CHILDREN'S NEUROPHYSIOLOGICAL COGNITIVE ASSESSMENT TEST

Information

  • Research Project
  • 7105075
  • ApplicationId
    7105075
  • Core Project Number
    R44HD040786
  • Full Project Number
    5R44HD040786-03
  • Serial Number
    40786
  • FOA Number
  • Sub Project Id
  • Project Start Date
    8/5/2005 - 19 years ago
  • Project End Date
    7/31/2008 - 16 years ago
  • Program Officer Name
    FREUND, LISA S
  • Budget Start Date
    8/1/2006 - 18 years ago
  • Budget End Date
    7/31/2007 - 17 years ago
  • Fiscal Year
    2006
  • Support Year
    3
  • Suffix
  • Award Notice Date
    7/31/2006 - 18 years ago
Organizations

CHILDREN'S NEUROPHYSIOLOGICAL COGNITIVE ASSESSMENT TEST

[unreadable] DESCRIPTION (provided by applicant): Children and adolescents can suffer from a variety of conditions associated with abnormalities in behavior and cognitive brain function. This project will create a tool for assessing cognitive brain function in juvenile populations that is robust, repeatable, and free of cultural bias. It builds on innovative methods we have developed that combine task-related measures of response speed and accuracy with concomitant monitoring of neurophysiologic signals. We have so far established that such combined measures improve sensitivity for detecting the neurocognitive effects of medical treatments, help to separate effects due to variations in level of effort or alertness from those related to the regulation of attention and memory, are stable over time in the absence of developmental or medical changes, and are highly correlated with conventional measures of cognitive ability. However these methods are currently limited to comparing a patient's post-treatment test results to that patient's own pre-treatment baseline. This limitation is analogous to a thermometer that only tells whether a patient's temperature changed from the last measurement or an automobile whose speedometer shows change in miles per hour from yesterday. The current project is concerned with overcoming this limitation by utilizing age-matched reference groups to derive assessments of the neural correlates of sustained attention and working memory that can be used to gauge whether a child's neurocognitive ability is within normal bounds and whether it follows a typically maturational progression when tested repeatedly over an extended period. This will be accomplished in Phase II by collecting and analyzing a normative database that will enable comparison of a child's behavioral and neural responses with those of healthy age-matched peers, as well as comparison of any changes observed over time to those which would be expected as a result of normal maturational processes. The improved measures will then be validated by application to data collected from children with several clinical disorders that affect neurocognitive function including sleep disorders, epilepsy, ADHD and mild traumatic head injury. The resulting method will be embodied in a first-of-its-kind, highly automated Children's Neurophysiologic Cognitive Assessment Test (CNCAT). Because there is a large population of children that could benefit from assessment with the CNCAT in conjunction with their medical care, the test has a promising commercial future. [unreadable] [unreadable]

IC Name
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
  • Activity
    R44
  • Administering IC
    HD
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    352966
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    865
  • Ed Inst. Type
  • Funding ICs
    NICHD:352966\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    SAM TECHNOLOGY, INC.
  • Organization Department
  • Organization DUNS
    161157318
  • Organization City
    SAN FRANCISCO
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    94117
  • Organization District
    UNITED STATES