. Optionally the length of the reservoir (for example the length of the cylindrical portion of the cavity holding the drug) may range between 2 to 5 cm and/or between 5 to 10 cm.

Optionally the width of the reservoir (for example the inner width and/or diameter of the cylindrical portion of the cavity holding the drug) may range for example between 0.5 cm to 2 cm and/or between 2 to 5 cm. In some embodiments, the injector may discharge the entire payload as a single dose. A drug delivery device may include, for example, a pen injector and/or a patch injector, and/or an internally powered driver to drive the stopper and/or discharge the payload. The reservoir of the injector may be oriented parallel to the skin of a subject and/or perpendicular to the skin and/or at an angle between parallel and perpendicular, for example between 60 to 90 degrees and/or between 30 to 60 degrees and/or between 0 to 30 degrees.

For the sake of this application an internally powered injector driver may be defined as a drive mechanism powered by energy stored at least temporarily within the injector.

Power may be stored in a power supply, for instance as chemical potential (for example a chemical that produces an expanding gas and/or a battery) and/or mechanical potential (for example stored in an elastic member and/or a spring and/or a pressurized gas). For example the driver may be designed to discharge the payload over a time period ranging between 20 and 120 seconds and/or between 120 and 600 seconds and/or between 600 and 7200 seconds and/or longer. In some embodiments, discharge may be driven by a driver. An internally powered driver may be powered by various mechanisms including for example a motor (including for example a DC motor, an actuator, a brushless motor) and/or a transmission including for example a telescoping assembly and/or a threaded element and/or a gear and/or a coupling and/or an elastic mechanism (for example a spring and/or a rubber band) and/or an expanding gas and/or a hydraulic actuator).

A drug delivery device in accordance with some embodiments of the current invention may include reservoir. For example a reservoir may include a medicine container and/or a standard type syringe. Optionally a standard type syringe may be preloaded with medicine using standard equipment and/or in an aseptic room. A preloaded standard type syringe may optionally include a proximal opening. A stopper may optionally seal the proximal opening and/or protect the sterility of the contents of the syringe.

A sterile needle (for example a hollow needle) may optionally be connected to the syringe barrel. For example, the hollow of the needle may be in fluid communication with the interior of the barrel. The needle may optionally be rigidly attached to the distal end of the barrel. The sterility of all and/or part of the needle may for example be protected by a sterile cover. The sterile cover may remain on the needle when the syringe is supplied and/or installed into an injector. For example, the medicine container may optionally include a cylindrical barrel rigidly attached to a needle. Optionally, the long axes of the needle and barrel of the syringe may be parallel and/or coaxial. Optionally, the needle may be mounted on the distal end of the barrel. Optionally the needle point may be pointing in the distal direction. In some embodiments a stopper may slide axially along the inside of the barrel to discharge a medicine payload. For example, the medicine may be discharged through the hollow needle.

In some embodiments, the exposed length of the needle (for example protruding from the skin contact surface during drug discharge and/or during insertion of a cannula) may be suitable for performing an injection. For example, the exposed length of the needle may be suitable for intradermal injection and/or have gauge ranging for example between 24G to 30G and/or length ranging for example from 7-10 mm and/or the exposed length of the needle may be suitable for subcutaneous injection and/or have gauge ranging for example between 23G to 28G and/or length ranging for example from 9-28 mm and/or the exposed length of the needle may be suitable for intramuscular injection and/or have gauge ranging for example between 18G to 23G and/or length ranging for example from 24-40 mm and/or the exposed length of the needle may be suitable for intravenous injection and/or have gauge ranging for example between 15G to 22G and/or length ranging for example from 24-40 mm.

In some embodiments, a TSA may produce a force ranging for example between 0.02 to 0.2 N and/or between 0.2 and 0.5 N and/or between 0.5 to 5 N and/or between 5 to 60 N and/or between 60 to 90 N. For example the force required to inject the drug may depend on the injection rate and/or the viscosity of the drug and/or the syringe geometry and/or the needle dimensions.

In some embodiments, the stress to inject a medicine may include a torque.

For example, injection of medicine may be driven by a stopper. The stopper may optionally be driven by a threaded assembly, for example a threaded screw and/or teeth and/or a telescoping assembly. Optionally the pitch of the teeth and/or an associated screw may range for example between 0.5 to 2 mm and/or between 2 to 4 mm and/or between 4 to 8 mm. The diameter of the screw may range for example between 4 to 15 mm. The torque to power injection may range for example between 0.2 to 1.0 N*cm and/or between 1.0 to 10 N*cm.

During injection, the linear movement of a stopper may range for example between 5-40 mm and/or between 40-50 mm. The length of movement of the stopper may vary for example with the volume of medicine to be injected that may range for example between 0.5 to 3 ml and/or between 3 to 10 ml and/or between 10 to 30 ml.

It is expected that during the life of a patent maturing from this application many relevant technologies will be developed and the scope of the terms is intended to include all such new technologies a priori.

As used herein the term “about” refers to ±5%.

The terms “comprises”, “comprising”, “includes”, “including”, “having” and their conjugates mean “including but not limited to”.

The term “consisting of” means “including and limited to”.

The term “consisting essentially of” means that the composition, method or structure may include additional ingredients, steps and/or parts, but only if the additional ingredients, steps and/or parts do not materially alter the basic and novel characteristics of the claimed composition, method or structure.

As used herein, the singular form “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. For example, the term “a compound” or “at least one compound” may include a plurality of compounds, including mixtures thereof.

Throughout this application, various embodiments of this invention may be presented in a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numbers within that range, for example, 1, 2, 3, 4, 5, and 6. This applies regardless of the breadth of the range. Whenever a numerical range is indicated herein, it is meant to include any cited numeral (fractional or integral) within the indicated range. The phrases “ranging/ranges between” a first indicate number and a second indicate number and “ranging/ranges from” a first indicate number “to” a second indicate number are used herein interchangeably and are meant to include the first and second indicated numbers and all the fractional and integral numerals therebetween.

It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination or as suitable in any other described embodiment of the invention. Certain features described in the context of various embodiments are not to be considered essential features of those embodiments, unless the embodiment is inoperative without those elements.

All publications, patents and patent applications mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference. In addition, citation or identification of any reference in this application shall not be construed as an admission that such reference is available as prior art to the present invention. To the extent that section headings are used, they should not be construed as necessarily limiting.

Claims

1. A medicament delivery device, comprising: a housing having a compartment;a cartridge bay configured to pivot relative to the housing between an open position and a closed position, wherein the cartridge bay is configured to receive a cartridge when in the open position and be received in the compartment when in the closed position;a motor within the housing; andan expanding assembly within the housing, the expanding assembly comprising: a driver configured to be rotated by the motor;a first mid screw threadedly connected around the driver;a second mid screw threadedly connected around the first mid screw;a plunger driver threadedly connected around the second mid screw, wherein the plunger driver is configured to push a plunger seal through a reservoir of the cartridge to deliver a medicament; andan anti-rotational guide disposed around the plunger driver and being configured to prevent rotation of the plunger driver relative to the housing.
2. The medicament delivery device of claim 1, further comprising: a needle shield; anda medicament delivery hole.
3. The medicament delivery device of claim 2, wherein the housing has a skin contact surface that is at least partially coated with an adhesive.
4. The medicament delivery device of claim 1, further comprising: an injection needle that is perpendicular to a longitudinal axis of the reservoir of the cartridge in an extended position;a coupler including a hollow needle; anda flexible tube that connects the injection needle and the coupler.
5. The medicament delivery device of claim 4, wherein a septum of the cartridge is pierced by the hollow needle when the cartridge is inserted into the cartridge bay.
6. The medicament delivery device of claim 5, wherein the expanding assembly is configured to push the cartridge longitudinally into the hollow needle to pierce the septum.
7. The medicament delivery device of claim 4, wherein the hollow needle of the coupler is mounted to the medicament delivery device at one end of the compartment, and the expanding assembly is mounted to the medicament delivery device at an opposing end of the compartment.
8. The medicament delivery device of claim 7, wherein the cartridge is positioned between the expanding assembly and the coupler.
9. The medicament delivery device of claim 7, wherein the expanding assembly is configured to expand along an axis of expansion that is coaxial to the cartridge.
10. The medicament delivery device of claim 1, wherein the cartridge includes a syringe having a flange configured to retain the syringe within the cartridge bay.
11. The medicament delivery device of claim 1, wherein the plunger driver is configured to move into an opening of the cartridge to engage the plunger seal, and to further expand after engaging the plunger seal to drive the plunger seal distally through the reservoir of the cartridge.
12. The medicament delivery device of claim 1, further comprising a guide track that is attached and/or intrinsic to the housing, wherein the guide track prevents rotation of the anti-rotational guide.
13. The medicament delivery device of claim 12, wherein the anti-rotational guide has a projection that is received in the guide track, and the projection slides down the guide track as the plunger driver pushes the plunger seal through the reservoir of the cartridge.
14. The medicament delivery device of claim 1, wherein the driver includes a bearing configured to push against the housing.
15. A medicament delivery assembly comprising: a cartridge having a reservoir containing a medicament and a plunger seal;a medicament delivery device comprising: a housing having a compartment,a cartridge bay configured to pivot relative to the housing between an open position and a closed position, wherein the cartridge bay is configured to receive the cartridge in the open position and be received in the compartment when in the closed position,a motor in the housing, andan expanding assembly in the housing, the expanding assembly comprising: a driver configured to be rotated by the motor;a first mid screw threadedly connected around the driver,a second mid screw threadedly connected around the first mid screw;a plunger driver threadedly connected around the second mid screw, wherein the plunger driver is configured to push the plunger seal through the reservoir to deliver the medicament; andan anti-rotational guide disposed around the plunger driver and being configured to prevent rotation of the plunger driver relative to the housing.
16. The medicament delivery assembly of claim 15, further comprising: a needle shield, anda medicament delivery hole on the housing.
17. The medicament delivery assembly of claim 16, wherein the housing of the medicament delivery device has a skin contact surface that is at least partially coated with an adhesive.
18. The medicament delivery assembly of claim 15, wherein the medicament delivery device further comprises: an injection needle that is perpendicular to a longitudinal axis of a fluid reservoir of the cartridge in an extended position,a coupler including a hollow needle, anda flexible tube that connects the injection needle and the coupler.
19. The medicament delivery assembly of claim 18, wherein the hollow needle of the coupler is mounted at one end of the compartment, and the expanding assembly is mounted at an opposing end of the compartment.
20. The medicament delivery assembly of claim 19, wherein the cartridge is positioned between the expanding assembly and the coupler.
21. The medicament delivery assembly of claim 19, wherein the expanding assembly is configured to expand along an axis of expansion that is coaxial to the cartridge.
22. The medicament delivery assembly of claim 15, wherein the cartridge includes a syringe having a flange configured to retain the syringe within the cartridge bay.
23. The medicament delivery assembly of claim 15, wherein the plunger driver is configured to move into an opening of the cartridge to engage the plunger seal and to further expand after engaging the plunger driver to drive the plunger seal distally through the reservoir of the cartridge.

