Claims
- 1. A cyclic diphosphonic acid having the structure: ##STR9## wherein R.sub.1 is one substituent selected from the group consisting of hydrogen, substituted or unsubstituted, saturated or unsaturated alkyl having from 1 to 6 carbon atoms, substituted and unsubstituted phenyl, substituted and unsubstituted naphthyl, substituted and unsubstituted benzyl, hydroxy, halogen, substituted and unsubstituted amino, amido, carboxy, carbonyl, and alkoxy, said alkoxy having from 1 to 6 carbon atoms; wherein said R.sub.1 groups, when substituted, are substituted with a group selected from methyl, amino, alkylamino, chloro, hydroxy, and methoxy; R.sub.2 is one substituent selected from the group consisting of hydrogen, substituted or unsubstituted, saturated or unsaturated alkyl having from 1 to 6 carbon atoms, substituted and unsubstituted phenyl, substituted and unsubstituted naphthyl, substituted and unsubstituted benzyl, hydroxy, halogen, substituted and unsubstituted amino, amido, carboxy, carbonyl, alkoxy, said alkoxy having from 1 to 6 carbon atoms, and nitro; wherein said R.sub.2 groups, when substituted, are substituted with a group selected from methyl, amino, alkylamino, chloro, hydroxy, and methoxy; and pharmaceutically-acceptable salts of said diphosphonic acids.
- 2. A cyclic diphosphonic acid having the structure: ##STR10## wherein R.sub.1 is one substituent selected from the group consisting of hydrogen, substituted or unsubstituted, saturated or unsaturated alkyl having from 1 to 6 carbon atoms, substituted and unsubstituted phenyl, substituted and unsubstituted naphthyl, substituted and unsubstituted benzyl, hydroxy, halogen, substituted and unsubstituted amino, amido, carboxy, carbonyl, and alkoxy, said alkoxy having from 1 to 6 carbon atoms; wherein said R.sub.1 groups, when substituted, are substituted with a group selected from methyl, amino, alkylamino, chloro, hydroxy, and methoxy; R.sub.2 is one substituent selected from the group consisting of hydrogen, substituted or unsubstituted, saturated or unsaturated alkyl having from 1 to 6 carbon atoms, substituted and unsubstituted phenyl, substituted and unsubstituted naphthyl, substituted and unsubstituted benzyl, hydroxy, halogen, substituted and unsubstituted amino, amido, carboxy, carbonyl, alkoxy, said alkoxy having from 1 to 6 carbon atoms, and nitro; wherein said R.sub.2 groups, when substituted, are substituted with a group selected from methyl, amino, alkylamino, chloro, hydroxy, and methoxy; and pharmaceutically acceptable salts of said diphosphonic acids.
- 3. A cyclic diphosphonic acid having the structure: ##STR11##
- 4. A cyclic diphosphonic acid having the structure: ##STR12## and pharmaceutically-acceptable salts thereof.
- 5. Indan-2,2-diphosphonic acid, and pharmaceutically-acceptable salts thereof.
- 6. A pharmaceutical composition comprising
- (a) from 15 mg P to 600 mg P of a diphosphonic acid compound of claim 1; and
- (b) a pharmaceutical carrier.
- 7. A pharmaceutical composition comprising
- (a) from 15 mg P to 600 mg P of a diphosphonic acid compound of claim 2; and
- (b) a pharmaceutical carrier.
- 8. A pharmaceutical composition comprising
- (a) from 15 mg P to 600 mg P of a diphosphonic acid compound of claim 3; and
- (b) a pharmaceutical carrier.
- 9. A pharmaceutical composition comprising
- (a) from 15 mg P to 600 mg P of a diphosphonic acid compound of claim 4, and
- (b) a pharmaceutical carrier.
- 10. A pharmaceutical composition comprising
- (a) from 15 mg P to 600 mg P of a diphosphonic acid compound of claim 5; and
- (b) a pharmaceutical carrier.
- 11. A method of treating diseases associated with abnormal calcium and phosphate metabolism, comprising administering to a person in need of such treatment a safe and effective amount of a compound of claim 1.
- 12. A method of treating diseases associated with abnormal calcium and phosphate metabolism, comprising administering to a person in need of such treatment a safe and effective amount of a compound of claim 2.
- 13. A method of treating diseases associated with abnormal calcium and phosphate metabolism, comprising administering to a person in need of such treatment a safe and effective amount of a compound of claim 3.
- 14. A method of treating diseases characterized by abnormal calcium and phosphate metabolism, comprising administering to a person in need of such treatment a safe and effective amount of a compound of claim 4.
- 15. A method of treating diseases characterized by abnormal calcium and phosphate metabolism, comprising administering to a person in need of such treatment a safe and effective amount of a compound of claim 5.
- 16. A method for treating osteoporosis in humans or lower animals comprising administering to a human or lower animal, afflicted with or at risk to osteoporosis, a safe and effective amount of a compound of claim 5.
Parent Case Info
This is a divisional of application Ser. No. 07/085,906 filed on Aug. 14, 1987, issued as U.S. Pat. No. 4,939,131 on July 3, 1990; which was a divisional of application Ser. No. 06/684,544 filed Dec. 21, 1984, issued as U.S. Pat. No. 4,687,768 on Aug. 18, 1987.
US Referenced Citations (8)
Non-Patent Literature Citations (2)
Entry |
Mustafa et al., Justus Liebigs Ann. Chem., 698, 109 (1966) (Chem. Abs. 66:75881). |
Gross et al., Justus Liebigs Ann. Chem., 707, 35 (1967) (Chem. Abs. 67:108709). |
Divisions (4)
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Number |
Date |
Country |
Parent |
85906 |
Aug 1987 |
|
Parent |
684544 |
Dec 1984 |
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Parent |
85906 |
Aug 1987 |
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Parent |
684544 |
Dec 1984 |
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