Claims
- 1. A compound of the formula: ##STR12## wherein R.sup.1 is amino or protected amino,
- R.sup.2 is lower alkyl substituted with 1 to 3 halogen atoms,
- R.sup.3 is thiadiazolylthiomethyl which may be substituted with lower alkyl, or tetrazolylthiomethyl which may be substituted with lower alkyl or lower alkenyl, and
- R.sup.4 is carboxy or protected carboxy,
- and a pharmaceutically acceptable salt thereof.
- 2. A compound of the claim 1, which is syn isomer.
- 3. A compound of claim 1,
- wherein R.sup.2 is lower alkyl substituted with 1 to 3 fluorine atoms.
- 4. A compound of claim 2,
- wherein
- R.sup.1 is amino or lower alkanoylamino,
- R.sup.3 is thiadiazolylthiomethyl which may be substituted with lower alkyl, or tetrazolylthiomethyl which may be substituted with lower alkyl or lower alkenyl, and
- R.sup.4 is carboxy or esterafied carboxy.
- 5. A compound of the claim 4,
- wherein
- R.sup.1 is amino or lower alkanoylamino,
- R.sup.3 is thiadiazolylthiomethyl, or tetrazolylthiomethyl which may be substituted with lower alkyl or lower alkenyl, and
- R.sup.4 is carboxy.
- 6. A compound of the claim 5, which is 7-[2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetamido]-3-(1-allyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (syn isomer).
- 7. A compound of the claim 5, which is 7-[2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetamido]-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid (syn isomer).
- 8. A compound of the claim 5, which is 7-[2-(2-aminothiazol-4-yl)-2-(2-bromoethoxyimino)acetamido]-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid (syn isomer).
- 9. A compound of the claim 5, which is 7-[2-(2-aminothiazol-4-yl)-2-(2,2,2-trifluoroethoxyimino)acetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (syn isomer).
- 10. A compound of the claim 5, which is 7-[2-(2-aminothiazol-4-yl)-2-(2,2,2-trifluoroethoxyimino)acetamido]-3-(1-allyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (syn isomer).
- 11. A compound of the claim 5, which is 7-[2-(2-aminothiazol-4-yl)-2-(2,2,2-trifluoroethoxyimino)acetamido]-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid (syn isomer).
- 12. A pharmaceutical antimicrofial composition which comprises an effective amount of a compound of claim 1 in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient.
Priority Claims (3)
Number |
Date |
Country |
Kind |
44226 |
Nov 1978 |
GBX |
|
7911536 |
Apr 1979 |
GBX |
|
7923193 |
Jul 1979 |
GBX |
|
Parent Case Info
This application is a continuation of application Ser. No. 715,400, filed Mar. 25, 1985, abandoned, which is a divisional of Ser. No. 06/091,961, filed Nov. 7, 1979, abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4024133 |
Cook et al. |
May 1977 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2714880 |
Oct 1978 |
DEX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
91961 |
Nov 1979 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
715400 |
Mar 1985 |
|