The following description relates to a catheter.
Central venous catheters (CVCs) are widely used for hemodialysis. Among the catheters, catheters having symmetrical tips are most widely used.
Hemodialysis using such a catheter is performed using a hemodialysis machine in a state in which the catheter is inserted into a patient's central vein, and progresses by a method of introducing blood into a first lumen through an inlet formed at a longitudinal end of the catheter, processing the blood introduced through the first lumen using the hemodialysis machine, and discharging the blood into a second lumen through an outlet formed at the longitudinal end of the catheter as well.
In this case, a recirculation phenomenon occurs in which the blood, which has been dialyzed and discharged through the outlet formed at the longitudinal end of the catheter, is reintroduced into the inlet, thereby reducing the efficiency of the hemodialysis.
Further, in the course of using the catheter, shear stress adversely affects blood cells, and thus increases the probability of formation of a thrombus. This clogs the inside of the catheter, resulting in loss of function of the catheter, and increases the cost for replacing the catheter, and increases the risk of cannulation when the catheter is replaced.
This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description. This Summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter.
In one general aspect, a catheter includes a first lumen and a second lumen in which fluid flows, and a longitudinal end part including a body portion having a constant diameter and a nozzle portion extending from a longitudinal end of the body portion with a gradually reducing diameter. A side surface of the body portion includes cavities fluidly communicating with the first lumen and the second lumen.
In a longitudinal end surface of the nozzle portion, an inlet may fluidly communicate with the first lumen through which the fluid is introduced, and an outlet may fluidly communicate with the second lumen through which the fluid is discharged. The catheter may further include a separation wall extending in an elongated manner from a partition wall partitioning the first lumen and the second lumen at the longitudinal end of the nozzle portion, and separates the inlet and the outlet.
An inlet fluidly communicating with the first lumen through which the fluid is introduced, and an outlet fluidly communicating with the second lumen through which the fluid is discharged may be formed in a shape in which a portion between a longitudinal end of the nozzle portion and a side surface of the nozzle portion may have a curved surface in a longitudinal direction.
An inclination of the curved surface may increase from a longitudinal end surface of the nozzle portion towards side surfaces of the nozzle portion.
An inlet fluidly communicating with the first lumen through which the fluid is introduced and an outlet fluidly communicating with the second lumen through which the fluid is discharged may be symmetrically formed to have a shape in which a portion between a longitudinal end surface of the nozzle portion and a side surface of the nozzle portion may have a diagonal cut.
A longitudinal end surface of the nozzle portion may include a partition wall having an I-beam shape partitioning the first lumen and the second lumen.
The longitudinal end surface of the nozzle portion may include a partition wall having an I-beam shape partitioning the first lumen and the second lumen.
Each of the cavities may have an oval shape.
A first one of the cavities may fluidly communicate with the first lumen, and another one of the cavities may fluidly communicate with the second lumen.
The first one of the cavities may be disposed opposite to the other one of the cavities.
Other features and aspects will be apparent from the following detailed description, the drawings, and the claims.
Throughout the drawings and the detailed description, the same reference numerals refer to the same elements. The drawings may not be to scale, and the relative size, proportions, and depiction of elements in the drawings may be exaggerated for clarity, illustration, and convenience.
The following detailed description is provided to assist the reader in gaining a comprehensive understanding of the methods, apparatuses, and/or systems described herein. However, various changes, modifications, and equivalents of the methods, apparatuses, and/or systems described herein will be apparent after an understanding of the disclosure of this application. For example, the sequences of operations described herein are merely examples, and are not limited to those set forth herein, but may be changed as will be apparent after an understanding of the disclosure of this application, with the exception of operations necessarily occurring in a certain order. Also, descriptions of features that are known after understanding of the disclosure of this application may be omitted for increased clarity and conciseness.
The features described herein may be embodied in different forms, and are not to be construed as being limited to the examples described herein. Rather, the examples described herein have been provided merely to illustrate some of the many possible ways of implementing the methods, apparatuses, and/or systems described herein that will be apparent after an understanding of the disclosure of this application.
Throughout the specification, when an element, such as a layer, region, or substrate, is described as being “on,” “connected to,” or “coupled to” another element, it may be directly “on,” “connected to,” or “coupled to” the other element, or there may be one or more other elements intervening therebetween. In contrast, when an element is described as being “directly on,” “directly connected to,” or “directly coupled to” another element, there can be no other elements intervening therebetween.
