The present invention relates generally to methods and devices for invasive medical treatment, and specifically to catheters.
Ablation of myocardial tissue is well known as a treatment for cardiac arrhythmias. In radio-frequency (RF) ablation, for example, a catheter is inserted into the heart and brought into contact with tissue at a target location. RF energy is then applied through an electrode on the catheter in order to create a lesion for the purpose of breaking arrhythmogenic current paths in the tissue.
Recently, circumferential ablation of the ostia of the pulmonary veins has gained acceptance as a treatment for atrial arrhythmias, and particularly for atrial fibrillation. For example, U.S. Pat. No. 6,064,902, whose disclosure is incorporated herein by reference, describes a catheter for ablating tissue on the inner wall of a blood vessel, such as a pulmonary vein. The tip portion of the catheter is deflectable from a first, generally straight, configuration, in which the proximal and distal sections are substantially co-linear, to a second, J-shaped, configuration in which the proximal and distal sections are generally parallel with a separation therebetween substantially corresponding to the inside diameter of the blood vessel. The distal end portion of the catheter is rotated about the longitudinal axis of the catheter to cause a circumferential displacement of proximal and distal ablation electrodes on the catheter along the inner wall of the pulmonary vein. In this way, the electrode catheter may be used to ablate a number of circumferentially-spaced sites on the inner wall of the pulmonary vein by ablating one or two sites at each circumferential position.
U.S. Patent Application Publication 2005/0033135, whose disclosure is incorporated herein by reference, describes a lasso for pulmonary vein mapping and ablation. A catheter for circumferentially mapping a pulmonary vein (PV) includes a curved section shaped to generally conform to the shape of the interior surface of the PV. The curved section comprises one or more sensing electrodes, and its proximal end is joined at a fixed or generally known angle to a base section of the catheter. Position sensors are fixed to the curved section of the catheter and to the distal end of the base section. The catheter is inserted into the heart, and the curved section is positioned in contact with the wall of the PV, while the base section remains within the left atrium, typically positioned such that the joint with the curved section is at the ostium of the vein. The information generated by the three position sensors is used to calculate the locations and orientations of the sensing electrodes, which enables mapping of the surface of the PV. The sensing electrodes may additionally perform ablation of selected sites, or the catheter may further comprise ablation elements.
U.S. Pat. No. 7,008,401, whose disclosure is incorporated herein by reference, describes compound steering assemblies, usable in both diagnostic and therapeutic applications, for steering the distal section of a catheter in multiple planes or complex curves. These assemblies are said to enable a physician to swiftly and accurately position and maintain ablation and/or mapping electrodes in intimate contact with an interior body surface. U.S. Pat. No. 5,820,591, whose disclosure is incorporated herein by reference, similarly describes compound steering assemblies of this sort.
Embodiments of the present invention that are described hereinbelow provide invasive devices and methods for contacting tissue within the body with enhanced ease and reliability.
There is therefore provided, in accordance with an embodiment of the present invention, a medical device, including an insertion shaft, having a longitudinal axis and having a distal end adapted for insertion into a body of a patient. A resilient end section is fixed to the distal end of the insertion shaft and is formed so as to define, when unconstrained, an arc oriented obliquely relative to the axis and having a center of curvature on the axis. One or more electrodes are disposed at respective locations along the end section.
In one embodiment, the arc subtends more than 300°. In other embodiments, the arc subtends less than 270°, and possibly 180°. Typically, the end section includes a base, which is connected to the distal end of the insertion shaft, and a tip, and has a helical form such that the tip protrudes axially in a distal direction relative to the base.
In some embodiments, the one or more electrodes include a tip electrode extending over the tip and a plurality of proximal electrodes distributed along the end section. The end section is configured so that when the unconstrained end section is advanced axially against a tissue surface in the body, the end section engages the tissue surface along the arc so that the tip electrode and at least some of the proximal electrodes contact the tissue surface simultaneously. Optionally, the end section includes one or more joints, which can be straightened and steered so as to bring the tip electrode alone into contact with the tissue surface.
In a disclosed embodiment, the device includes at least one position transducer, and possibly a plurality of position transducers distributed within the end section.
