Patent Application
20180116594
The present disclosure relates generally to quantifying grip strength and characterizing movement idioms based on fingernail deformation. These two functions are useful for evaluating subjects with degenerative neurological diseases or other conditions such as cardiovascular disease or sarcopenia where grip strength fluctuates in relation to disease state. They also enable a new type of human computer interface.
Patients with a degenerative neurological disease, like Parkinson's disease (PD), suffer from a diverse set of symptoms. The hallmark motor symptoms of Parkinson's disease are tremor, bradykinesia, rigidity, and postural instability. These symptoms change the way a patient moves and how they interact with objects in daily life.
In evaluating the effect of a Parkinson therapy, one problem is to categorize a patient's current status as ‘ON’ meaning relatively able to function given their current disease state, ‘OFF’ meaning not functioning well or actually being rigid or paralyzed, and ‘ON with complications’ meaning able to move but with extra movement problems (typically dyskinesias or dystonia). Patients with more ‘ON’ time with a new therapy relative to the previous therapy are considered to have benefitted.
For Parkinson's patients the burden of their disease is considerable, and the burden of medication is considerable so it is desirable not to add a burden of monitoring. For a population with increasing cognitive deficits, depression, apathy, and mobility issues monitoring and testing regimes can become challenging. Existing methods of characterizing a patient's state, which involve consciously performing tasks requiring manual dexterity (e.g., operating a mobile phone app) add a burden of tracking to an already overwhelmed patient. Schemes requiring consistently positioning sensors accurately on different parts of their bodies also add to this burden and result in lower compliance levels. One last challenge to wearable monitoring is the condition of a patient's skin. Many Parkinson's patients are older, having thin, brittle (friable) skin. In cases where wearable patches must be applied and removed on a daily basis, tears and resulting infection or other problems can result.
According to an exemplary embodiment of the present invention, a system includes a sensor having a bridge circuit including one or more strain gauges mounted on a nail plate, the bridge circuit outputting a voltage signal, an amplifier circuit amplifying the voltage signal output by the bridge circuit to generate an amplified signal, an analog-to-digital (A/D) converter converting the amplified signal into a digital signal, a controller receiving the digital signal and facilitating communication with a receiver, and an antenna configured to transmit the digital signal.
According to an exemplary embodiment of the present invention, a method of characterizing grip strength and movement idioms to track disease state in a subject includes measuring, using a sensor, strain on a nail plate of a subject, wherein the sensor outputs a data stream corresponding to the measuring, communicating the data stream to a receiver, and interpreting, by the receiver, the data stream to determine a parameter of interest of the subject.
As used herein, “facilitating” an action includes performing the action, making the action easier, helping to carry the action out, or causing the action to be performed. Thus, by way of example and not limitation, instructions executing on one processor might facilitate an action carried out by instructions executing on a remote processor, by sending appropriate data or commands to cause or aid the action to be performed. For the avoidance of doubt, where an actor facilitates an action by other than performing the action, the action is nevertheless performed by some entity or combination of entities.
One or more embodiments of the invention or elements thereof can be implemented in the form of a computer program product including a computer readable storage medium with computer usable program code for performing the method steps indicated. Furthermore, one or more embodiments of the invention or elements thereof can be implemented in the form of a system (or apparatus) including a memory, and at least one processor that is coupled to the memory and operative to perform exemplary method steps. Yet further, in another aspect, one or more embodiments of the invention or elements thereof can be implemented in the form of means for carrying out one or more of the method steps described herein; the means can include (i) hardware module(s), (ii) software module(s) stored in a computer readable storage medium (or multiple such media) and implemented on a hardware processor, or (iii) a combination of (i) and (ii); any of (i)-(iii) implement the specific techniques set forth herein.
Techniques of the present invention can provide substantial beneficial technical effects. For example, one or more embodiments may provide one or more of the following advantages:
These and other features and advantages of the present invention will become apparent from the following detailed description of illustrative embodiments thereof, which is to be read in connection with the accompanying drawings.