As used herein, the term “and/or” includes any one and any combination of any two or more of the associated listed items.
Although terms such as “first,” “second,” and “third” may be used herein to describe various members, components, regions, layers, or sections, these members, components, regions, layers, or sections are not to be limited by these terms. Rather, these terms are only used to distinguish one member, component, region, layer, or section from another member, component, region, layer, or section. Thus, a first member, component, region, layer, or section referred to in examples described herein may also be referred to as a second member, component, region, layer, or section without departing from the teachings of the examples.
Spatially relative terms such as “above,” “upper,” “below,” and “lower” may be used herein for ease of description to describe one element's relationship to another element as shown in the figures. Such spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, an element described as being “above” or “upper” relative to another element will then be “below” or “lower” relative to the other element. Thus, the term “above” encompasses both the above and below orientations depending on the spatial orientation of the device. The device may also be oriented in other ways (for example, rotated 90 degrees or at other orientations), and the spatially relative terms used herein are to be interpreted accordingly.
The terminology used herein is for describing various examples only, and is not to be used to limit the disclosure. The articles “a,” “an,” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise. The terms “comprises,” “includes,” and “has” specify the presence of stated features, numbers, operations, members, elements, and/or combinations thereof, but do not preclude the presence or addition of one or more other features, numbers, operations, members, elements, and/or combinations thereof.
Due to manufacturing techniques and/or tolerances, variations of the shapes shown in the drawings may occur. Thus, the examples described herein are not limited to the specific shapes shown in the drawings, but include changes in shape that occur during manufacturing.
The features of the examples described herein may be combined in various ways as will be apparent after an understanding of the disclosure of this application. Further, although the examples described herein have a variety of configurations, other configurations are possible as will be apparent after an understanding of the disclosure of this application.
According to the present disclosure, the catheter is formed with a first lumen 101 and a second lumen 102 therein through which a fluid flows. In this case, the first lumen 101 and the second lumen 102 may be partitioned by a partition wall 105 formed along the center of a circular tube. Thus, respective openings thereof may be formed to have a semicircular shape, but the present disclosure is not limited thereto.
In this case, as described below, an inlet 110 connected to the first lumen 101 and an outlet 120 connected to the second lumen 102 are formed in the longitudinal end part of the catheter. Thus, the blood introduced into the catheter through the inlet 110 flows through the first lumen 101 and is processed by a hemodialysis machine (not shown), and the processed blood flows through the second lumen 102 and is discharged through the outlet 120.
The longitudinal end part forming a tip of the catheter may include a body portion 150 and a nozzle portion 160, as shown in
The body portion 150 has a constant diameter in the form of a circular tube. A cavity or hole 155 communicates with the first lumen 101. The second lumen is formed at a symmetrical point in the outer surface of the body portion 150. Thus, the blood may be introduced into the inside of the catheter through the hole 155 communicating with the first lumen 101. Further, the blood processed by the hemodialysis machine may be discharged outside through the hole 155 communicating with the second lumen 102 on an opposite side.
The nozzle portion 160 extends from a longitudinal end of the body portion 150 and is formed so that the diameter of a tube gradually decreases. In this case, the inlet 110 connected to the first lumen 101 and through which the blood is introduced and the outlet 120 connected to the second lumen 102 and through which the blood is discharged are formed in a longitudinal end surface of the nozzle portion 160.
Recirculation of the catheter may occur while flow discharged from the outlet 120 formed at the longitudinal end of the catheter and flow introduced into the catheter from the inlet 110 overlap each other. That is, when the inlet 110 and the outlet 120 are formed to be adjacent to each other, recirculation is likely to occur. However, as in the present disclosure, when the hole 155 is formed in the body portion 150, the blood discharged through the hole 155 and the outlet 120 connected to the second lumen 102 may be dispersed. Thus the flow rate of the blood discharged through the outlet 120 formed at the longitudinal end of the catheter may be reduced. Thus, the flow rate at the longitudinal end of the catheter may be reduced, and thus a probability that the recirculation occurs between the inlet 110 and the outlet 120 in the longitudinal end of the catheter may be reduced.
For reference, in the present disclosure, as will be described below, a recirculation rate and thrombus formation are analyzed using a particle tracing simulation during computer simulation. In the particle tracing simulation, the recirculation rate is calculated by counting the number of particles introduced into the catheter through the inlet 110 again among particles discharged from the outlet 120, and the thrombus formation is predicted by calculating a BDI value by analyzing shear stresses received by the respective particles. In this case, a pulsatile flow in consideration of a heart beat is applied so that the simulation may be performed to be similar to an actual blood flow, and the simulation is performed in which the size of the particles are also set to a size similar to that of red blood cells. In this case, the BDI is an index indicating the accumulation of damage to cells in the blood due to the shear stress, and as the BDI value becomes higher, the probability that more of the cells are damaged and thus a thrombus is formed becomes higher.
