Claims
- 1. A compound of the formula: ##STR18## wherein: R.sub.1 represents hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms and R.sub.2 represents a group of the formula: ##STR19## or R.sub.2 represents hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms and R.sub.1 represents a group of the formula: ##STR20## wherein X is oxygen, methylene, or NH;
- Y is halogen, straight or branched chain lower alkyl having 1-6 carbon atoms, lower alkoxy having 1-6 carbon atoms, hydroxy, amino, aminoalkyl where the alkyl is straight or branched chain lower alkyl having 1-6 carbon atoms, SR.sub.3, SOR.sub.3, or SO.sub.2 R.sub.3 where R.sub.3 is straight or branched chain lower alkyl having 1-6 carbon atoms, or SO.sub.2 NR.sub.4 R.sub.5 where R.sub.4 and R.sub.5 are the same or different and represent hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms;
- Z is hydrogen, amino or NHR.sub.6 where R.sub.6 is lower alkyl having 1-6 carbon atoms;
- T is hydrogen, halogen, hydroxy, or lower alkoxy having 1-6 carbon atoms; and
- A is methylene, carbonyl or CHOH.
- 2. A compound according to claim 1, which is ##STR21## wherein X is oxygen, methylene, or NH;
- Y is halogen or straight or branched chain lower alkyl having 1-6 carbon atoms; and
- R.sub.1 represents hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms.
- 3. A compound according to claim 1, which is ##STR22## wherein Y is halogen or straight or branched chain lower alkyl having 1-6 carbon atoms; and
- R.sub.1 represents hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms.
- 4. A compound according to claim 1, which is ##STR23## wherein Y is halogen or straight or branched chain lower alkyl having 1-6 carbon atoms; and
- R.sub.1 represents methyl.
- 5. A compound according to claim 1 which is 3-(2-Chloro-10,11-dihydro-dibenzo�b,f!oxepin-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 6. A compound according to claim 1 which is 3-(2-Methyl-10,11-dihydro-dibenzo�b,f!oxepin-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 7. A compound according to claim 1 which is 3-(2-Bromo-10,11-dihydro-dibenzo�b,f!oxepin-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 8. A compound according to claim 1 which is 3-(2-Fluoro-10,11-dihydro-dibenzo�b,f!oxepin-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 9. A compound according to claim 1 which is 3-(2-Methoxy-10,11-dihydro-dibenzo�b,f!oxepin-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 10. A compound according to claim 1 which is 3-(2-Methylthio-10,11-dihydro-dibenzo�b,f!oxepin-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 11. A compound according to claim 1 which is 3-(2-Chloro-10,11-dihydro-dibenzo�b,f!azepin-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 12. A compound according to claim 1 which is 3-(2-Methyl-10,11-dihydro-dibenzo�b,f!azepin-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 13. A compound according to claim 1 which is 3-(2-Chloro-dibenzo�b,f!cycloheptan-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 14. A compound according to claim 1 which is 3-(2-Methyl-dibenzo�b,f!cycloheptan-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 15. A compound according to claim 1 which is 8-(2-Chloro-10,11dihydro-dibenzo�b,f!oxepin-10-yl)-3-methyl-3,8-diazabicyclo(3.2.1)octane.
- 16. A compound according to claim 1 which is 8-(2-Methyl-10,11-dihydro-dibenzo�b,f!oxepin-10-yl)-3-methyl-3,8-diazabicyclo(3.2.1)octane.
- 17. A compound according to claim 1 which is 3-(2-Methanesulfonyl-dibenzo�b,f!cycloheptan-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 18. A compound according to claim 1 which is 3-(2,4-Dichloro-10,11-dihydro-dibenzo�b,f!oxepin-10-yl)-8-methyl-3,8-diazabicyclo(3.2.1)octane.
- 19. A compound according to claim 1 which is 3-(2-Chloro-10H-dibenzo�b,f!oxepin-11-one-10-yl)-8methyl-3,8-diazabicyclo(3.2.1)octane.
- 20. A compound of the formula: ##STR24## wherein: X is NH or oxygen;
- Y is halogen, straight or branched chain alkyl having 1-6 carbon atoms, or straight or branched chain alkoxy having 1-6 carbon atoms; and
- R.sub.1 is straight or branched chain alkyl having 1-6 carbon atoms.
- 21. A compound of the formula: ##STR25## wherein: Y is halogen, straight or branched chain alkyl having 1-6 carbon atoms, or straight or branched chain alkoxy having 1-6 carbon atoms; and
- R.sub.1 methyl.
Parent Case Info
This is a continuation of application Ser. No. 08/001,259, filed Jan. 6, 1993 now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5344831 |
Satoh et al. |
Sep 1994 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
6306070 |
Jan 1994 |
JPX |
Continuations (1)
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Number |
Date |
Country |
Parent |
001259 |
Jan 1993 |
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