Patent Grant
11998741
The present invention relates to a pulse current generation circuit, a charge compensation circuit and method, and an implantable electrical retina stimulator for neural stimulation.
In the field of neural stimulation, electrical stimulation provided by stimulation electrodes can enable nerve tissue to react, thereby achieving a desired function. For example, in the existing vision repair system of artificial retina, in order to restore visual perception to the blind, it is generally necessary to put an implant into an eyeball of the blind. This implant replaces the function of light-sensitive cells damaged by retinal pigmentation (RP) or age-related macular degeneration (AMD). Under the condition that other functions of a visual pathway are retained, the stimulation electrodes in the implant can be used to stimulate other neural pathways with the retained intact retina to restore partial vision for the blind.
In an artificial retina system, an in-vitro camera captures a video image, and then an image processing device converts the video image into an electrical signal and sends the electrical signal to the implant. Then, the implant in the eye converts the electrical signal into a stimulation signal and stimulates ganglion cells in the retina through the stimulation electrodes of the implant, thereby enabling the blind to feel a sense of light in the cerebral cortex and restore partial vision.
However, in existing artificial retinas or artificial retinal systems such as implantable electrical retinal stimulators, the stimulation signal generated by the stimulation electrode generally can only stimulate nerve cells (such as ganglion cells) on a surface of the retina and cannot effectively stimulate bipolar cells slightly away from the retina on the surface of the retina. Therefore, a stimulation effect is often not ideal. In addition, there is still much to be improved in terms of stimulation resolution.
In addition, in the existing neural stimulation devices such as artificial retina systems, stimulation current generated for neural stimulation may not guarantee that the charge amount during one stimulation period is within a safe charge amount. The stimulated nerve tissue (such as ganglion cells or bipolar cells in the retina) may therefore have a net charge, such as positive charge or negative charge, resulting in damage to the nerve tissue such as ganglion cells or bipolar cells in the retina.
In order to ensure the balance of the stimulation charge received by the nerve tissue such as ganglion cells or bipolar cells in the retina, it is also considered to arrange a RC circuit between the pulse current generation circuit and a stimulated site to balance redundant charge on the ganglion cells or the bipolar cells. However, charge balance performance of the RC circuit is positively correlated with the capacitance of a capacitor in the RC circuit. In order to balance more positive or negative charges, the capacitance of the capacitor in the RC circuit needs to be increased. Thus, capacitance with a larger area is needed. However, in the field of neural stimulation, the circuit design space is often limited, and large capacitance with large occupied area cannot be integrated. Therefore, the ability of using the RC circuit to balance the charge cannot be fully achieved.
Through long-term research, the inventors found that the ganglion cells are connected with multiple bipolar cells in the retina, and bipolar cells in the macular area of the retina (usually the place where the artificial retina is implanted) are connected with single photoreceptor cells one by one. By stimulating the bipolar cells in the retina, the resolution of the stimulation can be effectively improved, thereby generating a more accurate and effective sense of light. For example, for the way of repair of an implantable electrical retina stimulator on the retina, the implanted stimulation electrode is often attached to the retina, and the part that the stimulation electrode can contact is mainly ganglion cells of the retina (especially the axons of ganglion cells). In order to enable the stimulation signal generated by the stimulation electrode to stimulate the bipolar cells slightly away from the stimulation electrode, the stimulation electrode is generally required to provide pulse current of, for example, a wide stimulation pulse. In addition, from the perspective of the safe charge amount of the stimulation electrode, if the stimulation pulse of the pulse current is wide, the amplitude of the pulse current shall be correspondingly reduced to ensure that the stimulation charge is within the safe charge amount.
In order to solve the existing problems mentioned above, the purpose of the present invention is to provide a pulse current generation circuit capable of enhancing effective stimulation resolution, a charge compensation circuit and method, and an implantable electrical retina stimulator for neural stimulation.
Thus, a first aspect of the present invention provides a pulse current generation circuit for neural stimulation, including an analogue signal receiving device for receiving an analogue signal; an analogue-to-digital converter for converting the analogue signal into a digital control signal; a current signal controller for producing, according to the digital control signal, pulse current parameters for generating bidirectional pulse current signals; and a current generator for generating, according to the pulse current parameters, bidirectional pulse current signals for neural stimulation, wherein the current generator can generate pulse currents of different precisions according to the pulse current parameters.
In the first aspect of the present invention, the current signal controller generates pulse current parameters for generating the bidirectional pulse current signals based on a digital control signal, and the current generator generates bidirectional pulse current signals with different precisions for neural stimulation according to the pulse current parameters. By using the current generator which can generate pulse currents of different precisions, bidirectional pulse current signals with different pulse widths and different precisions may be generated according to stimulation needs. Thus, not only the requirement of safe charge can be satisfied, but also the nerve cells (such as bipolar cells) that need to be stimulated can be effectively stimulated, thereby producing more effective stimulation effect. In another aspect, due to the pulse current generation circuit can achieve a wider pulse signal, therefore, the higher processing requirements can be adapted at a hardware level, such as stimulation algorithm optimization.
In addition, in the pulse current generation circuit according to the present invention, optionally, in one stimulation period, the total charge amount of the bidirectional pulse current signals is within the safe charge amount. Thus, the damage of the pulse current signal to human nerve tissue (such as ganglion cells or bipolar cells in retina) can be avoided, thereby ensuring the safety and the reliability of the pulse current generation circuit.
In the pulse current generation circuit according to the present invention, optionally, the pulse current parameters include a negative pulse width, a negative pulse amplitude, a positive pulse width, a positive pulse amplitude and a pulse interval. Thus, by controlling the pulse current parameters, different stimulation pulse currents can be realized.
In addition, in the pulse current generation circuit according to the present invention, optionally, the current generator generates low-precision pulse current or high-precision pulse current according to the pulse current parameters; and the current generator judges whether bidirectional pulse current signals to be generated are less than the critical value after receiving the pulse current parameters, generates the high-precision pulse current when the bidirectional pulse current signals to be generated are less than or equal to the critical value, and generates the low-precision pulse current when the bidirectional pulse current signals to be generated are greater than the critical value. Thus, the current generator can generate the corresponding pulse currents in different situations to meet the requirement of the stimulation signal.
In addition, in the pulse current generation circuit according to the present invention, optionally, the current generator generates the high-precision pulse current when the negative pulse width of the bidirectional pulse current signals is greater than the preset duration and the negative pulse amplitude is less than or equal to the critical value. In this case, nerve cells can be stimulated more effectively.
In addition, in the pulse current generation circuit according to the present invention, optionally, the precision of the pulse amplitude of the high-precision pulse current is greater than the precision of the pulse amplitude of the low-precision pulse current. Thus, the current generator can generate the pulse currents of different precisions according to actual situations, so as to meet the requirements of different neural stimulation signals.
In addition, in the pulse current generation circuit according to the present invention, optionally, the total charge amount of the positive pulse current or the negative pulse current during one stimulation period of the bidirectional pulse current signals is within the safe charge amount. Thus, long-term safety and reliability of the stimulation electrodes can be ensured.
