Claims
- 1. A method of inhibiting lipoxygenase or cyclogenase in a subject in which the inhibition of same would be beneficial comprising the administration, in a pharmaceutically acceptable carrier, of a lipoxygenase or cyclogenese inhibiting amount of a catechol derivative having the general formula ##STR35## wherein R represents a straight or branched chain acyclic saturated hydrocarbon group having from 1 to 8 carbon atoms, one of which is optionally asymmetric, a mono- or bicycloalkyl group optionally substituted by one or more alkyl groups having from 1 to 7 carbon atoms, one of the carbon atoms of the mono- or bicycloalkyl group optionally being asymmetric, a phenyl group, a halophenyl group, a nitrophenyl group or a phenyl group substituted by one or more alkyl groups having from 1 to 7 carbon atoms or trifluoromethyl groups or COOY groups wherein Y stands for an alkyl having from 1 to 5 carbon atoms.
- 2. A pharmaceutical composition for inhibiting lipoxygenase or cyclogenase comprising a pharmaceutically acceptable carrier, and a lipoxygenase or cyclogenase inhibiting amount of a catechol derivative having the formula ##STR36## wherein R represents a straight or branched chain acyclic saturated hydrocarbon group having from 1 to 8 carbon atoms, one of which is optionally asymmetric, a mono- or bicycloalkyl group optionally substituted by one or more alkyl groups having from 1 to 7 carbon atoms, one of the carbon atoms of the mono- or bicycloalkyl group optionally being asymmetric, a phenyl group, a halophenyl group, a nitrophenyl group or a phenyl group substituted by one or more alkyl groups having from 1 to 7 carbon atoms or trifluoromethyl groups or COOY groups wherein Y stands for an alkyl having from 1 to 5 carbon atoms.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8523776 |
Sep 1985 |
GBX |
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Parent Case Info
This is a continuation of application Ser. No. 239,049 filed Aug. 30, 1988, now abandoned, which in turn is a continuation of application Ser. No. 908,406 filed Sep. 16, 1986, now abandoned.
US Referenced Citations (8)
Foreign Referenced Citations (4)
Number |
Date |
Country |
60-260532 |
Dec 1985 |
JPX |
301687 |
Nov 1954 |
CHX |
301688 |
Nov 1954 |
CHX |
301691 |
Nov 1954 |
CHX |
Non-Patent Literature Citations (1)
Entry |
Corey et al., JACS, 1982, 104, 1750-1754. |
Continuations (2)
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Number |
Date |
Country |
Parent |
239049 |
Aug 1988 |
|
Parent |
908406 |
Sep 1986 |
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