CROSS-REFERENCE TO RELATED APPLICATION

This application is continuation of U.S. patent application Ser. No. 15/575,229, filed Nov. 17, 2017, which is a section 371 of International Application No. PCT/US2016/035720, filed Jun. 3, 2016, which was published in the English language on Dec. 8, 2016 under International Publication No. WO 2016/196934 A1, which claims the benefit of priority under 35 USC 119(e) of U.S. Provisional Patent Application No. 62/171,002, filed Jun. 4, 2015, the contents of which are incorporated herein by reference in their entirety.

US Referenced Citations (874)

Number	Name	Date	Kind
1795630	Wilson	Mar 1931	A
2860635	Wilburn	Nov 1958	A
3203269	Perrine	Aug 1965	A
3212685	Swan	Oct 1965	A
3782365	Pinna	Jan 1974	A
3794028	Mueller	Feb 1974	A
3946732	Hurscham	Mar 1976	A
3994295	Wulff	Nov 1976	A
4026128	Blanco	May 1977	A
4167663	Granzow, Jr.	Sep 1979	A
4195636	Behnke	Apr 1980	A
4218724	Kaufman	Aug 1980	A
4273122	Whitney	Jun 1981	A
4300554	Hessberg	Nov 1981	A
4396385	Kelly	Aug 1983	A
4403987	Gottinger	Sep 1983	A
4435173	Siposs	Mar 1984	A
4465478	Sabelman	Aug 1984	A
4565543	Bekkering	Jan 1986	A
4585439	Michel	Apr 1986	A
4599082	Grimard	Jul 1986	A
4601702	Hudson	Jul 1986	A
4634426	Kamen	Jan 1987	A
4685903	Cable	Aug 1987	A
4689043	Bisha	Aug 1987	A
4698055	Sealfon	Oct 1987	A
4810215	Kaneko	Mar 1989	A
4850966	Grau	Jul 1989	A
4867743	Vaillancourt	Sep 1989	A
4886499	Cirelli	Dec 1989	A
4908014	Kroyer	Mar 1990	A
4919596	Slate	Apr 1990	A
4929241	Kulli	May 1990	A
4950235	Slate	Aug 1990	A
4950246	Muller	Aug 1990	A
4955865	Steiner	Sep 1990	A
D322671	Szwarc	Dec 1991	S
5090877	D'Silva	Feb 1992	A
5109850	Blanco	May 1992	A
5112317	Michel	May 1992	A
5131816	Brown	Jul 1992	A
5183469	Capaccio	Feb 1993	A
5190521	Hubbard	Mar 1993	A
5254096	Rondelet	Oct 1993	A
5300045	Plassche, Jr.	Apr 1994	A
5342313	Campbell	Aug 1994	A
5348544	Sweeney	Sep 1994	A
5354287	Wacks	Oct 1994	A
5364364	Kasvikis	Nov 1994	A
5366498	Brannan	Nov 1994	A
5383865	Michel	Jan 1995	A
5411482	Campbell	May 1995	A
5445621	Poli	Aug 1995	A
5478315	Brothers	Dec 1995	A
5482446	Williamson	Jan 1996	A
5496274	Graves	Mar 1996	A
5501665	Jhuboo	Mar 1996	A
5505709	Funderburk et al.	Apr 1996	A
D372098	Lattin	Jul 1996	S
5558639	Gangemi	Sep 1996	A
5562686	Sauer	Oct 1996	A
5593390	Castellano	Jan 1997	A
5616132	Newman	Apr 1997	A
5643218	Lynn	Jul 1997	A
5645955	Maglica	Jul 1997	A
5647853	Feldmann	Jul 1997	A
5658133	Anderson	Aug 1997	A
5662678	Macklin	Sep 1997	A
5672160	Oesterlind	Sep 1997	A
D384745	Lattin	Oct 1997	S
5690618	Smith	Nov 1997	A
D393314	Meisner	Apr 1998	S
5741227	Sealfon	Apr 1998	A
5766186	Faraz	Jun 1998	A
5779676	Kriesel	Jul 1998	A
5795675	Maglica	Aug 1998	A
5800420	Gross	Sep 1998	A
5807375	Gross	Sep 1998	A
5814020	Gross	Sep 1998	A
5820406	Hetherington	Oct 1998	A
5830187	Kriesel	Nov 1998	A
5836920	Robertson	Nov 1998	A
5848991	Gross	Dec 1998	A
5851197	Marano	Dec 1998	A
5858001	Tsals	Jan 1999	A
5858008	Capaccio	Jan 1999	A
5865804	Bachynsky	Feb 1999	A
5868710	Battiato	Feb 1999	A
5925018	Ungerstedt	Jul 1999	A
5931814	Alex	Aug 1999	A
5941850	Shah	Aug 1999	A
5948392	Haslwanter	Sep 1999	A
5954697	Srisathapat et al.	Sep 1999	A
5957895	Sage	Sep 1999	A
5968011	Larsen	Oct 1999	A
5993423	Choi	Nov 1999	A
5997501	Gross	Dec 1999	A
6004297	Steenfeldt-Jensen	Dec 1999	A
6033245	Yamkovoy	Mar 2000	A
6033377	Rasmussen	Mar 2000	A
6064797	Crittendon	May 2000	A
6074369	Sage	Jun 2000	A
6117575	Dinsdale	Sep 2000	A
6149614	Dunshee	Nov 2000	A
6160487	Deluca	Dec 2000	A
6175688	Cassidy	Jan 2001	B1
6186982	Gross	Feb 2001	B1
6200289	Hochman	Mar 2001	B1
6200296	Dibiasi	Mar 2001	B1
6224569	Brimhall	May 2001	B1
6248093	Moberg	Jun 2001	B1
6277095	Kriesel	Aug 2001	B1
6277098	Klitmose	Aug 2001	B1
6277099	Strowe	Aug 2001	B1
6287283	Ljunggreen	Sep 2001	B1
6293925	Safabash	Sep 2001	B1
6302633	Poe	Oct 2001	B1
6305908	Hermann	Oct 2001	B1
6336729	Pavelle	Jan 2002	B1
6345968	Shupe	Feb 2002	B1
6362591	Moberg	Mar 2002	B1
6377848	Garde	Apr 2002	B1
6391005	Lum	May 2002	B1
6423029	Elsberry	Jul 2002	B1
6423036	Van Huizen	Jul 2002	B1
D465026	May	Oct 2002	S
6458102	Mann	Oct 2002	B1
6485461	Mason	Nov 2002	B1
6485465	Moberg	Nov 2002	B2
6500150	Gross	Dec 2002	B1
6503231	Prausnitz	Jan 2003	B1
6511336	Turek	Jan 2003	B1
6517517	Farrugia	Feb 2003	B1
D471274	Diaz	Mar 2003	S
D471983	Hippolyte	Mar 2003	S
6530901	Tsukada	Mar 2003	B1
6555986	Moberg	Apr 2003	B2
6558351	Steil	May 2003	B1
6558365	Zinger	May 2003	B2
6589229	Connelly	Jul 2003	B1
6595956	Gross	Jul 2003	B1
6595960	West	Jul 2003	B2
6599272	Hjertman	Jul 2003	B1
6632201	Mathias	Oct 2003	B1
6645181	Lavi	Nov 2003	B1
6652482	Hochman	Nov 2003	B2
6656158	Dwayne	Dec 2003	B2
6656159	Flaherty	Dec 2003	B2
6659980	Moberg	Dec 2003	B2
6673033	Sciulli	Jan 2004	B1
6679862	Diaz	Jan 2004	B2
6689118	Alchas	Feb 2004	B2
6699218	Flaherty	Mar 2004	B2
6722916	Buccinna	Apr 2004	B2
6736796	Shekalim	May 2004	B2
6740059	Flaherty	May 2004	B2
6743211	Prausnitz	Jun 2004	B1
6749587	Flaherty	Jun 2004	B2
6752787	Causey, III	Jun 2004	B1
6768425	Flaherty	Jul 2004	B2
6786890	Preuthun	Sep 2004	B2
6800071	Mcconnell et al.	Oct 2004	B1
6805687	Dextradeur	Oct 2004	B2
6810350	Blakley	Oct 2004	B2
6824529	Gross	Nov 2004	B2
6843782	Gross	Jan 2005	B2
6854620	Ramey	Feb 2005	B2
6905298	Haring	Jun 2005	B1
6908452	Diaz	Jun 2005	B2
6950028	Zweig	Sep 2005	B2
6960192	Flaherty	Nov 2005	B1
6972002	Thorne	Dec 2005	B2
6997727	Legrady	Feb 2006	B1
7001360	Veasey	Feb 2006	B2
7034223	Fan	Apr 2006	B2
7048715	Diaz	May 2006	B2
7060054	Nissels	Jun 2006	B2
7060059	Keith	Jun 2006	B2
7097637	Triplett	Aug 2006	B2
7128727	Flaherty	Oct 2006	B2
7144384	Gorman	Dec 2006	B2
7193521	Moberg	Mar 2007	B2
7214209	Mazzoni	May 2007	B2
D544092	Lewis	Jun 2007	S
7225694	Said	Jun 2007	B2
7247149	Beyerlein	Jul 2007	B2
7250037	Shermer	Jul 2007	B2
7267669	Staunton	Sep 2007	B2
7291132	DeRuntz	Nov 2007	B2
7291159	Schmelzeisen-Redeker	Nov 2007	B2
7303549	Flaherty	Dec 2007	B2
7344385	Chen	Mar 2008	B2
7364570	Gerondale	Apr 2008	B2
7377907	Shekalim	May 2008	B2
7390314	Stutz, Jr.	Jun 2008	B2
7407493	Cane	Aug 2008	B2
D578210	Muta	Oct 2008	S
7455663	Bikovsky	Nov 2008	B2
7465290	Reilly	Dec 2008	B2
7488181	Van Haaster	Feb 2009	B2
7497842	Diaz	Mar 2009	B2
7501587	English	Mar 2009	B2
7503786	Kato	Mar 2009	B2
7524304	Genosar	Apr 2009	B2
7530964	Lavi	May 2009	B2
7547281	Hayes	Jun 2009	B2
7563253	Tanner	Jul 2009	B2
7565208	Harris	Jul 2009	B2
7569050	Moberg	Aug 2009	B2
D600341	Loerwald	Sep 2009	S
7585287	Bresina	Sep 2009	B2
7588559	Aravena	Sep 2009	B2
7589974	Grady	Sep 2009	B2
D602155	Foley	Oct 2009	S
D602586	Foley	Oct 2009	S
D604835	Conley	Nov 2009	S
7621893	Moberg	Nov 2009	B2
7628770	Ethelfeld	Dec 2009	B2
7628772	McConnell	Dec 2009	B2