Preferred embodiments of the present invention will be described below in more detail, with reference to the accompanying drawings:
According to an embodiment of the present invention, a continuous data stream is collected that is interpreted by software to measure grip strength and characterize movement idioms. These measurements are correlated with disease state in patients, who may be limited in their ability to remember and perform explicit tasks, operate mobile phones, or wear sensors on their skin.
According to one or more embodiments of the present invention, a plurality of strain gauges with accompanying circuitry measure a deformation of an unguis (i.e., fingernail or toenail) in longitudinal and transverse directions, and to transmit this information wirelessly to a receiver such as a smartwatch or mobile phone.
It should be understood herein that the electrical conductance of a strain gauge (typically formed of a doped silicon or metal) varies with its geometry, such that a deformation of the strain gauge results in a change in its electrical resistance. The stress on a strain gauge can therefore be inferred from a measured resistance of the strain gauge using a known gauge factor, which is a ratio of relative change is resistance to the strain on the test piece. The resistance of the strain gauge can be measured using a Wheatstone bridge. Strain gauges measure strain that can be related to stress, force, torque and a host of other stimuli including displacement, acceleration and position.
According to one or more embodiments of the present invention, anatomical features of primate fingers and toes cause nails to deform in certain predictable ways under direct, longitudinal, and shear forces. According to an embodiment of the present invention, a strain gauge is mounted on a nail plate to measure this deformation, which is then used to estimate the force and direction causing the deformation. Flexion and extension of the fingers and toes also causes deformation of the nail plate, such that motion without touching an object can be characterized. A deformation data stream is used to estimate grip strength in the hands or pressure exerted by the toes (e.g., for balance).
According to one or more embodiments of the present invention, grip strength is characterized as a maximum grip force generated by a subject and the time it takes to develop the maximum strength. According to one or more embodiments of the present invention, the maximum and average grip strength, as well as number and speed of finger motions, is used to estimate a subject's fluidity versus rigidity, bradykinesia, and hand strength parameters. According to one or more embodiments of the present invention, using the data stream from the strain gauge, activities of daily living such as tying a necktie and buttoning/unbuttoning a shirt can be identified as an idiom and characterized and compared on a day to day basis. According to one or more embodiments of the present invention, characterized movements can include a subject making a pass-movement to identify themselves (similar to a password). According to one or more embodiments of the present invention, characterized movements can include specifying characters or letters by writing them on any surface with a finger appropriately configured with a sensor, or making gestures to control a computer such as scrolling, paging, selecting, or compressing files. Characteristics of motion idioms such as duration, force, and fluency can be used in determining a subject's state. In at least one embodiment of the present invention, parameters are used as proxies for the subject's ON, OFF state as part of a Parkinson's therapy.
Advantageously, embodiments of the present invention capture fine finger motions and forces transmitted through fingers and toes. Wearable actigraphy (i.e., non-invasive monitoring of rest/activity cycles) and inertial measurement unit (IMU) devices do not perform this function.
Advantageously, embodiments of the present invention of a nail mounted sensor do not require touching a subject's skin. If the normal rate of growth is taken as approximately 3 millimeters per month, a sensor bonded to a subject's nail plate would not need replacement for at least a month. Moreover, older patients typically exhibit slower rates, thus the time for replacement of the sensor is elongated. In the exemplary case of a clinical trial a new sensor can be bonded by a nail technician during each clinical visit. The sensor itself requires no attention or maintenance from the subject.
According to one or more embodiments of the present invention,
Direct Force Detection:
Referring to
Left and Right Shear (Transverse) Forces:
If the finger is pressed against an object and moved leftward or rightward the deformable pulp 107 shifts to the following side and transverse nail plate deformation is more pronounced on that side. For example, with a rightward movement 201 (from the subject's point of view), the following side, i.e., 202 and transverse nail plate deformation is more pronounced on that side and would be sensed by strain gauge 113 as compared to strain gauge 112.