Further, the formation of the thrombus when the catheter is used is caused by the shear stress applied to the flow inside or outside the catheter, which occurs when the flow is concentrated in one place. Thus, as in the present disclosure, a flow rate Qside discharged through the hole 155 of the body portion 150 and the flow rate Qtip discharged through the outlet 120 at the longitudinal end of the catheter may be dispersed, and thus the probability of formation of the thrombus may be reduced.
In this case, the hole 155 may be formed in the form of an oval forming a long axis in a longitudinal direction that is a lengthwise direction of the catheter.
Next, in the present disclosure, the nozzle portion 160 that is tapered so that the diameter of the tube gradually decreases is formed at the longitudinal end of the catheter.
In
Further, in
In this way, as in the present disclosure, the nozzle portion 160, in which the diameter of the tube is gradually reduced, is formed at the longitudinal end part of the catheter, and the hole 155 is formed in the side surface of the body portion 150. Thus, the flow rate Qtip discharged from the outlet 120 at the longitudinal end of the catheter and the flow rate Qside discharged through the hole 155 of the body portion 150 may be properly dispersed. Therefore, the recirculation rate and the probability of formation of the thrombus can be reduced. Preferably, as described above, the hole 155 may be formed in an oval shape that is long in the longitudinal direction of the catheter.
Further, when the flow between the outlet 120 and the inlet 110 formed in the longitudinal end surface of the catheter is separated as much as possible, the recirculation rate can be further improved, and the description thereof will be described below.
According to the present disclosure, various embodiments related to the shape of the catheter will be described first with reference to
As described with reference to
As shown in
Next, as shown in
Further, when the inlet 110 and the outlet 120 are formed in a shape cut between the longitudinal end of the nozzle portion 160 and the side surfaces of the nozzle portion 160 in the longitudinal direction, as shown in
For reference,
Next, as shown in
Even in the present embodiment, as in the above-described embodiments, the longitudinal end surface of the nozzle portion 160 may be formed in an I shape.
Further, as described above, the longitudinal end part of the nozzle portion 160 has a shape cut in the form of not a flat surface but a curved surface in the longitudinal direction. In general, since the shear stress increases in the cut surface, the wider the cut surface, the higher the probability of thrombus formation. Thus, as the cut surface is made deeper into the catheter, the recirculation rate can be reduced, but at the same time, the cut surface is also widened, thereby increasing the probability of formation of the thrombus. As shown in
As can be seen in
According to a catheter according to the present disclosure, due to features of an end tip of the catheter, a recirculation rate is lowered, and thus hemodialysis efficiency can be improved.
Further, by reducing the probability of formation of a thrombus, the lifetime of the catheter can be extended.
Further, since the lifetime of the catheter can be extended, costs of replacement can be reduced, and the risk of cannulation can be reduced during replacement.
While this disclosure includes specific examples, it will be apparent after an understanding of the disclosure of this application that various changes in form and details may be made in these examples without departing from the spirit and scope of the claims and their equivalents. The examples described herein are to be considered in a descriptive sense only, and not for purposes of limitation. Descriptions of features or aspects in each example are to be considered as being applicable to similar features or aspects in other examples. Suitable results may be achieved if the described techniques are performed in a different order, and/or if components in a described system, architecture, device, or circuit are combined in a different manner, and/or replaced or supplemented by other components or their equivalents. Therefore, the scope of the disclosure is defined not by the detailed description, but by the claims and their equivalents, and all variations within the scope of the claims and their equivalents are to be construed as being included in the disclosure.
Number | Date | Country | Kind |
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10-2019-0059399 | May 2019 | KR | national |
Pursuant to 35 USC 120 and 365(c), this application is a continuation of International Application No. PCT/KR2020/006024 filed on May 7, 2020, which claims the benefit of Korean Patent Application No 10-2019-0059399 filed on May 21, 2019, in the Korean Intellectual Property Office, the entire disclosures of which are incorporated herein by reference for all purposes.
Number | Date | Country | |
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Parent | PCT/KR2020/006024 | May 2020 | US |
Child | 17527692 | US |