7628782	Adair	Dec 2009	B2
7637891	Wall	Dec 2009	B2
7637899	Woolston	Dec 2009	B2
7641649	Moberg	Jan 2010	B2
7660627	Mcnichols	Feb 2010	B2
7678079	Shermer	Mar 2010	B2
7682338	Griffin	Mar 2010	B2
7686787	Moberg	Mar 2010	B2
7699829	Harris	Apr 2010	B2
7699833	Moberg	Apr 2010	B2
7704088	Sakamoto	Apr 2010	B2
7704227	Moberg	Apr 2010	B2
7704229	Moberg	Apr 2010	B2
7704231	Pongpairochana	Apr 2010	B2
7708717	Estes	May 2010	B2
7713238	Mernoe	May 2010	B2
7713240	Istoc	May 2010	B2
7717913	Novak	May 2010	B2
7722574	Toman	May 2010	B2
7736344	Moberg	Jun 2010	B2
7744589	Mounce	Jun 2010	B2
7749194	Edwards	Jul 2010	B2
7753879	Mernoe	Jul 2010	B2
7766873	Moberg	Aug 2010	B2
7776030	Estes	Aug 2010	B2
7780636	Radmer	Aug 2010	B2
7780637	Jerde	Aug 2010	B2
7789857	Moberg	Sep 2010	B2
7789862	Thorne, Jr.	Sep 2010	B2
7794426	Briones	Sep 2010	B2
7801599	Young	Sep 2010	B2
7806868	De Polo	Oct 2010	B2
7815622	Istoc	Oct 2010	B2
7828528	Estes	Nov 2010	B2
7837659	Bush, Jr.	Nov 2010	B2
7846132	Gravesen	Dec 2010	B2
7850661	Chevallier	Dec 2010	B2
7854723	Hwang	Dec 2010	B2
7857131	Vedrine	Dec 2010	B2
7879025	Jacobson	Feb 2011	B2
7879026	Estes	Feb 2011	B2
7892206	Moberg	Feb 2011	B2
7918825	O'Connor	Apr 2011	B2
7918843	Genosar	Apr 2011	B2
7935104	Yodfat	May 2011	B2
7935105	Miller	May 2011	B2
7938803	Mernoe	May 2011	B2
7955305	Moberg	Jun 2011	B2
7967784	Pongpairochana	Jun 2011	B2
7967795	Cabiri	Jun 2011	B1
7981105	Adair	Jul 2011	B2
7988683	Adair	Aug 2011	B2
7993300	Nyholm	Aug 2011	B2
7993301	Boyd	Aug 2011	B2
7998111	Moberg	Aug 2011	B2
8021357	Tanaka	Sep 2011	B2
8025658	Chong	Sep 2011	B2
8029469	Ethelfeld	Oct 2011	B2
8034019	Nair	Oct 2011	B2
8038666	Triplett	Oct 2011	B2
8057431	Woehr	Nov 2011	B2
8057436	Causey	Nov 2011	B2
8062253	Nielsen	Nov 2011	B2
8062257	Moberg	Nov 2011	B2
8065096	Moberg	Nov 2011	B2
8066694	Wagener	Nov 2011	B2
D650079	Presta	Dec 2011	S
D650903	Kosinski	Dec 2011	S
8086306	Katzman	Dec 2011	B2
D652503	Cameron, III	Jan 2012	S
8105279	Mernoe	Jan 2012	B2
8114046	Covino	Feb 2012	B2
8114064	Alferness	Feb 2012	B2
8114066	Naef	Feb 2012	B2
D657462	Siroky	Apr 2012	S
8147446	Yodfat	Apr 2012	B2
8152764	Istoc	Apr 2012	B2
8152770	Reid	Apr 2012	B2
8152779	Cabiri	Apr 2012	B2
8152793	Keinaenen	Apr 2012	B2
8157693	Waksmundzki	Apr 2012	B2
8157769	Cabiri	Apr 2012	B2
8162674	Cho	Apr 2012	B2
8162923	Adams	Apr 2012	B2
8167841	Teisen-Simony	May 2012	B2
8172591	Wertz	May 2012	B2
8172804	Bikovsky	May 2012	B2
8182447	Moberg	May 2012	B2
8182462	Istoc	May 2012	B2
8197444	Bazargan	Jun 2012	B1
8206351	Sugimoto	Jun 2012	B2
8221356	Enggaard	Jul 2012	B2
8226610	Edwards	Jul 2012	B2
8267893	Moberg	Sep 2012	B2
8267921	Yodfat	Sep 2012	B2
8287520	Drew	Oct 2012	B2
8292647	Mcgrath	Oct 2012	B1
8308679	Hanson	Nov 2012	B2
8323250	Chong	Dec 2012	B2
8348898	Cabiri	Jan 2013	B2
8372039	Mernoe	Feb 2013	B2
8373421	Lindegger	Feb 2013	B2
8409142	Causey	Apr 2013	B2
8414557	Istoc	Apr 2013	B2
8414563	Kamen	Apr 2013	B2
8430847	Mernoe	Apr 2013	B2
D685083	Schneider	Jun 2013	S
8465455	Cabiri	Jun 2013	B2
8469942	Kow	Jun 2013	B2
D687141	Schneider	Jul 2013	S
8474332	Bente, IV	Jul 2013	B2
8475408	Mernoe	Jul 2013	B2
8479595	Vazquez	Jul 2013	B2
8483980	Moberg	Jul 2013	B2
8495918	Bazargan	Jul 2013	B2
8496862	Zelkovich	Jul 2013	B2
D687536	Guarraia	Aug 2013	S
8512287	Cindrich	Aug 2013	B2
8517987	Istoc	Aug 2013	B2
8523803	Favreau	Sep 2013	B1
D692552	Lovell	Oct 2013	S
8556856	Bazargan	Oct 2013	B2
8562364	Lin	Oct 2013	B2
8574216	Istoc	Nov 2013	B2
8603026	Favreau	Dec 2013	B2
8603027	Favreau	Dec 2013	B2
8617110	Moberg	Dec 2013	B2
8628510	Bazargan	Jan 2014	B2
8647074	Moberg	Feb 2014	B2
8647296	Moberg	Feb 2014	B2
8668672	Moberg	Mar 2014	B2
8674288	Hanson	Mar 2014	B2
8679060	Mernoe	Mar 2014	B2
8679062	Yodfat et al.	Mar 2014	B2
8681010	Moberg	Mar 2014	B2
8690855	Alderete, Jr.	Apr 2014	B2
8708961	Field	Apr 2014	B2
8751237	Kubota	Jun 2014	B2
8753326	Chong	Jun 2014	B2
8753331	Murphy	Jun 2014	B2
8764707	Moberg	Jul 2014	B2
8764723	Chong	Jul 2014	B2
8771222	Kanderian, Jr.	Jul 2014	B2
8777896	Starkweather	Jul 2014	B2
8777924	Kanderian, Jr.	Jul 2014	B2
8777925	Patton	Jul 2014	B2
8784369	Starkweather	Jul 2014	B2
8784370	Lebel	Jul 2014	B2
8790295	Sigg	Jul 2014	B1
8795224	Starkweather	Aug 2014	B2
8795231	Chong	Aug 2014	B2
8795260	Drew	Aug 2014	B2
8801668	Ali	Aug 2014	B2
8801679	Iio	Aug 2014	B2
8810394	Kalpin	Aug 2014	B2
8814379	Griffiths	Aug 2014	B2
8827964	Boyd	Sep 2014	B2
8915882	Cabiri	Dec 2014	B2
8920374	Bokelman	Dec 2014	B2
D723157	Clemente	Feb 2015	S
8945051	Schriver et al.	Feb 2015	B2
9061104	Daniel	Jun 2015	B2
9061110	Avery	Jun 2015	B2
9072827	Cabiri	Jul 2015	B2
9079949	Andrien, Jr.	Jul 2015	B1
9089475	Fangrow	Jul 2015	B2
9089641	Kavazov	Jul 2015	B2
9149575	Cabiri	Oct 2015	B2
9181008	Milan	Nov 2015	B2
D747799	Norton	Jan 2016	S
9233213	Olson	Jan 2016	B2
9242044	Markussen	Jan 2016	B2
9278177	Edwards	Mar 2016	B2
9302089	Besko	Apr 2016	B2
9339610	Julian	May 2016	B2
9393365	Cabiri	Jul 2016	B2
9421321	Hanson et al.	Aug 2016	B2
9452255	Tieck	Sep 2016	B2
D768288	O'Connor	Oct 2016	S
9463280	Cabiri	Oct 2016	B2
9470587	Greene	Oct 2016	B1
9492610	Cabiri	Nov 2016	B2
9492618	Day	Nov 2016	B2
D774640	Tyce	Dec 2016	S
9511190	Cabiri	Dec 2016	B2
9522234	Cabiri	Dec 2016	B2
9526826	Nagar	Dec 2016	B2
D776262	Tyce	Jan 2017	S
D776263	Tyce	Jan 2017	S
D776264	Tyce	Jan 2017	S
D776265	Tyce	Jan 2017	S
9572926	Cabiri	Feb 2017	B2
9610404	Rotstein	Apr 2017	B2
9682199	Walsh	Jun 2017	B2
9707335	Agard	Jul 2017	B2
D794776	Tyce	Aug 2017	S
9737655	Clemente	Aug 2017	B2
9782545	Gross	Oct 2017	B2
9802030	Clemente	Oct 2017	B2
D804019	Costello	Nov 2017	S
9814832	Agard	Nov 2017	B2
9821118	Adlon	Nov 2017	B2
D804650	Costello	Dec 2017	S
D805186	Costello	Dec 2017	S
D805187	Costello	Dec 2017	S
D805188	Costello	Dec 2017	S
D805189	Costello	Dec 2017	S
D805190	Costello	Dec 2017	S
9844629	Cronenberg	Dec 2017	B2
9861759	Gross	Jan 2018	B2
D810278	Cabiri	Feb 2018	S
D810279	Cabiri	Feb 2018	S
D811583	Cabiri	Feb 2018	S
D811584	Cabiri	Feb 2018	S
9907911	Constantineau	Mar 2018	B2
9931461	Kamen	Apr 2018	B2
D817481	Cabiri	May 2018	S
9987416	Mcnall, III	Jun 2018	B2
10071196	Cabiri	Sep 2018	B2
10137243	Wang	Nov 2018	B2
10149943	Bar-El	Dec 2018	B2
10155085	Gescheit	Dec 2018	B2
10201692	Chang	Feb 2019	B2
D851752	Nazzaro	Jun 2019	S
10335553	Bendek	Jul 2019	B2
10391261	Glammeier	Aug 2019	B1
D865945	Nazzaro	Nov 2019	S
10463847	Shaked	Nov 2019	B2
10639417	Roberts	May 2020	B2
10688243	Cabiri	Jun 2020	B2
10765808	Day et al.	Sep 2020	B2
10780232	Jugl	Sep 2020	B2
10792435	Davis	Oct 2020	B2
10835690	Xiang	Nov 2020	B2
11103651	Sanders	Aug 2021	B2
11110230	Maxfield	Sep 2021	B2
11179518	Gertsenchtein	Nov 2021	B2
11207465	Bar-El	Dec 2021	B2
20010025168	Gross	Sep 2001	A1
20010041869	Causey	Nov 2001	A1