There is also provided, in accordance with an embodiment of the present invention, a medical device, including an insertion shaft, having a longitudinal axis and having a distal end adapted for insertion through a body passage into a cavity within a body of a patient. A resilient end section includes a base, which is connected to the distal end of the insertion shaft, and a tip, and is formed so as to define, when unconstrained, an arc that is oriented obliquely relative to the axis and has a helical form such that the tip protrudes axially in a distal direction relative to the base. One or more electrodes are disposed at respective locations along the end section.
There is additionally provided, in accordance with an embodiment of the present invention, medical apparatus, including a probe for insertion into a body of a patient. The probe includes an insertion shaft, having a longitudinal axis and having a distal end adapted for insertion into the body. A resilient end section is fixed to the distal end of the insertion shaft and is formed so as to define, when unconstrained, an arc oriented obliquely relative to the axis and having a center of curvature on the axis. One or more electrodes are disposed at respective locations along the end section and configured to contact tissue in the body. A radio frequency (RF) generator is coupled to supply RF energy through the probe to at least one of the electrodes so as to ablate the tissue.
In a disclosed embodiment, the probe includes a position transducer in the end section, and the apparatus includes a position sensing system, which is configured to communicate with the position transducer so as to determine a position of the end section within the body.
In some embodiments, the apparatus includes a sheath, which is configured to be inserted through a body passage into a cavity within the body, and the probe is configured to be inserted through the sheath into the cavity. In one embodiment, the sheath is configured to be inserted through a blood vessel into a chamber of a heart, and wherein the end section is configured to engage, along the arc, a tissue in the chamber. Typically, the insertion shaft is configured to be rotated about the axis within the sheath, so as to cause the arc to describe an annular path on the tissue.
There is further provided, in accordance with an embodiment of the present invention, a method for medical treatment, including inserting into a body of a patient a probe including an insertion shaft, having a longitudinal axis and a distal end, and a resilient end section, which is fixed to the distal end of the insertion shaft and is formed so as to define, when unconstrained, an arc oriented obliquely relative to the axis and having a center of curvature on the axis, with electrodes disposed at respective locations along the end section. The probe is advanced axially so that the end section engages a tissue in the body along the arc, causing at least some of the electrodes to contact the tissue simultaneously. The insertion shaft is rotated about the axis, so as to cause the arc to describe an annular path on the tissue while the at least some of the electrodes contact the tissue.
In disclosed embodiments, the method includes applying energy through the electrodes so as to ablate the tissue along the annular path. In one embodiment, inserting the probe includes passing the probe through a blood vessel into a chamber of a heart and tracing the annular path around an ostium of a pulmonary vein in a left atrium of the heart.
The present invention will be more fully understood from the following detailed description of the embodiments thereof, taken together with the drawings in which:
Lasso catheters, as described above, may be used for ablating tissue along an arc surrounding an anatomical structure, such as the ostium of a pulmonary vein. The lasso is generally made thin and flexible, for purposes of maneuverability, with large ring electrodes to minimize electrical resistance. U.S. patent application Ser. No. 12/345,720, filed Dec. 30, 2008, which is assigned to the assignee of the present patent application and whose disclosure is incorporated herein by reference, describes an alternative design in which the lasso is thicker and stiffer. Even so, operators often find lasso catheters to be difficult to maneuver within the heart, and particularly difficult to position in such a way that the entire circumference of the lasso is in contact with the tissue, as is desirable for effective pulmonary vein isolation, for example.
Embodiments of the present invention that are described hereinbelow provide probes, such as catheters, with improved lasso-type structures to facilitate maneuvering and positioning of the structure in the heart. Such catheters can be used to produce curved ablation paths, as well as sensing electrical activity at points along a curve.
In the disclosed embodiments, a catheter comprises an insertion shaft having a longitudinal axis. A resilient end section, with electrodes disposed along its length, is fixed to the distal end of the insertion shaft. This end section is formed so as to define, when unconstrained, an arc oriented obliquely relative to the longitudinal axis of the insertion shaft and having a center of curvature on the axis. The term “oblique,” in the context of the present patent application and in the claims, means that the plane in space that best fits the arc is angled relative to the shaft axis. The angle between the plane and the axis is typically at least 45°, and in the embodiments shown below is approximately 90°.