Positive and Negative Longitudinal Forces:
If the finger is pressed directly against an object and moved positively or negatively in the longitudinal direction the nail plate 101 will arch or bow, respectively. Similarly, if the tip of the finger is pressed into an object.
Extension and flexion of the fingertip also produces a deformation of the nail plate 101. Extension and flexion of the finger generated by the extensor and flexor tendons causes the nail plate 101 to bow or arch, respectively. That is, finger movement, without contacting an object, generates deformation that can be measured by the strain gauges.
According to one or more embodiments of the present invention, the system can be implemented as a Unified Parkinson's Disease Rating Scale (UPDRS) item used in daily neurological examinations. In this case, bradykinesia and disturbances of rhythm formation occurring in PD subjects can be assessed using a finger-tapping test. The evaluation of bradykinesia and disturbances of rhythm formation includes velocity, amplitude, and rhythm parameters. Conventional techniques relied on subject observation of these parameters.
According to one or more embodiments of the present invention,
According to one or more embodiments of the present invention, the sensor 400 comprises the power supply 401 providing a voltage V to the components of the sensor 400, the bridge circuit 402 including one or more strain gauges mounted on a nail plate, the bridge circuit 402 outputting a voltage signal, the amplifier circuit 403 amplifying the voltage signal output by the bridge circuit 402 to generate an amplified signal, the analog-to-digital (A/D) converter 404 converting the amplified signal into a digital signal, the communications controller 405 receiving the digital signal and facilitating communication with a receiver 500, and the antenna 406 configured to transmit the digital signal. According to one or more embodiments of the present invention, the communications controller 405 controls input signals corresponding to strain information and transmits the input signals to the receiver 500, external to the sensor 400.
According to an embodiment of the present invention, the sensor 400 includes a micro-controller 409. According to one or more embodiments of the present invention, the functions of the amplifier 403 and the A/D converter 404 are implemented by software, which is executed by the micro controller 409 (e.g., a processor) as illustrated by
According to one or more embodiments of the present invention, the receiver 500 comprises an antenna 501, a communications controller 502 and a processing unit 503. The processing unit 503 comprises a processor 504, a storage medium 505 and a display 506. The sensor 400 and the receiver 500 support wireless network such as Bluetooth and/or NFC and/or BAN. According to one or more embodiments of the present invention, the receiver 400 executes signal processing software running on the processor 504 that interprets a signal received from a sensor 400 and estimates parameters including for example, force, direction, and gesture for each input (e.g., stress on the nail plate).
According to at least one embodiment of the present invention, an electromagnetic field generated by the receiver 500 supplies power to the sensor 400, e.g., during a recharge operation recharging the power supply 401. According to at least one embodiment of the present invention, the sensor 400 is configured to communicate data to the receiver 500. According to at least one embodiment of the present invention, the data communication between the sensor 400 and the receiver 500 is bidirectional.
According to at least one embodiment of the present invention, the receive 500 can be embodied as a computer system including a desktop computer, cloud based server, a wearable computing device, such as a smart watch or disposed in a footwear (e.g., in a sole of a shoe near to a sensor disposed on a toenail), and the like.
According to an exemplary embodiment of the present invention, the power supply 401 is a battery (e.g., a lithium ion battery), wireless power transfer circuitry, or the like.
According to an exemplary embodiment of the present invention, a sensor 600 (
According to be exemplary embodiment of the present invention, each strain gauge is connected to individual a bridge circuit 402 (e.g., a Wheatstone bridge circuit, half-bridge circuit), wherein each strain gauge generates an output signal. One or more strain gauges can be connected to the same bridge circuit, for example, for temperature compensation, to cancel a thermal effect of lead wires, to reduce the number of Wheatstone bridge circuit, etc.
According to an exemplary embodiment of the present invention, the amplifier circuit 403, analog-to-digital (A/D) converter 404, communications controller 405 and antenna 406 are mounted to a printed circuit board 602 (see
where:
e1 is the voltage output;
E1 is the exciting voltage;
K is a gauge factor; and
ε1 is the strain of the test piece (e.g., nail plate) measured by the strain gauge Rg.