20020010423	Gross	Jan 2002	A1
20020029018	Jeffrey	Mar 2002	A1
20020040208	Flaherty	Apr 2002	A1
20020043951	Moberg	Apr 2002	A1
20020055711	Lavi	May 2002	A1
20020065488	Suzuki	May 2002	A1
20020072733	Flaherty	Jun 2002	A1
20020107487	Preuthun	Aug 2002	A1
20020123740	Flaherty	Sep 2002	A1
20020161332	Ramey	Oct 2002	A1
20020169215	Meng	Nov 2002	A1
20020188419	Slate	Dec 2002	A1
20030009133	Ramey	Jan 2003	A1
20030109827	Lavi	Jun 2003	A1
20030125671	Aramata	Jul 2003	A1
20030135159	Daily	Jul 2003	A1
20030160683	Blomquist	Aug 2003	A1
20030171717	Farrugia	Sep 2003	A1
20030181868	Swenson	Sep 2003	A1
20030199825	Flaherty	Oct 2003	A1
20030199827	Thorne	Oct 2003	A1
20030236498	Gross	Dec 2003	A1
20040002682	Kovelman	Jan 2004	A1
20040010207	Flaherty	Jan 2004	A1
20040015131	Flaherty	Jan 2004	A1
20040064088	Gorman	Apr 2004	A1
20040085215	Moberg	May 2004	A1
20040092873	Moberg	May 2004	A1
20040116866	Gorman	Jun 2004	A1
20040127857	Shemesh	Jul 2004	A1
20040158172	Hancock	Aug 2004	A1
20040186419	Cho	Sep 2004	A1
20040186424	Hjertman	Sep 2004	A1
20040260233	Garibotto	Dec 2004	A1
20050033234	Sadowski	Feb 2005	A1
20050049553	Triplett	Mar 2005	A1
20050065466	Vedrine	Mar 2005	A1
20050065472	Cindrich	Mar 2005	A1
20050070845	Faries	Mar 2005	A1
20050071487	Lu	Mar 2005	A1
20050075608	Holdgate	Apr 2005	A1
20050113761	Faust	May 2005	A1
20050159706	Wilkinson	Jul 2005	A1
20050171476	Judson	Aug 2005	A1
20050171512	Flaherty	Aug 2005	A1
20050177136	Miller	Aug 2005	A1
20050197650	Sugimoto	Sep 2005	A1
20050203461	Flaherty	Sep 2005	A1
20050238507	DiIanni	Oct 2005	A1
20050283114	Bresina	Dec 2005	A1
20060013716	Nason	Jan 2006	A1
20060030816	Zubry	Feb 2006	A1
20060095014	Ethelfeld	May 2006	A1
20060122577	Poulsen	Jun 2006	A1
20060173406	Hayes	Aug 2006	A1
20060173408	Wyrick	Aug 2006	A1
20060173410	Moberg	Aug 2006	A1
20060173439	Thorne, Jr.	Aug 2006	A1
20060184154	Moberg	Aug 2006	A1
20060195029	Shults	Aug 2006	A1
20060211982	Prestrelski	Sep 2006	A1
20060229569	Lavi	Oct 2006	A1
20060253086	Moberg et al.	Nov 2006	A1
20060264831	Skwarek	Nov 2006	A1
20060264889	Moberg	Nov 2006	A1
20060264890	Moberg	Nov 2006	A1
20060264894	Moberg	Nov 2006	A1
20060270987	Peter	Nov 2006	A1
20060283465	Nickel	Dec 2006	A1
20060293722	Slatkine	Dec 2006	A1
20070016381	Kamath	Jan 2007	A1
20070021733	Hansen	Jan 2007	A1
20070049865	Radmer	Mar 2007	A1
20070073228	Mernoe	Mar 2007	A1
20070106218	Yodfat	May 2007	A1
20070118405	Campbell	May 2007	A1
20070123819	Mernoe	May 2007	A1
20070129688	Scheurer	Jun 2007	A1
20070149926	Moberg	Jun 2007	A1
20070167912	Causey	Jul 2007	A1
20070185449	Mernoe	Aug 2007	A1
20070191770	Moberg	Aug 2007	A1
20070197968	Pongpairochana	Aug 2007	A1
20070203454	Shermer	Aug 2007	A1
20070219480	Kamen	Sep 2007	A1
20070233038	Pruitt	Oct 2007	A1
20070239116	Follman	Oct 2007	A1
20070282269	Carter	Dec 2007	A1
20080021439	Brittingham	Jan 2008	A1
20080033367	Haury	Feb 2008	A1
20080033369	Kohlbrenner	Feb 2008	A1
20080033393	Edwards	Feb 2008	A1
20080051710	Moberg	Feb 2008	A1
20080051711	Mounce	Feb 2008	A1
20080051727	Moberg	Feb 2008	A1
20080051730	Bikovsky	Feb 2008	A1
20080059133	Edwards	Mar 2008	A1
20080097381	Moberg	Apr 2008	A1
20080108951	Jerde	May 2008	A1
20080108953	Moser	May 2008	A1
20080125700	Moberg	May 2008	A1
20080140006	Eskuri	Jun 2008	A1
20080140018	Enggaard	Jun 2008	A1
20080147004	Mann	Jun 2008	A1
20080156476	Smisson	Jul 2008	A1
20080167641	Hansen	Jul 2008	A1
20080188813	Miller	Aug 2008	A1
20080195049	Thalmann	Aug 2008	A1
20080208138	Lim	Aug 2008	A1
20080215006	Thorkild	Sep 2008	A1
20080215015	Cindrich	Sep 2008	A1
20080221522	Moberg	Sep 2008	A1
20080221523	Moberg	Sep 2008	A1
20080234627	Dent	Sep 2008	A1
20080243087	Enggaard	Oct 2008	A1
20080249473	Rutti	Oct 2008	A1
20080255516	Yodfat	Oct 2008	A1
20080262436	Olson	Oct 2008	A1
20080269687	Chong	Oct 2008	A1
20080269689	Edwards	Oct 2008	A1
20080269723	Mastrototaro	Oct 2008	A1
20080274630	Shelton	Nov 2008	A1
20080275407	Scheurer	Nov 2008	A1
20080281270	Cross	Nov 2008	A1
20080294143	Tanaka	Nov 2008	A1
20080306449	Kristensen	Dec 2008	A1
20080312601	Cane	Dec 2008	A1
20080312604	Boesen	Dec 2008	A1
20080319416	Yodfat	Dec 2008	A1
20090024112	Edwards	Jan 2009	A1
20090030366	Hochman	Jan 2009	A1
20090041805	Walker	Feb 2009	A1
20090043253	Podaima	Feb 2009	A1
20090048347	Cohen	Feb 2009	A1
20090054750	Jennewine	Feb 2009	A1
20090054852	Takano	Feb 2009	A1
20090062767	Van Antwerp	Mar 2009	A1
20090069784	Estes	Mar 2009	A1
20090076360	Brister	Mar 2009	A1
20090076453	Mejlhede	Mar 2009	A1
20090088694	Carter	Apr 2009	A1
20090088731	Campbell	Apr 2009	A1
20090093792	Gross et al.	Apr 2009	A1
20090093793	Gross	Apr 2009	A1
20090105650	Wiegel	Apr 2009	A1
20090124977	Jensen	May 2009	A1
20090131860	Nielsen	May 2009	A1
20090139724	Gray	Jun 2009	A1
20090143730	De Polo	Jun 2009	A1
20090143735	De Polo	Jun 2009	A1
20090149830	Spector	Jun 2009	A1
20090182277	Carter	Jul 2009	A1
20090204076	Liversidge	Aug 2009	A1
20090209896	Selevan	Aug 2009	A1
20090216103	Brister	Aug 2009	A1
20090216194	Elgaard Pedersen	Aug 2009	A1
20090234319	Marksteiner	Sep 2009	A1
20090240240	Hines	Sep 2009	A1
20090243234	Sharifi	Oct 2009	A1
20090253973	Bashan	Oct 2009	A1
20090259176	Yairi	Oct 2009	A1
20090281585	Katzman	Nov 2009	A1
20090299290	Moberg	Dec 2009	A1
20090299397	Ruan	Dec 2009	A1
20090326459	Shipway	Dec 2009	A1
20090326509	Muse	Dec 2009	A1
20100030156	Beebe	Feb 2010	A1
20100030198	Beebe	Feb 2010	A1
20100037680	Moberg	Feb 2010	A1
20100049128	Mckenzie	Feb 2010	A1
20100049144	Mcconnell	Feb 2010	A1
20100057057	Hayter	Mar 2010	A1
20100076412	Rush	Mar 2010	A1
20100081993	O'Connor	Apr 2010	A1
20100094255	Nycz	Apr 2010	A1
20100100076	Rush	Apr 2010	A1
20100100077	Rush	Apr 2010	A1
20100106098	Atterbury	Apr 2010	A1
20100121314	Iobbi	May 2010	A1
20100137790	Yodfat	Jun 2010	A1
20100137831	Tsals	Jun 2010	A1
20100145303	Yodfat	Jun 2010	A1
20100145305	Alon	Jun 2010	A1
20100152658	Hanson	Jun 2010	A1
20100162548	Leidig	Jul 2010	A1
20100168607	Miesel	Jul 2010	A1
20100168683	Cabiri	Jul 2010	A1
20100198157	Gyrn	Aug 2010	A1
20100204657	Yodfat	Aug 2010	A1
20100211005	Edwards	Aug 2010	A1
20100211011	Haar	Aug 2010	A1
20100217192	Moberg	Aug 2010	A1
20100217193	Moberg	Aug 2010	A1
20100234767	Sarstedt	Sep 2010	A1
20100234805	Kaufmann	Sep 2010	A1
20100234830	Straessler	Sep 2010	A1
20100241065	Moberg	Sep 2010	A1
20100264931	Lindegger	Oct 2010	A1
20100274112	Hoss	Oct 2010	A1
20100274192	Mernoe	Oct 2010	A1
20100274202	Hyde	Oct 2010	A1
20100276411	Hansen	Nov 2010	A1
20100280499	Yodfat	Nov 2010	A1
20100331826	Field	Dec 2010	A1
20110034900	Yodfat	Feb 2011	A1
20110054399	Chong	Mar 2011	A1
20110054400	Chong	Mar 2011	A1
20110060284	Harr	Mar 2011	A1
20110066131	Cabiri	Mar 2011	A1
