Claims
- 1. A compound of the formula: ##STR35## or the pharmaceutically acceptable addition salts thereof, wherein: R.sub.1 and R.sub.2 independently represent hydrogen, fluoro, chloro, bromo, C.sub.2 -C.sub.6 alkyl, trifluoromethyl, trifluoromethoxy or SO.sub.2 NH.sub.2, provided that at least one of R.sub.1 and R.sub.2 is not hydrogen;
- R.sub.3 and R.sub.4 are the same or different and represent hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, alkylthio, hydroxy, amino, mono or dialkyl amino where each alkyl is C.sub.1 -C.sub.6 alkyl, cyano or trifluoromethyl; and
- R.sub.5, R.sub.6, and R.sub.7 are the same or different and represent hydrogen or C.sub.1 -C.sub.6 alkyl.
- 2. A compound according to claim 1, wherein ##STR36## represents 4-alkylquinolinyl, 4,6-dialkylquinolinyl, 4,7-dialkylquinolinyl, 4,8-dialkylquinolinyl, 4-haloquinolinyl, or 4-alkyl-6-alkoxyquinolinyl.
- 3. A compound according to claim 1, which is 1-(quinolin-2-yl)-4-(1-[4-ethylphenyl]methyl)piperazine.
- 4. A compound according to claim 1, which is 1-(quinolin-2-yl)-4-(1-[4-tert-butylphenyl]methyl)piperazine.
- 5. A compound according to claim 1, which is 1-(quinolin-2-yl)-4-(1-[4-fluorophenyl]methyl)piperazine.
- 6. A compound according to claim 1, which is 1-(quinolin-2-yl)-4-(1-[4-chlorophenyl]methyl)piperazine.
- 7. A compound according to claim 1, which is 1-(quinolin-2-yl)-4-(1-[3,4-dichlorophenyl]methyl)piperazine.
- 8. A compound according to claim 1, which is 1-(quinolin-2-yl)-4-(1-[4-trifluoromethylphenyl]methyl)piperazine.
- 9. A compound according to claim 1, which is 1-(quinolin-2-yl)-4-(1-[4-trifluoromethoxyphenyl]methyl)piperazine.
- 10. A compound according to claim 1, which is 1-(quinolin-2-yl)-4-(1-[4-sulfonamidophenyl]methyl)piperazine.
- 11. A compound according to claim 1, which is 1-(5,6,7,8-tetrahydroquinolin-2-yl)-4-(1-[4-chlorophenyl]methyl)piperazine
- 12. A compound according to claim 2, which is 1-(4-methylquinolin-2-yl)-4-(1-[4-chlorophenyl]methyl)piperazine.
- 13. A compound according to claim 2, which is 1-(4,6-dimethylquinolin-2-yl)-4-(1-[4-chlorophenyl]methyl)piperazine.
- 14. A compound according to claim 2, which is 1-(4,7-dimethylquinolin-2-yl)-4-(1-[4-chlorophenyl]methyl)piperazine.
- 15. A compound according to claim 2, which is 1-(4,8-dimethylquinolin-2-yl)-4-(1-[4-chlorophenyl]methyl)piperazine.
- 16. A compound according to claim 2, which is 1-(6-methoxy-4-methylquinolin-2-yl)-4-(1-[4-chlorophenyl]methyl)piperazine.
- 17. A compound according to claim 1, which is 1-(quinolin-2-yl)-4-(1-[4-chlorophenyl]ethyl)piperazine.
- 18. A compound according to claim 2, which is 1-(4-fluoroquinolin-2-yl)-4-(1-phenylmethyl)piperazine.
- 19. A compound according to claim 2, which is 1-(4-fluoroquinolin-2-yl)-4-(1-[4-fluorophenyl]methyl)piperazine.
- 20. A compound according to claim 1, wherein ##STR37## represents a group of the formula ##STR38##
- 21. A compound according to claim 20, wherein at least one of R.sub.1 and R.sub.2 is chloro, fluoro, ethyl, butyl, isopropyl, n-propyl, trifluoromethyl, or trifluoromethoxy.
- 22. A compound according to claim 2, wherein represents a group of the formula ##STR39##
- 23. A compound according to claim 1, wherein at least one of R.sub.1 and R.sub.2 is chloro, fluoro, ethyl, butyl, isopropyl, n-propyl, trifluoromethyl, or trifluoromethoxy.
Parent Case Info
This application claims the benefit of U.S. provisional application Ser. No. 60/063,149, filed Oct. 24, 1997.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
9739748 |
Oct 1997 |
WOX |
Non-Patent Literature Citations (2)
Entry |
Terron et al. Arch.Med. Res., 25 (4), p. 435-440, 1994. |
Terron et al. Chemical Abstracts, vol. 122, No. 204541, 1995. |