An operator inserts the catheter into a body cavity, such as a heart chamber, and advances the distal end of the catheter axially toward a tissue in the body, such as the inner heart wall. (The term “axial” refers to the direction parallel to the longitudinal axis of the insertion shaft.) As a result, the end section of the catheter will engage the tissue surface frontally along the arc, and some or all of the electrodes on the end section will thus contact the tissue surface simultaneously.
For improved contact, the arc may have a helical form, whereby the distal tip of the end section protrudes axially in the distal direction relative to the base of the end section, which connects to the insertion shaft (i.e., when the end section is unconstrained, the tip is slightly ahead of the base). The helical form is compressed axially and thus flattened as the end section is advanced against the tissue, so that there is positive pressure between each of the electrodes and the tissue.
After bringing the end section into engagement with the tissue at the target location, the operator rotates the insertion shaft about its axis, thus causing the arc to describe an annular path on the tissue while the electrodes contact the tissue. Because the arc is centered on the axis, simple rotation of the shaft is sufficient to engender this annular motion, typically without the need for additional manipulation or steering of the catheter. In this manner, for example, the operator can cause the end section to trace an annular path around an anatomical feature, such as the ostium of a pulmonary vein in the left atrium. The operator may apply energy, such as radio frequency (RF) electrical current, through the electrodes so as to ablate the tissue along this annular path. This arrangement provides an easy and reliable way to create annular lesions in the tissue, as well as sensing signals along annular paths.
In the pictured embodiment, system 20 uses magnetic position sensing to determine position coordinates of the end section of the catheter inside heart 26. To determine the position coordinates, a driver circuit 34 in console 30 drives field generators 32 to generate magnetic fields within the body of patient 28. Typically, field generators 32 comprise coils, which are placed below the patient's torso at known positions external to the body. These coils generate magnetic fields in a predefined working volume that contains heart 26. One or more magnetic field sensors within the end section of catheter 24 (as shown in
Alternatively or additionally, system 20 may comprise an automated mechanism (not shown) for maneuvering and operating catheter 24 within the body of patient 28. Such mechanisms are typically capable of controlling both the longitudinal motion (advance/retract) and the rotation of catheter 24. In such embodiments, console 30 generates a control input for controlling the motion of the catheter based on the signals provided by the position sensing system.
Although
Operator 22 aligns the longitudinal axis of sheath 40 (and of catheter 24) inside left atrium 46 with the axis of one of pulmonary veins 50. The operator may carry out this alignment using the position sensing methods described above, along with a pre-acquired map or image of heart 26. Alternatively or additionally, the alignment may be performed under fluoroscopic or other means of visualization. The operator advances end section 52 of the catheter toward the target pulmonary vein so that the arc contacts the ostium, so that the end section either partly or fully surrounds the vein (depending on the angle subtended by the arc). The operator then rotates the catheter about its axis within the sheath so that the end section traces an annular path around the circumference of the vein. Meanwhile, the operator actuates RF generator 36 to ablate the tissue along the path. After completing this procedure around one pulmonary vein, the operator may shift the sheath and catheter and repeat the procedure around one or more of the other pulmonary veins.
The above procedures may be carried out without the use of any steering mechanism in catheter 24: Due to the curved shape of the catheter, only advancement/retraction and rotation of the catheter are required. The absence of an internal steering mechanism reduces the size and cost of the catheter relative to devices that are known in the art. As noted earlier, the above procedures may be carried out by an automated mechanism, rather than manually by the operator as illustrated in
Optionally, catheter 24 may contain a steering mechanism (not shown), which enables operator 22 to straighten the joints of end section 52. In this configuration, the operator may manipulate catheter 24 in order to trace (and possibly ablate) other sorts of paths or to sense or ablate tissue at specific, discrete points in the heart wall, either in left atrium 46 or elsewhere.