In addition, a second aspect of the present invention provides a charge compensation circuit configured for conducting charge compensation on the pulse current generation circuit which is configured for generating bidirectional pulse current for neural stimulation; the charge compensation circuit includes: a detection circuit for detecting the total charge amount during one stimulation period of the bidirectional pulse current signals generated by the pulse current generation circuit; a judgment circuit for judging whether the total charge amount detected by the detection circuit exceeds the safe charge amount; and a compensation circuit for generating a compensation pulse current signal with a net charge amount when the judgment circuit judges that the total charge amount exceeds the safe charge amount, so that the total charge amount is within the safe charge amount.
In the second aspect of the present invention, the detection circuit is configured for detecting the total charge amount during one stimulation period of the bidirectional pulse current signals generated by the pulse current generation circuit, and the judgment circuit is configured for judging whether the total charge amount detected by the detection circuit exceeds the safe charge amount. Moreover, the compensation circuit is configured for generating a compensation pulse current signal with a net charge amount when the judgment circuit judges that the total charge amount exceeds the safe charge amount, so that the total charge amount is within the safe charge amount. In this way, the compensation pulse current signal with a net charge amount is transmitted to conduct charge balance on the bidirectional pulse current signals under the condition that a large capacitor (RC circuit) with large occupied area is not used. Thus, charge balance capability can be fully enhanced within a limited space.
In addition, in the charge compensation circuit according to the present invention, in the compensation circuit, when the judgment circuit judges that the total charge amount is a positive value, a compensation pulse current signal with a negative compensation charge amount is generated so that the total charge amount is within the safe charge amount; and when the judgment circuit judges that the total charge amount is a negative value, a compensation pulse current signal with a positive compensation charge amount is generated so that the total charge amount is within the safe charge amount. Thus, the total charge amount for neural stimulation is effectively ensured to be within the safe charge amount.
In addition, in the charge compensation circuit according to the present invention, optionally, the amplitude of the compensation pulse current signal is lower than a preset amplitude, and the period of the compensation pulse current signal is less than the period of the bidirectional pulse current signals. In this case, charge compensation may be rapidly completed through multiple compensations.
In addition, in the charge compensation circuit according to the present invention, optionally, in the bidirectional pulse current signals, a waveform of a positive pulse current signal is opposite to a waveform of a negative pulse current signal; the detection circuit detects the charge amount of the positive pulse current signal and an absolute value of the charge amount of the negative pulse current signal; and the judgment circuit compares the charge amount of the positive pulse current signal with the absolute value of the charge amount of the negative pulse current signal to judge whether the total charge amount exceeds the safe charge amount.
In addition, in the charge compensation circuit according to the present invention, optionally, the detection circuit detects an average value of the bidirectional pulse current signals generated by the pulse current generation circuit; the judgment circuit judges whether an absolute value of the average value is greater than a preset value; and when the absolute value of the average value is greater than the preset value, the compensation circuit generates a compensation pulse current signal with a net charge amount, so that the total charge amount is within the safe charge amount. In this case, it can be determined conveniently whether to provide charge compensation by detecting whether the average value is greater than the preset value.
In addition, in the charge compensation circuit according to the present invention, optionally, the detection circuit detects a current average value of the bidirectional pulse current signals generated by the pulse current generation circuit, and converts the current average value into a voltage average value; the judgment circuit judges whether an absolute value of the voltage average value is greater than a preset voltage value; and when the absolute value of the voltage average value is greater than the preset voltage value, the compensation circuit generates a compensation pulse current signal with a net charge amount, so that the total charge amount is within the safe charge amount. In this case, the current average value may be converted into the voltage average value for detection; the absolute value of the voltage average value is compared with the preset voltage value; and when the absolute value of the voltage average value is greater than the preset voltage value, the total charge amount for neural stimulation is within the safe charge amount through the compensation of the compensation circuit.
In addition, in the charge compensation circuit according to the present invention, optionally, when the absolute value of the voltage average value is greater than the preset voltage value and the voltage average value is a positive value, the compensation circuit generates a compensation pulse current signal with a negative net charge amount so that the total charge amount for neural stimulation is within the safe charge amount; and when the absolute value of the voltage average value is greater than the preset voltage value and the voltage average value is a negative value, the compensation circuit generates a compensation pulse current signal with a positive net charge amount so that the total charge amount for neural stimulation is within the safe charge amount.
In addition, in the charge compensation circuit according to the present invention, the preset amplitude is a minimum current amplitude which can play a stimulation effect on nerve tissue. Thus, the compensation pulse current signal can be prevented to producing a false stimulation on the nerve tissue.
In addition, a third aspect of the present invention provides a charge compensation method configured for conducting charge compensation on the pulse current generation circuit which is configured for generating bidirectional pulse current for neural stimulation. The charge compensation method includes: detecting the total charge amount during one stimulation period of the bidirectional pulse current signals generated by the pulse current generation circuit; judging that the total charge amount detected by the detection circuit is less than or equal to the safe charge amount; and generating a compensation pulse current signal with a net charge amount when the judgment circuit judges that the total charge amount exceeds the safe charge amount, so that the total charge amount is within the safe charge amount.
In addition, in the charge compensation method according to the present invention, optionally, when the total charge amount is judged to be a positive value, a compensation pulse current signal with a negative compensation charge amount is generated so that the total charge amount is within the safe charge amount; and when the total charge amount is judged to be a negative value, a compensation pulse current signal with a positive compensation charge amount is generated so that the total charge amount is within the safe charge amount. Thus, the total charge amount for neural stimulation is effectively ensured to be within the safe charge amount.
In addition, a fourth aspect of the present invention provides an implantable electrical retina stimulator, including: an implanted device having at least one of the pulse current generation circuit or the charge compensation circuit mentioned above; a video recording device configured to capture a video image and convert the video image into a visual signal; a video processing device connected with the video recording device and configured to process the visual signal to generate a modulation signal; and an analogue signal transmitting device configured to transmit the modulation signal to the implanted device, wherein the implanted device converts the received modulation signal into the bidirectional pulse current signals used as electrical stimulation signals, so as to transmit the bidirectional pulse current signals for ganglion cells or bipolar cells of the retina to generate a sense of light.
According to the present invention, a more effective stimulation effect can be generated. Moreover, a higher processing requirement, such as stimulation algorithm optimization, can be adapted at a hardware level. The charge compensation circuit actively compensates possible redundant net charge on the nerve tissue (such as ganglion cells or bipolar cells), which can improve the efficiency of charge balance on stimulation charge and ensure safety and reliability of neural stimulation. In addition, under the condition that a large capacitor with large occupied area is not used, charge balance capability can be fully enhanced within a limited space.
Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description, the same components are denoted by the same reference numerals, and the description thereof will not be repeated. In addition, the drawings are merely schematic views, and the ratio of the dimensions of the components to each other or the shapes of the components may be different from the actual ones.
In the present embodiment, as shown in
In some examples, the implanted device 10 primarily includes a substrate (not shown) as well as an electronic package body 11, a stimulation electrode structure 12 and the receiving antenna 13 which are disposed on the substrate. In addition, the substrate in the implanted device 10 may be fixed to the eyeball 20 in, for example, a stitching manner.