20110092917	Wei	Apr 2011	A1
20110119033	Moberg	May 2011	A1
20110125056	Merchant	May 2011	A1
20110137239	Debelser	Jun 2011	A1
20110137247	Mesa	Jun 2011	A1
20110144584	Wozencroft	Jun 2011	A1
20110152780	Villette	Jun 2011	A1
20110160654	Hanson	Jun 2011	A1
20110160655	Hanson	Jun 2011	A1
20110160666	Hanson	Jun 2011	A1
20110160669	Gyrn	Jun 2011	A1
20110172645	Moga	Jul 2011	A1
20110172745	Na	Jul 2011	A1
20110178463	Cabiri	Jul 2011	A1
20110178472	Cabiri	Jul 2011	A1
20110184342	Pesach	Jul 2011	A1
20110201998	Pongpairochana	Aug 2011	A1
20110224614	Moberg	Sep 2011	A1
20110238031	Adair	Sep 2011	A1
20110245773	Estes	Oct 2011	A1
20110264383	Moberg	Oct 2011	A1
20110270160	Mernoe	Nov 2011	A1
20110282282	Lorenzen	Nov 2011	A1
20110282296	Harms	Nov 2011	A1
20110295205	Kaufmann	Dec 2011	A1
20110313238	Reichenbach	Dec 2011	A1
20110313351	Kamen	Dec 2011	A1
20110319861	Wilk	Dec 2011	A1
20110319919	Curry	Dec 2011	A1
20120004602	Hanson	Jan 2012	A1
20120010594	Holt	Jan 2012	A1
20120022344	Kube	Jan 2012	A1
20120022499	Anderson	Jan 2012	A1
20120025995	Moberg	Feb 2012	A1
20120029431	Hwang	Feb 2012	A1
20120035546	Cabiri	Feb 2012	A1
20120041364	Smith	Feb 2012	A1
20120041370	Moberg	Feb 2012	A1
20120041414	Estes	Feb 2012	A1
20120059332	Woehr	Mar 2012	A1
20120071819	Brueggemann	Mar 2012	A1
20120071828	Tojo	Mar 2012	A1
20120096953	Bente, IV	Apr 2012	A1
20120096954	Vazquez	Apr 2012	A1
20120101436	Bazargan	Apr 2012	A1
20120108933	Liang	May 2012	A1
20120116311	Brueggemann et al.	May 2012	A1
20120129362	Hampo	May 2012	A1
20120143136	Constantineau	Jun 2012	A1
20120160033	Kow	Jun 2012	A1
20120165733	Bazargan	Jun 2012	A1
20120165780	Bazargan	Jun 2012	A1
20120172804	Plumptre	Jul 2012	A1
20120215169	Moberg	Aug 2012	A1
20120215199	Moberg	Aug 2012	A1
20120226234	Bazargan	Sep 2012	A1
20120259282	Alderete, Jr.	Oct 2012	A1
20120310153	Moberg	Dec 2012	A1
20130012875	Gross	Jan 2013	A1
20130030378	Jugl	Jan 2013	A1
20130041346	Alon	Feb 2013	A1
20130060233	O'Connor	Mar 2013	A1
20130068319	Plumptre	Mar 2013	A1
20130085457	Schiff	Apr 2013	A1
20130089992	Yang	Apr 2013	A1
20130096509	Avery	Apr 2013	A1
20130110049	Cronenberg et al.	May 2013	A1
20130133438	Kow	May 2013	A1
20130175192	Iio	Jul 2013	A1
20130190691	Cabiri	Jul 2013	A1
20130211330	Pedersen	Aug 2013	A1
20130218089	Davies	Aug 2013	A1
20130218092	Davies	Aug 2013	A1
20130226098	Tokumoto	Aug 2013	A1
20130237953	Kow	Sep 2013	A1
20130245595	Kow	Sep 2013	A1
20130245596	Cabiri et al.	Sep 2013	A1
20130245604	Kouyoumjian et al.	Sep 2013	A1
20130253419	Favreau	Sep 2013	A1
20130253420	Favreau	Sep 2013	A1
20130253421	Favreau	Sep 2013	A1
20130253432	Avery	Sep 2013	A1
20130253434	Cabiri	Sep 2013	A1
20130253472	Cabiri	Sep 2013	A1
20130281936	Kemp	Oct 2013	A1
20130296785	Cabiri	Nov 2013	A1
20130296792	Cabiri	Nov 2013	A1
20130296799	Degtiar et al.	Nov 2013	A1
20130304021	Cabiri et al.	Nov 2013	A1
20130310753	Cabiri	Nov 2013	A1
20130323699	Edwards	Dec 2013	A1
20130331791	Gross	Dec 2013	A1
20140055073	Favreau	Feb 2014	A1
20140055076	Favreau	Feb 2014	A1
20140058349	Bazargan	Feb 2014	A1
20140074041	Pedersen	Mar 2014	A1
20140083517	Moia	Mar 2014	A1
20140094755	Bazargan	Apr 2014	A1
20140128807	Moberg	May 2014	A1
20140128815	Cabiri	May 2014	A1
20140128835	Moberg	May 2014	A1
20140135692	Alderete, Jr.	May 2014	A1
20140135694	Moberg	May 2014	A1
20140142499	Moberg	May 2014	A1
20140148784	Anderson	May 2014	A1
20140148785	Moberg	May 2014	A1
20140155827	Ostrander	Jun 2014	A1
20140163522	Alderete, Jr.	Jun 2014	A1
20140171881	Cabiri	Jun 2014	A1
20140174223	Gross	Jun 2014	A1
20140188073	Cabiri	Jul 2014	A1
20140194819	Maule	Jul 2014	A1
20140194854	Tsals	Jul 2014	A1
20140207064	Yavorsky	Jul 2014	A1
20140207065	Yavorsky	Jul 2014	A1
20140207066	Yavorsky	Jul 2014	A1
20140210631	Zavis	Jul 2014	A1
20140213975	Clemente	Jul 2014	A1
20140236087	Alderete, Jr.	Aug 2014	A1
20140261758	Wlodarczyk	Sep 2014	A1
20140288511	Tan-Malecki	Sep 2014	A1
20140322935	Filman	Oct 2014	A1
20140330240	Cabiri	Nov 2014	A1
20140343503	Holmqvist	Nov 2014	A1
20150011965	Cabiri	Jan 2015	A1
20150011976	Vouillamoz	Jan 2015	A1
20150032084	Cabiri	Jan 2015	A1
20150057613	Clemente	Feb 2015	A1
20150061389	Song	Mar 2015	A1
20150080810	Henderson	Mar 2015	A1
20150119797	Cabiri	Apr 2015	A1
20150165121	Murakami et al.	Jun 2015	A1
20150180146	Filman	Jun 2015	A1
20150224253	Cabiri	Aug 2015	A1
20150224258	Holtwick et al.	Aug 2015	A1
20150320990	Burton	Nov 2015	A1
20150374926	Gross	Dec 2015	A1
20160015910	Mukai	Jan 2016	A1
20160030665	Cabiri	Feb 2016	A1
20160038691	Mounce et al.	Feb 2016	A1
20160051765	Morris et al.	Feb 2016	A1
20160051767	Higgins et al.	Feb 2016	A1
20160058941	Wu	Mar 2016	A1
20160106929	Fournier	Apr 2016	A1
20160136353	Adams	May 2016	A1
20160158436	Yang	Jun 2016	A1
20160175539	Riedel	Jun 2016	A1
20160199590	Schabbach	Jul 2016	A1
20160199592	Eggert et al.	Jul 2016	A1
20160213840	Schabbach	Jul 2016	A1
20160228644	Cabiri	Aug 2016	A1
20160256352	Bar-El	Sep 2016	A1
20160259913	Yu	Sep 2016	A1
20160296716	Cabiri	Oct 2016	A1
20160303324	Cabiri	Oct 2016	A1
20160317736	Schabbach et al.	Nov 2016	A1
20160317737	Schabbach et al.	Nov 2016	A1
20160346478	Bar-El	Dec 2016	A1
20160366946	Murison	Dec 2016	A1
20170007774	Brockmeier	Jan 2017	A1
20170028132	Cronenberg	Feb 2017	A1
20170043092	Murakami	Feb 2017	A1
20170080158	Cabiri	Mar 2017	A1
20170106138	Cabiri	Apr 2017	A1
20170165414	Schieve	Jun 2017	A1
20170182303	Tallarida	Jun 2017	A1
20170224915	Destefano	Aug 2017	A1
20170224934	Shultz	Aug 2017	A1
20170281859	Agard	Oct 2017	A1
20170312450	Gross	Nov 2017	A1
20170348478	Tobescu	Dec 2017	A1
20170354781	Cronenberg	Dec 2017	A1
20170354782	Quinn	Dec 2017	A1
20170354783	Gazeley	Dec 2017	A1
20170354785	Gazeley	Dec 2017	A1
20170354788	Quinn	Dec 2017	A1
20180001073	Clemente	Jan 2018	A1
20180008769	O'Connor	Jan 2018	A1
20180021508	Destefano	Jan 2018	A1
20180028747	Hanson	Feb 2018	A1
20180043091	Agard	Feb 2018	A1
20180055995	Hanson	Mar 2018	A1
20180152281	Zigelboim	May 2018	A1
20180154081	Bar-El	Jun 2018	A1
20180236173	Mccaffrey	Aug 2018	A1
20190046720	Kamen	Feb 2019	A1
20190091404	Nazzaro	Mar 2019	A1
20190117880	Hirschel	Apr 2019	A1
20190117902	Hodgson	Apr 2019	A1
20190151565	Groetzbach	May 2019	A1
20190201634	Newton	Jul 2019	A1
20190209787	Bendek	Jul 2019	A1
20190336701	Moore	Nov 2019	A1
20190351149	Ward	Nov 2019	A1
20190366012	Gross	Dec 2019	A1
20190374727	Dugand	Dec 2019	A1
20200038598	Chu	Feb 2020	A1
20200046910	Maxfield	Feb 2020	A1
20200054823	Baier	Feb 2020	A1
20200085695	O'Keefe	Mar 2020	A1
20200114068	Schmidlin	Apr 2020	A1
20200121909	Shaked	Apr 2020	A1
20200222623	Roberts	Jul 2020	A1
20200222638	Lafever	Jul 2020	A1
20200238012	Bar-El	Jul 2020	A1
20200397977	Keitzmann	Dec 2020	A1