Reference is now made to
Shaft 54 and end section 52 typically comprise an outer shell made from a suitable flexible biocompatible material, such as polyurethane, having a diameter around 2-3 mm, with internal wires and tubing as required. In one embodiment, in which the catheter is designed for therapeutic ablation, the size of the shaft is 7 Fr (about 2.3 mm diameter), while the end section is of the same or slightly larger size (such as 7.5 Fr). In other embodiments, for diagnostic measurements, the shaft is 7 Fr, while the end section has a diameter between 1 and 2.5 mm.
End section 52 is formed as a partial lasso, i.e., as a preformed arcuate structure, which is centered on the axis of shaft 54 and loops through considerably less than 360°, and typically less than 270°. In the pictured embodiment, for example, the catheter ends in a “half-lasso” arc of about 180°. This sort of shape makes the end section easier to maneuver and position accurately. The radius of curvature of end section 52, when unconstrained, is typically between 7.5 mm and 15 mm. Because the arc structure is resilient and, possibly, slightly helical, when end section 52 is positioned in the heart (half surrounding the ostium of a pulmonary vein, for example), and insertion shaft 54 is advanced distally, the end section will press against the heart tissue over the entire length of the arc, thus facilitating good tissue contact.
The arcuate, helical shape of end section 52 may be maintained, for example, by incorporating a thin strut made from a shape memory material, such as Nitinol, in the desired shape (not shown in the figures) within the end section. The strut is typically made sufficiently flexible to permit the end section to straighten during insertion through sheath 40, and then to resume its arcuate form when it is unconstrained inside the heart chamber. Typically, the strut is designed so that an axial force of 5 grams or greater is required to flatten the helical shape so that the entire length of the arcuate end section presses against the tissue.
End section 52 comprises an array of electrodes along its length, including, in this example, a tip electrode 56 extending over the distal tip of the end section and proximal electrodes 58 distributed along the end section. Typically, the electrodes have a width between 1 mm and 4 mm, and are spaced between 1 mm and 10 mm apart. The electrodes are connected to the connector at the proximal end of catheter 24 by wires (not shown) running through the catheter. Alternatively, other electrode configurations may be used. For example, the end section may include only ring electrodes, without a tip electrode. As another example, the end section may include smaller “bump” electrodes, as described in the above-mentioned U.S. patent application Ser. No. 12/345,720. In any of these configurations, the electrodes may be used for sensing and/or ablation. In order to ablate an entire annulus around a pulmonary vein, for example, catheter 24 may be rotated (“clocked”) about its axis, as noted above.
To provide local cooling and prevent adhesion during ablation, electrodes 56 and 58 may have perforations for irrigation. (Perforations of this type are described and shown in U.S. patent application Ser. No. 12/345,720.) The perforations are coupled to a lumen (not shown) in end section 52, which carries irrigation fluid from shaft 54 to the electrodes and to the tissue surrounding them. The pressure of irrigation fluid tends to be lower at the distal end of the end section than at the proximal. To counteract this pressure difference, the irrigation holes in the distal electrodes may be relatively larger and/or more numerous than in the proximal electrodes.
Optionally, end section 52 comprises an internal steering mechanism (not shown), which can be operated to straighten the joints of the end section and to bring tip electrode 56 alone into contact with the tissue surface. For example, the steering mechanism may comprise one or more pull-wires, which run through a lumen in the catheter, as is known in the art. (The catheter may contain multiple lumens, for pull-wires and the strut mentioned above, for irrigation fluid, and for electrical wires connected to the electrodes and position transducers.) When ablation or sensing at a single point is required, the tip electrode can be brought into contact with the point and actuated by itself. On the other hand, when the half-lasso configuration of
Catheter 24 may also include one of more position transducers, such as positions sensors 60 and 62 shown in
Catheter 70 differs from catheter 24 in that an arcuate end section 72 of catheter 70 is formed as a full (or nearly full) loop, subtending more than 300°, and possibly the full 360°. Therefore, end section 72 is capable of covering an entire annular ablation or sensing path with little or no rotation of shaft 54. End section 72, like end section 52 of catheter 24, is centered on the axis of shaft 54 and helical in shape. These features make the end section easier to position in the desired anatomical location and facilitate good contact between electrodes 58 and the target tissue over the entire length of the end section.