Furthermore, as shown in
In general, for example, for patients with retinitis pigmentosa (RP) or age-related macular degeneration (AMD), photoreceptor cells decay or die due to the RP or AMD, i.e. normal visual pathways are hindered by the lesions of photoreceptor cell diseases, and light that normally enters eyes cannot be converted into visual electrical signals so that the patients lose the sense of sight. In the present embodiment, the stimulation end 12a of the stimulation electrode structure 12 is equivalent to replace the photoreceptor cells; and the stimulation end 12a stimulates the ganglion cells or bipolar cells of the retina (see
In addition, it should be noted that although the present embodiment focuses on the description of optic neural stimulation of the implantable electrical retina stimulator, the present embodiment is not limited to the field of artificial retina, and instead, the pulse current generation circuit 100 according to the present embodiment may also be applied to other neural stimulation fields such as cochlear implants, deep brain stimulation, cardiac pacemakers, spinal cord stimulators.
(In-Vitro Device)
In the present embodiment, as shown in
In some examples, the video recording device 31 may be a device having a video recording function such as a video camera, a digital camera, a CCD camera or the like. For example, an image of the outside world can be captured by the video recording device 31. Besides, for the convenience of use, a smaller video camera may be embedded in glasses. Moreover, lightweight glasses having the video recording function may be worn as the video recording device 31 to capture the video image. Furthermore, the video recording device 31 may also be implemented through Google Glass® or the like. In addition, the image may be acquired by ultrasonic imaging (for example, sonar) or electromagnetic wave imaging (for example, radar), or other devices capable of generating range and angle information in the present embodiment.
As shown in
The analogue signal transmitting device (i.e., the transmitting antenna 33) may transmit the energy signal provided by the video processing device 32 and the processed visual signal as modulation signals (for example, RF modulation signals) to the implanted device 10 of the artificial retina.
In another aspect, the implanted device 10 may be configured to receive the modulation signals transmitted by the video processing device 32 via, for example, the transmitting antenna 33, and further process the modulation signals to generate the bidirectional pulse current as a stimulation current (stimulation signal) for neural stimulation.
Specifically, the receiving antenna 13 (i.e., a specific embodiment of the analogue signal receiving device 101 described later) shown in
(Pulse Current Generation Circuit)
As shown in
In the present embodiment, the pulse current generation circuit 100 may be applied to the implantable electrical retina stimulator shown in
In some examples, for example, in the implanted device 10, the pulse current generation circuit 100 can generate the bidirectional pulse current signals for stimulating the ganglion cells or bipolar cells of the retina. Furthermore, in some examples, the bidirectional pulse current signals generated by the pulse current generation circuit 100 can be issued to, for example, the ganglion cells or bipolar cells of the retina by the stimulation end 12a (see
(Analogue Signal Receiving Device)
In the present embodiment, the analogue signal receiving device 101 is configured to receive an analogue signal in the form of an antenna. The analogue signal receiving device 101 transmits the received analogue signal to the analogue-to-digital converter 102. As described above, the analogue signal receiving device 101 may be the receiving antenna 13 composed of receiving coils. Herein, the coils of the receiving antenna 13 may be formed by winding metal wires such as gold wires. In addition, the number of turns of the coils of the receiving antenna 13 is not particularly limited and may be set as needed.
(Analogue-to-Digital Converter)
The analogue-to-digital converter 102 can convert the analogue signal received by the analogue signal receiving device 101 into a digital control signal and transmit the digital control signal to the current signal controller 103. In the present embodiment, a circuit structure of the analogue-to-digital converter 102 is not particularly limited; and analogue-to-digital converters with different resolutions such as 4 bits, 6 bits, 8 bits, 10 bits, 14 bits, 16 bits, etc. may be used as needed. In addition, the analogue-to-digital converter 102 may be a successive approximation type analogue-to-digital converter, a parallel comparison type analogue-to-digital converter, or an integral type analogue-to-digital converter. In addition, the digital control signal may be a series of digital signal streams, which indicate pulse current parameters of the bidirectional pulse current signals to be generated subsequently.
(Current Signal Controller)
The current signal controller 103 may produce the pulse current parameters for generating the bidirectional pulse current signals according to the digital control signal outputted by the analogue-to-digital converter 102. Herein, the bidirectional pulse current as the stimulation signal may include a positive pulse current and a negative pulse current. For the neural stimulation field, the charge of the positive pulse current of the bidirectional pulse current and the charge of the negative pulse current generally need to be equal to ensure the safety when nerve tissue is stimulated. The effect of the bidirectional pulse current on the neural stimulation will be described in more detail later.
In some examples, the bidirectional pulse current may be a bidirectional pulse current of square waveform. In this case, the pulse current parameters of the bidirectional pulse current may include a negative pulse width t1, a negative pulse amplitude I1, a positive pulse width t2, a positive pulse amplitude I2 and a pulse interval t3 (see
As described above, the current signal controller 103 may produce the pulse current parameters for generating the bidirectional pulse current signals according to the digital control signal. In some examples, the digital control signal can instruct the current controller 103 to generate the bidirectional pulse current having a wider negative pulse width t1 (for example, t1>t2). In other examples, the digital control signal may instruct the current controller 103 to generate the bidirectional pulse current having a smaller negative pulse amplitude I1 (for example, I1<I2).
(Current Generator)
The current generator 104 may generate the bidirectional pulse current signals for neural stimulation according to the pulse current parameters. In the present embodiment, since the pulse current generation circuit 100 for neural stimulation can maintain the high precision of the pulse current while increasing the width of the stimulation pulse current, a more effective current stimulation effect can be provided, for example, the bipolar cells of the retina can be stimulated effectively. In another aspect, since a wider pulse modulation range can be realized, higher processing requirements such as stimulation algorithm optimization can be adapted at a hardware level.
In the present embodiment, the current generator 104 may generate at least two pulse currents of different precision according to the pulse current parameters. In some examples, the current generator 104 can generate two pulse currents of different precision. In other examples, the current generator 104 can generate three, four, five or more than five pulse currents of different precision. In addition, the different precision multiples between the adjacent different pulse currents may be twice, for example, in the situation that current generator 104 generates five pulse currents of different precision including a first pulse current, a second pulse current, a third pulse current, a fourth pulse current and a fifth pulse current, the precision of the fifth pulse current is twice the precision of the fourth pulse current, the precision of the fourth pulse current is twice the precision of the third pulse current, the precision of the third pulse current is twice the precision of the second pulse current, and the precision of the second pulse current is twice the precision of the first pulse current. In addition, the present embodiment is not limited thereto, and other pulse currents of different precisions may also be adopted.
(Impedance Load)
As shown in
Hereinafter, the current generator 104 according to the present embodiment will be described in more detail with reference to
As shown in
When the current generator 104 is composed of the N current sources mentioned above, the magnitude of the pulse current may be determined by the opening and closing of (N+1) current sources, and the precision of the pulse current may be determined by the size of the reference current source 1041. Specifically, the magnitude of the reference current source 1041 is the magnitude of the precision of the pulse current. For example, if the reference current source 1041 is 1 μA (microamperes), the precision of the pulse current is 1 μA, and a current value of each mirror current source in (N−1) mirror current sources, i.e., a current source 1042, a current source 1043, . . . , and a current source 104(N) is the same as the current value of the reference current source 1041. After the magnitude of the reference current source 1041 is set, the current value of each mirror current source in the current source 1042, the current source 1043, . . . , and the current source 104(N) is equal to the reference current source 1041.