According to an embodiment of the present invention, in the circuit diagram of
where:
e2 is the voltage output;
E2 is the exciting voltage;
K is a gauge factor;
ε1 is the strain of the test piece (e.g., nail plate) measured by the strain gauge Rg1; and
ε2 is the relative strain of the test piece (e.g., nail plate) measured by the gauge Rg2.
The circuit of
According to an embodiment of the present invention, the strain gauges Rg1 and Rg2 depicted in
According to an embodiment of the present invention,
According to an embodiment of the present invention, in the circuit diagram of
where:
e3 is the voltage output;
E3 is the exciting voltage;
K is a gauge factor;
ε1 is the relative strain of the test piece (e.g., nail plate) measured by the gauge Rg1; and
ε2 is the relative strain of the test piece (e.g., nail plate) measured by the gauge Rg2.
According to an embodiment of the present invention, in the circuit diagram of
where:
e4 is the voltage output;
E4 is the exciting voltage;
K is a gauge factor; and
ε1 is the strain of the test piece (e.g., nail plate 101) measured by the gauge Rg1;
ε2 is the strain of the test piece (e.g., nail plate 101) measured by the gauge Rg2;
ε3 is the strain of the test piece (e.g., nail plate 101) measured by the gauge Rg3; and
ε4 is the strain of the test piece (e.g., nail plate 101) measured by the gauge Rg4.
Referring to
According to one or more embodiments of the present invention, a method 1500 of quantifying grip strength and characterizing movement idioms includes providing a sensor comprising one or more strain gauges establishing a human-computer interface with a subject's nail plate 1501, outputting, by the sensor, a signal related to stress on the strain gauge 1502, receiving, at a receiver, the signal output by the sensor 1503, and processing the signal to determining a parameter of interest 1504. According to one or more embodiments of the present invention, the parameter of interest is one of grip strength and a characterization of a movement idiom, which can be used in determining one or more further parameters, such as an ON or OFF state. It should be understood that the parameters described herein are exemplary, and that one of ordinary skill in the art would recognize that additional parameters can be mapped to the signal output by the sensor.
According to one or more embodiments of the present invention, the method further includes a machine learning process 1505, which establishes for the sensor, a mapping from the signal (e.g., a waveform signal) to a parameter of interest 1504. The mapping is used in processing the signal at 1504. For example, the output of the sensor can be instrumented to determine that a given waveform corresponds to certain grip strength for movement idiom.
According to one or more embodiments of the present invention, the machine learning process 1505 and signal processing 1504 are adapted to an application, e.g., grip force measurement, character and gesture recognition, etc.
According to an embodiment of the present invention, for grip force measurements, the machine learning 1505 includes a training session with a hand dynamometer and sensors yielding finger nail strain measurements and corresponding grip force measurements. The machine learning process 1505 further includes an estimation of a piece-wise linear regression model from the finger nail strain measurements and grip force measurements. Given the piece-wise linear regression model (i.e., 1505), the signal processing 1504 inputting the signal into the model to predict a parameter of interest, in this exemplary case, a grip force of the subject. According to an embodiment of the present invention, the signal processing 1504 comprises grouping/clustering the received strain signals (see block 1503) into idioms. The signal processing 1504 includes recording strain signals over time (e.g., at different visits to a physician or technician, when in wireless communications range of a receiver, etc.), wherein a strain is observed for one or more of the idioms, and is compared over time. This comparison can be of a parameter of interest, such as grip force, and in one or more embodiments, yields outputs such as a maximum grip force, average grip force, a duration of a strain, speed of a grip force activation, etc.