Although the embodiments described above relate specifically to catheters for use in certain intracardiac procedures, probes made in accordance with the principles set forth in this patent application may similarly be used in diagnostic and therapeutic procedures of other types, both in the heart and in other body organs. It will thus be appreciated that the embodiments described above are cited by way of example, and that the present invention is not limited to what has been particularly shown and described hereinabove. Rather, the scope of the present invention includes both combinations and subcombinations of the various features described hereinabove, as well as variations and modifications thereof which would occur to persons skilled in the art upon reading the foregoing description and which are not disclosed in the prior art.
Number | Name | Date | Kind |
---|---|---|---|
3971364 | Fletcher et al. | Jul 1976 | A |
4488561 | Doring | Dec 1984 | A |
4764114 | Jeffcoat et al. | Aug 1988 | A |
4856993 | Maness et al. | Aug 1989 | A |
4917102 | Miller et al. | Apr 1990 | A |
4917104 | Rebell | Apr 1990 | A |
5263493 | Avitall | Nov 1993 | A |
5368564 | Savage | Nov 1994 | A |
5391199 | Ben Haim | Feb 1995 | A |
5487757 | Truckai et al. | Jan 1996 | A |
5499542 | Morlan | Mar 1996 | A |
5558091 | Acker et al. | Sep 1996 | A |
5563354 | Kropp | Oct 1996 | A |
5643197 | Brucker et al. | Jul 1997 | A |
5662124 | Wilk | Sep 1997 | A |
5673695 | McGee et al. | Oct 1997 | A |
5680860 | Imran | Oct 1997 | A |
5685878 | Falwell et al. | Nov 1997 | A |
5730127 | Avitall | Mar 1998 | A |
5769843 | Abela et al. | Jun 1998 | A |
5820591 | Thompson et al. | Oct 1998 | A |
5826576 | West | Oct 1998 | A |
5836894 | Sarvazyan | Nov 1998 | A |
5860920 | McGee et al. | Jan 1999 | A |
5860974 | Abele | Jan 1999 | A |
5865815 | Tihon | Feb 1999 | A |
5871523 | Fleischman et al. | Feb 1999 | A |
5902248 | Millar et al. | May 1999 | A |
5916147 | Boury | Jun 1999 | A |
5938694 | Jaraczewski et al. | Aug 1999 | A |
5944022 | Nardella et al. | Aug 1999 | A |
5964757 | Ponzi | Oct 1999 | A |
5974320 | Ward et al. | Oct 1999 | A |
5983126 | Wittkampf | Nov 1999 | A |
6002955 | Willems et al. | Dec 1999 | A |
6048329 | Thompson et al. | Apr 2000 | A |
6063022 | Ben Haim | May 2000 | A |
6064902 | Haissaguerre et al. | May 2000 | A |
6123699 | Webster, Jr. | Sep 2000 | A |
6171277 | Ponzi | Jan 2001 | B1 |
6177792 | Govari et al. | Jan 2001 | B1 |
6183463 | Webster, Jr. | Feb 2001 | B1 |
6198974 | Webster, Jr. | Mar 2001 | B1 |
6201387 | Govari | Mar 2001 | B1 |
6203493 | Ben Haim | Mar 2001 | B1 |
6216027 | Willis et al. | Apr 2001 | B1 |
6226542 | Reisfeld | May 2001 | B1 |
6239724 | Doron et al. | May 2001 | B1 |
6241724 | Fleischman et al. | Jun 2001 | B1 |
6267781 | Tu | Jul 2001 | B1 |
6272371 | Shlomo | Aug 2001 | B1 |
6272672 | Conway | Aug 2001 | B1 |
6301496 | Reisfeld | Oct 2001 | B1 |