In some examples, if the number of the reference current sources 1041 and the (N−1) mirror current sources is N=512 in total, and the precision of the reference current source 1041 is set to 1 μA, the current generator 104 may generate a pulse current having the precision of 1 μA and 512 pulse amplitudes, i.e., the current generator 104 may generate a total of 512 different current amplitudes including 1 μA, 2 μA, 3 μA, . . . , and 512 μA by controlling the switch S1, the switch S2, . . . , and the switch S(N). In other examples, if the number of the reference current sources 1041 and the (N−1) mirror current sources is N=512 in total, and the precision of the reference current source 1041 is set to 4 μA, the current generator 104 may generate a pulse current having the precision of 4 μA and 128 pulse amplitudes, i.e., the current generator 104 may generate a total of 128 different current amplitudes including 4 μA, 8 μA, 12 μA, . . . , and 512 μA by controlling the switch S1, the switch S2, . . . , and the switch S(N). In some other examples, if the number of the reference current sources 1041 and the (N−1) mirror current sources is N=512 in total, and the precision of the reference current source 1041 is set to 8 μA, the current generator 104 may generate a pulse current having the precision of 8 μA and 64 pulse amplitudes, i.e., the current generator 104 may generate a total of 64 different current amplitudes including 8 μA, 16 μA, 24 μA, . . . , and 512 μA by controlling the switch S1, the switch S2, . . . , and the switch S(N). Although the current precisions 1 μA, 4 μA and 8 μA are introduced as examples in the above description, the present embodiment is not limited thereto, and the pulse current generation circuit 100 according to the present embodiment may also generate currents having, for example, 2 μA, 6 μA, 12 μA and other precisions.
As described above, since different current precisions may be realized by setting the reference current sources 1041 of different current magnitudes, the precisions of the generated pulse currents can be set by setting a plurality of different reference current sources in the present embodiment, so that a plurality of pulse currents of different precisions can be generated. In the present embodiment, two different reference current sources may be set, and pulse currents of two different precisions (high precision and low precision) may be realized in this case.
In some examples, the current generator 104 may generate the bidirectional pulse currents of two different precisions including a first pulse amplitude precision (high precision) and a second pulse amplitude precision (low precision). For example, a first pulse amplitude precision may be set to 1 μA/step, the range of current amplitude is 0-8 μA; and a second pulse amplitude precision may be set to 8 μA/step, the range of current amplitude is 8-512 μA (see
(Bidirectional Pulse Current Signals)
In some examples, the total charge amount during one stimulation period T of the bidirectional pulse current signals generated by the current generator 104 is within the safe charge amount (for example, the total charge amount is zero). Specifically, in the neural stimulation field, in order to prevent the pulse current signal from generating a net charge on human nerve tissue such as ganglion cells or bipolar cells of the retina to damage the human nerve tissue, it should be ensured that the total charge amount of the bidirectional pulse current signals during one stimulation period T is within the safe charge amount.
Herein, the “safe charge amount” is the maximum value of the net charge which can be withstood by the nerve tissue (for example, the ganglion cells or bipolar cells of the retina) within a safe range. The net charge exceeding the safe charge amount may cause damage to the nerve tissue. Herein, one stimulation period T is a period time at which a stimulation signal is generated. Therefore, during actual neural stimulation, it should be ensured that the total charge amount during one stimulation period T is controlled within the safe charge amount. Herein, one stimulation period T is a period time at which a stimulation signal is generated. The total charge amount refers to the total charge amount of the net charge of the bidirectional pulse current signals during one stimulation period T. In some examples, the safe charge amount may also be set to zero for convenience.
In addition, in the present embodiment, if it is ensured that the total charge amount of the bidirectional pulse current during one stimulation period T is within the safe charge amount, the waveform of the pulse current is not limited.
As shown in
As described above, the current generator 104 may generate the bidirectional pulse current signals according to the pulse current parameters. Specifically, the bidirectional pulse current signals may include effective stimulation current signals and balanced current signals, wherein the effective stimulation current signals are current signals having a stimulating effect on neural stimulation objects such as the ganglion cells or bipolar cells; and the balanced current signals are current signals for balancing the charge generated by the effective stimulation current signals. Generally, if the effective stimulation signals are positive pulses, the balanced current signals are negative pulses; if the effective stimulation signals are negative pulses, the balanced current signals are positive pulses. Thus, it can be ensured that the total charge amount of the bidirectional pulse current signals during one stimulation period T is within the safe charge amount. (For example, the total charge amount is zero).
In the present embodiment, as described above, the current signal controller 103 produces the pulse current parameters for generating the bidirectional pulse current signals. Thus, the total charge amount of the bidirectional pulse current signals theoretically generated by the current generator 104 during one stimulation period is within the safe charge amount by setting the pulse current parameters. In addition, in order to suppress the influence of the net charge which may be accumulated by the stimulation current signals on a human body, the bidirectional pulse current signals are usually set such that only one of the positive pulse and the negative pulse is the stimulation signal, and the other is the balanced current signal. Thus, it is ensured that the total charge amount of the bidirectional pulse current signals during one stimulation period T is within the safe charge amount.
As a specific example, during one stimulation period T, an integral of the negative pulse signal of the bidirectional pulse current signals in time may be equal to an absolute value of the integral of the positive pulse signal of the bidirectional pulse current signals in time. Thus, the total charge amount of the bidirectional pulse current signals during one stimulation period T is within the safe charge amount. In addition, with reference to
As described above, the current generator 104 provides two different pulse amplitude precisions including a first pulse amplitude precision and a second pulse amplitude precision, wherein the first pulse amplitude precision is 1 μA/step, and the amplitude range is 0-8 μA (for example, 1 μA, 2 μA, 3 μA, . . . , and 8 μA); the second pulse amplitude precision is 8 μA/step, and the amplitude range is 8-512 μA (for example, 8 μA, 16 μA, 24 μA, . . . , and 512 μA) (see
In some examples, as shown in
In the present embodiment, the current generator 104 may provide pulse amplitudes of at least two different precisions and generate pulse currents of at least two different precisions, thereby, a more efficient current stimulation manner can be provided.
In some examples, the current generator 104 may generate the low-precision pulse current or the high-precision pulse current according to the pulse current parameters. Specifically, the current generator 104 judges whether the pulse amplitude of the bidirectional pulse current signals to be generated is less than a critical value after receiving the pulse current parameters. When the pulse amplitude of the bidirectional pulse current signals to be generated is less than or equal to the critical value, the current generator 104 generates the high-precision pulse current; and when the pulse amplitude of the bidirectional pulse current signals to be generated is greater than the critical value the current generator 104 generates the low-precision pulse current. Thus, the current generator 104 may generate corresponding pulse currents under different conditions to meet the requirements of different neural stimulation signals.
