Claims
- 1. A compound having the general structure of Formula I:
- 2. The compound according to claim 1, wherein said hydrophilic polymer is non-immunogenic or weakly immunogenic.
- 3. The compound according to claim 1, wherein W is a polymer selected from the group consisting of PEG, polyamide, polylactic acid, polyglycolic acid, polylactic acid/polyglycolic acid copolymers and combinations thereof, said polymer having a molecular weight of about 250 to about 7000 daltons.
- 4. The compound according to claim 1, wherein Y comprises a least one basic amino acid or derivative thereof.
- 5. The compound according to claim 1, wherein Y has at least 4 positive charges at a selected pH.
- 6. The compound according to claim 1, wherein Y has at least 8 positive charges at a selected pH.
- 7. The compound according to claim 4, wherein Y comprises an amino acid selected from the group consisting of lysine, arginine, asparagine, glutamine, derivatives thereof and combinations thereof.
- 8. The compound according to claim 2, wherein
A is a member selected from the group consisting of a diacylglycerolyl moiety, a dialkylglycerolyl moiety, a N—N-dialkylamino moiety, a 1,2-diacyloxy-3-aminopropane moiety and a 1,2,dialkyl-3-aminopropane moiey.
- 9. The compound according to claim 3, wherein W is PEG.
- 10. The compound according to claim 3, wherein W is a polyamide polymer.
- 11. The compound according to claim 3, wherein W has a molecular weight of about 250 to about 2000 daltons.
- 12. The compound according to claim 9, having the general structure of Formula II:
- 13. The compound according to claim 12, wherein X is a member selected from the group consisting of a single bond, phosphatidylethanolamino, phosphatidylethanolamido, phosphoro, phospho, phosphoethanolamino, phosphoethanolamido, carbonyl, carbamate, carboxyl, carbonate, amido, thioamido, oxygen, sulfur and NR, wherein R is a hydrogen or alkyl group.
- 14. The compound according to claim 12, wherein Z is a member selected from the group consisting of a single bond, phosphatidylethanolamino, phosphatidylethanolamido, phosphoro, phospho, phosphoethanolamino, phosphoethanolamido, carbonyl, carbamate, carboxyl, carbonate, amido, thioamido, oxygen, sulfur and NR, wherein R is a hydrogen or alkyl group.
- 15. The compound according to claim 12, wherein
A is a diacylglycerolyl moiety; X is phosphoethanolamido; Z is NR, wherein R is a hydrogen atom; and Y comprises about 1 to about 10 basic amino acids or derivatives thereof.
- 16. The compound according to claim 15, where A is a diacylglycerolyl moiety having 2 fatty acyl chains, wherein each acyl chain is independently between 2 and 30 carbons in length and is either saturated or has vary degrees of saturation.
- 17. The compound according to claim 15, wherein Y comprises an amino acid selected from the group consisting of lysine, arginine, glutamine, derivatives thereof and combinations thereof.
- 18. The compound according to claim 15, wherein
A is a diacylglycerolyl moiety having 2 fatty acyl chains, wherein each acyl chain is a saturated C-18 carbon chain; and Y is a cationic group comprising 4 lysine residues or derivatives thereof.
- 19-54. (canceled)
RELATED APPLICATIONS
[0001] This application claims priority to U.S. Provisional Patent Application Ser. No. 60/130,151 filed Apr. 20, 1999, the teachings of which are incorporated herein by reference in their entirety for all purposes.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60130151 |
Apr 1999 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09553639 |
Apr 2000 |
US |
Child |
10884690 |
Jul 2004 |
US |