Claims
- 1. A compound of formula I
- 2. A compound according to claim 1 of formula Ia
- 3. A compound according to claim 2 of formula Ib
- 4. A compound according to claim 3 of formula Ic
- 5. A compound according to claim 1 of formula 1, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 6. A compound according to claim 2 of formula Ia, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 7. A compound according to claim 3 of formula Ib, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 8. A compound according to claim 4 of formula Ic, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 9. A compound selected from 19-[(aminocarbonyl)oxy]-3,5,7,11,17-pentahydroxy-2,3,4,10,12,14,16,18,20-nonamethyl-21-(phenylmethoxy)-8,13-heneicosadienoic acid 5-lactone and 13-[[5-[(aminocarbonyl)oxy]-3-hydroxy-2,4,6-trimethyl-1-oxo-7,9-decadienyl]methylamino]-3,5,7,11-tetrahydroxy-2,4,10,12-tetramethyl-8-tridecenoic acid 8-lactone, or a pharmaceutically acceptable acid or base addition salt thereof.
- 10. A compound selected from
(2R,3S,4S,5S,7S,8Z,10S,11S,12S,13Z,16S,17R,18S,19S,20S)-19-[(aminocarbonyl)oxy]-3,5,7,11,17-pentahydroxy-2,3,4,10,12,14,16,18,20-nonamethyl-21-(phenylmethoxy)-8,13-heneicosadienoic acid 6-lactone and (2R,3S,4R,5S,7S,8Z)-13-[[(2R,3S,4S,5S,6S,7Z)-5-[(aminocarbonyl)oxy]-3-hydroxy-2,4,6-trimethyl-1-oxo-7,9-decadienyl]methylamino]-3,5,7,11-tetrahydroxy-2,4,10,12-tetramethyl-8-tridecenoic acid δ-lactone, or a pharmaceutically acceptable acid or base addition salt thereof.
- 11. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a therapeutically effective amount of a compound according to claim 5, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 12. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a therapeutically effective amount of a compound according to claim 6, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 13. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a therapeutically effective amount of a compound according to claim 7, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 14. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a therapeutically effective amount of a compound according to claim 8, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 15. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a therapeutically effective amount of a compound according to claim 9, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 16. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a therapeutically effective amount of a compound according to claim 10, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 17. A method of treating tumors comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound according to claim 5, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 18. A method of treating tumors comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound according to claim 6, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 19. A method of treating tumors comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound according to claim 7, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 20. A method of treating tumors comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound according to claim 8, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 21. A method of treating tumors comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound according to claim 9, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
- 22. A method of treating tumors comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound according to claim 10, or a pharmaceutically acceptable acid or base addition salt thereof, where possible.
Parent Case Info
[0001] This application claims the benefit of Provisional Application No. 60/343,394, filed Dec. 21, 2001, and Provisional Application No. 60/332,399, filed Nov. 16, 2001, both of the contents of which are incorporated herein by reference.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60343394 |
Dec 2001 |
US |
|
60332399 |
Nov 2001 |
US |