Claims
- 1. A complex comprising a polypeptide bound to the chelating agent HETA of the formula: ##STR2## wherein X is selected from the group consisting of O.sub.2, NBr, H.sub.2, HCOCH.sub.2 Br and CS; and Y is selected from the group consisting of H, CH.sub.3 and C.sub.2 H.sub.5.
- 2. The complex of claim 1, wherein the polypeptide is an antibody.
- 3. The complex of claim 1, comprising a radionuclide bound to the chelating agent.
- 4. A complex comprising a polypeptide bound to the chelating agent DICAP: ##STR3##
- 5. The complex of claim 4 comprising a radionuclide bound to the chelating agent DICAP.
- 6. The complex of claim 4 comprising a metal bound to the chelating agent DICAP.
- 7. A complex comprising a polypeptide bound to the chelating agent LiLo: ##STR4## wherein n is 1 or 2.
- 8. The complex of claim 7 comprising a radionuclide bound to the chelating agent LiLo.
- 9. The complex of claim 7 comprising a metal bound to the chelating agent LiLo.
- 10. A complex comprising a polypeptide bound to the starburst LiLo ligand: ##STR5## wherein Z is ##STR6## until a desired number of COO binding sites are available in n rows of N, and a number of COO for binding=2.sup.n+1) ] and R is NCS, NHCOCH.sub.2 Br or N.sub.2 Br.
- 11. The complex of claim 10 comprising a radionuclide bound to the starburst LiLo ligand chelating agent.
- 12. The complex of claim 10 comprising a metal bound to the starburst LiLo ligand chelating agent.
- 13. The complex of claim 10, wherein the polypeptide is an antibody.
- 14. The complex of claim 1, comprising a metal bound to the chelating agent.
- 15. The complex of claim 4, wherein the polypeptide is an antibody.
- 16. The complex of claim 7, wherein the polypeptide is an antibody.
Parent Case Info
This is a continuation of U.S. patent application Ser. No. 07/720,277 filed Jun. 24, 1991, now abandoned, which is a continuation of U.S. patent application Ser. No. 07/438,558, filed Nov. 17, 1989, now abandoned, which is a continuation-in-part of U.S. Ser. No. 07/358,917 filed May 26, 1989, now abandoned.
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|
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|
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|
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Country |
0238196 |
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EPX |
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Non-Patent Literature Citations (3)
Entry |
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Subramanian et al., "New Chelating Agent for Attaching Indium-111 to Monoclonal Antibodies: In Vitro and In Vivo Evalution", Bioconjugate Chemistry, (3) 1992. |
Continuations (2)
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Number |
Date |
Country |
Parent |
720277 |
Jun 1991 |
|
Parent |
438558 |
Nov 1989 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
358917 |
May 1989 |
|