Foreign Referenced Citations (246)

Number	Date	Country
1224341	Jul 1999	CN
1376524	Oct 2002	CN
1408443	Apr 2003	CN
1636605	Jul 2005	CN
1747683	Mar 2006	CN
1756573	Apr 2006	CN
1863566	Nov 2006	CN
1929884	Mar 2007	CN
101001661	Jul 2007	CN
101027094	Aug 2007	CN
101090749	Dec 2007	CN
101239205	Aug 2008	CN
101262898	Sep 2008	CN
101460207	Jun 2009	CN
101528286	Sep 2009	CN
101631585	Jan 2010	CN
101687083	Mar 2010	CN
101868273	Oct 2010	CN
101970033	Feb 2011	CN
201941304	Aug 2011	CN
102186733	Sep 2011	CN
102256657	Nov 2011	CN
102271735	Dec 2011	CN
102378638	Mar 2012	CN
102497909	Jun 2012	CN
102753233	Oct 2012	CN
103118723	May 2013	CN
103269730	Aug 2013	CN
103687636	Mar 2014	CN
103727021	Apr 2014	CN
103874460	Jun 2014	CN
104136059	Nov 2014	CN
104271043	Jan 2015	CN
104321093	Jan 2015	CN
104853787	Aug 2015	CN
104870049	Aug 2015	CN
105188636	Dec 2015	CN
105263562	Jan 2016	CN
105492039	Apr 2016	CN
105517593	Apr 2016	CN
205287099	Jun 2016	CN
105899248	Aug 2016	CN
106029122	Oct 2016	CN
106029127	Oct 2016	CN
106029128	Oct 2016	CN
106456892	Feb 2017	CN
106470719	Mar 2017	CN
1064693	Sep 1959	DE
0017412	Oct 1980	EP
0222656	May 1987	EP
0401179	Dec 1990	EP
0744975	Dec 1996	EP
1530979	May 2005	EP
1666080	Jun 2006	EP
2060606	May 2009	EP
2231234	Sep 2010	EP
2345441	Jul 2011	EP
2361648	Aug 2011	EP
2364741	Sep 2011	EP
2459251	Jun 2012	EP
2498589	Sep 2012	EP
2529776	Dec 2012	EP
2698180	Feb 2014	EP
2727617	May 2014	EP
2729203	May 2014	EP
2862588	Apr 2015	EP
2873431	May 2015	EP
2454483	Aug 2015	EP
2932993	Oct 2015	EP
2944340	Nov 2015	EP
2285360	Apr 2016	EP
3031486	Jun 2016	EP
3100754	Dec 2016	EP
3226944	Oct 2017	EP
3260149	Dec 2017	EP
3409312	Dec 2018	EP
3458131	Mar 2019	EP
2244765	Aug 2019	EP
3552642	Oct 2019	EP
3618903	Mar 2020	EP
3626291	Mar 2020	EP
3659652	Jun 2020	EP
3501584	Sep 2020	EP
2905273	Mar 2008	FR
2552340	Jan 2018	GB
H09505758	Jun 1997	JP
2001512992	Aug 2001	JP
2002500525	Jan 2002	JP
2002505601	Feb 2002	JP
2002507459	Mar 2002	JP
2002528676	Sep 2002	JP
2003501157	Jan 2003	JP
2003527138	Sep 2003	JP
2003534061	Nov 2003	JP
2004501721	Jan 2004	JP
2004512100	Apr 2004	JP
2005523127	Aug 2005	JP
2005270629	Oct 2005	JP
2007509661	Apr 2007	JP
2008043761	Feb 2008	JP
2008508950	Mar 2008	JP
2008534131	Aug 2008	JP
2008220961	Sep 2008	JP
2009502273	Jan 2009	JP
4305704	Jul 2009	JP
2011519712	Jul 2011	JP
2012501771	Jan 2012	JP
2012050847	Mar 2012	JP
2012115675	Jun 2012	JP
2012516737	Jul 2012	JP
4996811	Aug 2012	JP
2013504405	Feb 2013	JP
2013-521084	Jun 2013	JP
2013542807	Nov 2013	JP
2014510571	May 2014	JP
2014516667	Jul 2014	JP
2014516701	Jul 2014	JP
2014516702	Jul 2014	JP
2015536696	Dec 2015	JP
5885667	Mar 2016	JP
2016507290	Mar 2016	JP
2016513509	May 2016	JP
2016516553	Jun 2016	JP
2016518879	Jun 2016	JP
2016523123	Aug 2016	JP
2017510419	Apr 2017	JP
2017086630	May 2017	JP
2017513623	Jun 2017	JP
6957525	Nov 2021	JP
20140000766	Feb 2014	KR
8911302	Nov 1989	WO
9009202	Aug 1990	WO
9307922	Apr 1993	WO
9407553	Apr 1994	WO
9513838	May 1995	WO
9521645	Aug 1995	WO
9609083	Mar 1996	WO
9632975	Oct 1996	WO
9700091	Jan 1997	WO
9710012	Mar 1997	WO
9721457	Jun 1997	WO
9733638	Sep 1997	WO
9857683	Dec 1998	WO
9929151	Jun 1999	WO
9959665	Nov 1999	WO
0025844	May 2000	WO
0187384	Nov 2001	WO
0189607	Nov 2001	WO
0189613	Nov 2001	WO
0202165	Jan 2002	WO
0234315	May 2002	WO
02072182	Sep 2002	WO
0390833	Nov 2003	WO
2004032990	Apr 2004	WO
2004069302	Aug 2004	WO
2004105841	Dec 2004	WO
2005018703	Mar 2005	WO
2005037350	Apr 2005	WO
2005077441	Aug 2005	WO
2006037434	Apr 2006	WO
2006069380	Jun 2006	WO
2006102676	Sep 2006	WO
2006104806	Oct 2006	WO
2006108809	Oct 2006	WO
2007051563	May 2007	WO
2007056504	May 2007	WO
2007092618	Aug 2007	WO
2007130868	Nov 2007	WO
2008001377	Jan 2008	WO
2008014908	Feb 2008	WO
2008024810	Feb 2008	WO
2008024814	Feb 2008	WO
2008057976	May 2008	WO
2008072229	Jun 2008	WO
2008076459	Jun 2008	WO
2008078318	Jul 2008	WO
2008129549	Oct 2008	WO
2009044401	Apr 2009	WO
2009046989	Apr 2009	WO
2009081262	Jul 2009	WO
2009088956	Jul 2009	WO
2009125398	Oct 2009	WO
2009144085	Dec 2009	WO
2010078227	Jul 2010	WO
2010078242	Jul 2010	WO
2011014704	Feb 2011	WO
2011034799	Mar 2011	WO
2011075105	Jun 2011	WO
2011090956	Jul 2011	WO
2011090955	Jul 2011	WO
2011104711	Sep 2011	WO
2011113806	Sep 2011	WO
2011156373	Dec 2011	WO
2012013140	Feb 2012	WO
2012032411	Mar 2012	WO
2012040528	Mar 2012	WO
WO-2012032411	Mar 2012	WO
2012064258	May 2012	WO
2012108955	Aug 2012	WO
2012160157	Nov 2012	WO
2012160160	Nov 2012	WO
2013036602	Mar 2013	WO
2013115843	Aug 2013	WO
2013148270	Oct 2013	WO
2013148435	Oct 2013	WO
2013173092	Nov 2013	WO
2014052676	Apr 2014	WO
2014070453	May 2014	WO
2014107408	Jul 2014	WO
2014111332	Jul 2014	WO
2014144096	Sep 2014	WO
2014159017	Oct 2014	WO
2014179210	Nov 2014	WO
2014179774	Nov 2014	WO
2015007857	Jan 2015	WO
2015018787	Feb 2015	WO
2015032745	Mar 2015	WO
2015044561	Apr 2015	WO
2015061389	Apr 2015	WO
2015070914	May 2015	WO
2015164649	Oct 2015	WO
2016033496	Mar 2016	WO
2016033507	Mar 2016	WO
2016089864	Jun 2016	WO
2016113409	Jul 2016	WO
2016196934	Dec 2016	WO
2017004315	Jan 2017	WO
2017062931	Apr 2017	WO
2017064483	Apr 2017	WO
2017089266	Jun 2017	WO
2017090019	Jun 2017	WO
2017127215	Jul 2017	WO
2017210448	Dec 2017	WO
2018018165	Feb 2018	WO
2018018167	Feb 2018	WO
2018060023	Apr 2018	WO
2018070978	Apr 2018	WO
2018096231	May 2018	WO
2018131046	Jul 2018	WO
2018222521	Dec 2018	WO
2019074788	Apr 2019	WO
2019091626	May 2019	WO
2019101613	May 2019	WO
2019123073	Jun 2019	WO
2019197381	Oct 2019	WO
2020070260	Apr 2020	WO