In the present embodiment, the critical value may be set in advance. In addition, the amplitude precision of the high-precision pulse current and the amplitude precision of the low-precision pulse current may also be set in advance. For example, as shown in
In this case, when the current generator 104 judges that the amplitude of the bidirectional pulse current signals to be generated is less than or equal to 8 μA, the current generator 104 generates the high-precision (1 μA/step) pulse current; and when the current generator 104 judges that the amplitude of the bidirectional pulse current signals to be generated is greater than 8 μA, the current generator 104 generates the low-precision (8 μA/step) pulse current. In this way, the current generator 104 may provide the pulse currents of two different precisions. When the ganglion cells or bipolar cells require a smaller pulse current, the high-precision pulse current is provided so that the bipolar cells of the retina can be stimulated more accurately, and the more efficient stimulation manner can be provided.
In some examples, when the positive pulse width of the bidirectional pulse current signals is greater than a preset duration and the positive pulse amplitude is less than the critical value, or when the negative pulse width of the bidirectional pulse current signals is greater than the preset duration and the negative pulse amplitude is less than the critical value, the current generator 104 generates the high-precision pulse current.
For the width (stimulation time) of the stimulation pulse current, although the action mechanism is still unclear, deeper nerve cells are more likely stimulated by extending the stimulation pulse width (for example, the negative pulse width), thereby, more efficient neural stimulation can be acquired. For example, for the implantable electrical retina stimulator, a wide stimulation pulse can stimulate the bipolar cells of the retina more effectively, thereby, more effective and more precise neural stimulation can be provided.
Specifically, when the negative pulse width of the bidirectional pulse current signals is greater than the preset duration and the negative pulse amplitude is less than the critical value, the bidirectional pulse current signals can stimulate the bipolar cells of the retina more precisely. Since the one-to-one correspondence of the bipolar cells in the visual pathways is superior to that of the ganglion cells, the precise stimulation of the bipolar cells may form a more accurate sense of light. In addition, higher processing requirements such as stimulation algorithm optimization can also be adapted at a hardware level.
In this way, when the positive pulse width of the bidirectional pulse current signals is greater than the preset duration and the positive pulse amplitude is less than the critical value, or when the negative pulse width of the bidirectional pulse current signals is greater than the preset duration and the negative pulse amplitude is less than the critical value, the current generator 104 generates the high-precision pulse current for precisely stimulating the bipolar cells to form a more accurate sense of light, thereby providing a more efficient stimulation manner for the blind.
The pulse current generation circuit 200 according to the second embodiment differs from the pulse current generation circuit 100 according to the first embodiment in that besides the analogue signal receiving device 101, the analogue-to-digital converter 102, the current signal controller 103 and the current generator 104 according to the first embodiment, the charge compensation circuit 106 is also included.
Furthermore, it should be noted that although the present embodiment focuses on the description of the visual stimulation of the implantable electrical retina stimulator, however, the present embodiment is not limited to the field of artificial retina, and instead, the charge compensation circuit 106 according to the present embodiment may also be applied to other neural stimulation fields such as cochlear implants, deep brain stimulation, cardiac pacemakers, spinal cord stimulators.
As shown in
In the present embodiment, as shown in
In addition, the judgment circuit 1062 may be configured to judge whether the total charge amount detected by the detection circuit 1061 exceeds the safe charge amount. Furthermore, the compensation circuit 1063 may be configured to generate a compensation pulse current signal with a net charge amount when the judgment circuit 1062 judges that the total charge amount exceeds the safe charge amount so that the total charge amount for neural stimulation is within the safe charge amount. Herein, the net charge amount may be a negative charge amount or a positive charge amount based on the case where compensation is required.
Theoretically, the pulse current parameters (for example, the pulse current parameters may include a positive pulse width, a positive pulse amplitude, a positive pulse amplitude, a negative pulse width, a negative pulse amplitude, a pulse interval, etc.) of the bidirectional pulse current signals can be set such that the total charge amount of the bidirectional pulse current signals during one stimulation period T is within the safe charge amount. However, in an actual application circuit, the total charge amount of the bidirectional pulse current signals generated by the pulse current generation circuit 200 during one stimulation period T is likely to exceed the safe charge amount due to various factors. In this case, the net charge accumulated-by the bidirectional pulse current signals may cause damage to the ganglion cells or bipolar cells of human eyes.
In the present embodiment, redundant net charge accumulated on nerve tissue (for example, the ganglion cells or bipolar cells) is actively compensated by the charge compensation circuit 106 so that the ability to balance the stimulation charge can be improved and the safety and reliability of neural stimulation can be ensured, thereby playing a role of protecting human nerve tissue such as the ganglion cells or bipolar cells of the retina.
In the present embodiment, the detection circuit 1061 can be configured to detect the total charge amount during one stimulation period T of the bidirectional pulse current signals generated by the pulse current generation circuit 200. Next, the judgment circuit 1062 judges whether the total charge amount during one stimulation period T of the bidirectional pulse current signals detected by the detection circuit 1061 exceeds the safe charge amount. If the total charge amount during one stimulation period T of the bidirectional pulse current signals is within the safe charge amount, the compensation circuit 1063 does not work; and if the total charge amount during one stimulation period T of the bidirectional pulse current signals exceeds the safe charge amount, the compensation circuit 1063 generates a compensation pulse current signal with a net charge amount, so that the total charge amount for neural stimulation is within the safe charge amount.
Specifically, when the judgment circuit 1062 judges that the total charge amount during one stimulation period T of the bidirectional pulse current signals is a positive charge, the compensation circuit 1063 produces a negative current pulse so that the total charge amount for neural stimulation is within the safe charge amount. When the judgment circuit 1062 judges that the total charge amount during one stimulation period T of the bidirectional pulse current signals is a negative charge, the compensation circuit 1063 produces a positive current pulse so that the total charge amount for neural stimulation is within the safe charge amount.
In the present embodiment, the compensation circuit 1063 may actively conduct charge compensation. Once the judgment circuit 1062 judges that the total charge amount during one stimulation period produced by the pulse current generation circuit 200 and detected by the detection circuit 1061 exceeds the safe charge amount, the compensation circuit 1063 may conduct charge compensation in time, thereby enhancing charge balance efficiency or capability and ensuring safety of the stimulated nerve tissue.
In some examples, the compensation circuit 1063 may generate a compensation pulse current signal with a net charge amount when the judgment circuit 1062 judges that the total charge amount during one stimulation period T of the bidirectional pulse current signals exceeds the safe charge amount, so that the total charge amount for neural stimulation is within the safe charge amount. In addition, the compensation circuit 1063 may generate a compensation pulse current signal with a positive net charge amount when the judgment circuit 1062 judges that the total charge amount during one stimulation period T of the bidirectional pulse current signals is less than zero, so that the total charge amount for neural stimulation is within the safe charge amount.
For example, when the judgment circuit 1062 judges that the total charge amount during one stimulation period T of the bidirectional pulse current signals is negative charge of −1×10−7 coulombs, the compensation circuit 1063 produces positive charge with a total charge amount of 1×107 coulombs (for example, the compensation circuit 1063 may produce a positive pulse with a pulse width of 1 millisecond and a pulse amplitude of 100 microamps, or the compensation circuit 1063 may produce a positive pulse with a pulse width of 10 milliseconds and a pulse amplitude of 10 microamps), so that the total charge amount for neural stimulation is within the safe charge amount. For example, when the judgment circuit 1062 judges that the total charge amount during one stimulation period T of the bidirectional pulse current signals is positive charge of 1×10−7 coulombs, the compensation circuit 1063 produces negative charge with a total charge amount of −1×10−7 coulombs (for example, the compensation circuit 1063 may produce a negative pulse with a pulse width of 1 millisecond and a pulse amplitude of 100 microamps, or the compensation circuit 1063 may produce a negative pulse with a pulse width of 10 milliseconds and a pulse amplitude of 10 microamps), so that the total charge amount for neural stimulation is within the safe charge amount.