According to one or more embodiments of the present invention, for character and gesture detection, the machine learning 1505 includes training sessions with multiple subjects yielding nail strain measurements for known characters or gestures (for example, a subject uses their figure to trace a character or make a gesture on a surface and a sensor records a strain measurement). Given the strain measurements and the known character tracing or gestures, the machine learning 1505 includes grouping the strain measurements corresponding to the known characters and/or gesture actions, applying dynamic time warping (DTW), and identifying idioms. DTW is a method of measuring the similarity between two temporal sequences that vary in speed. In one or more embodiments of the present invention, a DTW method is applied to compensate for variability (e.g., different subjects doing things at different speeds), wherein the DTW outputs a set of aligned strain measurements. The machine learning 1505 further includes generating a classifier (e.g., k-nearest neighbors, support vector machines (SVM), neural networks, etc.) trained using the strain measurements mapped to character and gesture labels. According to an embodiment of the present invention, the signal processing 1504 includes receiving signals from the sensor and predicting characters and/or gestures from the received signals using the classifier.
According to an embodiment of the present invention, a method of tracking progression of a disease in a subject includes mounting at least one sensor to a nail plate of the subject, measuring, using a sensor, strain on the nail plate to output a data stream, communicating the data stream to a receiver, and interpreting, by the receiver, the data stream to determine a state of the subject.
According to an embodiment of the present invention a wire-based communication implementation is contemplated, wherein the sensor including one or more strain gauges is physically connected to the receiver, for example, by a wire.
According to an embodiment of the present invention, a sensor can be used as an input device of a computer system. For example, passwords are typically restricted to sets of characters that can be guessed and enumerated with brute force methods. Pass-Movements, as measured by a sensor according to an embodiment of the present invention, can be recorded from directional movements, tapping, squeezing, rhythmic motions, etc., and related to a subject's physiognomy. Advantageously a pass-movement recording using a sensor according to an embodiment of the present invention inherently combines the physical characteristics of the subject's finger with finger movement, and can include further measured data such as a time between motions.
The trend to smaller devices, such as smart watches without keyboards or mice, and smaller screens, are constraining options for input. Advantageously, a sensor according to an embodiment of the present invention enables a subject to write on any surface, using the surface as an input device.
Recapitulation:
According to an embodiment of the present invention, the sensor 400 comprises the power supply 401, the bridge circuit 402 powered by the power supply 401 and including one or more strain gauges mounted on a nail plate, the bridge circuit 402 outputting a voltage signal, the amplifier circuit 403 amplifying the voltage signal output by the bridge circuit 402 to generate an amplified signal, the analog-to-digital (A/D) converter 404 converting the amplified signal into a digital signal, the communications controller 405 receiving the digital signal and facilitating communication with a receiver 500, and the antenna 406 configured to transmit the digital signal.
The methodologies of embodiments of the disclosure may be particularly well-suited for use in an electronic device or alternative system. Accordingly, embodiments of the present invention may take the form of an entirely hardware embodiment or an embodiment combining software and hardware aspects that may all generally be referred to herein as a “processor,” “circuit,” “module” or “system.”
Furthermore, it should be noted that any of the methods described herein can include an additional step of providing a computer system (e.g., the receiver 500) for characterizing a deformation data stream. Further, a computer program product can include a tangible computer-readable recordable storage medium with code adapted to be executed to carry out one or more method steps described herein, including the provision of the system with the distinct software modules.
Referring to
In different applications, some of the components shown in
The processor 1601 may be configured to perform one or more methodologies described in the present disclosure, illustrative embodiments of which are shown in the above figures and described herein. Embodiments of the present invention can be implemented as a routine that is stored in memory 1602 and executed by the processor 1601 to process the signal from the media 1607. As such, the computer system is a general-purpose computer system that becomes a specific purpose computer system when executing routines of the present disclosure.
Although the computer system described in
The present invention may be a system, a method, and/or a computer program product at any possible technical detail level of integration. The computer program product may include a computer readable storage medium (or media) having computer readable program instructions thereon for causing a processor to carry out aspects of the present invention.