Non-Patent Literature Citations (149)

Entry
Int'l Preliminary Report on Patentability dated Dec. 5, 2017 in In'll Application No. PCT/US2016/035720.
Int'l Search Report and Written Opinion dated Aug. 12, 2016 in Int'l Application No. PCT/US2016/035720.
Office Action dated Nov. 29, 2019 in CN Application No. CN 201680032632.3.
Office Action dated Mar. 23, 2015 in JP Application No. 2012-550068. 6 pages.
Office Action dated Mar. 5, 2014 in CN Application No. 200880117084.X. 8 pages.
Office Action dated May 1, 2015 in U.S. Appl. No. 14/638,525 by Filman. 6 pages.
Office Action dated May 13, 2015 in CN Application No. 201380025566.3. 6 pages.
Office Action dated May 16, 2012 in U.S. Appl. No. 12/615,828. 10 pages.
Office Action dated May 17, 2016 in U.S. Appl. No. 13/886,867 by Cabiri. 18 pages.
Office Action dated May 18, 2015 in U.S. Appl. No. 13/429,942 by Cabiri. 9 pages.
Office Action dated May 18, 2016 in U.S. Appl. No. 13/667,739 by Cabiri. 11 pages.
Office Action dated May 23, 2014 in U.S. Appl. No. 13/472,112 by Cabiri. 9 pages.
Office Action dated May 24, 2017 in CN Application No. 201380057196.1. 20 pages.
Office Action dated May 3, 2012 in CN Application No. 200880117084.X. 8 pages.
Office Action dated Nov. 16, 2015 in U.S. Appl. No. 13/733,516 by Cabiri. 9 pages.
Office Action dated Nov. 2, 2014 in CN Application No. 201180006571.0. 8 pages.
Office Action dated Nov. 2, 2016 in CN Application No. 2013800571961. 16 pages.
Office Action dated Nov. 21, 2014 in U.S. Appl. No. 13/429,840 by Cabiri. 10 pages.
Office Action dated Nov. 21, 2014 in U.S. Appl. No. 13/472,112 by Cabiri. 10 pages.
Office Action dated Nov. 25, 2015 in U.S. Appl. No. 14/372,384 by Cabiri. 24 pages.
Office Action dated Nov. 4, 2013 in EP Application No. 11 709 234.6. 4 pages.
Office Action dated Nov. 5, 2013 in JP Application No. 2010-527595. 6 pages.
Office Action dated Nov. 5, 2014 in U.S. Appl. No. 13/643,470 by Alon. 15 pages.
Office Action dated Nov. 6, 2015 in U.S. Appl. No. 14/715,791 by Cabiri. 8 pages.
Office Action dated Oct. 11, 2017 in U.S. Appl. No. 29/605,061, by Cabiri. 9 pages.
Office Action dated Oct. 28, 2011 in U.S. Appl. No. 12/615,828. 10 pages.
Office Action dated Oct. 28, 2015 in U.S. Appl. No. 13/429,942 by Cabiri. 8 pages.
Office Action dated Oct. 5, 2017 in U.S. Appl. No. 29/605,068, by Cabiri. 9 pages.
Office Action dated Oct. 6, 2017 in U.S. Appl. No. 29/604,616, by Cabiri. 11 pages.
Office Action dated Oct. 6, 2017 in U.S. Appl. No. 29/605,051, by Cabiri. 11 pages.
Office Action dated Oct. 9, 2014 in U.S. Appl. No. 13/873,335. 6 pages.
Office Action dated Sep. 13, 2017 in EP Application No. 13783458.6. 4 pages.
Office Action dated Sep. 18, 2015 in U.S. Appl. No. 13/874,085 by Cabiri. 11 pages.
Office Action dated Sep. 2, 2010 in U.S. Appl. No. 12/244,688. 9 pages.
Office Action dated Sep. 21, 2010 in U.S. Appl. No. 12/244,666. 12 pages.
Office Action dated Sep. 29, 2013 in CN Application No. 201080040968.7. 8 pages.
Office Action dated Sep. 30, 2010 in U.S. Appl. No. 12/689,250. 10 pages.
Office Action dated Sep. 30, 2015 in U.S. Appl. No. 13/667,739 by Cabiri. 11 pages.
Office Action dated Sep. 6, 2011 in U.S. Appl. No. 12/345,818. 6 pages.
Office Action dated Sep. 9, 2015 in U.S. Appl. No. 13/643,470 by Alon. 24 pages.
Office Action dated Feb. 19, 2016 in U.S. Appl. No. 14/553,399 by Cabiri. 7 pages.
Office Action dated Feb. 28, 2014 in CN Application No. 201180006571.0. 9 pages.
Office Action dated Feb. 3, 2016 in U.S. Appl. No. 14/931,439 by Cabiri. 8 pages.
Office Action dated Jan. 8, 2013 in JP Application No. 2010-527595. 8 pages.
Office Action dated Jul. 1, 2016 in U.S. Appl. No. 15/132,740 by Cabiri. 10 pages.
Office Action dated Jul. 8, 2016 in CN Application No. 201510695320.8. 11 pages.
Office Action dated Jul. 14, 2020 in Japanese Application No. 2020-507099. 6 pages.
Office Action dated May 4, 2016 in U.S. Appl. No. 15/069,080 by Cabiri. 7 pages.
U.S. Appl. No. 60/997,459, filed Oct. 2, 2007.
Notice of Allowance dated Apr. 25, 2016 in U.S. Appl. No. 14/553,399 by Cabiri. 6 pages.
Notice of Allowance dated May 11, 2016 in U.S. Appl. No. 14/931,439 by Cabiri. 6 pages.
Office Action dated Apr. 19, 2016 in U.S. Appl. No. 14/372,384, by Cabiri. 23 pages.
Office Action dated Apr. 23, 2015 in JP Application No. 2012-550069. 6 pages.
Office Action dated Apr. 24, 2013 in CN Application No. 201080040968.7. 8 pages.
Office Action dated Apr. 5, 2010 in U.S. Appl. No. 12/244,666. 11 pages.
Office Action dated Apr. 5, 2010 in U.S. Appl. No. 12/244,688. 14 pages.
Office Action dated Aug. 13, 2015 in U.S. Appl. No. 14/553,399 by Cabiri. 6 pages.
Office Action dated Aug. 13, 2018 in IN Application No. 857/KOLNP/2012. 4 pages.
Office Action dated Aug. 15, 2013 in CN Application No. 200880117084.X. 8 pages.
Office Action dated Aug. 15, 2013 in U.S. Appl. No. 13/429,942 by Cabiri. 12 pages.
Office Action dated Aug. 26, 2014 in CN Application No. 201180006567.4. 10 pages.
Office Action dated Aug. 29, 2014 in JP Application No. 2012-550068. 8 pages.
Office Action dated Aug. 29, 2014 in JP Application No. 2012-550069. 6 pages.
Office Action dated Aug. 6, 2014 in EP Application No. 11 707 942.6. 4 pages.
Office Action dated Dec. 10, 2013 in CN Application No. 201180006567.4. 8 pages.
Office Action dated Dec. 12, 2013 in JP Application No. 2012-529808. 11 pages.
Office Action dated Dec. 29, 2016 in CN Application No. 201510695320.8. 12 pages.
Office Action dated Dec. 3, 2015 in CN Application No. 201280068544.0. 16 pages.
Office Action dated Feb. 20, 2015 in U.S. Appl. No. 13/521,181 by Cabiri. 13 pages.
Office Action dated Feb. 21, 2012 in U.S. Appl. No. 12/689,249. 6 pages.
Office Action dated Feb. 24, 2015 in U.S. Appl. No. 14/258,661 by Cabiri. 7 pages.
Office Action dated Feb. 24, 2016 in U.S. Appl. No. 13/429,942 by Cabiri. 8 pages.
Office Action dated Feb. 4, 2014 in EP Application No. 11 707 942.6. 6 pages.
Office Action dated Jan. 15, 2016 in U.S. Appl. No. 13/472,112 by Cabiri. 8 pages.
Office Action dated Jan. 16, 2014 in U.S. Appl. No. 13/429,942 by Cabiri. 10 pages.
Office Action dated Jan. 28, 2015 in U.S. Appl. No. 13/429,942 by Cabiri. 9 pages.
Office Action dated Jan. 30, 2013 in CN Application No. 200880117084.X. 8 pages.
Office Action dated Jan. 4, 2016 in U.S. Appl. No. 13/892,905 by Cabiri. 17 pages.
Office Action dated Jan. 5, 2016 in U.S. Appl. No. 14/696,644 by Cabiri. 13 pages.
Office Action dated Jan. 8, 2014 in U.S. Appl. No. 13/521,167 by Cabiri. 7 pages.
Office Action dated Jul. 13, 2011 in U.S. Appl. No. 12/559,563. 9 pages.
Office Action dated Jul. 14, 2020 in Japanese Application No. 2020-507100. 6 pages.
Office Action dated Jul. 2, 2012 in U.S. Appl. No. 13/272,555. 13 pages. 13 pages.
Office Action dated Jul. 29, 2013 in JP Application No. 2012-529808. 10 pages.
Office Action dated Jul. 29, 2016 in U.S. Appl. No. 14/696,644, by Cabiri. 11 pages.
Office Action dated Jul. 31, 2015 in U.S. Appl. No. 13/521, 181 by Cabiri. 11 pages.
Office Action dated Jul. 7, 2014 in U.S. Appl. No. 12/244,666 by Gross. 16 pages.