In the present embodiment, the amplitude of the compensation pulse current signal may be lower than a preset amplitude, and the period of the compensation pulse current signal may be less than the period of the bidirectional pulse current signals. Herein, the preset amplitude is a minimum current amplitude which can play a stimulation effect on nerve tissue (such as ganglion cells or bipolar cells). The amplitude of the compensation pulse current signal is set to be lower than the preset amplitude so as to prevent the compensation pulse current signal from producing a false stimulation on the nerve tissue (such as ganglion cells or bipolar cells) and inhibiting the nerve tissue (such as ganglion cells or bipolar cells) from producing unnecessary excitement due to possible reception of the compensation pulse current signal. In addition, the period of the compensation pulse current signal may also be set to be less than the period of the bidirectional pulse current signals. Thus, charge compensation may be conducted within short time. For example, charge compensation may be conducted rapidly through multiple compensations.
In some examples, in the bidirectional pulse current signals, a waveform of a positive pulse current signal may be opposite to a waveform of a negative pulse current signal. Namely, in the bidirectional pulse current signals, the waveform of the pulse currents are identical except that the waveform of the positive pulse current signal is opposite to the waveform of the negative pulse current signal. In this way, the detection circuit 1061 may detect the charge amount of the positive pulse current signal and an absolute value of the charge amount of the negative pulse current signal. Then, the judgment circuit 1062 compares the charge amount of the positive pulse current signal with the absolute value of the charge amount of the negative pulse current signal to judge whether the total charge amount exceeds the safe charge amount.
Again referring to
In some examples, the detection circuit 1061 may detect an average value of the bidirectional pulse current signals generated by the pulse current generation circuit 200. Specifically, the net charge amounts between the negative charge amount and the positive charge amount of the bidirectional pulse current signals is directly computed, and the net charge amounts are averaged, thereby obtaining that whether a net charge exists in the total charge amount of the bidirectional pulse current signals generated by the pulse current generation circuit 200. Then, the judgment circuit 1062 may judge whether an absolute value of the average value is greater than a preset value; and when the absolute value of the average value is greater than the preset value, the compensation circuit 1063 may generate a compensation pulse current signal with a net charge amount, so that the total charge amount for neural stimulation is within the safe charge amount.
In the present embodiment, the average value of the bidirectional pulse current signals may be a current average value, an average charge value, etc. of the bidirectional pulse current signals. In addition, the preset value may be a preset current value, a preset charge value, etc.
In some examples, the average value of the bidirectional pulse current signals may be the current average value of the bidirectional pulse current signals. In this case, the detection circuit 1061 may detect the current average value of the bidirectional pulse current signals, Ia=|(I1×t1+I2×t2)/(t1+t2)|, wherein I2 is a negative value. The preset current value is set as I′ (I′>0), and the judgment circuit 1062 may judge whether Ia is greater than I′. If Ia is greater than I′, then the compensation circuit 1063 generates a compensation pulse current signal with a net charge amount so that the total charge amount for neural stimulation is within the safe charge amount. If Ia is less than or equal to I′, then the compensation circuit 1063 does not work.
In some examples, the average value of the bidirectional pulse current signals may be the average charge value of the bidirectional pulse current signals. In this case, the detection circuit 1061 may detect the average charge value of the bidirectional pulse current signals, Q==|(I1×t1+I2×t2)/2|, wherein I2 is a negative value. The preset charge value is set as Q′ (Q′>0), and the judgment circuit 1062 may judge whether Qa is greater than Q′. If Qa is greater than Q′, then the compensation circuit 1063 generates a compensation pulse current signal with a net charge amount so that the total charge amount for neural stimulation is within the safe charge amount. If Qa is less than or equal to Q′, then the compensation circuit 1063 does not work.
In some examples, the detection circuit 1061 may detect the current average value of the bidirectional pulse current signals generated by the pulse current generation circuit 200 and converts the current average value into a voltage average value. In this case, the judgment circuit 1062 may judge whether the absolute value of the voltage average value is greater than the preset voltage value. In this case, when the absolute value of the voltage average value is greater than the preset voltage value, the compensation circuit 1063 may generate a compensation pulse current signal with a net charge amount so that the total charge amount for neural stimulation is within the safe charge amount.
For example, the current average value is converted into the voltage average value through a current and voltage conversion circuit, and the preset voltage value is set as a safe voltage value. When the voltage average value is lower than the preset voltage value, it indicates that the bidirectional pulse current signals generated by the pulse current generation circuit 200 have no damage to human ganglion cells or bipolar cells (without exceeding the safe charge amount), and the compensation circuit 1063 does not need to conduct charge compensation. When the voltage average value is higher than the preset voltage value, it indicates that the bidirectional pulse current signals generated by the pulse current generation circuit 200 may have damage to human ganglion cells or bipolar cells and the compensation circuit 1063 generates a compensation pulse current signal with a net charge amount so that the total charge amount for neural stimulation is within the safe charge amount.
In the present embodiment, the detection circuit 1061 converts the detected average current value into the voltage average value which is easily judged by the judgment circuit 1062 (for example, the judgment circuit 1062 may judge using a voltage comparator); it is convenient for the judgment circuit 1062 to judge whether the compensation circuit 1063 needs charge compensation; and the accuracy of a judgment result of the judgment circuit 1062 can be enhanced.
In addition, in some examples, when the absolute value of the voltage average value is greater than the preset voltage value and the voltage average value is a positive value, the compensation circuit 1063 may generate a compensation pulse current signal with a negative net charge amount so that the total charge amount for neural stimulation is within the safe charge amount; and when the absolute value of the voltage average value is greater than the preset voltage value and the voltage average value is a negative value, the compensation circuit 1063 generates a compensation pulse current signal with a positive net charge amount so that the total charge amount for neural stimulation is within the safe charge amount.
In the present embodiment, the detection circuit 1061 may detect a current average value of the bidirectional pulse current signals generated by the pulse current generation circuit 200, and converts the current average value into a voltage average value. The judgment circuit 1062 may judge whether an absolute value of the voltage average value is greater than a preset voltage value. When the absolute value of the voltage average value is greater than the preset voltage value and the voltage average value is a positive value, the compensation circuit 1063 generates a compensation pulse current signal with a negative net charge amount, so that the total charge amount is within the safe charge amount. When the absolute value of the voltage average value is greater than the preset voltage value and the voltage average value is a negative value, the compensation circuit 1063 generates a compensation pulse current signal with a positive net charge amount, so that the total charge amount for neural stimulation is within the safe charge amount.
