Claims
- 1. A compound of formula (I) ##STR56## wherein R is a member selected from the group consisting of
- (a) --COOR.sub.c wherein R.sub.c is hydrogen, C.sub.1 -C.sub.12 alkylor C.sub.2 -C.sub.12 alkenyl; or
- (b) ##STR57## wherein each of the R' groups, which are the same or different, is C.sub.1 -C.sub.6 alkyl or phenyl;
- Z.sub.1 is hydrogen or halogen;
- p is zero or an integer of 1 to 7;
- q is 1;
- R.sub.1 is hydrogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, benzyloxy, C.sub.2 -C.sub.12 alkanoyloxy or benzoyloxy;
- Y is a member selected from the group consisting of --CH.sub.2 --CH.sub.2, --C.tbd.C--, ##STR58## wherein Z.sub.2 is hydrogen or halogen; one of R.sub.2 and R.sub.5 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or phenyl, .alpha.-naphthylor .beta.-naphthyl, and the other is hydroxy, C.sub.1 -C.sub.6 alkoxy, benzyloxy, or R.sub.2 and R.sub.5, taken together, form an oxo group;
- each of R.sub.3 and R.sub.4, which are the same or different, may be hydrogen, C.sub.1 -C.sub.6 alkyl or fluorine or R.sub.3 and R.sub.4, taken together, with the carbon atom to which they are linked, form the radical ##STR59## or the radical ##STR60## each of n.sub.1 and n.sub.2, which are the same or different, is zero or an integer of 1 to 6;
- X is a member selected from the group consisting of --O--, --S-- and --(CH.sub.2).sub.m --, wherein m is zero or 1;
- R.sub.6 is tetrahydro thienyl or a heterobicyclic ring selected from the group consisting of thiabicyclooctyl and thiabicyclo-nonyl, and the pharmaceutically or veterinarily acceptable salts thereof.
- 2. A compound of formula (I) ##STR61## wherein R is a member selected from the group consisting of
- (a) --COOR.sub.c wherein R.sub.c is hydrogen, C.sub.1 -C.sub.12 alkyl or C.sub.2 -C.sub.12 alkenyl; or
- (b) ##STR62## wherein each of the R' groups, which are the same or different, is C.sub.1 -C.sub.6 alkyl or phenyl;
- Z.sub.1 is hydrogen or halogen;
- p is zero or an integer of 1 to 7;
- q is 1;
- R.sub.1 is hydrogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, benzyloxy, C.sub.2 -C.sub.12 alkanoyloxy or benzoyloxy;
- Y is a member selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --C.tbd.C--, ##STR63## wherein Z.sub.2 is hydrogen or halogen; one of R.sub.2 and R.sub.5 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or phenyl, .alpha.-naphthyl or .beta.-naphthyl, and the other is hydroxy, C.sub.1 -C.sub.6 alkoxy, benzyloxy, or R.sub.2 and R.sub.5, taken together, form an oxo group;
- each of R.sub.3 and R.sub.4, which are the same or different, may be hydrogen, C.sub.1 -C.sub.6 alkyl or fluorine or R.sub.3 and R.sub.4, taken together, with the carbon atom to which they are linked, form the radical ##STR64## or the radical ##STR65## each of n.sub.1 and n.sub.2, which are the same or different, is zero or an integer of 1 to 6;
- X is a member selected from the group consisting of --O--, --S-- and --(CH.sub.2).sub.m --, wherein m is zero or 1;
- R.sub.6 is tetrahydrothienyl or a heterobicyclic ring selected from the group consisting of 2-thiabicyclo[3.3.0]octyl, 2-thia-bicyclo[3.4.0]nonyl and their aromatic analogs, and the pharmaceutically or veterinarily acceptable salts thereof.
- 3. The compound of any of claims 1 or 2 wherein R is a free or salified carboxy group.
- 4. The compound of any of claims 1 or 2 wherein R is an esterified carboxy group of formula --COOR.sub.c wherein R.sub.c is C.sub.1 -C.sub.12 alkyl or C.sub.2 -C.sub.12 alkenyl.
- 5. The compound of any of claims 1 or 2 wherein p is an integer of 1 to 3.
- 6. The compound of any of claims 1 or 2 wherein R.sub.1 is hydrogen or hydroxy.
- 7. The compound of any of claim 1 or 2 wherein R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl and fluorine.
- 8. The compound of any of claims 1 or 2 wherein n.sub.1 is zero or an integer of 1 to 3.
- 9. The compound of any of claims 1 or 2 wherein n.sub.2 is an integer of 1 to 3.
- 10. The compound 13t-6.beta.-H-6,9.alpha.-oxide-11.alpha.,15S-dihydroxy-17-(2'-tetrahydrothienyl)-20,19,18-trinorprost-13-enoic acid and the pharmaceutically or veterinarily acceptable salts thereof.
- 11. A pharmaceutical or veterinary composition, suitable for use as a hypotensive agent, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
- 12. A pharmaceutical or veterinary composition, suitable for use as a vasodilatory agent, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
- 13. A pharmaceutical or veterinary composition, suitable for use as an anti-aggregating agent, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
- 14. A pharmaceutical or veterinary composition, suitable for use as an anti-thrombotic agent, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
- 15. A pharmaceutical or veterinary composition, suitable for use as a luteolytic agent, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
- 16. A pharmaceutical or veterinary composition, suitable for use as a cytoprotective agent active on the mucous membranes of the gastrointestinal tract, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
- 17. A pharmaceutical or veterinary composition, suitable for use as an anti-secretory agent, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
- 18. A pharmaceutical or veterinary composition, suitable for use as a bronchodilatory agent, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
- 19. A pharmaceutical or veterinary composition, suitable for use as an anti-asthmatic agent, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
- 20. A pharmaceutical or veterinary composition, suitable for use as an uterus stimulant, said composition comprising a therapeutically effective amount of a compound as claimed in any of claims 1 to 10, and a pharmaceutically and/or veterinarily acceptable carrier and/or diluent.
Priority Claims (5)
| Number |
Date |
Country |
Kind |
| 31401 A/76 |
Dec 1976 |
ITX |
|
| 19283 A/77 |
Jan 1977 |
ITX |
|
| 21171 A/77 |
Mar 1977 |
ITX |
|
| 21412 A/77 |
Mar 1977 |
ITX |
|
| 21863 A/77 |
Mar 1977 |
ITX |
|
Parent Case Info
This is a divisional application of Ser. No. 920,166, filed June 29, 1978, which is a divisional of Ser. No. 859,703, filed Dec. 12, 1977, now abandoned.
Foreign Referenced Citations (2)
| Number |
Date |
Country |
| 1-270 |
Apr 1979 |
EPX |
| 2009148 |
Jun 1979 |
GBX |
Divisions (2)
|
Number |
Date |
Country |
| Parent |
920166 |
Jun 1978 |
|
| Parent |
859703 |
Dec 1977 |
|
Patent Grant
4242508