Office Action dated Jul. 7, 2016 in U.S. Appl. No. 13/892,905 by Cabiri. 19 pages.
Office Action dated Jun. 1, 2016 in CN Application No. 201380027455.6. 10 pages.
Office Action dated Jun. 16, 2021 in Chinese Office Action 201880065173.8. 20 pages.
Office Action dated Jun. 17, 2016 in CN Application No. 201280068544.0. 20 pages.
Office Action dated Jun. 2, 2021 in Japanese Application No. 2020-506901. 6 pages.
Office Action dated Jun. 3, 2014 in JP Application No. 2010-527595. 8 pages.
Office Action dated Jun. 4, 2015 in U.S. Appl. No. 13/667,739 by Cabiri. 10 pages.
Office Action dated Mar. 10, 2015 in CN Application No. 201180006567.4. 9 pages.
Office Action dated Mar. 10, 2015 in U.S. Appl. No. 12/244,666 by Gross. 17 pages.
Office Action dated Mar. 10, 2015 in U.S. Appl. No. 13/643,470 by Alon. 16 pages.
Office Action dated Mar. 15, 2018 in U.S. Appl. No. 29/628,592 by Cabiri. 11 pages.
Office Action dated Mar. 17, 2020 in JP Application No. 2019-554804. 12 pages.
Christoph Kapitza, M.D.; Basal-Prandial Insulin Delivery in Type 2 Diabetes Mellitusvia the V-Go™; Jan. 2008; Diabetes Tech. Society; vol. 2, Issue 1; (Year: 2008). 7 pages.
Copaxone®, Innovative Drugs, Teva Pharmaceuticals, downloaded from webpage: http://tevapharm.com/copaxone/, Download date: Jan. 2009, original posting date: unknown, 3 pages.
Daikyo Crystal Zenith® polymer, Manufactured by Daikyo Seiko, Ltd. (Jun. 25, 2008). 2 pages.
Extended European Search Report dated Aug. 5, 2020 in European Application No. 18780556.9. 13 pages.
Extended European Search Report dated Aug. 7, 2014 in EP Application No. 1417477.4. 7 pages.
Extended European Search Report dated Feb. 23, 2015 in EP Application No. 14166596.8. 6 pages.
Extended European Search Report dated Feb. 23, 2015 in EP Application No. 14166591.9. 6 pages.
Extended European Search Report dated Mar. 27, 2014 in EP Application No. 14154717.4. 6 pages.
Int'l Preliminary Report of Patentability dated Feb. 11, 2020 in Int'l Application No. PCT/US2018/045506. 8 pages.
Int'l Preliminary Report on Patentability dated Apr. 7, 2010 in Int'l Application No. PCT/IL2008/001312. 14 pages.
Int'l Preliminary Report on Patentability dated Aug. 14, 2014 in Int'l Application No. PCT/US2012/050696. 8 pages.
Int'l Preliminary Report on Patentability dated Aug. 2, 2012 in Int'l Application No. PCT/US2011/021604. 6 pages.
Int'l Preliminary Report on Patentability dated Feb. 7, 2013 in Int'l Application No. PCT/US2011/021605. 9 pages.
Int'l Preliminary Report on Patentability dated Jul. 16, 2015 in Int'l Application No. PCT/US2013/078040. 9 pages.
Int'l Preliminary Report on Patentability dated May 14, 2015 in Int'l Application No. PCT/US2013/065211. 10 pages.
Int'l Preliminary Report on Patentability dated Nov. 27, 2014 in Int'l Application No. PCT/US2013/039465. 8 pages.
Int'l Preliminary Report on Patentability dated Oct. 9, 2014 in Int'l Application No. PCT/US2013/033118. 7 pages.
Int'l Preliminary Report on Patentability dated Sep. 1, 2011 in Int'l Application No. PCT/US2010/048556. 6 pages.
Int'l Preliminary Report on Patentability dated Feb. 11, 2020 in Int'l Application No. PCT/US2018/045004. 6 pages.
Int'l Preliminary Report on Patentability dated Feb. 26, 2020 in Int'l Application No. PCT/IB2018/001164. 5 pages.
Int'l Preliminary Report on Patentability dated Jun. 23, 2020 in Int'l Application No. PCT/US2018/066660. 8 pages.
Int'l Preliminary Reporton Patentability dated Dec. 4, 2019 in Int'l Application No. PCT/US2018/045114. 15 pages.
Int'l Preliminary Reporton Patentability dated Oct. 28, 2019 issued in Int'l Application No. PCT/US2018/044993. 10 pages.
Int'l Search Report and Written Opinion dated Apr. 3, 2014 in Int'l Application No. PCT/US2013/078040. 10 pages.
Int'l Search Report and Written Opinion dated Apr. 5, 2013 in Int'l Application No. PCT/US2012/050696. 13 pages.
Int'l Search Report and Written Opinion dated Aug. 28, 2014 in Int'l Application No. PCT/US2014/035662. 15 pages.
Int'l Search Report and Written Opinion dated Aug. 5, 2013 in Int'l Application No. PCT/US2013/033118. 9 pages.
Int'l Search Report and Written Opinion dated Jan. 12, 2011 in Int'l Application No. PCT/US2010/048556; Written Opinion. 9 pages.
Int'l Search Report and Written Opinion dated Jan. 7, 2014 in Int'l Application No. PCT/US2013/065211. 13 pages.
Int'l Search Report and Written Opinion dated Jul. 12, 2018 in Int'l Application No. PCT/US2018/026556. 6 pages.
Int'l Search Report and Written Opinion dated Jul. 31, 2014 in Int'l Application No. PCT/US2014/033598. 8 pages.
Int'l Search Report and Written Opinion dated Jun. 30, 2014 in Int'l Application No. PCT/US2013/031598. 19 pages.
Int'l Search Report and Written Opinion dated May 13, 2009 in Int'l Application No. PCT/IL2008/001312. 16 pages.
Int'l Search Report and Written Opinion dated Nov. 5, 2012 in Int'l Application No. PCT/US2012/039465. 11 pages.
Int'l Search Report and Written Opinion dated Oct. 23, 2018 in Int'l Application No. PCT/US2018/045114. 13 pages.
Int'l Search Report and Written Opinion dated Oct. 25, 2018 in Int'l Application No. PCT/US2018/044993. 17 pages.
Int'l Search Report and Written Opinion dated Oct. 26, 2018 in Int'l Application No. PCT/US2018/045506. 24 pages.
Int'l Search Report and Written Opinion dated Jan. 4, 2019 in Int'l Application No. PCT/US2018/045004. 15 pages.
Int'l Search Report and Written Opinion dated Apr. 23, 2019 in Int'l Application No. PCT/US2018/066660. 13 pages.
Int'l Search Report and Written Opinion dated Jan. 1, 2019 in Int'l Application No. PCT/IB2018/001164. 13 pages.
Int'l Search Report dated Apr. 26, 2010 in Int'l Application No. PCT/US2009/069552. 8 pages.
Int'l Search Report dated Jun. 17, 2011 in Int'l Application No. PCT/US2011/021604. 8 pages.
Int'l Search Report dated Oct. 12, 2011 in Int'l Application No. PCT/US2011/021605.16 pages.
Int'l Search Report dated Sep. 22, 2011 in Int'l Application No. PCT/IL11/00368; Written Opinion. 8 pages.
International Preliminary Report on Patentability and Written Opinion dated Jul. 5, 2011 in International Application No. PCT/US2009/069552. 6 pages.
International Preliminary Report on Patentability dated Aug. 12, 2019 in International Application No. PCT/US2018/045084. 23 pages.
International Preliminary Report on Patentability dated Oct. 8, 2019 in Int'l Application No. PCT/US2018/026556. 5 pages.
International Search Report and Written Opinion dated Dec. 19, 2018 in International Application No. PCT/US2018/045084. 16 pages.
International Search Report and Written Opinion dated Nov. 15, 2018 in International Appl. No. PCT/US2018/045149. 11 pages.
Notice of Allowance dated Aug. 24, 2015 in U.S. Appl. No. 29/479,307 by Norton. 10 pages.

Related Publications (1)

	Number	Date	Country
	20220080125 A1	Mar 2022	US

Provisional Applications (1)

	Number	Date	Country
	62171002	Jun 2015	US

Continuations (1)

	Number	Date	Country
Parent	15575229		US
Child	17531730		US

Cartridge insertion for drug delivery device

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