For example, if the preset voltage value is 5 millivolt (mv), when the voltage average value is greater than 5 mv (i.e., the absolute value of the voltage average value is greater than the preset voltage value and the voltage average value is a positive value), the compensation circuit 1063 generates a compensation pulse current signal with a negative net charge amount, so that the total charge amount for neural stimulation is within the safe charge amount. For example, the compensation pulse current signal generated by the compensation circuit 1063 is a negative pulse. In addition, when the voltage average value is less than −5 mv (i.e., the absolute value of the voltage average value is greater than the preset voltage value and the voltage average value is a negative value), the compensation circuit 1063 generates a compensation pulse current signal with a positive net charge amount, so that the total charge amount for neural stimulation is within the safe charge amount. For example, the compensation pulse current signal generated by the compensation circuit 1063 is a positive pulse.
In addition, the judgment circuit 1062 may specifically include a first voltage comparator U1 and a second voltage comparator U2, wherein an in-phase input end of the first voltage comparator U1 and an in-phase input end of the second voltage comparator U2 are electrically connected to the first end of the second resistor R2; a reverse-phase input end of the first voltage comparator U1 is connected to a preset positive voltage VTH+; a reverse-phase input end of the second voltage comparator U2 is connected to a preset negative voltage VTH−; a power supply end of the first voltage comparator U1 and a power supply end of the second comparator U2 are connected to a power voltage VDD; a grounding end of the first voltage comparator U1 and a grounding end of the second comparator U2 are connected to the common voltage VSS; an output end Out1 of the first voltage comparator U1 is electrically connected to a first control end C+ of the compensation circuit 1063; an output end Out2 of the second voltage comparator U2 is electrically connected to a second control end C− of the compensation circuit 1063; a power supply end of the compensation circuit 1063 is connected to the power voltage VDD; a grounding end of the compensation circuit 1063 is connected to the common voltage VSS; an output end of the compensation circuit 1063 is connected to the input end of the pulse current generation circuit 200; a power supply end of the pulse current generation circuit 200 is connected to the power voltage VDD; a grounding end of the pulse current generation circuit 200 is connected to the common voltage VSS; and an output end of the pulse current generation circuit 200 is connected to the impedance load 110.
In addition, the detection circuit 1061 may detect a total charge amount in one stimulation period T and a current average value in one stimulation period T for the bidirectional pulse current signals generated by the pulse current generation circuit 200, and converts the current average value in one stimulation period T into a voltage average value. The judgment circuit 1062 may judge whether the voltage average value mentioned above is between the preset positive voltage VTH+ and the preset negative voltage VTH−. If the above voltage average value is between the preset positive voltage VTH+ and the preset negative voltage VTH−, then the compensation circuit 1063 does not need to conduct charge compensation. If the voltage average value mentioned above is not between the preset positive voltage VTH+ and the preset negative voltage VTH−, then the compensation circuit 1063 conducts charge compensation to generate a compensation pulse current signal with a net charge amount, so that the total charge amount for neural stimulation is within the safe charge amount.
In the present embodiment, the detection circuit 1061 may be configured to detect a total charge amount in one stimulation period T for the bidirectional pulse current signals generated by the current generator 104. In some examples, the detection circuit 1061 may be formed by an integral circuit. The integral circuit may integrate the charge of the bidirectional pulse current signals generated by the current generator 104 within one stimulation period T, thereby obtaining the total charge amount of the bidirectional pulse current signals in one stimulation period T.
As a specific example, if the absolute value of the total charge amount of the bidirectional pulse current signals generated by the pulse current generation circuit 200 in one stimulation period T (e.g., the period is one second) exceeds 5×10−7 coulombs, then the compensation circuit 1063 conducts charge compensation, i.e., when the current average value of the bidirectional pulse current signals is greater than 5×10−7 mA or less than −5×10−7 mA, then the compensation circuit 1063 conducts charge compensation. If a resistance value of the second resistor R2 is 10 kΩ, the preset positive voltage VTH+ may be 5 mv and the preset negative voltage VTH− may be −5 mv. When the judgment circuit 1062 judges that the voltage average value mentioned above exceeds 5 mv, the output end Out1 of the first voltage comparator U1 outputs a high level and the output end Out2 of the second voltage comparator U2 outputs a high level. When the judgment circuit 1062 judges that the voltage average value mentioned above is lower than −5 mv, the output end Out1 of the first voltage comparator U1 outputs a low level and the output end Out2 of the second voltage comparator U2 outputs a low level. When the judgment circuit 1062 judges that the voltage average value mentioned above is between −5 mv and 5 mv, the output end Out1 of the first voltage comparator U1 outputs a low level and the output end Out2 of the second voltage comparator U2 outputs a high level.
In the present embodiment, the compensation pulse current signal outputted by the output end of the compensation circuit 1063 is related to the first control end C+ of the compensation circuit 1063 and the second control end C− of the compensation circuit 1063. See Table 1 below.
When the judgment circuit 1062 judges that the above voltage average value exceeds 5 mv, the compensation circuit 1063 needs to compensate a negative pulse. At this moment, the output end Out1 of the first voltage comparator U1 outputs a high level and the output end Out2 of the second voltage comparator U2 outputs a high level, i.e., the first control end C+ is a high level and the second control end C− is a high level, as shown in Table 1. The compensation pulse current signal generated by the compensation circuit 1063 is a negative pulse.
In addition, when the judgment circuit 1062 judges that the voltage average value mentioned above is lower than −5 mv, the compensation circuit 1063 needs to compensate a positive pulse. At this moment, the output end Out1 of the first voltage comparator U1 outputs a low level and the output end Out2 of the second voltage comparator U2 outputs a low level, i.e., the first control end C+ is a low level and the second control end C− is a low level, as shown in Table 1. The compensation pulse current signal generated by the compensation circuit 1063 is a positive pulse.
In addition, when the judgment circuit 1062 judges that the voltage average value mentioned above is between −5 mv and 5 mv, the compensation circuit 1063 does not need to conduct charge compensation. The output end Out1 of the first voltage comparator U1 outputs a low level and the output end Out2 of the second voltage comparator U2 outputs a high level, i.e., the first control end C+ is a low level and the second control end C− is a high level, as shown in Table 1. The compensation circuit 1063 does not conduct charge compensation.
In the present embodiment,
In addition, the charge compensation method according to in the present embodiment is a charge compensation method for conducting charge compensation on the pulse current generation circuit 200. The pulse current generation circuit 200 generates bidirectional pulse currents for neural stimulation. The charge compensation method includes: detecting the total charge amount during one stimulation period of the bidirectional pulse current signals generated by the pulse current generation circuit 200; judging whether the total charge amount detected by the detection circuit 1061 is less than or equal to the safe charge amount; and generating a compensation pulse current signal with a net charge amount when the judgment circuit 1062 judges that the total charge amount exceeds the safe charge amount, so that the total charge amount is within the safe charge amount.
In addition, in the charge compensation method, when the judgment circuit judges that the total charge amount is a positive value, a compensation pulse current signal with a negative compensation charge amount is generated so that the total charge amount is within the safe charge amount; and when the judgment circuit judges that the total charge amount is a negative value, a compensation pulse current signal with a positive compensation charge amount is generated so that the total charge amount is within the safe charge amount. Thus, the total charge amount for neural stimulation is more effectively ensured to be within the safe charge amount.