The computer readable storage medium can be a tangible device that can retain and store instructions for use by an instruction execution device. The computer readable storage medium may be, for example, but is not limited to, an electronic storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing. A non-exhaustive list of more specific examples of the computer readable storage medium includes the following: a portable computer diskette, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), a static random access memory (SRAM), a portable compact disc read-only memory (CD-ROM), a digital versatile disk (DVD), a memory stick, a floppy disk, a mechanically encoded device such as punch-cards or raised structures in a groove having instructions recorded thereon, and any suitable combination of the foregoing. A computer readable storage medium, as used herein, is not to be construed as being transitory signals per se, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through a waveguide or other transmission media (e.g., light pulses passing through a fiber-optic cable), or electrical signals transmitted through a wire.
Computer readable program instructions described herein can be downloaded to respective computing/processing devices from a computer readable storage medium or to an external computer or external storage device via a network, for example, the Internet, a local area network, a wide area network and/or a wireless network. The network may comprise copper transmission cables, optical transmission fibers, wireless transmission, routers, firewalls, switches, gateway computers and/or edge servers. A network adapter card or network interface in each computing/processing device receives computer readable program instructions from the network and forwards the computer readable program instructions for storage in a computer readable storage medium within the respective computing/processing device.
Computer readable program instructions for carrying out operations of the present invention may be assembler instructions, instruction-set-architecture (ISA) instructions, machine instructions, machine dependent instructions, microcode, firmware instructions, state-setting data, configuration data for integrated circuitry, or either source code or object code written in any combination of one or more programming languages, including an object oriented programming language such as Smalltalk, C++, or the like, and procedural programming languages, such as the “C” programming language or similar programming languages. The computer readable program instructions may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the latter scenario, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet Service Provider). In some embodiments, electronic circuitry including, for example, programmable logic circuitry, field-programmable gate arrays (FPGA), or programmable logic arrays (PLA) may execute the computer readable program instructions by utilizing state information of the computer readable program instructions to personalize the electronic circuitry, in order to perform aspects of the present invention.
Aspects of the present invention are described herein with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the invention. It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer readable program instructions.
These computer readable program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks. These computer readable program instructions may also be stored in a computer readable storage medium that can direct a computer, a programmable data processing apparatus, and/or other devices to function in a particular manner, such that the computer readable storage medium having instructions stored therein comprises an article of manufacture including instructions which implement aspects of the function/act specified in the flowchart and/or block diagram block or blocks.
The computer readable program instructions may also be loaded onto a computer, other programmable data processing apparatus, or other device to cause a series of operational steps to be performed on the computer, other programmable apparatus or other device to produce a computer implemented process, such that the instructions which execute on the computer, other programmable apparatus, or other device implement the functions/acts specified in the flowchart and/or block diagram block or blocks.
The flowchart and block diagrams in the Figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of the present invention. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of instructions, which comprises one or more executable instructions for implementing the specified logical function(s). In some alternative implementations, the functions noted in the blocks may occur out of the order noted in the Figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems that perform the specified functions or acts or carry out combinations of special purpose hardware and computer instructions.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms “a”, “an” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms “comprises” and/or “comprising,” when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
The corresponding structures, materials, acts, and equivalents of all means or step plus function elements in the claims below are intended to include any structure, material, or act for performing the function in combination with other claimed elements as specifically claimed. The description of the present invention has been presented for purposes of illustration and description, but is not intended to be exhaustive or limited to the invention in the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the invention. The embodiment was chosen and described in order to best explain the principles of the invention and the practical application, and to enable others of ordinary skill in the art to understand the invention for various embodiments with various modifications as are suited to the particular use contemplated.
This application is a continuation of U.S. patent application Ser. No. 15/410,836, filed Jan. 20, 2017, which claims the benefit of U.S. Provisional Patent Application No. 62/401,117 filed on Sep. 28, 2016, the complete disclosure of which is expressly incorporated by reference herein in its entirety for all purposes.
| Number | Date | Country | |
|---|---|---|---|
| 62401117 | Sep 2016 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 15410836 | Jan 2017 | US |
| Child | 15856435 | US |