6332089 | Acker et al. | Dec 2001 | B1 |
6335617 | Osadchy et al. | Jan 2002 | B1 |
6371955 | Fuimaono et al. | Apr 2002 | B1 |
6436059 | Zanelli | Aug 2002 | B1 |
6456864 | Swanson et al. | Sep 2002 | B1 |
6468260 | Bumbalough et al. | Oct 2002 | B1 |
6484118 | Govari | Nov 2002 | B1 |
6500167 | Webster, Jr. | Dec 2002 | B1 |
6522933 | Nguyen | Feb 2003 | B2 |
6551302 | Rosinko et al. | Apr 2003 | B1 |
6574492 | Ben Haim et al. | Jun 2003 | B1 |
6584856 | Biter et al. | Jul 2003 | B1 |
6592581 | Bowe | Jul 2003 | B2 |
6602242 | Fung et al. | Aug 2003 | B1 |
6612992 | Hossack et al. | Sep 2003 | B1 |
6618612 | Acker et al. | Sep 2003 | B1 |
6669692 | Nelson et al. | Dec 2003 | B1 |
6690963 | Ben Haim et al. | Feb 2004 | B2 |
6695808 | Tom | Feb 2004 | B2 |
6711429 | Gilboa et al. | Mar 2004 | B1 |
6712815 | Sampson et al. | Mar 2004 | B2 |
6723094 | Desinger | Apr 2004 | B1 |
6727371 | Muller et al. | Apr 2004 | B2 |
6814733 | Schwartz et al. | Nov 2004 | B2 |
6835173 | Couvillon, Jr. | Dec 2004 | B2 |
6892091 | Ben Haim et al. | May 2005 | B1 |
6908464 | Jenkins et al. | Jun 2005 | B2 |
6911019 | Mulier et al. | Jun 2005 | B2 |
6915149 | Ben Haim | Jul 2005 | B2 |
6945956 | Waldhauser et al. | Sep 2005 | B2 |
6964205 | Papakostas et al. | Nov 2005 | B2 |
6973339 | Govari | Dec 2005 | B2 |
6997924 | Schwartz et al. | Feb 2006 | B2 |
7008401 | Thompson et al. | Mar 2006 | B2 |
7008418 | Hall et al. | Mar 2006 | B2 |
7077823 | McDaniel | Jul 2006 | B2 |
7156816 | Schwartz et al. | Jan 2007 | B2 |
7235070 | Vanney | Jun 2007 | B2 |
7285119 | Stewart et al. | Oct 2007 | B2 |
7306593 | Keidar et al. | Dec 2007 | B2 |
7311704 | Paul et al. | Dec 2007 | B2 |
7397364 | Govari | Jul 2008 | B2 |
7419489 | Vanney et al. | Sep 2008 | B2 |
7481774 | Brockway et al. | Jan 2009 | B2 |
7517349 | Truckai et al. | Apr 2009 | B2 |
7536218 | Govari et al. | May 2009 | B2 |
7604605 | Zvuloni | Oct 2009 | B2 |
7681432 | Hay et al. | Mar 2010 | B2 |
7686767 | Maschke | Mar 2010 | B2 |
8066702 | Rittman et al. | Nov 2011 | B2 |
8083691 | Goldenberg et al. | Dec 2011 | B2 |
20010047129 | Hall et al. | Nov 2001 | A1 |
20010047133 | Gilboa et al. | Nov 2001 | A1 |
20020002329 | Avitall | Jan 2002 | A1 |
20020022839 | Stewart et al. | Feb 2002 | A1 |
20020065455 | Ben Haim et al. | May 2002 | A1 |
20020068866 | Zikorus et al. | Jun 2002 | A1 |
20020165461 | Hayzelden et al. | Nov 2002 | A1 |
20020193781 | Loeb | Dec 2002 | A1 |
20030105453 | Stewart et al. | Jun 2003 | A1 |
20030120195 | Milo et al. | Jun 2003 | A1 |
20030130615 | Tom | Jul 2003 | A1 |
20030158494 | Dahl et al. | Aug 2003 | A1 |
20030216722 | Swanson | Nov 2003 | A1 |
20040049255 | Jain et al. | Mar 2004 | A1 |
20040064024 | Sommer | Apr 2004 | A1 |
20040068178 | Govari | Apr 2004 | A1 |
20040082948 | Stewart et al. | Apr 2004 | A1 |
20040097806 | Hunter et al. | May 2004 | A1 |
20040102769 | Schwartz et al. | May 2004 | A1 |
20040143175 | Coleman et al. | Jul 2004 | A1 |