In some examples, when the judgment circuit 1062 judges that the total charge amount of the bidirectional pulse current signals within one stimulation period T is positive, the compensation circuit 1063 conducts negative charge compensation on the bidirectional pulse current signals generated by the current generator 104. When the judgment circuit 1062 judges that the total charge amount of the bidirectional pulse current signals within one stimulation period T is negative, the compensation circuit 1063 may generate a positive current pulse to conduct positive charge compensation on the bidirectional pulse current signals generated by the current generator 104. In the above charge compensation process, the compensation circuit 1063 preferably adopts a successive approximation charge compensation method, so as to gradually conduct charge compensation and enhance the accuracy of charge compensation. For example, the compensation circuit 1063 may generate a small current pulse to repeatedly conduct charge compensation on the bidirectional pulse current signals generated by the current generator 104. Herein, the net charge amount of the small current pulse generated by the compensation circuit 1063 may be positive or negative.
In addition, in one preferred embodiment, a charge convergence compensation method may be used to conduct charge compensation step by step, so as to improve the accuracy of charge compensation. In some examples, the detection circuit 1061 may detect the total charge amount of the bidirectional pulse current signals generated by the pulse current generation circuit 200 within one stimulation period T. The judgment circuit 1062 may judge whether the absolute value of the total charge amount of the bidirectional pulse current signals in one stimulation period T is greater than the safe charge amount. When the judgment circuit 1062 judges that the absolute value of the total charge amount of the bidirectional pulse current signals in one stimulation period T is greater than the safe charge amount, the compensation circuit 1063 conducts partial charge compensation. For example, when the judgment circuit 1062 judges that the total charge amount of the bidirectional pulse current signals in one stimulation period T is Q1 and the absolute value of Q1 is greater than Qs (Qs is the safe charge amount), the compensation circuit 1063 conducts partial charge compensation. Herein, the partial charge compensation may be proportional charge compensation. For example, charge compensation is conducted according to proportion values such as 30%, 40%, 50%, 60%, 70% and 80%.
For example, assuming that the safe charge amount is 5×10−8 coulombs, when the judgment circuit 1062 judges that the total charge amount of the bidirectional pulse current signals in one stimulation period T is negative charge of 1×10−7 coulombs, the compensation circuit 1063 may conduct positive charge compensation according to a proportion of 50%, i.e., the compensation circuit 1063 may conduct positive charge compensation of 5×10−8 coulombs. Then, the detection circuit 1061 may continue to detect the total accumulated charge amount generated by the pulse current generation circuit 200. If the judgment circuit 1062 judges that the total accumulated charge amount generated by the pulse current generation circuit 200 is negative charge of 6×10−8 coulombs, the compensation circuit 1063 conducts positive charge compensation of 3×10−8 coulombs. Next, the detection circuit 1061 continues to detect the total accumulated charge amount generated by the pulse current generation circuit 200. When the judgment circuit 1062 judges that the total accumulated charge amount generated by the pulse current generation circuit 200 exceeds the safe charge amount (5×10−8), the compensation circuit 1063 continues to conduct charge compensation according to a proportion of 50%; and the compensation circuit 1063 stops charge compensation until the judgment circuit 1062 judges that the absolute value of the total accumulated charge amount generated by the pulse current generation circuit 200 is within the safe charge amount. Of course, after the compensation circuit 1063 stops charge compensation, the detection circuit 1061 may continue to detect the total accumulated charge amount generated by the pulse current generation circuit 200, i.e., the detection circuit 1061 may be always in a working state to detect in real time. Once it is detected that the charge amount exceeds the standard (the absolute value of the total accumulated charge amount generated by the pulse current generation circuit 200 is greater than the safe charge amount), the compensation circuit 1063 may conduct charge compensation.
In some examples, the detection circuit 1061 may detect the total charge amount of the bidirectional pulse current signals generated by the pulse current generation circuit 200 within one stimulation period T. The judgment circuit 1062 may judge whether the total charge amount of the bidirectional pulse current signals in one stimulation period T is greater than the safe charge amount. When the judgment circuit 1062 judges that the total charge amount of the bidirectional pulse current signals in one stimulation period T is greater than the safe charge amount, the compensation circuit 1063 conducts partial charge compensation. For example, when the judgment circuit 1062 judges that the total charge amount of the bidirectional pulse current signals in one stimulation period T is Q1 and Q1 is greater than the safe charge amount, the compensation circuit 1063 conducts partial charge compensation. Herein, the partial charge compensation may be proportional charge compensation. For example, charge compensation is conducted according to proportion values such as 30%, 40%, 50%, 60%, 70% and 80%.
For example, when the judgment circuit 1062 judges that the total charge amount of the bidirectional pulse current signals in one stimulation period T is positive charge of 1×10−7 coulombs, the compensation circuit 1063 may conduct positive charge compensation according to a proportion of 50%, i.e., the compensation circuit 1063 may conduct negative charge compensation of 5×10−8 coulombs. Then, the detection circuit 1061 may continue to detect the total accumulated charge amount generated by the pulse current generation circuit 200. If the judgment circuit 1062 judges that the total accumulated charge amount generated by the pulse current generation circuit 200 is positive charge of 6×10−8 coulombs, the compensation circuit 1063 may continue to conduct negative charge compensation of 3×10−8 coulombs. Next, the detection circuit 1061 may continue to detect the total accumulated charge amount generated by the pulse current generation circuit 200. When the judgment circuit 1062 judges that the total accumulated charge amount generated by the pulse current generation circuit 200 exceeds the safe charge amount, the compensation circuit 1063 may continue to conduct charge compensation according to a proportion of 50%; and the compensation circuit 1063 may stop conducting charge compensation on the pulse current generation circuit 200 until the judgment circuit 1062 judges that the total accumulated charge amount generated by the pulse current generation circuit 200 is within the safe charge amount. Of course, after the compensation circuit 1063 stops charge compensation, the detection circuit 1061 may continue to detect the total accumulated charge amount generated by the pulse current generation circuit 200, i.e., the detection circuit 1061 may be always in a working state to detect in real time. Once it is detected that the charge amount exceeds the safe charge amount, the compensation circuit 1063 may conduct charge compensation.
While the present invention has been described in detail with reference to the drawings and embodiments, it is understood that the description mentioned above does not limit the present invention in any form. The present invention may be modified and changed as needed by those skilled in the art without departing from the spirit and scope of the present invention, and such modifications and variations are within the scope of the present invention.
| Number | Date | Country | Kind |
|---|---|---|---|
| 201610875326.8 | Sep 2016 | CN | national |
| 201610879293.4 | Sep 2016 | CN | national |
This application is a continuation of U.S. application Ser. No. 16/337,920, filed on Mar. 28, 2019 and issued as U.S. Pat. No. 11,097,105 on Aug. 24, 2021, the entire content of which is incorporated herein by reference and relied upon.
| Number | Name | Date | Kind |
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| 20030181957 | Greenberg et al. | Sep 2003 | A1 |
| 20070299484 | Greenberg et al. | Dec 2007 | A1 |
| Number | Date | Country |
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| 103052424 | Apr 2013 | CN |
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| Number | Date | Country | |
|---|---|---|---|
| 20220032056 A1 | Feb 2022 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 16337920 | US | |
| Child | 17445214 | US |
