Claims
- 1. A compound of the formula: ##STR136## wherein R.sup.1 is pyridyl; R.sup.2 is phenyl, thienyl, furyl, naphthyl, benzothienyl or pyridyl, optionally substituted by a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R.sup.3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6; Y is a sulphur atom, methylene group or a group of the formula: ##STR137## wherein R.sup.4 is hydrogen atom or acetyl group, and m is 0 or 1.
- 2. A compound as claimed in claim 1, wherein R.sup.1 is 3-pyridyl.
- 3. A compound as claimed in claim 1, wherein Y is a sulphur atom or methylene group.
- 4. A compound as claimed in claim 1, wherein R.sup.2 is phenyl, thienyl, furyl or naphthyl.
- 5. A compound as claimed in claim 1, wherein n is 1 to 4.
- 6. A compound as claimed in claim 1, wherein R.sup.3 is hydrogen.
- 7. A compound as claimed in claim 1, wherein R.sup.3 is a lower alkyl group.
- 8. A compound as claimed in claim 1, wherein R.sup.1 is 3-pyridyl; R.sup.2 is phenyl, thienyl, furyl or naphthyl; Y is a sulphur atom or methylene group; and n is an integer of 1 to 4.
- 9. A compound as claimed in claim 1, wherein the compound is 7-(3,4-methylenedioxyphenyl)-7-(3-pyridyl)-6-heptenoic acid.
- 10. A compound as claimed in claim 1, wherein the compound is 7-(3-pyridyl)-7-(2-thienyl)-6-heptenoic acid.
- 11. A compound as claimed in claim 1, wherein the compound is methyl 7-(3-pyridyl)-7-phenyl-6-heptenoate.
- 12. A compound as claimed in claim 1, wherein the compound is 7-(3-pyridyl)-7-(3-thienyl)-6-heptenoic acid.
- 13. A compound as claimed in claim 1, wherein the compound is 8-(3-pyridyl)-8-phenyl-7-octenoic acid.
- 14. A pharmaceutical composition suitable for inhibiting activity of thromboxane synthetase in a mammal, which comprises, as an active ingredient, an effective amount of a compound of the formula: ##STR138## wherein R.sup.1 is pyridyl; R.sup.2 is phenyl, thienyl, furyl, naphthyl, benzothienyl or pyridyl, optionally substituted by a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group; R.sup.3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6; Y is a sulphur atom, methylene group or a group of the formula: ##STR139## wherein R.sup.4 is hydrogen atom or acetyl group, and m is 0 or 1, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient therefor.
Priority Claims (2)
Number |
Date |
Country |
Kind |
57-102488 |
Jun 1982 |
JPX |
|
57-211753 |
Dec 1982 |
JPX |
|
Parent Case Info
This application is a continuation of Ser. No. 502,603, filed June 9, 1983, now U.S. Pat. No. 4,727,078.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4518602 |
Terao et al. |
May 1985 |
|
4563446 |
Terao et al. |
Jan 1986 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
502603 |
Jun 1983 |
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