Claims
- 1. A cephem derivative represented by the formula: ##STR45## wherein n is 1 or 2, Y is CH, R.sub.1 is lower alkyl, lower alkenyl, lower alkynyl or a carboxyl-substituted, a carbamoyl-substituted or a cyclopropyl-substituted lower alkyl group, and R.sub.2 is hydroxyl, hydroxy-substituted lower alkyl or carbamoyl, or a pharmaceutically acceptable salt thereof.
- 2. An antibacterial composition comprising a compound represented by the formula: ##STR46## wherein n is 1 or 2, Y is CH, R.sub.1 is lower alkyl, lower alkenyl, lower alkynyl or a carboxyl-substituted, a carbamoyl-substituted or a cyclopropyl-substituted lower alkyl group, and R.sub.2 is hydroxyl, hydroxy-substituted lower alkyl or carbamoyl, or a pharmaceutically acceptable salt thereof, and
- a pharmaceutically acceptable carrier therefor.
- 3. The compound as claimed in claim 1, wherein R.sub.2 is hydroxyl.
- 4. The compound as claimed in claim 1, wherein R.sub.2 is hydroxy-substituted lower alkyl.
- 5. The compound as claimed in claim 1, wherein R.sub.2 is carbamoyl.
- 6. The compound as claimed in claim 1, wherein R.sub.1 is lower alkyl.
- 7. The compound as claimed in claim 1, wherein R.sub.1 is methyl or ethyl and R.sub.2 is hydroxyl or carbamoyl.
- 8. The compound as claimed in claim 1, which is 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(4-hydroxy-1,4-methylene-1-piperidinio)methyl-3-cephem-4-carboxylate represented by the following formula: ##STR47## or a pharmaceutically acceptable salt thereof.
- 9. The compound as claimed in claim 1, which is 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(4-hydroxy-1-quinuclidinio)methyl-3-cephem-4-carboxylate represented by the following formula: ##STR48## or a pharmaceutically acceptable salt thereof.
- 10. The compound as claimed in claim 1, which is 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(4-carbamoyl-1-quinuclidinio)methyl-3-cephem-4-carboxylate represented by the following formula: ##STR49## or a pharmaceutically acceptable salt thereof.
Priority Claims (3)
Number |
Date |
Country |
Kind |
60-3181 |
Jan 1985 |
JPX |
|
60-75333 |
Apr 1985 |
JPX |
|
60-174326 |
Aug 1985 |
JPX |
|
Parent Case Info
This application is a division of Ser. No. 818,824 filed Jan. 14, 1986, now U.S. Pat. No. 4,748,171.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4525473 |
Aluraki et al. |
Jun 1985 |
|
4698336 |
Saito et al. |
Oct 1987 |
|
4748171 |
Yamauchi et al. |
May 1988 |
|
4929612 |
Machida et al. |
May 1990 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
0062321 |
Oct 1982 |
EPX |
03938 |
Sep 1985 |
WOX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
818824 |
Jan 1986 |
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