20040147920 | Keidar | Jul 2004 | A1 |
20040152974 | Solomon et al. | Aug 2004 | A1 |
20040244464 | Hajdukiewicz et al. | Dec 2004 | A1 |
20040254458 | Govari | Dec 2004 | A1 |
20050004565 | Vanney | Jan 2005 | A1 |
20050010095 | Stewart et al. | Jan 2005 | A1 |
20050033135 | Govari | Feb 2005 | A1 |
20050070894 | McClurken | Mar 2005 | A1 |
20050080429 | Freyman et al. | Apr 2005 | A1 |
20050187544 | Swanson et al. | Aug 2005 | A1 |
20050277875 | Selkee | Dec 2005 | A1 |
20060009690 | Fuimaono et al. | Jan 2006 | A1 |
20060009735 | Viswanathan et al. | Jan 2006 | A1 |
20060015096 | Hauck et al. | Jan 2006 | A1 |
20060020264 | Crowley et al. | Jan 2006 | A1 |
20060106295 | Jais et al. | May 2006 | A1 |
20060173480 | Zhang | Aug 2006 | A1 |
20060200049 | Leo et al. | Sep 2006 | A1 |
20060235381 | Whayne et al. | Oct 2006 | A1 |
20060247618 | Kaplan et al. | Nov 2006 | A1 |
20060253116 | Avitall et al. | Nov 2006 | A1 |
20070021742 | Viswanathan | Jan 2007 | A1 |
20070060832 | Levin | Mar 2007 | A1 |
20070060847 | Leo et al. | Mar 2007 | A1 |
20070100332 | Paul et al. | May 2007 | A1 |
20070106114 | Sugimoto et al. | May 2007 | A1 |
20070142749 | Khatib et al. | Jun 2007 | A1 |
20070151391 | Larkin et al. | Jul 2007 | A1 |
20070156114 | Worley et al. | Jul 2007 | A1 |
20070161882 | Pappone | Jul 2007 | A1 |
20070179492 | Pappone | Aug 2007 | A1 |
20070185397 | Govari et al. | Aug 2007 | A1 |
20070191829 | McGee et al. | Aug 2007 | A1 |
20070197939 | Wallace et al. | Aug 2007 | A1 |
20070282211 | Ofek et al. | Dec 2007 | A1 |
20080009750 | Aeby et al. | Jan 2008 | A1 |
20080015568 | Paul et al. | Jan 2008 | A1 |
20080051704 | Patel et al. | Feb 2008 | A1 |
20080065111 | Blumenkranz et al. | Mar 2008 | A1 |
20080071267 | Wang et al. | Mar 2008 | A1 |
20080077049 | Hirshman | Mar 2008 | A1 |
20080097394 | Lampropoulos et al. | Apr 2008 | A1 |
20080161774 | Hastings et al. | Jul 2008 | A1 |
20080161795 | Wang et al. | Jul 2008 | A1 |
20080183075 | Govari et al. | Jul 2008 | A1 |
20080249522 | Pappone et al. | Oct 2008 | A1 |
20080255540 | Selkee | Oct 2008 | A1 |
20080275428 | Tegg et al. | Nov 2008 | A1 |
20080275442 | Paul et al. | Nov 2008 | A1 |
20080275465 | Paul et al. | Nov 2008 | A1 |
20080281319 | Paul et al. | Nov 2008 | A1 |
20080287777 | Li et al. | Nov 2008 | A1 |
20080288038 | Paul et al. | Nov 2008 | A1 |
20080294144 | Leo et al. | Nov 2008 | A1 |
20080294158 | Pappone et al. | Nov 2008 | A1 |
20090010021 | Smith et al. | Jan 2009 | A1 |
20090093806 | Govari et al. | Apr 2009 | A1 |
20090138007 | Govari | May 2009 | A1 |
20090158511 | Maze et al. | Jun 2009 | A1 |
20090254083 | Wallace et al. | Oct 2009 | A1 |
20090287118 | Malek | Nov 2009 | A1 |
20090306650 | Govari et al. | Dec 2009 | A1 |
20100030209 | Govari et al. | Feb 2010 | A1 |
20100063478 | Selkee | Mar 2010 | A1 |
20100137845 | Ramstein et al. | Jun 2010 | A1 |
20100152574 | Erdman et al. | Jun 2010 | A1 |
20100168548 | Govari | Jul 2010 | A1 |
20100168620 | Klimovitch et al. | Jul 2010 | A1 |
20100168918 | Zhao et al. | Jul 2010 | A1 |
20100222859 | Govari | Sep 2010 | A1 |
20110054287 | Schultz | Mar 2011 | A1 |
20110054446 | Schultz | Mar 2011 | A1 |
20110130648 | Beeckler et al. | Jun 2011 | A1 |
20110144639 | Govari et al. | Jun 2011 | A1 |
20110184406 | Selkee | Jul 2011 | A1 |
20120053403 | Ducharme et al. | Mar 2012 | A1 |
20120143088 | Schultz | Jun 2012 | A1 |
20120172703 | Esguerra et al. | Jul 2012 | A1 |
20130006238 | Ditter et al. | Jan 2013 | A1 |
Number | Date | Country |
---|---|---|
19750441 | Jun 1999 | DE |
856292 | Aug 1998 | EP |
928601 | Jul 1999 | EP |
1042990 | Oct 2000 | EP |
1181896 | Feb 2002 | EP |
1502555 | Feb 2005 | EP |
1586281 | Oct 2005 | EP |
1690564 | Aug 2006 | EP |
1743575 | Jan 2007 | EP |
1820464 | Aug 2007 | EP |
1897581 | Mar 2008 | EP |
2000789 | Dec 2008 | EP |
2047797 | Apr 2009 | EP |
2127604 | Dec 2009 | EP |
2130508 | Dec 2009 | EP |
2171240 | Apr 2010 | EP |
2 229 904 | Sep 2010 | EP |
2289403 | Mar 2011 | EP |
2289408 | Mar 2011 | EP |
2338411 | Jun 2011 | EP |
2338412 | Jun 2011 | EP |
2005345215 | Dec 2005 | JP |
2006064465 | Mar 2006 | JP |
9510326 | Apr 1995 | WO |
WO 9605768 | Feb 1996 | WO |
9729678 | Aug 1997 | WO |
9729709 | Aug 1997 | WO |
9729710 | Aug 1997 | WO |
9829032 | Jul 1998 | WO |
9956812 | Nov 1999 | WO |
03020139 | Mar 2003 | WO |
2006003216 | Jan 2006 | WO |
2006029563 | Mar 2006 | WO |
2006086152 | Aug 2006 | WO |
2006092563 | Sep 2006 | WO |
2007025230 | Mar 2007 | WO |
2007050960 | May 2007 | WO |
2007067938 | Jun 2007 | WO |
2007082216 | Jul 2007 | WO |
2007098494 | Aug 2007 | WO |
2007111182 | Oct 2007 | WO |
2009078280 | Jun 2009 | WO |
2009085470 | Jul 2009 | WO |
2009147399 | Dec 2009 | WO |
2010008975 | Jan 2010 | WO |
Entry |
---|
Extended European Search Report dated Nov. 15, 2012 from related European Application No. 12185274.3. |
Office Action dated Nov. 14, 2012 received from the European Patent Office from related European Application No. 10 252 246.3. |
Biter, W.J. et al., “Magnetic Wire Strain Sensor,” 33rd International Sample Technical Conference, Nov. 2001, vol. 33, pp. 12-23, Seattle, WA. |
Biter, W.J. et al. “Magnetic Wire for Monitoring Strain in Composites,” Sensors, Jun. 2001, www.sensormag.com, pp. 110-114. |
Okumura, Y. et al. “A Systematic Analysis of in Vivo Contact Forces on Virtual Catheter Tip-Tissue Surface Contact During Cardiac Mapping and Intervention,” J. of Cardiovasc Electrophysiol, vol. 19, pp. 632-640, Jun. 2008. |
English abstract of DE 19750441 A, Jun. 10, 1999. |
European Patent Convention Communication dated Aug. 29, 2013, from corresponding European Application No. 10 252 246.3. |
European Patent Convention Communication dated Aug. 29, 2013, from corresponding European Application No. 12 185 274.3. |
Number | Date | Country | |
---|---|---|---|
20110160719 A1 | Jun 2011 | US |